Research Lab Results for pathogenesis
Alison Moliterno LabPrincipal Investigator:
Alison Moliterno, M.D.
The Alison Moliterno Lab studies the molecular pathogenesis of myeloproliferative disorders (MP...Ds), including polycythemia vera, essential thrombocytosis and idiopathic myelofibrosis. Our research is focused on the genetic and epigenetic lesions associated with MPDs, with the goal of improving diagnosis and treatment for these disorders. view moreResearch Areas: blood disorders, idiopathic myelofibrosis, essential thrombocytosis, epigenetics, genomics, polycythemia vera, myeloproliferative disorders
Andrew Lane LabPrincipal Investigator:
Andrew Lane, M.D.
Otolaryngology - Head and Neck Surgery
The Lane laboratory is focused on understanding molecular mechanisms underlying chronic rhinosi...nusitis, particularly the pathogenesis of nasal polyps, as well as inflammation on the olfactory epithelium. Diverse techniques in molecular biology, immunology, and physiology are utilized to study epithelial cell innate immunity, olfactory loss, and response to viral infection. Ongoing work explores how epithelial cells of the sinuses and olfactory mucosa participate in the immune response and contribute to chronic inflammation. The lab creates and employs transgenic mouse models of chronic nasal/sinus inflammation to support research in this area. Collaborations are in place with the School of Public Health to explore mechanisms of anti-viral immunity in influenza and COVID-19. view moreResearch Areas: nasal polyps, immunology, COVID-19, olfaction, cell culture, transgenic mice, chronic rhinosinusitis, innate immunity, neuroscience, molecular biology
Bert Vogelstein LaboratoryLab WebsitePrincipal Investigator:
Bert Vogelstein, M.D.
The Bert Vogelstein Laboratory seeks to develop new approaches to the prevention or treatment o...f cancers through a better understanding of the genes and pathways underlying their pathogenesis.Research Areas: rectal cancer, colon cancer, genomics, pathogenesis
Our major focus is on cancers of the colon and rectum. We have shown that each colon neoplasm arises from a clonal expansion of one transformed cell. This expansion gives rise to a small benign colon tumor (called a polyp or adenoma). This clonal expansion and subsequent growth of the tumors appears to be caused by mutations in oncogenes and tumor suppressor genes, and the whole process is accelerated by defects in genes required for maintaining genetic instability. Mutations in four or five such genes are required for a malignant tumor to form, while fewer mutations suffice for benign tumorigenesis. As the mutations accumulate, the tumors become progressively more dangerous.
Current studies are aimed at the further characterization of the mechanisms through which these genes act, the identification of other genes that play a role in this tumor type, and the application of this knowledge to patient management. view more
Brain Tumor Cancer Genetics LabLab WebsitePrincipal Investigator:
Chetan Bettegowda, M.D., Ph.D.
The lab explores the genetic underpinnings that drive the pathogenesis of a variety of primary ...central nervous system neoplasms. We are interested in exploiting genetic changes for both diagnostic and therapeutic purposes. Our lab is currently working on understanding the extreme responders and extreme clinical phenotypes of brain and spinal cord tumors to identify factors that may modulate responses to therapy. view moreResearch Areas: brain tumor genetics, brain tumor
Brendan Cormack LaboratoryPrincipal Investigator:
Brendan Cormack, Ph.D.
Molecular Biology and Genetics
The Brendan Cormack Laboratory studies fungal pathogenesis, particularly the host-pathogen inte...raction for the yeast pathogen Candida glabrata.Research Areas: candida glabrata, pathogenesis, virulence genes, yeast, molecular biology
We are trying to identify virulence genes (genes that evolved in response to the host environment) by screening transposon mutants of C. glabrata for mutants that are specifically altered in adherence to epithelial cells, in survival in the presence of macrophages and PMNs. We also screen mutants directly in mice for those unable to colonize or persist in the normal target organs (liver, kidney and spleen).
We also focus research on a family of genes--the EPA genes--that allow the organism to bind to host cells. Our research shows that a subset of them are able to mediate adherence to host epithelial cells. We are trying to understand the contribution of this family to virulence in C. glabrata by figuring out what the ligand specificity is of different family members, how genes are normally regulated during infection, and what mechanisms normally act to keep the genes transcriptionally silent and how that silence is regulated. view more
David Graham LabPrincipal Investigator:
David Graham, Ph.D., M.S.
