The Antoine Azar Lab conducts research on topics related to primary immunodeficiency diseases, ...allergies and lung disease. Specifically, we explore the role of primary immunodeficiency in certain difficult-to-treat chronic lung diseases, such as COPD, emphysema and asthma. view more

The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned an...d characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.

Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S. view more

The Gregory Diette Laboratory studies the epidemiology of lung diseases. Our focus is on asthma..., chronic obstructive pulmonary disease (COPD) and environmental causes of lung disease, including allergens and particulate matter. view more

Work in the Robert H. Brown Lab explores several topics within pulmonary physiology, with a lon...g-term goal of understanding the structural changes in the lungs that lead to the pathophysiology of lung disease. Our core studies examine the structure-function relationship of pulmonary airways and vessels as well as their role in chronic obstructive pulmonary disease (COPD) and reactive airway disease. Recent research has involved studying the mechanisms and treatment of COPD progression, new methods for treating asthma, and lung inflation and airway hyperresponsiveness. We are also exploring the impact of HIV infection on the etiology of lung disease and the pathophysiologic consequences of lung distention. view more

The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD).... We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma. view more