Research Lab Results for vision
Cochlear Center for Hearing and Public HealthLab WebsitePrincipal Investigator:
Frank Lin, M.D., Ph.D.
Otolaryngology - Head and Neck Surgery
The Cochlear Center for Hearing and Public Health is dedicated to training clinicians, research...ers and public health experts to study and address the impact that hearing loss has on older adults and public health. We aim to make measured local, national and global impacts through a macro level (e.g., public policy legislation), micro level (e.g., programs to deliver hearing care to individuals in a particular community), and everywhere in between (e.g., influential research publications, etc.) to adhere to our center’s overall mission and vision of effectively optimizing the health and function of an aging society and become the premier global resource for ground-breaking research and training on hearing loss and public health. view moreResearch Areas: otolaryngology, public health, audiology, gerontology, hearing loss, societal perspectives
Dagnelie Ultra Low Vision LabLab WebsitePrincipal Investigator:
Gislin Dagnelie, Ph.D., M.S.
The Ultra Low Vision Lab is interested in assessing and enhancing the functional visual abiliti...es of individuals with ultra-low vision. The lab uses psychophysical experiments to investigate innovative methods for improving visual prostheses. view moreResearch Areas: cortical and retinal visual prosthesis, retinitis pigmentosa, vision rehabilitation, low vision
King-Wai Yau LaboratoryLab WebsitePrincipal Investigator:
King-Wai Yau, Ph.D.
The King-Wai Yau Laboratory is interested in the area of sensory transduction. Specifically, we... study visual and olfactory transductions, which are the processes by which the senses of vision and olfaction are initiated.Research Areas: phototransduction, vision, sensory transduction, olfactory system
Rods and cones are the retinal photoreceptors that absorb light for initiating image vision. We are studying the cellular and molecular details underlying rod and cone phototransduction. view more
Singh Lab: Stem Cell Transplant GroupLab WebsitePrincipal Investigator:
Mandeep Singh, M.B.B.S., M.D., Ph.D.
The goal of the Singh Lab is to cure retinal degeneration due to genetic disease in patients. T...here are many retinal diseases such as Stargardts, Macular Degeneration, and Retinitis Pigmentosa, that are currently incurable. These diseases damage and eventually eliminate photoreceptors in the retina. The lab's aim is to take healthy photoreceptors derived from stem cells and transplant them into the patient’s retina to replace the lost photoreceptors. The transplanted photoreceptors are left to mature, make connections with the recipient’s remaining retina, and restore vision. Further, the lab is most interested in the cone-photoreceptor rich region of the macula, which is the central zone of the human retina, enabling high-acuity vision for tasks such as facial recognition and reading. view moreResearch Areas: photoreceptor transplantation, retinal surgery technology and device development, retinal stem cell transplantation, clinical trials in retinal gene therapy
Systems Neurobiology LaboratoryLab WebsitePrincipal Investigator:
Sascha du Lac, Ph.D.
Otolaryngology - Head and Neck Surgery
The Systems neurobiology Laboratory is a group of laboratories that all study various aspects o...f neurobiology. These laboratories include: (1) computational neurobiology Laboratory: The goal of their research is to build bridges between brain levels from the biophysical properties of synapses to the function of neural systems. (2) computational Principles of Natural Sensory Processing: Research in this lab focuses on the computational principles of how the brain processes information. (3) Laboratory for Cognitive neuroscience: This laboratory studies the neural and genetic underpinnings of language and cognition. (4) Sloan-Swartz Center for Theoretical neurobiology: The goal of this laboratory is develop a theoretical infrastructure for modern experimental neurobiology. (5) Organization and development of visual cortex: This laboratory is studying the organization and function of neural circuits in the visual cortex to understand how specific neural components enable visual perception and to elucidate the basic neural mechanisms that underlie cortical function. (6) Neural mechanism of selective visual attention: This laboratory studies the neural mechanisms of selective visual attention at the level of the individual neuron and cortical circuit, and relates these findings to perception and conscious awareness. (7) Neural basis of vision: This laboratory studies how sensory signals in the brain become integrated to form neuronal representation of the objects that people see. view moreResearch Areas: cognition, systems biology, brain, vision, neuroscience, perception
The Swenor Research GroupLab WebsitePrincipal Investigator:
Bonnielin Swenor, Ph.D., M.P.H.
The Swenor Research Group focuses on examining the interrelationship between vision loss and ag...ing. This includes determining the effects of visual impairment and eye disease on physical and cognitive functioning in older adults, and identifying interventions that could enhance the health of older adults with visual impairment and eye disease. view moreResearch Areas: cognitive functioning, access to care, vision impairment, reading, frailty, physical functioning, dual sensory impairment
Vestibular NeuroEngineering LabLab WebsitePrincipal Investigator:
Charles Della Santina, M.D., Ph.D.
Otolaryngology - Head and Neck Surgery
Research in the Vestibular NeuroEngineering Lab (VNEL) focuses on restoring inner ear function ...through “bionic” electrical stimulation, inner ear gene therapy, and enhancing the central nervous system’s ability to learn ways to use sensory input from a damaged inner ear. VNEL research involves basic and applied neurophysiology, biomedical engineering, clinical investigation and population-based epidemiologic studies. We employ techniques including single-unit electrophysiologic recording; histologic examination; 3-D video-oculography and magnetic scleral search coil measurements of eye movements; microCT; micro MRI; and finite element analysis. Our research subjects include computer models, circuits, animals and humans. For more information about VNEL, click here.Research Areas: neuroengineering, audiology, multichannel vestibular prosthesis, balance disorders, balance, vestibular, prosthetics, cochlea, vestibular implant
VNEL is currently recruiting subjects for two first-in-human clinical trials:
1) The MVI Multichannel Vestibular Implant Trial involves implantation of a “bionic” inner ear stimulator intended to partially restore sensation of head movement. Without that sensation, the brain’s image- and posture-stabilizing reflexes fail, so affected individuals suffer difficulty with blurry vision, unsteady walking, chronic dizziness, mental fogginess and a high risk of falling. Based on designs developed and tested successfully in animals over the past the past 15 years at VNEL, the system used in this trial is very similar to a cochlear implant (in fact, future versions could include cochlear electrodes for use in patients who also have hearing loss). Instead of a microphone and cochlear electrodes, it uses gyroscopes to sense head movement, and its electrodes are implanted in the vestibular labyrinth. For more information on the MVI trial, click here.
2) The CGF166 Inner Ear Gene Therapy Trial involves inner ear injection of a genetically engineered DNA sequence intended to restore hearing and balance sensation by creating new sensory cells (called “hair cells”). Performed at VNEL with the support of Novartis and through a collaboration with the University of Kansas and Columbia University, this is the world’s first trial of inner ear gene therapy in human subjects. Individuals with severe or profound hearing loss in both ears are invited to participate. For more information on the CGF166 trial, click here. view more