Molecular and Comparative Pathobiology
The David Graham Lab studies the consequences of HIV interactions with the immune system, the r...esulting pathogenesis and how to sabotage these interactions. We apply advanced technologies like mass spectrometry to dissect processes at the molecular level. We are also actively involved in cardiovascular research and studies the ways proteins are organized into functional units in different cell types of the heart.Research Areas: immunology, mass spectrometry, HIV, cardiovascular, SIV, pathogenesis
Major projects in our lab are organized into three major areas: (1) H/SIV pathogenesis and neuropathogenesis, (2) Cardiovascular disease, and (3) High technology development
David Thomas LabPrincipal Investigator:
David Thomas, M.D., M.P.H.
The David Thomas Lab oversees clinical research projects that aim to understand the natural his...tory and pathogenesis of hepatitis C virus infection. A special area of clinical and research focus is liver disease in HIV-infected people. view moreResearch Areas: HIV, hepatitis C, liver diseases
Diane Griffin LabPrincipal Investigator:
M. Griffin, M.D., Ph.D.
Research in the Diane Griffin Lab focuses on the viral, cellular and immunologic determinants o...f diseases caused by alphaviruses and the measles virus. Our current studies aim to understand the immune-system mechanisms behind viral clearance and disease enhancement. Our team is also working to understand the pathogenesis of the measles virus, with a focus on developing new vaccines and learning how the virus induces immunosuppression. view moreResearch Areas: immunology, vaccines, measles, alphavirus, encephalitis
Douglas Ball LabPrincipal Investigator:
Douglas Ball, M.D.
The Douglas Ball Lab conducts clinical trials and pre-clinical laboratory studies of thyroid ca...ncer. Our clinical trials, performed in collaboration with research staff in the upper aero-digestive group in the Sidney Kimmel Comprehensive Cancer Center, have included protocols for advanced radioiodine-refractory differentiated thyroid cancer and medullary thyroid cancer. Our pre-clinical research, conducted with Dr. Nelkin, Dr. Agrawal and other Kimmel Cancer Center researchers, includes pathogenesis and mechanisms of treatment resistance in medullary thyroid cancer, and pathogenesis and immune-directed therapy of anaplastic thyroid cancer. view moreResearch Areas: thyroid cancer, medullary thyroid cancer, cancer, anaplastic thyroid cancer
Fuchs LaboratoryLab WebsitePrincipal Investigator:
Paul Fuchs, Ph.D.
Otolaryngology - Head and Neck Surgery
The Fuchs Laboratory uses cellular electrophysiology, immunolabeling and electron microscopy to... study synaptic connections between sensory hair cells and neurons in the cochlea. One effort focuses on an unusual cholinergic receptor that mediates efferent inhibition of hair cells, driving discovery of the molecular mechanisms, and offering a target for protection against acoustic trauma. A second topic concerns the small number of unmyelinated "type II" afferent neurons whose synaptic connectivity and response properties argue for a role as the pathway for noxious (too loud) sound. Our studies are motivated by curiosity about fundamental mechanisms, and to provide a foundation for understanding cochlear pathogenesis. view moreResearch Areas: synaptic connections, immunolabeling, neurons, elecrophysiology, audiology, cellular electrophysiology, hearing loss, electron microscopy, cochlea, cochlear pathogensesis
Hamid Rabb LabPrincipal Investigator:
Hamid Rabb, M.D.
Dr. Rabb’s lab is involved in translational research aimed at understanding the molecular patho...genesis of kidney ischemia/reperfusion injury. The lab is interested in the development of novel treatments for kidney IRI. view moreResearch Areas: kidney diseases, kidney ischemia/reperfusion injuries, nephrology
IBD and Autoimmune Liver Diseases LaboratoryPrincipal Investigator:
Xu Li, Ph.D.
