Dr. Jantzie, associate professor, received her Ph.D. in Neurochemistry from the University of A...lberta in 2008. In 2013 she completed her postdoctoral fellowship in the Department of Neurology at Boston Children's Hospital & Harvard Medical School and became faculty at the University of New Mexico. Dr. Jantzie then joined the faculty Departments of Pediatrics (Neonatal-Perinatal Medicine) and Neurology at Johns Hopkins University and the Kennedy Krieger Institute in January 2019. Her lab investigates the pathophysiology of encephalopathy of prematurity, and pediatric brain injury common to infants and toddlers. Dr. Jantzie is dedicated to understanding disease processes in the developing brain as a means to identifying new therapeutic strategies and treatment targets for perinatal brain injury. Her lab studies neural substrates of cognition and executive function, inhibitory circuit formation, the role of an abnormal intrauterine environment on brain development, mechanisms of neurorepair and microglial activation and polarization. Using a diverse array of clinically relevant techniques such as MRI, cognitive assessment, and biomarker discovery, combined with traditional molecular and cellular biology, the Jantzie lab is on the front lines of translational pediatric neuroscience.? view more

Research in the Jennifer Lee-Summers Lab explores cerebrovascular autoregulation, particularly ...during anesthesia. Our previous studies have examined cerebrovascular autoregulation and blood flow in patients with hypothermia, in neonatal patients with hypoxic-ischemic encephalopathy and in pediatric patients with moyamoya disease. view more

Researchers in the Laboratory for Fetal and Neonatal Organ Regeneration in the Department of Su...rgery at the Johns Hopkins School of Medicine are studying whether cellular reprogramming, stem cells, and ex vivo modeling can be applied to improve organ regeneration in pediatric surgical patients.

To execute these aims, the lab collaborates with developmental biologists and biomedical engineers throughout the country and employs cutting-edge molecular strategies and pre-clinical animal models. view more

Dr. Raul Chavez-Valdez is an assistant professor in the Department of Pediatrics with great int...erest in the mechanisms of delayed injury and repair/regeneration in the developing neonatal brain following injury, specifically following hypoxic-ischemic encephalopathy (birth asphyxia). He collaborates with Dr. Frances Northington (Pediatrics) and Dr. Lee Martin (Pathology/Neuroscience) in unveiling the importance of programmed necrosis in the setting of brain injury induced by birth asphyxia. He is especially interested in the role of brain derived neurotrophic factor and neurotrophin-4 following birth asphyxia and the changes that may explain the suspected excitatory/ inhibitory (E/I) imbalance particularly in the hippocampus. His work is highly translational since delayed hippocampal injury due to E/I imbalance may explain memory deficits observed despite therapeutic hypothermia in neonates suffering birth asphyxia. All of these aspects of developmental neuroplasticity are the base of his Career Development Award (NIH/NINDS-K08 award) and applications to other agencies. Additionally, he is part of multiple clinical efforts as part of the Neuroscience Intensive Care Nursery (NICN). He has been a Sutland-Pakula Endowed Fellow of Neonatal Research since September 2013. view more