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Richard W. TeLinde Gynecologic Pathology Research Program

The Richard W. TeLinde Gynecologic Pathology Research Program continues the tradition of its namesake by researching new ways to improve the detection, treatment and prevention of all gynecologic malignancies. Richard W. TeLinde was a former chair of the Department of Gynecology and Obstetrics and author of Operative Gynecology, the premier text in gynecologic surgery for more than 60 years.

Our strong commitment to continuing his legacy is evident in our basic science and translational research, which focuses on ovarian, uterine, and cervical cancers, as well as gestational trophoblastic diseases (tumors arising in the placental cells during the early stages of pregnancy). The research of our clinical gynecologists includes identifying biomarkers for preventing gynecologic cancer and innovative surgical techniques to reduce recurrence.

Ovarian Cancer Research

Ovarian cancer is one of the most aggressive gynecologic cancers and remains one of the least understood. Our scientists are developing new tools to identify and characterize molecular alterations that occur during the formation and progression of ovarian cancers. Recent genome-wide analyses by Johns Hopkins investigators have resulted in pinpointing molecular changes in several new cancer-associated genes, including ARID1A, Rsf-1, SYK, NAC-1 and Notch3. Our translational research includes a focus on early cancer detection cancer using body fluid samples and applying innovative molecular techniques ("liquid biopsy"). We are also studying new reagents and immunotherapies that target cancer-associated molecules, with the goal of developing new drugs to treat recurrent ovarian cancer.

Uterine Cancer Research

Uterine corpus cancer is the most common gynecologic cancer. In order to better understand how it develops and progresses, the investigators at Johns Hopkins are studying its causes at the molecular level. Our researchers are also developing new molecular methods that can be introduced to clinics for screening uterine cancer using cervical cytology specimens (like the Pap smear). Our clinical scientists are evaluating new therapeutic strategies to benefit patients who suffer from specific types of uterine cancer in a clinical trial setting.

Cervical Cancer Research

Johns Hopkins is a member of the Specialized Program of Research Excellence in Cervical Cancer. With the support from the National Cancer Institute, we are conducting basic, translational and clinical studies to prevent and treat cervical cancers. Previous studies have identified connections between immune system genes and HPV16. Current projects include the development of next-generation HPV vaccines to control HPV-associated precursor lesions and invasive cancer. Our dedicated researchers are working to extend the techniques used in HPV vaccine development to the creation of vaccines targeting other cancers with defined tumor antigens.

Gestational Trophoblastic Disease Research

Gestational trophoblastic disease includes a heterogeneous group of tumors and tumor-like lesions with specific clinical features, morphologic characteristics and pathogenesis. The investigators in our program have a long interest in studying their pathogenesis by demonstrating molecular alterations that are associated with the development of various types of trophoblastic tumors. Since a correct diagnosis of different types of trophoblastic disease is critical to direct clinical management, the gynecologic pathologists in this program have applied both morphology-based and molecular tests to precisely diagnose thsese lesions. 


The Richard W. TeLinde Distinguished Professor of Gynecologic Pathology:

Photo of Dr. Ie-Ming Shih, M.D., Ph.D.

Shih, Ie-Ming, M.D., Ph.D.

Professor of Gynecology and Obstetrics
Professor of Oncology
Professor of Pathology
Richard W. TeLinde Distinguished Professor, Department of Gynecology and Obstetrics
Director of TeLinde Gynecologic Pathology Laboratory
Co-Director, Womens' Malignancy Program, Sidney Kimmel Comprehensive Cancer Center
Research Interests: Cancer Pathogenesis, Cancer Diagnostics, Molecular Cancer Therapy, Molecular and Cellular Biology
 

Researchers

Photo of Dr. Chien-Fu Hung, Ph.D.

Hung, Chien-Fu, Ph.D.

Associate Professor of Pathology
Associate Professor of Gynecology and Obstetrics
Associate Professor of Oncology
Research Interests: Gene therapies, cancer vaccines, ovarian cancer immunotherapy, cancer immunology
 
Photo of Dr. Richard B. S. Roden, Ph.D.

Roden, Richard B. S., Ph.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Professor of Oncology
Co-Director, Cancer Prevention and Control Program, Sidney Kimmel Comprehensive Cancer Center
Research Interests: Human papillomavirus (HPV), ovarian cancer, HPV virology, HPV preventive vaccine, ovarian cancer pathogenesis, proteosome inhibitor, experimental therapeutics
 
Photo of Dr. Brigitte Maria Ronnett, M.D.

Ronnett, Brigitte Maria, M.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Co-director, Johns Hopkins Gynecologic Pathology Consultation Service
Research Interests: Gynecologic pathology, molecular diagnosis of molar pregnancy, pathology of ovarian mucinous neoplasms, clinicopathological characterization of gynecologic neoplasms
 
Photo of Dr. Russell Stephen Vang, M.D.

Vang, Russell Stephen, M.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Director, Division of Gynecologic Pathology In-house Service
Co-Director, Gynecologic Pathology Fellowship Training Program
Co-Director, Gynecologic Pathology Consultation Service
Research Interests: Primary and secondary epithelial tumors of the ovary and fallopian tube, diagnostic gynecologic pathology, serous borderline tumor
 
Photo of Dr. Tian-Li Wang, Ph.D.

Wang, Tian-Li, Ph.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Professor of Oncology
Director of the Molecular Genetics Laboratory of Female Reproductive Cancer
Research Interests: Cancer genetics, epigenomics, chemoresistance in ovarian cancer, early detection of cancer, notch signaling, female reproductive cancer, chromatin remodeling and DNA damage repair
 
Photo of Dr. Tzyy-Choou Wu, M.D., M.P.H., Ph.D.

Wu, Tzyy-Choou, M.D., M.P.H., Ph.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Professor of Oncology
Director, Gynecologic Pathology Division
Director, Cervical Cancer Research Lab
Research Interests: CD8+ T lymphocytes, cervical cancer, vaccination, human papillomavirus (HPV), HPV vaccine, cellular pathology, molecular pathology, T cell biology, tumor immunology, HPV immunology