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Infectious Diseases Labs

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  • Kelly Gebo Lab

    Work in the Kelly Gebo Lab focuses on topics such as evidence-based practice, health utilization, policy generation, health disparities in patient access to health care, HIV/AIDS, aging and hepatitis. As part of the HIV Research Network (HIVRN), our lab gathers clinical and demographic data on HIV-infected patients to help develop a single, nationwide research database. In addition, our ongoing research explores evidence-based practice in relation to the management of hepatitis C as well as HIV/AIDS in mentally ill patients. We also investigate racial and gender disparities in patients who receive highly active antiretroviral therapy.

    Research Areas: Hepatitis, AIDS, HIV, aging, health care policy, evidence-based medicine, health disparities

    Principal Investigator

    Kelly Gebo, M.D., M.P.H.

    Department

    Medicine

  • Lamichhane Lab

    Our research focuses on the biology of the peptidoglycan of Mycobacterium tuberculosis, the organism that causes tuberculosis, and Mycobacteroides abscessus, a related bacterium that causes opportunistic infections. We study basic mechanisms associated with peptidoglycan physiology but with an intent to leverage our findings to develop tools that will be useful in the clinic to treat mycobacterial infections.

    Peptidoglycan is the exoskeleton of bacteria that not only provides structural rigidity and cell shape but also several vital physiological functions. Breaching this structure is often lethal to bacteria. We are exploring fundamental mechanisms by which bacteria synthesize and preserve their peptidoglycan. Although our lab uses genetic, biochemical and biophysical approaches to study the peptidoglycan, we pursue questions irrespective of the expertise required to answer those questions. It is through these studies that we identified synergy between two beta-lactam antibiotics a...gainst select mycobacteria. view more

    Research Areas: biochemistry, infectious disease, Mycobacterium tuberculosis, genomics, tuberculosis, RNA

    Lab Website

    Principal Investigator

    Gyanu Lamichhane, Ph.D.

    Department

    Medicine

  • Larry Chang Lab

    Research in the Larry Chang Lab focuses on innovative, multidisciplinary and pragmatic approaches to impacting the HIV/AIDS pandemic. Our research investigates ways to improve HIV/AIDS care in low- and middle-income settings through strategies that include quantitative methods, qualitative methods, community-based trial designs, and behavioral science and economic evaluations. In addition, we research mobile technologies for health (mHealth) strategies for improving global public health and clinical care, including novel applications for intimate-partner violence intervention, dengue surveillance, and HIV care, surveillance and prevention.

    Research Areas: global health, infectious disease, AIDS, HIV, mHealth

    Principal Investigator

    Larry Chang, M.D., M.P.H.

    Department

    Medicine

  • Lisa Maragakis Lab

    Researchers in the Lisa Maragakis Lab are interested in health care-acquired infections and antimicrobial-resistant Gram-negative bacilli. We are particularly interested in the epidemiology, prevention and management of these infections.

    Research Areas: epidemiology, infections, health care-acquired infections, resistant organisms

    Principal Investigator

    Lisa Maragakis, M.D., M.P.H.

    Department

    Medicine

  • Mark Sulkowski Lab

    Research in the Mark Sulkowski Lab focuses on hepatitis B and hepatitis C. We've conducted clinical research related to the management of viral hepatitis, including novel agents. Other studies focus on adult patients at the Johns Hopkins site of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hepatitis B Clinical Research Network as well as the National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group.

    Research Areas: infectious disease, hepatitis B, hepatitis C

    Lab Website

    Principal Investigator

    Mark Sulkowski, M.D.

    Department

    Medicine

  • Maunank Shah Lab

    Work in the Maunank Shah Lab focuses on infectious disease modeling and health economics, and seeks to investigate new strategies for diagnosing HIV and tuberculosis (TB) in areas with limited resources, both domestically and abroad. Our primary focus is TB diagnostics, with studies examining the diagnostic test accuracy, cost-effectiveness and programmatic impact of emerging diagnostics. We have developed mobile health initiatives to incorporate video-based therapy for TB treatment, and we have a longstanding interest in interventions that help to reduce or prevent HIV transmission.

    Research Areas: health economics, mobile health, infectious disease, AIDS, HIV, tuberculosis

    Lab Website

    Principal Investigator

    Maunank Shah, M.D.

    Department

    Medicine

  • Meg Doherty Lab

    Research in the Meg Doherty Lab examines a broad range of global health priorities, including HIV/AIDS, tuberculosis, sexually transmitted infections, maternal and child health, and general infectious diseases. Research interests include HIV prevention, resistance and treatment, specifically prevention and HIV/STI treatment among commercial sex workers in Ethiopia, and isoniazid preventive treatment for HIV-infected patients. We also have a long-standing interest in the effectiveness of medical education building programs and e-learning/CME programs for resource-limited settings.

    Research Areas: global health, infectious disease, AIDS, HIV, sexually transmitted infections, tuberculosis

    Principal Investigator

    Meg Doherty

    Department

    Medicine

  • Michael Melia Lab

    Research in the Michael Melia Lab focuses primarily on nocardia infections, Lyme disease and hepatitis C. Our studies have included key topics such as risk factors for incident infections during hepatitis C treatment, racial differences in eligibility for hepatitis C treatment and misdiagnosis of Lyme arthritis using the Borrelia burgdorferi immunoblot testing method. We also have a longstanding interest in medical education and work on curriculum to improve the quality of education for medical students and interns.

    Research Areas: medical education, nocardia infections, infectious disease, AIDS, HIV, Lyme disease, hepatitis C

    Principal Investigator

    Michael Melia, M.D.

    Department

    Medicine

  • Paul Auwaerter Lab

    Research in the Paul Auwaerter Lab focuses on tick-borne diseases, include Lyme disease. We’re also interested in point-of-care information technology. Recent research includes investigating the significance of positive test results for Lyme disease in low-prevalence regions and examining the geographic expansion of Lyme disease in the southeastern U.S. from 2000 to 2014.

    Research Areas: tick-borne diseases, Lyme disease, information technology

    Principal Investigator

    Paul Auwaerter, M.B.A., M.D.

    Department

    Medicine

  • Richard Chaisson Lab

    Research in the Richard Chaisson Lab primarily examines tuberculosis and HIV infection, with specific focus on global epidemiology, clinical trials, diagnostics and public health interventions. Our recent research has involved evaluating a molecular diagnostic test for tuberculosis in HIV patients; observing TB responses during treatment of pulmonary tuberculosis; and examining antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in Southern Africa.

    Research Areas: global health, epidemiology, infectious disease, AIDS, HIV, tuberculosis

    Principal Investigator

    Richard Chaisson, M.D.

    Department

    Medicine

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