Pulmonary and Critical Care Medicine Labs

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Robert Wise Lab

The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD). We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma.

Research Areas: critical care medicine, emphysema, scleroderma, pulmonary medicine, asthma, lung-volume reduction surgery, COPD

Principal Investigator

Robert Wise, M.D.

Department

Medicine
Roy Brower Lab

The Roy Brower Lab conducts clinical trials related to the management of acute respiratory distress syndrome (ARDS). Our research also involves oxygen toxicity, a potentially fatal condition caused by too much supplemental oxygen.

Research Areas: acute respiratory distress syndrome, oxygen toxicity, acute lung injury

Principal Investigator

Roy Brower, M.D.

Department

Medicine
Sonye Danoff Lab

Research in the Sonye Danoff Lab includes both basic and translational studies of lung fibrosis. We have explored topics such as the role of support measures and palliative care, pulmonary manifestations of Sjogren's syndrome, idiopathic inflammatory myopathies and the treatment of cough in idiopathic pulmonary fibrosis. Our research has also involved investigating the lung as a potential target for the immune reaction in myositis.

Research Areas: myositis, interstitial lung diseases, Sjogren's syndrome, lung disease, pulmonary fibrosis, autoimmune diseases

Principal Investigator

Sonye Danoff, M.D., Ph.D.

Department

Medicine
Stephen Mathai Lab

The Stephen Mathai Lab focuses its research on pulmonary medicine. We're particularly interested in scleroderma-associated pulmonary hypertension, pulmonary complications of connective tissue disease, idiopathic pulmonary fibrosis and pulmonary hypertension.

Research Areas: scleroderma, pulmonary medicine, hypertension, pulmonary fibrosis, connective tissue disease

Principal Investigator

Stephen Mathai, M.D., M.H.S.

Department

Medicine
Susheel Patil Lab

Research in the Susheel Patil Lab focuses on the origination and development obstructive sleep apnea (OSA). Specifically, we’re interested in how obesity, adipokines and inflammation affect mechanisms that contribute to upper airway collapsibility. We’ve studied various patient groups affected by OSA, including patients who've had bariatric surgery, are HIV-infected or have non-alcoholic fatty liver disease.

Research Areas: upper airway obstruction, pulmonary medicine, pathogenesis, sleep apnea

Principal Investigator

Susheel Patil, M.D., Ph.D.

Department

Medicine
Venkataramana Sidhaye Lab

We are interested in basic and translational studies looking at the effects of environmental exposures, including cigarette smoke and electronic cigarettes, on lung epithelial function. We are focused on mechanisms to reverse injury to promote lung health, primarily in the context of Chronic Obstructive Pulmonary Disease (COPD).

Research Areas: pulmonary medicine, epithelial cells, biology, aquaporins

Lab Website

Principal Investigator

Venkataramana Sidhaye, M.D.

Department

Medicine
William Checkley Lab

Research in the William Checkley Lab explores the field of lung health, with an emphasis on the epidemiology of obstructive lung diseases as well as acute lung injury and mechanical ventilation. We also explore the interactions between nutrition and infection, and the impact of environmental exposures to health.

Research Areas: critical care medicine, epidemiology, international lung health, mechanical ventilation, acute lung injury, lung disease

Lab Website

Principal Investigator

William Checkley, M.D., Ph.D.

Department

Medicine