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  • Laboratory of Auditory Neurophysiology

    Lab Website

    Research in the Laboratory of Auditory Neurophysiology aims to understand brain mechanism respo...nsible for auditory perception and vocal communication in a naturalistic environment. We are interested in revealing neural mechanisms operating in the cerebral cortex and how cortical representations of biologically important sounds emerge through development and learning.

    We use a combination of state-of-the-art neurophysiological techniques and sophisticated computational and engineering tools to tackle our research questions.

    Current research in our laboratory includes the following areas (1) neural basis of auditory perception, (2) neural mechanisms for vocal communication and social interaction, and (3) cortical processing of cochlear implant stimulation.
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    Research Areas: neurophysiology, neuroengineering, audiology, cochlear implant, learning, language
  • Laboratory of Richard L. Huganir

    Lab Website
    Principal Investigator:
    Richard Huganir, Ph.D.
    Neuroscience

    The Laboratory of Richard L. Huganir is interested in the mechanisms that regulate synaptic tra...nsmission and synaptic plasticity. Our general approach is to study molecular and cellular mechanisms that regulate neurotransmitter receptors and synapse function. We are currently focusing our efforts on the mechanisms that underlie the regulation of the glutamate receptors, the major excitatory neurotransmitter receptors in the brain. view more

    Research Areas: synapses, neurotransmitters, cell biology, brain, molecular biology
  • Lee Martin Laboratory

    Lab Website
    Principal Investigator:
    Lee Martin, Ph.D.
    Pathology

    In the Lee Martin Laboratory, we are testing the hypothesis that selective vulnerability--the p...henomenon in which only certain groups of neurons degenerate in adult onset neurological disorders like amyotrophic lateral sclerosis and Alzheimer's disease--is dictated by brain regional connectivity, mitochondrial function and oxidative stress. We believe it is mediated by excitotoxic cell death resulting from abnormalities in excitatory glutamatergic signal transduction pathways, including glutamate transporters and glutamate receptors as well as their downstream intracellular signaling molecules.

    We are also investigating the contribution of neuronal/glial apoptosis and necrosis as cell death pathways in animal (including transgenic mice) models of acute and progressive neurodegeneration. We use a variety of anatomical and molecular neurobiological approaches, including neuronal tract-tracing techniques, immunocytochemistry, immunoblotting, antipeptide antibody production, transmission electron microscopy and DNA analysis to determine the precise regional and cellular vulnerabilities and the synaptic and molecular mechanisms that result in selective neuronal degeneration.
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    Research Areas: ALS, neurodegeneration, selective vulnerability, cell death, Alzheimer's disease
  • Loyal Goff Laboratory

    Lab Website
    Principal Investigator:
    Loyal Goff, Ph.D.
    Neuroscience

    The Loyal Goff Laboratory seeks to answer a fundamental biological question: How is the genome... properly interpreted to coordinate the diversity of cell types observed during neuronal development? We are focused on the acquisition of specific cellular identities in neuronal development and identifying the molecular determinants responsible for proper brain development. Using novel experimental approaches for the enrichment and purification of specific neuronal cell types and recent technological advances in single-cell RNA sequencing, we can discover and explore the cellular factors that contribute to neuronal cell fate decisions during mammalian brain development. view more

    Research Areas: brain, neuronal development, genomics, RNA
  • Machine Biointerface Lab

    Lab Website

    Dr. Fridman's research group invents and develops bioelectronics for Neuroengineering and Medic...al Instrumentation applications. We develop innovative medical technology and we also conduct the necessary biological studies to understand how the technology could be effective and safe for people.

    Our lab is currently focused on developing the "Safe Direct Current Stimulation" technology, or SDCS. Unlike the currently available commercial neural prosthetic devices, such as cochlear implants, pacemakers, or Parkinson's deep brain stimulators that can only excite neurons, SDCS can excite, inhibit, and even sensitize them to input. This new technology opens a door to a wide range of applications that we are currently exploring along with device development: e.g. peripheral nerve stimulation for suppressing neuropathic pain, vestibular nerve stimulation to correct balance disorders, vagal nerve stimulation to suppress an asthma attack, and a host of other neuroprosthetic applications.

    Medical Instrumentation MouthLab is a "tricorder" device that we invented here in the Machine Biointerface Lab. The device currently obtains all vital signs within 60s: Pulse rate, breathing rate, temperature, blood pressure, blood oxygen saturation, electrocardiogram, and FEV1 (lung function) measurement. Because the device is in the mouth, it has access to saliva and to breath and we are focused now on expanding its capability to obtaining measures of dehydration and biomarkers that could be indicative of a wide range of internal disorders ranging from stress to kidney failure and even lung cancer.
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    Research Areas: medical instruments, bioelectricities, neuroengineering, nerve stimulation
  • Marshall Shuler Laboratory

    Lab Website
    Principal Investigator:
    Marshall Shuler, Ph.D.
    Neuroscience

    The Marshall Shuler Laboratory aims to understand the means by which brain reward systems conve...y reward value, expectancy, quality, probability and utility, and the rules by which such activity is used to affect synaptic weight within brain networks to encode stimulus-action associations. We use an interdisciplinary approach combining multisite recordings of neural activity, targeted pharmacological manipulation, viral-mediated gene transfer and behavior to study the neural mechanisms of reward-based interval learning in the primary visual cortex. view more

    Research Areas: neural circuits, reward-based systems, brain, vision, pharmacology
  • Marvel Cognitive Neuropsychiatric Research Laboratory

    Lab Website
    Principal Investigator:
    Cherie Marvel, Ph.D.
    Neurology

    The Cognitive Neuropsychiatric Research Laboratory (CNRLab) is part of the Division of Cognitiv...e Neuroscience within the Department of Neurology at the Johns Hopkins University School of Medicine. Its current projects include investigating the motor system's contribution to cognitive function; HIV-related neuroplasticity and attention-to-reward as predictors of real world function; and brain function and cognition in Lyme disease. view more

    Research Areas: HIV, neuroplasticity, movement disorders, cognitive function
  • Mollie Meffert Lab

    Lab Website

    The Mollie Meffert Lab studies mechanisms underlying enduring changes in brain function. We are... interested in understanding how programs of gene expression are coordinated and maintained to produce changes in synaptic, neuronal and cognitive function. Rather than concentrating on single genes, our research is particularly focused on understanding the upstream processes that allow neuronal stimuli to synchronously orchestrate both up and down-regulation of the many genes required to mediate changes in growth and excitation. This process of gene target specificity is implicit to the appropriate production of gene expression programs that control lasting alterations in brain function. view more

    Research Areas: cognition, neuronal function, synaptic function, brain, genomics
  • Motion Analysis Laboratory

    Lab Website

    Our team is focused on understanding how complex movements are normally learned and controlled,... and how damage to specific brain areas impairs these processes. We employ several techniques to quantify movement including: 3-dimensional tracking and reconstruction of movement, recordings of muscle activity, force plate recordings, and calculation of joint forces and torques. These techniques allow for very precise measurements of many different types of movements including: walking, reaching, leg movements, hand movements and standing balance. All studies are designed to test specific hypotheses about the function of different brain areas, the cause of specific impairments and/or the effects of different interventions. view more

    Research Areas: cerebellar function, neurological diseases, motor learning
  • Neuroengineering and Biomedical Instrumentation Lab

    Lab Website

    The mission and interest of the neuroengineering and Biomedical Instrumentation Lab is to devel...op novel instrumentation and technologies to study the brain at several levels--from single cell to the whole brain--with the goal of translating the work into practical research and clinical applications.

    Our personnel include diverse, independent-minded and entrepreneurial students, post docs, and research faculty who base their research on modern microfabrication, stem cell biology, electrophysiology, signal processing, image processing, and integrated circuit design technologies.
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    Research Areas: stem cells, imaging, brain, electrophysiology, neuroengineering, biomedical engineering, neuroscience
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