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Pulmonary and Critical Care Medicine Labs

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  • Larissa Shimoda Lab

    Research in the Larissa Shimoda Lab focuses on several important topics within pulmonary and critical care medicine. We primarily study pulmonary arterial responses to chronic hypoxia as well as hypoxic pulmonary vasoconstriction and oxidant-mediated lung injury. Our recent research has included investigating the effects of chronic hypoxia on pulmonary circulation and the ways in which hypoxia-inducible factors impact pulmonary vascular responses to hypoxia. We have also studied vascular remodeling in patients with pulmonary hypertension.

    Research Areas: critical care medicine, lung injury, pulmonary medicine, lung disease, hypoxia

    Principal Investigator

    Larissa Shimoda, M.S., Ph.D.

    Department

    Medicine

  • Lonny Yarmus Lab

    Clinical trials conducted in the Lonny Yarmus Lab focus primarily on minimally-invasive diagnostic testing for patients with lung cancer and local therapy options for malignant airway obstructions. We investigate ways to improve the early diagnosis of lung cancer, as well as the treatment of later-stage cancer, using the least invasive methods possible. We are also part of the LIBERATE clinical study for patients who have difficulty breathing and suffer from severe emphysema.

    Research Areas: emphysema, interventional pulmonology, airway stenosis, minimally-invasive diagnostic testing, lung cancer, central airway obstructions, lung transplant

    Principal Investigator

    Lonny Yarmus, D.O.

    Department

    Medicine

  • Mahendra Damarla Lab

    Work in the Mahendra Damarla Lab focuses primarily on the field of vascular biology. Much of our research involves exploring alternatives to mechanical ventilation as a therapy for acute lung injury. We investigate mitogen-activated protein kinase-activated protein kinase 2 as a method to mediate apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. We have also conducted research on the prevalence of confirmatory tests in patients hospitalized with congestive heart failure or chronic obstructive pulmonary disease (COPD).

    Research Areas: critical care medicine, acute lung injury, lung disease, COPD, vascular biology, hypoxia

    Principal Investigator

    Mahendra Damarla, M.D.

    Department

    Medicine

  • Maureen Horton Lab

    The Maureen Horton Lab conducts research on pulmonary fibrosis through the use of both preclinical models and human trials. Our studies have helped to develop novel, genetic, tissue-specific models of immune dysfunction, which have aided in defining the immune regulation of fibrosis and in the development of treatment strategies. We have used T-cell skewing immunotherapy to prevent and reverse chemical-induced lung fibrosis and have conducted clinical trials for idiopathic pulmonary fibrosis (IPF), which led to one of the first treatments that helped to improve quality of life in IPF patients.

    Research Areas: interstitial lung diseases, idiopathic pulmonary fibrosis, pulmonary fibrosis, autoimmune diseases, occupational lung diseases, T cells

    Principal Investigator

    Maureen Horton, M.D.

    Department

    Medicine

  • Meredith McCormack Lab

    Research in the Meredith McCormack Lab deals primarily with pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and the role of environmental exposures in lung diseases. We have researched the factors that contribute to inner-city asthma, with a focus on how particulate matter air pollution impacts pulmonary function. We are also part of the LIBERATE clinical study, which is focused on patients who experience difficulty breathing and have been diagnosed with severe emphysema. We also have a longstanding interest in the effects of race/ethnicity, poverty and urbanization on nutrition and food allergies.

    Research Areas: emphysema, environmental exposure, asthma, lung disease, COPD, health disparities

    Principal Investigator

    Meredith McCormack, M.D., M.H.S.

    Department

    Medicine

  • Michael Drummond Lab

    Research in the Michael Drummond Lab focuses primarily on obstructive lung diseases and HIV. We work to characterize the mechanisms for development of chronic lung disease in patients with HIV, with an emphasis on studying the pulmonary compartment of smokers who have HIV and are at risk for or have developed chronic obstructive pulmonary disease (COPD). Our lab also explores the longitudinal impact of smoking, HIV infection and tobacco use on long-term outcomes in COPD patients. In addition, we investigate smoking cessation in inner-city populations and are involved in the LIBERATE study of patients with severe emphysema.

    Research Areas: critical care medicine, emphysema, smoking cessation, asthma, HIV, lung disease, COPD

    Principal Investigator

    M. Bradley Drummond

    Department

    Medicine

  • Michelle Eakin Lab

    The Michelle Eakin Lab conducts research on behavioral science and adherence and asthma outcomes in inner-city children. Our studies into behavioral science have included exploring the impact of medication adherence on lung health outcomes in patients with cystic fibrosis, disparities in anti-hypertensive medication adherence in adolescents and other key topics. We also investigate methods for improving asthma care and treatment as well as health disparities among various ethnicities, particularly in pediatric patients.

    Research Areas: cystic fibrosis, asthma, behavioral medicine, health disparities

    Principal Investigator

    Michelle Eakin, M.A., Ph.D.

    Department

    Medicine

  • Nadia Hansel Lab

    Research in the Nadia Hansel Lab investigates the clinical, pathophysiologic and public health aspects of pulmonary diseases, with a focus on asthma and chronic obstructive pulmonary disease (COPD). We have explored how environmental exposures, nutrition and diet, comorbidity and other factors influence the outcomes of diseases such as asthma and COPD.

    Research Areas: airway diseases, immunology, asthma, allergies, lung disease, COPD

    Principal Investigator

    Nadia Hansel, M.D., M.P.H.

    Department

    Medicine

  • Naresh Punjabi Lab

    The Naresh Punjabi Lab primarily studies sleep apnea, epidemiology, cardiovascular disease, insulin resistance and type 2 diabetes. Our current research focuses on the epidemiology of sleep apnea with a particular emphasis on associated sequelae, including insulin resistance, type 2 diabetes mellitus and cardiovascular disease. We have been part of the multi-center Sleep Heart Health Study, an epidemiological study on the longitudinal effects of sleep apnea on hypertension, cardiovascular disease and mortality. Our lab is examining the independent effects of intermittent hypoxia on various pathways to help elucidate the links between sleep apnea, insulin resistance and metabolic dysfunction.

    Research Areas: epidemiology, type 2 diabetes, insulin resistance, cardiovascular diseases, sleep apnea

    Principal Investigator

    Naresh Punjabi

    Department

    Medicine

  • Natalie West Lab

    The Natalie West Lab collaborates with Noah Lechtzin’s lab to study cystic fibrosis, with a particular focus on new resistant bacteria and their effect on the lung function of people with cystic fibrosis.

    Research Areas: microbiology, cystic fibrosis, resistant organisms

    Lab Website

    Principal Investigator

    Natalie West, M.D., M.H.S.

    Department

    Medicine

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