Investigators in the IBD and Autoimmune Liver Diseases Laboratory conduct basic and translation...al research in inflammatory bowel disease (IBD) and autoimmune liver diseases. One area of focus is discovering and developing biomarkers for diagnosing and prognosticating IBD and other autoimmune liver diseases (AILDs). We also are exploring the molecular pathogenesis of—and developing novel therapies for—IBD. In addition, we are working to understand the molecular reason why many IBD patients fail to respond to mainstay drug therapies—and to develop diagnostic assays that can predict non-responders before starting them on those therapies. These biomarker studies have led to our application for four U.S. and international patents. view moreResearch Areas: inflammatory bowel disease, Crohn’s disease, gastrointestinal system, colitis, autoimmune diseases, pathogenesis, celiac disease, liver diseases
J. Marie Hardwick LaboratoryLab WebsitePrincipal Investigator:
J. Hardwick, Ph.D.
Pharmacology and Molecular Sciences
Our research is focused on understanding the basic mechanisms of programmed cell death in disea...se pathogenesis. Billions of cells die per day in the human body. Like cell division and differentiation, cell death is also critical for normal development and maintenance of healthy tissues. Apoptosis and other forms of cell death are required for trimming excess, expired and damaged cells. Therefore, many genetically programmed cell suicide pathways have evolved to promote long-term survival of species from yeast to humans. Defective cell death programs cause disease states. Insufficient cell death underlies human cancer and autoimmune disease, while excessive cell death underlies human neurological disorders and aging. Of particular interest to our group are the mechanisms by which Bcl-2 family proteins and other factors regulate programmed cell death, particularly in the nervous system, in cancer and in virus infections. Interestingly, cell death regulators also regulate many other cellular processes prior to a death stimulus, including neuronal activity, mitochondrial dynamics and energetics. We study these unknown mechanisms.Research Areas: cell death
We have reported that many insults can trigger cells to activate a cellular death pathway (Nature, 361:739-742, 1993), that several viruses encode proteins to block attempted cell suicide (Proc. Natl. Acad. Sci. 94: 690-694, 1997), that cellular anti-death genes can alter the pathogenesis of virus infections (Nature Med. 5:832-835, 1999) and of genetic diseases (PNAS. 97:13312-7, 2000) reflective of many human disorders. We have shown that anti-apoptotic Bcl-2 family proteins can be converted into killer molecules (Science 278:1966-8, 1997), that Bcl-2 family proteins interact with regulators of caspases and regulators of cell cycle check point activation (Molecular Cell 6:31-40, 2000). In addition, Bcl-2 family proteins have normal physiological roles in regulating mitochondrial fission/fusion and mitochondrial energetics to facilitate neuronal activity in healthy brains. view more
James Hamilton LabPrincipal Investigator:
James Hamilton, M.D.
The main research interests of the James Hamilton Lab are the molecular pathogenesis of hepatoc...ellular carcinoma and the development of molecular markers to help diagnose and manage cancer of the liver. In addition, we are investigating biomarkers for early diagnosis, prognosis and response to various treatment modalities. Results of this study will provide a molecular classification of HCC and allow us to identify targets for chemoprevention and treatment. Specifically, we extract genomic DNA and total RNA from liver tissues and use this genetic material for methylation-specific PCR (MSP), cDNA microarray, microRNA microarray and genomic DNA methylation array experiments. view moreResearch Areas: Copper homeostasis, Wilson's disease, cancer, molecular genetics, Early detection biomarker discovery for hepatocellular carcinoma, genomics, pathogenesis, liver injury, liver diseases, regulation of lipid metabolism, hepatocellular carcinoma, Pathogenesis of Liver fibrosis and cancer
Jean Kim LabPrincipal Investigator:
Jean Kim, M.D., Ph.D.
Otolaryngology - Head and Neck Surgery
The Jean Kim Laboratory performs translational research in theResearch Areas: nasal polyps, chronic rhinosinusitis, hyperplastic nasal polyposis
area of chronic rhinosinusitis,... with a niche interest in the pathogenesis of hyperplastic nasal
polyposis. Studies encompass clinical research to basic wet laboratory research in
studying the underlying immune and autoimmune mediated mechanism of polyp growth and
perpetuation of disease. Human cell and tissue culture models are used. Techniques in the
laboratory include cell and tissue culture, real time PCR, immunoblot, ELISA, flow cytometry,
immunohistochemistry, electron microscopy, gene array analysis, and other molecular
approaches including genetic knockdowns. Approaches used in Dr. Kim’s clinical study
designs include prospective and retrospective analysis of patient outcomes and clinical
biomarkers, as wells controlled clinical trials.
