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Charles E. Dohme Memorial Symposium

Johns Hopkins Medicine
Media Relations and Public Affairs
Media Contacts: Audrey Huang; 410-614-5105;
Nick Zagorski; 443-287-2251;
September 26, 2007


WHAT:  Charles E. Dohme Memorial Symposium 
“Discoveries in Immunology and Vaccine Development”
To honor the career and scientific contributions of Dr. Joseph Thomas August.

WHO:  Six world-renowned scientists presenting the latest research in immunology and vaccine development to an audience of hundreds of research scientists.

WHEN: Tuesday, Oct. 2, 9 a.m. to 5 p.m.
WHERE: Johns Hopkins Medicine Cancer Research Building Auditorium
First floor, CRB/CRB II Connector
1650 Orleans Street, Baltimore

This year’s installment of the Charles E. Dohme sponsored distinguished lecture series will highlight an important and emerging discipline in pharmacology - immunology and vaccine development - that aims toward new approaches in vaccines against infectious diseases and cancer. This symposium also will serve to honor Dr. J. Thomas August, former director of pharmacology at Hopkins and a leader in this scientific field.

August’s research has focused on developing vaccines against several viruses, including HIV, dengue, influenza and West Nile. In 1980 he discovered a family of proteins called lysosome-associated membrane proteins (LAMP), which act in concert with other immune system proteins to activate immune responses by delivering antigens to helper T cells. This discovery prompted an explosion in immunology and led to the development of DNA vaccines targeting and enhancing the delivery of the antigens to the helper T cell pathway.

Joseph Thomas August graduated from Stanford University (B.A., 1951; M.D., 1954) and trained in medicine as the resident house physician to Sir Stanley Davidson, Royal Infirmary, University of Edinburgh, Scotland; medical resident, Beth Israel Hospital, Boston; and research fellow in medicine under Professor George Thorn, Peter Bent Brigham Hospital, Harvard Medical School. After being on the faculty at Stanford University School of Medicine, New York University School of Medicine and Albert Einstein College of Medicine, in 1976, Dr. August was appointed director of pharmacology and experimental therapeutics at The Johns Hopkins University School of Medicine. He is a Markley Scholar in Medical Sciences, a career scientist of the Health Research Council of New York and a fellow of the John Simon Guggenheim Memorial Foundation.

Symposium presentations:

“Lineage Commitment in the Immune System”
Laurie H. Glimcher, M.D.
Harvard School of Public Health

“T Cell Immune Responses to HIV: Opportunity for Vaccines”
Andrew J. McMichael, M.D., Ph.D.
John Radcliffe Hospital/Weatherall Institute of Molecular Medicine

“Understanding Immune Recognition of Complex Antigens: Experimental and Bioinformatic Approaches”
Alessandro Sette, Dr. Biol. Sc.
La Jolla Institute for Allergy and Immunology

“Harnessing Dendritic Cell Biology in Vaccine Design”
Ralph M. Steinman, M.D.
The Rockefeller University

“The Role of IL-15 in Vaccines to Elicit Long-Lived, High Avidity CTL and Overcome T Helper Deficiency”
Jay A. Berzofsky, M.D, Ph.D.
National Cancer Institute/Center for Cancer Research

“Engendering Protective Immunity in Cancer Patients-A Multi-Pronged Approach”
Eli Gilboa, Ph.D.
University of Miami/Miller School of Medicine

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