Pulmonary and Critical Care Medicine Labs

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Alison E. Turnbull Lab

Research in the Alison E. Turnbull Lab focuses on patient-clinician interactions. We study decision-making processes for ICU patients and their families and focus on the long-term outcomes of ICU survivors. Additional research examines ways to improve end-of-life care for patients.

Research Areas: epidemiology, palliative care, medical decision making, ICU

Lab Website

Principal Investigator

Alison Turnbull, D.V.M., M.P.H., Ph.D.

Department

Medicine
Brian Garibaldi Lab

Research in the Brian Garibaldi Lab focuses on acute lung injury (ALI) resolution. Recently, we evaluated the mechanisms underlying mobility therapy and found that therapeutic exercise reduces neutrophilic lung injury and skeletal muscle wasting in ALI mice.

Research Areas: pulmonary medicine, acute lung injury

Principal Investigator

Brian Garibaldi, M.D.

Department

Medicine
Charles Wiener Lab

The Charles Wiener Lab primarily conducts research on pulmonary circulation and hypoxia as well as respiratory muscle function in patients with neuromuscular diseases. Our recent studies have included investigating the treatment of pericardial effusions in patients with pulmonary arterial hypertension and examining the use of non-invasive ventilation in patients with amyotrophic lateral sclerosis (ALS). We also have an interest in medical education research. Our work in this area has included reviewing the role of academic medical centers in emerging health care markets.

Research Areas: respiratory system, neuromuscular diseases, ALS, pulmonary medicine, hypertension, hypoxia

Principal Investigator

Charles Wiener, M.D.

Department

Medicine
Christian Merlo Lab

Work in the Christian Merlo Lab includes studies on pulmonary arteriovenous malformations, outcomes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. Our recent research has also explored recipient and donor variables in the success or failure of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients.

Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant

Principal Investigator

Christian Merlo, M.D., M.P.H.

Department

Medicine
David Feller-Kopman Lab

Research interests in the David Feller-Kopman Lab include improving the multidisciplinary treatment of patients with complex airway disease, investigating the physiology and pathophysiology of non-malignant central airway obstruction and pleural disease, and developing novel methods to teach procedural skills.

Research Areas: medical education, non-malignant central airway obstruction, pathophysiology, physiology, COPD

Principal Investigator

David Feller-Kopman

Department

Medicine
David Hager Lab

Research in the David Hager Lab focuses on critical care medicine. Recent studies includes an analysis of advances in the management of the acute respiratory distress syndrome (ARDS) and the development of a targeted real-time early warning score predicting septic shock. Other interests include ventilator-induced lung injury and high-frequency ventilation.

Research Areas: critical care medicine, acute respiratory distress syndrome, high-frequency ventilation, ventilator-induced lung injury

Principal Investigator

David Hager, M.D., Ph.D.

Department

Medicine
David Moller Lab

Research in the David Moller Lab focuses on sarcoidosis, a potentially fatal inflammatory disease characterized by tiny clumps of inflammatory cells that scar the lungs, lymph nodes, skin and other major organs. We’re currently involved in a clinical trial related to genomic research in sarcoidosis and a clinical trial related to genomic research in Alpha-1 antitrypsin deficiency. Previously, we led a project that identified a potential protein trigger responsible for sarcoidosis.

Research Areas: Alpha-1 antitrypsin deficiency, sarcoidosis, genomics

Principal Investigator

David Moller, M.D.

Department

Medicine
Edward Chen Lab

Research efforts in the Edward Chen Lab focus on bleomycin-induced pulmonary fibrosis and granulomatous inflammation as well as clinical and translational studies in sarcoidosis. Our studies have included topics such as the etiologies of sarcoidosis, hylleraas hydride binding energy in diatomic electron affinities, and molecular convergence of neurodevelopmental disorders. We have also investigated the use of quantitative mass spectrometric analysis to better understand the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.

Research Areas: pulmonary medicine, sarcoidosis, granulomatous inflammation, pulmonary fibrosis

Principal Investigator

Edward Chen, M.D.

Department

Medicine
Elizabeth Daugherty Lab

The Elizabeth Daugherty Lab conducts research on patient safety, critical care infection control and critical care disaster response. We investigate methods of improving patient safety through improved infection control, with a focus on clinical outcomes, nosocomial infection rates and the individual and organizational obstacles to personal protective equipment adherence.

Research Areas: critical care medicine, patient safety, infection control, nosocomial infections

Principal Investigator

Elizabeth Daugherty, M.D., M.P.H.

Department

Medicine
Elizabeth Wagner Lab

The Elizabeth Wagner Lab conducts research on several topics within the field of pulmonary medicine. Our key areas of investigation include angiogenesis of the lung and its dependence upon systemic vascularization to regions without pulmonary perfusion as well as the role of bronchial circulation in the uptake of hydrophilic particles that are delivered to the airway surface. In addition, we are conducting several specific studies that examine the relationship between the bronchial vasculature and the influx of inflammatory cells to a patientÕs airways.

Research Areas: lung ischemia, pulmonary medicine, vascular remodeling, vascular biology, angiogenesis

Principal Investigator

Elizabeth Wagner

Department

Medicine