Laboratory of Airway ImmunityPrincipal Investigator:
Stephane Lajoie, Ph.D., M.Sc.
Otolaryngology - Head and Neck Surgery
We are interested in understanding how innate immune responses regulate lung health. Innate imm...unity involves ancient, and well-conserved mediators and their actions regulate the balance between homeostasis and pathogenesis. In the lungs, innate immunity play a critical role in response to environmental exposures such as allergen and ambient particulate matter. My lab focuses on how these exposures can promote aberrant mucosal responses that can drive the development of diseases like asthma. view moreResearch Areas: allergy, type 2 immunity, asthma, particulate matter, allergens, innate immunity
Michael B. Streiff LabPrincipal Investigator:
Michael Streiff, M.D.
The Michael B. Streiff Lab conducts clinical and laboratory research of thrombophilia associate...d with malignancy. We are interested in the application of novel coagulation assays to explore the pathogenesis of thrombosis and the development of strategies to enhance the clinical management of anti-thrombotic agents. view moreResearch Areas: cancer, thrombophilia
Michael Kornberg LabLab WebsitePrincipal Investigator:
Michael Kornberg, M.D., Ph.D., M.S.
Our laboratory conducts basic and translational research aimed at better understanding the path...ogenesis of multiple sclerosis (MS) and the role of the immune system in CNS disease, particularly the processes that drive progressive disability such as neurodegeneration and remyelination failure. We currently have three parallel research programs: 1. Metabolism as a modulator of MS: We are studying how basic metabolic pathways regulate the immune system and how these pathways might be exploited to protect neurons and myelin-forming oligodendrocytes from injury. 2. Identifying pathways by which nitric oxide (NO) and other free radicals cause neuronal and axonal damage. Our lab is identifying specific signaling pathways initiated by NO and other free radicals that can be targeted by drugs to produce neuroprotection. 3. Modulating the innate immune system in MS: In collaboration with others at Johns Hopkins, we are studying ways to enhance the reparative functions of microglia while preventing maladaptive responses. This work has identified bryostatin-1 as a potential drug that may be re-purposed for this task. view moreResearch Areas: multiple sclerosis
Mohamed Atta LabPrincipal Investigator:
Mohamed Atta, M.B.B.Ch., M.D., M.P.H.
Dr. Atta and his research team explore the epidemiological and clinical interventions of a vari...ety of kidney diseases. Our goal is not only to advance the understanding of many kidney diseases but also to capitalize on novel discoveries of basic science to treat a wide range of rare and common kidney disorders.Research Areas: kidney diseases, HIV, hepatitis C
- Multi-international observational study of a rare form of amyloid (LECT2 amyloid) to understand its natural history with the ultimate interest of treating this condition.
- Our group has launched a project investigating the impact of COVID19 on the kidney to identify risk factors influencing outcome across different clinical phenotypes
- In collaboration with the Division of Infectious Diseases and the School of Public Health, our research has focused on the epidemiology of HIV and kidney disease. We also study clinical markers and contributing factors in the progression of kidney disease, and the association between kidney disease and heart disease.
- Our research group is participating in a multicenter consortium serving as a clinical core site to study the pathogenesis of HIV-associated kidney disease by providing well-characterized clinical specimens and corresponding clinical and laboratory data.
Neuroimmunopathology LabPrincipal Investigator:
Carlos Pardo-Villamizar, M.D.
The research activities of the Neuroimmunopathology Laboratory focus on studies of immunologica...l and molecular mechanisms involved in the pathogenesis of neurological disorders. Our main areas of research include studies of neurological complications of HIV infection and AIDS, multiple sclerosis, transverse myelitis, autism and epilepsy. We seek to explore and identify immunopathological mechanisms associated with neurological disease that may be the target of potential therapeutic interventions. The laboratory collaborates with other researchers and laboratories at Johns Hopkins and other institutions in projects related with studies of the interaction between the immune and central nervous systems in pathological processes leading to neurological dysfunction. view moreResearch Areas: multiple sclerosis, autism, epilepsy, HIV, transverse myelitis