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Pulmonary and Critical Care Medicine Labs

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  • Enid Neptune Lab

    Work in the Enid Neptune Lab focuses on topics within the fields of pulmonary and critical care medicine. Our research centers primarily on therapeutic strategies for Marfan syndrome and hepatocyte growth factor signaling in airspace homeostasis. We also conduct research on chronic obstructive pulmonary disease (COPD), with a focus on its mechanisms and potential methods for preventing its progression. Our research within critical care has most recently involved investigating superoxide dismutase 3 dysregulation in neonatal lung injuries.

    Research Areas: critical care medicine, pulmonary medicine, COPD, Marfan syndrome

    Principal Investigator

    Enid Neptune, M.D.

    Department

    Medicine

  • Franco D’Alessio Lab

    The Franco D’Alessio Lab investigates key topics within the fields of critical care, internal and pulmonary medicine. We primarily explore immunological determinants of acute lung inflammation and repair. Our lab also investigates age-dependent lung immune response in patients with acute lung injury and acute respiratory distress syndrome (ARDS), regulatory T-cells in lung injury and repair, and modulation of alveolar macrophage innate immune response in ARDS.

    Research Areas: critical care medicine, acute respiratory distress syndrome, acute lung injury, lung inflammation, lung disease, T cells

    Principal Investigator

    Franco D'Alessio, M.D.

    Department

    Medicine

  • Gregory Diette Laboratory

    The Gregory Diette Laboratory studies the epidemiology of lung diseases. Our focus is on asthma, chronic obstructive pulmonary disease (COPD) and environmental causes of lung disease, including allergens and particulate matter.

    Research Areas: epidemiology, asthma, allergies, lung disease, COPD

    Principal Investigator

    Gregory Diette, M.D.

    Department

    Medicine

  • Hartmut Schneider Lab

    The Hartmut Schneider Lab studies sleep medicine and respiratory physiology during sleep. Our team develops ways to diagnose and treat patients with obstructive sleep apnea and chronic obstructive pulmonary disease (COPD). Recent inventions include a disposable pneumotachometer and a device for nasal air insufflations (NI). We recently developed a way to use both sleep and nasal insufflation treatments to reduce metabolic demand in patients with cystic fibrosis, a discovery which is now being tested in a clinical trial evaluating ways to slow down pulmonary cachexia.

    Research Areas: respiratory system, sleep medicine, cystic fibrosis, obstructive sleep apnea, COPD, nasal air insufflations

    Principal Investigator

    Hartmut Schneider

    Department

    Medicine

  • Henry Fessler Lab

    Research in the Henry Fessler Lab is focused on pulmonary medicine. We are interested in heart-lung interaction, mechanical ventilation and lung mechanics. We’re also interested in medical education and recently examined contemporary strategies for effective lecturing.

    Research Areas: medical education, heart-lung interaction, pulmonary medicine

    Principal Investigator

    Henry Fessler, M.D.

    Department

    Medicine

  • James Sham Lab

    Research in the James Sham Lab focuses on pulmonary arteries. Studies include local calcium signaling in the pulmonary arteries and transient receptor potential (TRP) channels in pulmonary arterial smooth muscle cells. We’re also interested in calcium regulation in chronic hypoxic pulmonary hypertension.

    Research Areas: chronic hypoxic pulmonary hypertension, pulmonary medicine, arteries

    Principal Investigator

    James Sham, Ph.D.

    Department

    Medicine

  • Jason Kirkness Lab

    Research in the Jason Kirkness Lab focuses on sleep disorders, including obstructive sleep apnea. We’re also interested in nocturnal ventilation and upper airways construction. We’ve used inspiratory airflows during standard polysomnography to assess pharyngeal function in children during sleep and examined the impact of increased lung volume in chronic obstructive pulmonary disease (COPD) on upper airway obstruction during sleep.

    Research Areas: nocturnal ventilation, upper airway obstruction, COPD, sleep disorders, sleep apnea

    Principal Investigator

    Jason P. Kirkness

    Department

    Medicine

  • Jonathan Jun Lab

    The Jonathan Jun Lab studies the function of lipolysis in intermittent hypoxia-induced insulin resistance.

    Research Areas: critical care medicine, lipolysis, pulmonary medicine, intermittent hypoxia-induced insulin resistance

    Lab Website

    Principal Investigator

    Jonathan Jun, M.D.

    Department

    Medicine

  • Kristin Riekert Lab

    Work in the Kristin Riekert Lab focuses on methods for improving health care quality and delivery, particularly among underserved and disadvantaged populations. Our research covers a range of important topics, including health beliefs, treatment adherence, doctor-patient communication, self-management interventions, mobile health initiatives, health disparities and patient-reported outcome methodology. We also work with the National Institutes of Health on multiple intervention trials focused on improving adherence and health outcomes in asthma, chronic kidney disease, cystic fibrosis (CF), sickle cell disease and secondhand smoke reduction.

    Research Areas: health care quality, treatment adherence, cystic fibrosis, patient-provider relationships, chronic illnesses, health disparities

    Principal Investigator

    Kristin Riekert, Ph.D.

    Department

    Medicine

  • Landon King Lab

    The Landon King Lab studies aquaporins water-specific membrane channel proteins. We hope to understand how these proteins contribute to water homeostasis in the respiratory tract and how their expression or function may be altered in disease states.

    Research Areas: respiratory system, proteomics, aquaporins

    Principal Investigator

    Landon King, M.D.

    Department

    Medicine

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