Research Lab Results for chronic rhinosinusitis
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Andrew Lane Lab
The Lane laboratory is focused on understanding molecular mechanisms underlying chronic rhinosi...nusitis, particularly the pathogenesis of nasal polyps, as well as inflammation on the olfactory epithelium. Diverse techniques in molecular biology, immunology, and physiology are utilized to study epithelial cell innate immunity, olfactory loss, and response to viral infection. Ongoing work explores how epithelial cells of the sinuses and olfactory mucosa participate in the immune response and contribute to chronic inflammation. The lab creates and employs transgenic mouse models of chronic nasal/sinus inflammation to support research in this area. Collaborations are in place with the School of Public Health to explore mechanisms of anti-viral immunity in influenza and COVID-19. view more
Research Areas: nasal polyps, immunology, COVID-19, olfaction, cell culture, transgenic mice, chronic rhinosinusitis, innate immunity, neuroscience, molecular biology -
Jean Kim Lab
The Jean Kim Laboratory performs translational research in the
Research Areas: nasal polyps, chronic rhinosinusitis, hyperplastic nasal polyposis
area of chronic rhinosinusitis,... with a niche interest in the pathogenesis of hyperplastic nasal
polyposis. Studies encompass clinical research to basic wet laboratory research in
studying the underlying immune and autoimmune mediated mechanism of polyp growth and
perpetuation of disease. Human cell and tissue culture models are used. Techniques in the
laboratory include cell and tissue culture, real time PCR, immunoblot, ELISA, flow cytometry,
immunohistochemistry, electron microscopy, gene array analysis, and other molecular
approaches including genetic knockdowns. Approaches used in Dr. Kim’s clinical study
designs include prospective and retrospective analysis of patient outcomes and clinical
biomarkers, as wells controlled clinical trials.
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Nicholas Rowan Lab
Dr. Rowan is actively involved in both outcomes and translational research relating to chronic ...rhinosinusitis and endoscopic skull base surgery. He has a keen interest patient-reported quality of life outcomes as well as those that pertain to smell and taste. Dr. Rowan is also involved in sinus-related clinical trials, pursuing new medical therapies and technological advancements for the treatment of patients with chronic rhinosinusitis. view more
Research Areas: clinical trials, smell and taste outcomes, Quality of life outcomes
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