Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and a...n increasing cause of death in persons living with HIV/AIDS. Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance. We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV. view more

Research in the Thomas Quinn Lab encompasses epidemiology, pathogenesis and clinical features o...f HIV/AIDS internationally, which includes the interaction between STDs and tropical diseases on the natural history and spread of HIV/AIDS in developing countries. Our recent research has examined the viral kinetics and transmission probabilities of HIV among discordant couples with the subsequent design and application of interventions, including therapy to prevent transmission of HIV. Molecular studies have mapped the molecular epidemic of HIV on a global basis, linking virologic changes to the spread of HIV and measuring the demographic impact of the epidemic. view more

Dr. Wu leads a multi-disciplinary team with collaborators from the Bloomberg School of Public H...ealth, JHU Whiting School of Engineering, and JHU Krieger School of Arts and Sciences. She conducts ongoing investigations with the Multicenter AIDS Cohort Study and Women’s Inter-agency Health Study. Her lab’s goals are to develop, implement, and validate novel imaging-based metrics of cardiac structure and function to improve risk prediction and stratification at the individual patient-level.

Research Focuses:

Predictors of Sudden Cardiac Death by Magnetic Resonance Imaging
Subclinical myocardial disease in people living with HIV
Individualized risk prediction
Cardiac structural and mechanical modeling view more