Research Lab Results for autoimmune rheumatic diseases
Antony Rosen LabPrincipal Investigator:
Antony Rosen, M.B.Ch.B., M.S.
Research in the Antony Rosen Lab investigates the mechanisms shared by the autoimmune rheumatic... diseases such as lupus, myositis, rheumatoid arthritis, scleroderma and SjogrenÕs syndrome. We focus on the fate of autoantigens in target cells during various circumstances, such as viral infection, relevant immune effector pathways and exposure to ultraviolet radiation. Our recent research has sought to define the traits of autoantibodies that enable them to induce cellular or molecular dysfunction. We also work to better understand the mechanisms that form the striking connections between autoimmunity and cancer. view moreResearch Areas: myositis, lupus, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases, rheumatoid arthritis
Konig LabPrincipal Investigator:
Maximilian Konig, M.D.
The Konig Lab focuses on chimeric T cell- and antibody-based strategies for the treatment of au...toimmune rheumatic diseases and cancer. A primary goal of the translational research program is the development of antigen-specific and personalized immunotherapies for autoimmune diseases, with the intent to achieve sustained disease remission and functional cure. The lab further aims to establish precision T cell-targeting therapies for the treatment of various autoimmune diseases. Applying these tools to immuno-oncology, the lab utilizes cellular engineering strategies to augment the cytotoxic killing of solid cancers by the immune system. view moreResearch Areas: antigen-specific immunotherapy, myositis, autoimmunity, citrullination, rheumatology, antiphospholipid antibody syndrome, chimeric antigen receptor (CAR) T cell therapy, immuno-oncology, autoimmune rheumatic diseases, rheumatoid arthritis
Livia Casciola-Rosen LabPrincipal Investigator:
Livia Casciola-Rosen, Ph.D.
Work in the Livia Casciola-Rosen Lab explores the shared mechanisms present in autoimmune rheum...atic diseases, specifically scleroderma, Sjogren's syndrome and myositis. We use disease-specific autoantibodies to identify the factors that cause the autoimmune response in such diseases. Our current research involves identifying the antigen targets of autoimmune diseases, investigating the autoantigens targeted in cancers associated with rheumatic diseases and finding unique clinical biomarkers, such as the anti-HMGCR antibody specificity. view moreResearch Areas: autoantibodies, myositis, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases