Pulmonary and Critical Care Medicine Labs

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Neil Aggarwal Lab

Research interests in the Neil Aggarwal Lab include the onset and treatment of acute respiratory distress syndrome. We’re also interested in genotyping and acute lung injury. Recently, we conducted a comprehensive review comparing the diagnostic accuracy of established and emerging imaging modalities for cardiac sarcoidosis.

Research Areas: acute respiratory distress syndrome, acute lung injury, genotypes

Principal Investigator

Neil Aggarwal

Department

Medicine
Noah Lechtzin Lab

Research in the Noah Lechtzin Lab investigates several important aspects of cystic fibrosis (CF), including the impact of antibiotic-resistant bacterial infections in CF patients and new therapy options for individuals with CF. Our research into new CF therapies has included studies on home electronic symptom and lung function monitoring, transbronchial needle aspiration and bedside percutaneous endoscopic gastrostomy tube placement. We also explore the role of metabolic complications in CF patients by examining how the disease is impacted by factors such as vitamin D deficiency, osteoporosis and testosterone deficiency.

Research Areas: osteoporosis, cystic fibrosis, pulmonary medicine, metabolism, antibiotic-resistant bacterial infections, testosterone

Principal Investigator

Noah Lechtzin, M.D., M.H.S.

Department

Medicine
Outcomes After Critical Illness and Surgery Group

The Outcomes After Critical Illness and Surgery Group is focused on understanding and improving patient outcomes after critical illness and surgery. Research projects include improving long-term outcomes research for acute respiratory distress syndrome/acute respiratory failure (ARDS/ARF) patients; examining the long-term outcomes for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) patients; and evaluating the effects of lower tidal volume ventilation and other aspects of critical illness and ICU care on the long-term physical and mental health outcomes of ALI/ARDS patients.

Research Areas: critical care medicine, acute respiratory distress syndrome, pulmonary medicine, acute lung injury, rehabilitation

Lab Website

Principal Investigator

Dale Needham, M.D., Ph.D.

Department

Medicine
Pali Shah Lab

Research in the Pali Shah Lab focuses on lung transplants. Specifically, we’re interested in chronic rejection and quality and safety as they relate to lung transplants.

Research Areas: health care quality, pulmonary medicine, safety, lung transplant

Principal Investigator

Pali Shah, M.D.

Department

Medicine
Patrick Sosnay Lab

The Patrick Sosnay Lab conducts translational research on cystic fibrosis. We also study genotype-phenotype relationships in patients with cystic fibrosis.

Research Areas: cystic fibrosis, genomics, genotype-phenotype relationships

Principal Investigator

Patrick Sosnay

Department

Medicine
Paul M. Hassoun Lab

The Paul M. Hassoun Lab leads research on the source and treatment of pulmonary arterial hypertension in scleroderma.

Research Areas: pulmonary arterial hypertension, scleroderma, hypertension, lung disease

Principal Investigator

Paul Hassoun, M.D.

Department

Medicine
Peter Terry Lab

Work in the Peter Terry Lab deals primarily with ethical questions surrounding patientsÕ end-of-life care and decision making. We explore topics such as family involvement in health care decision making, informed consent in clinical medicine and effectiveness of palliative support care. Our team has investigated the development and validation of a family decision-making self-efficacy scale. Our research has also included exploring the ethics around the allocation of lifesaving resources during a disaster.

Research Areas: palliative care, decision making, bioethics

Principal Investigator

Peter Terry, M.D.

Department

Medicine
Philip Smith Lab

Work in the Philip Smith Lab explores several key topics within the field of sleep medicine. We investigate the role of obesity and neural control in sleep-disordered breathing as well as the impact of metabolic function on sleep apnea. We also research the ways in which HIV and its treatments impact a patient’s sleep. Our studies have included the effects of HIV and highly active antiretroviral therapy (HAART) on both sleep and daytime function as well as the relationship between systemic inflammation and sleep apnea in men with HIV.

Research Areas: AIDS, sleep medicine, obesity, HIV, metabolic function, sleep apnea

Principal Investigator

Philip Smith, M.D.

Department

Medicine
Rachel Damico Lab

Work in the Rachel Damico Lab explores topics within the fields of vascular biology and pulmonary medicine, with a focus on acute lung injury and apoptosis in lung diseases. Our studies have included examining idiopathic and scleroderma-associated pulmonary arterial hypertension, vascular receptor autoantibodies, and the link between inflammation and the Warburg phenomenon in patients with pulmonary arterial hypertension. We have also researched the inhibitory factor of macrophage migration and its governing of endothelial cell sensitivity to LPS-induced apoptosis.

Research Areas: critical care medicine, acute lung injury, lung disease, vascular biology, apoptosis

Principal Investigator

Rachel Damico, M.D., Ph.D.

Department

Medicine
Rashmi Nisha Aurora Lab

Work in the Rashmi Nisha Aurora Lab explores topics within the field of sleep medicine, with a focus on pulmonary diseases that are disruptive to sleep and the use of polysomnography for diagnosing sleep disorders. Our recent research has included studies on home sleep testing for sleep apnea patients, the relationship between sleep-disordered breathing and caffeine consumption, and how obstructive sleep apnea impacts type 2 diabetes in older adults. We also have an interest in critical care medicine and have conducted studies on the ongoing effects of traumatic brain injuries on sleep.

Research Areas: critical care medicine, restless leg syndrome, sleep medicine, pulmonary medicine, polysomnography, lung disease, sleep disorders, sleep apnea

Principal Investigator

Nisha Aurora

Department

Medicine