Infectious Diseases Labs

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Robert Bollinger Lab

The key research interests in the Robert Bollinger Lab include identifying biological and behavioral risk factors for HIV transmission as well as characterizing the clinical progression and treatment of HIV and related infectious diseases. We also have a long-standing interest in optimizing health care capacity and delivery in settings with limited resources. Our work includes implementing science research projects to explore the effectiveness of initiatives such as task-shifting, clinical education, distance learning and mobile health programs as a way to improve health care in these locations.

Research Areas: mobile health, international health, infectious disease, HIV, public health, point-of-care diagnostics, tropical medicine, tuberculosis, health care capacity

Principal Investigator

Robert Bollinger, M.D., M.P.H.

Department

Medicine
Stuart C. Ray Lab

Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and an increasing cause of death in persons living with HIV/AIDS. Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance. We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV.

Research Areas: immunology, Hepatitis, AIDS, HIV, hepatitis B, hepatitis C, liver diseases, synthetic biology

Lab Website

Principal Investigator

Stuart Ray, M.D.

Department

Medicine
The Transplant and Oncology Infectious Diseases (TOID) Center

The mission of the Transplant and Oncology Infectious Diseases (TOID) Center is to expand institutional expertise in clinical and academic activities focused on infectious complications in transplant (solid organ and stem cell) and oncology patients at Johns Hopkins medical institutions. Key efforts include developing standardized algorithms for the prevention and treatment of infections in these vulnerable patients and to establish an expanded infrastructure to facilitate clinical and translational studies at TOID. Current research projects focus on diagnostics for invasive fungal infections and specialized studies of the pathogenesis of candidiasis and aspergillosis.

Research Areas: transplants, candidiasis, fungal infections, infectious disease, cancer, aspergillosis

Lab Website

Principal Investigator

Kieren Marr

Department

Medicine
Thomas Quinn Lab

Research in the Thomas Quinn Lab encompasses epidemiology, pathogenesis and clinical features of HIV/AIDS internationally, which includes the interaction between STDs and tropical diseases on the natural history and spread of HIV/AIDS in developing countries. Our recent research has examined the viral kinetics and transmission probabilities of HIV among discordant couples with the subsequent design and application of interventions, including therapy to prevent transmission of HIV. Molecular studies have mapped the molecular epidemic of HIV on a global basis, linking virologic changes to the spread of HIV and measuring the demographic impact of the epidemic.

Research Areas: epidemiology, infectious disease, AIDS, HIV, sexually transmitted diseases, pathogenesis

Principal Investigator

Thomas Quinn

Department

Medicine
Trish Perl Lab

Research in the Trish Perl Lab focuses on health care-associated infections and resistant and epidemiologically significant organisms. We've been recognized globally for our innovation and use of research knowledge in the health care setting. Past projects include multiple studies funded by the Centers for Disease Control and Prevention and the VeteranÕs Affairs Administration.

Research Areas: epidemiology, infectious disease, infections, resistant organisms

Principal Investigator

Trish Perl

Department

Medicine
William Bishai Laboratory

The William Bishai Laboratory studies the molecular pathogenesis of tuberculosis. The overall goal of our laboratory is to better understand tuberculosis pathogenesis and then to employ this understanding toward improved drugs, vaccines and diagnostics. Since Mycobacterium tuberculosis senses and adapts to a wide array of conditions during the disease process, it is clear that the regulation of expression of virulence factors plays an important role in pathogenesis. As a result, a theme of our research is to assess mycobacterial genes important in gene regulation. We are also interested in cell division in mycobacteria and the pathogenesis of caseation and cavitation.

Research Areas: vaccines, genomics, drugs, pathogenesis, tuberculosis

Lab Website

Principal Investigator

William Bishai, M.D., Ph.D.

Department

Medicine
Yukari Manabe Lab

Investigators in the Yukari Manabe Lab evaluate the accuracy of rapid, point-of-care diagnostics for HIV, tuberculosis and related infectious diseases in resource-limited settings particularly sub-Saharan Africa and examine the impact of diagnostic interventions on disease detection and patient outcomes. The team also conducts operational and translational research in tuberculosis and HIV co-infection.

Research Areas: Africa, infectious disease, AIDS, HIV, point-of-care diagnostics, resource limitations, tuberculosis

Principal Investigator

Yuka Manabe, M.D.

Department

Medicine