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Research Lab Results for cardiovascular

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  • Nicholas Flavahan Lab

    Lab Website

    The Nicholas Flavahan Lab primarily researches the cellular interactions and subcellular signal...ing pathways that control normal vascular function and regulate the initiation of vascular disease. We use biochemical and molecular analyses of cellular mediators and cell signaling mechanisms in cultured vascular cells, while also conducting physiological assessments and fluorescent microscopic imaging of signaling systems in isolated blood vessels. A major component of our research involves aterioles, tiny blood vessles that are responsible for controlling the peripheral resistance of the cardiovascular system, which help determine organ blood flow. view more

    Research Areas: biochemistry, Raynaud's phenomenon, vascular biology, vasospasms
  • Nicola Heller Lab

    Lab Website

    Research in the Nicola Heller Lab focuses on the immunobiology of macrophages. Our team explore...s how these cells impact diseases with an inflammatory element, such as cancer, cardiovascular disease and obesity. Using a variety of techniques, including molecular and cellular biology, biochemistry, mouse models and more, we study the role of IL-4/IL-13 signaling in asthma and allergic disease, as well as the role of alternatively activated macrophages (AAM) in the pathogenesis of allergic inflammation. Currently, we are researching the links between asthma and obesity, with a focus on the roles of gender and race. view more

    Research Areas: asthma, allergies, immunobiology, inflammation, macrophages
  • Obesity Hypertension Clinic: Reversing the Negative Cardiovascular Effects of Weight (ReNEW)

    Lab Website
    Principal Investigator:
    Tammy Brady, M.D., Ph.D.
    Medicine
    Pediatrics

    Hypertension in children is a major cause of disease, including early onset heart disease. Up t...o 25% of children who are overweight or obese have hypertension (high blood pressure), and children with obesity are at greater risk for having other cardiovascular disease risk factors such as high cholesterol and diabetes. The ReNEW Clinic at The Johns Hopkins University provides an innovative multidisciplinary approach to the evaluation and treatment of obesity-related hypertension to help prevent and treat cardiovascular disease. This clinic is designed for children with elevated blood pressure (prehypertension and hypertension) and a BMI at or above the 85th percentile. Many children in this clinic are enrolled in a longitudinal registry to help researchers learn how to better care for children with multiple risk factors for heart disease.

    Read more about the ReNEW clinic: Childhood Obesity: A Focus on Hypertension

    view more

    Research Areas: obesity, hypertension, pediatric cardiology
  • Paul Ladenson Lab

    Principal Investigator:
    Paul Ladenson, M.D.
    Medicine

    The Paul Ladenson Lab studies the application of thyroid hormone analogues for treating cardiov...ascular disease; novel approaches to thyroid cancer diagnosis and management; and the health economic analyses related to thyroid patient care. view more

    Research Areas: thyroid cancer, cardiovascular diseases, endocrinology
  • Pediatric Cardiology Core Imaging Laboratory

    Principal Investigator:
    Shelby Kutty, M.D., Ph.D., M.S.
    Medicine

    The lab’s assets include three MRI systems available for pediatric studies, cardiac imaging pro...cessing, cardiovascular imaging and therapeutic ultrasound. A robust echocardiogram program conducts 10,000 transthoracic echocardiograms and 1,300 fetal echocardiograms per year, and maintains a database with 10 years of data. view more

    Research Areas: cardiac imaging, pediatric cardiology
  • Platelet Physiology Research Lab

    Principal Investigator:
    Marlene Williams, M.D.
    Medicine

    Dr. Williams' research focuses on platelet physiology particularly as it relates to acute coron...ary syndromes and depression. Her laboratory specifically examines platelet aggregation, flow cytometric analysis to measure platelet activation, platelet luminescence as a measure of the platelet release reaction, many Elisa preparations in order to measure platelet function, platelet genotyping to determine the presence of certain platelet polymorphisms, and various other assays to distinguish mechanisms of platelet dysfunction. The goal for her cardiovascular platelet laboratory is to identify the etiology of platelet dysfunction in many disease states and apply methods that may improve this dysfunction that can eventually be translated to therapies for patients with cardiovascular disease. Scientific techniques performed in the lab include: flow cytometric analysis, platelet microparticle identification, and protein immunoprecipitation among other techniques. view more

    Research Areas: platelets, Platelet drug response, Platelet Flow cytometric analysis, Platelet Aggregation
  • Pluznick Lab

    Lab Website
    Principal Investigator:
    Jennifer Pluznick, Ph.D.
    Physiology

    The Pluznick Lab is interested in the role that chemosensation plays in regulating physiologica...l processes, particularly in the kidney and the cardiovascular system. We have found that sensory receptors (olfactory receptors, taste receptors, and other G-protein coupled receptors) are expressed in the kidney and in blood vessels, and that individual receptors play functional roles in whole-animal physiology. We are currently working to identify the full complement of sensory receptors found in the kidney, and are working to understand the role that each receptor plays in whole-animal physiology by using a variety of in vitro (receptor localization, ligand screening) and in vivo (whole-animal physiology) techniques. view more

    Research Areas: sensory receptors, cardiovascular, physiology, chemosensation, renal
  • Post Lab

    Lab Website
    Principal Investigator:
    Wendy Post, M.D., M.S.
    Medicine

    The Post Lab is involved in the Multi-Ethnic Study of Atherosclerosis (MESA), a collaborative s...tudy of the characteristics of subclinical cardiovascular disease (that is, disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.

    As MESA researchers, we study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.

    Participants were recruited from six field centers across the United States, including Johns Hopkins University. Each participant received an extensive physical exam to determine a number of conditions, including coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors.

    Selected repetition of subclinical disease measures and risk factors at follow-up visits have allowed study of the progression of disease. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality.

    Wendy S. Post, MD, MS, is an associate faculty, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, and a professor of medicine.
    view more

    Research Areas: coronary artery disease, cardiovascular, ethnicity, pathogenesis, atherosclerosis, sudden cardiac death
  • Ratchford Lab

    Principal Investigator:
    Elizabeth Ratchford, M.D.
    Medicine

    Prospective registry looking at cardiovascular risk assessment and risk reduction among firefig...hters. view more

    Research Areas: Cardiovascular Disease Prevention
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