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Geriatric Medicine Labs

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  • Alicia Arbaje Lab

    Research in the Alicia Arbaje Lab aims to help older adults maintain dignity and quality of life as they age. We are particularly interested in creating health care systems to improve safety and outcomes for older adults.

    Research Areas: safety, gerontology, health care systems

    Principal Investigator

    Alicia Arbaje, M.D., M.P.H., Ph.D.

    Department

    Medicine

  • Ariel Green Lab

    Research in the Ariel Green Lab focuses on informing and improving decisions surrounding the use of invasive medical technologies for older adults with complex medical diseases. Our long-term goals are to conduct epidemiologic research, create public health initiatives, and help shape policies that improve the lives of older adults.

    Research Areas: epidemiology, health care policy, decision making, gerontology

    Principal Investigator

    Ariel R. Green, M.D., M.P.H., Ph.D.

    Department

    Medicine

  • Bruce Leff Lab

    Research interests in the Bruce Leff Lab include home hospital, guided care, medical education and long-term care.

    Research Areas: medical education, gerontology, home hospital

    Principal Investigator

    Bruce Leff, M.D.

    Department

    Medicine

  • Center on Aging and Health

    The Center on Aging and Health pursues creative approaches to solve the important health and health care problems for an aging population. Research in our center involves population-based and clinical studies of the causes, correlates, and consequences of aging-related conditions, including frailty, disability, and social isolation. We house four distinct research working groups: the Frailty and Multisystem Dysregulation Working Group; the Family and Social Resources Working Group; the Cognitive and Sensory Functions Working Group; and the Biostatistics, Design and Analysis Working Group. We provide key infrastructure, such as the statistical data core, that supports clinical- and population-based research and education with expertise in research with older adults.

    Research Areas: cognition, disabilities, behavioral research, stroke, frailty, biostatistics, dementia, gerontology

    Lab Website

    Principal Investigator

    David Roth, M.A., Ph.D.

    Department

    Medicine

  • Colleen Christmas Lab

    The Colleen Christmas Lab studies geriatric medicine, with a focus on geriatric education, interventions to reduce inappropriate nursing home citations by state surveyors, nutrition and fall prevention for geriatric patients, and perioperative geriatric care.

    Research Areas: medical education, nutrition, perioperative geriatric care, fall prevention, gerontology

    Principal Investigator

    Colleen Christmas, M.D.

    Department

    Medicine

  • Cynthia Boyd Lab

    Research in the Cynthia Boyd Lab concentrates on the clinical care of comorbid chronically ill and frail older adults, both chronically and during acute illnesses. Current projects focus on the treatment burden among older adults with multimorbidity, the importance of competing risks in decision-making for the elderly, the effects of guided care on the quality of care and the improvement of clinical practice guidelines for the elderly.

    Research Areas: quality of life, comorbidity, frailty, gerontology

    Principal Investigator

    Cynthia Boyd, M.D., M.P.H.

    Department

    Medicine

  • Danelle O. Cayea Lab

    Researchers in the Danelle O. Cayea Lab develop and evaluate curriculum that teaches the care of older adults to residents and medical students. Our work includes older adults with complex heath issues who receive care in hospital and ambulatory environments.

    Research Areas: medical education, gerontology

    Principal Investigator

    Danelle Cayea, M.D., M.S.

    Department

    Medicine

  • Esther Oh Lab

    The Esther Oh Lab is interested in developing biological markers for pre-clinical stages of Alzheimer's disease (AD). Our current research involves using transgenic models of AD to develop peripheral injections of monoclonal antibodies against amyloid-beta as a tool to detect a level of amyloid-beta that would be correlative to the amyloid-beta level in the brain.

    Research Areas: amyloid-beta, dementia, Alzheimer's disease, monoclonal antibodies

    Principal Investigator

    Esther Oh, M.D., Ph.D.

    Department

    Medicine

  • Jennifer Hayashi Lab

    Research in the Jennifer Hayashi Lab is focused on educational research related to teaching home care for doctors and interdisciplinary teams. Recently, we created a four-step process preparing a residency program for an anticipated short-term weather emergency.

    Research Areas: medical education, gerontology, in-home care

    Principal Investigator

    Jennifer Hayashi

    Department

    Medicine

  • Jeremy Barron Lab

    Research in the Jeremy Barron Lab focuses on geriatric medicine. We’re particularly interested in the health benefits of productive aging—for example, engaging in activities such as volunteering—and occupational geriatrics.

    Research Areas: occupational geriatrics, aging, gerontology

    Principal Investigator

    Jeremy Barron

    Department

    Medicine

  • Matthew McNabney Lab

    Research interests in the Matthew McNabney Lab include community-based long-term care.

    Research Areas: long-term care, gerontology

    Principal Investigator

    Matthew McNabney, M.D.

    Department

    Medicine

  • Michelle Belantoni Lab

    Research interests in the Michelle Belantoni Lab include osteoporosis screening using heel ultrasonography and quality outcomes in post-acute care settings.

    Research Areas: osteoporosis, gerontology, ultrasonography

    Principal Investigator

    Michele Bellantoni, M.D.

    Department

    Medicine

  • Older Americans Independence Center

    The Older Americans Independence Center (OAIC) studies frailty, an age-related condition in which older adults lose the capacity to cope with stressors and become vulnerable to functional decline, loss of independence and mortality. Since its original funding in 2003, the center has helped demonstrate that frailty is a syndrome caused by multiple biological mechanisms that are expressed through characteristics of decreased resiliency and reserve in older adults. The mission of OAIC is to provide a hypothesis-driven, frailty-focused, highly interdisciplinary center where supported investigators receive the expertise, resources and training necessary to make fundamental discoveries related to the origins and causes of frailty and then move these discoveries towards frailty-focused interventions.

    Research Areas: frailty, gerontology, biology

    Lab Website

    Principal Investigator

    Jeremy Walston, M.D.

    Department

    Medicine

  • Peter Abadir Lab

    Research in the Peter Abadir Lab focuses on the renin-angiotensin system (RAS), a signaling pathway that regulates blood pressure and has been linked independently to both aging and inflammation. We’re particularly interested in changes in RAS that occur with aging. We also study signal transduction and the role of the crosstalk between angiotensin II receptor in aging and are interested in understanding the function of angiotensin II in the process of vascular aging.

    Research Areas: renin-angiotensin system, aging, inflammation, gerontology

    Principal Investigator

    Peter Abadir, M.D.

    Department

    Medicine

  • Pilot and Exploratory Studies Core

    The Pilot and Exploratory Studies Core supports pilot and exploratory studies related to developing effective prevention of and therapies for frailty in older adults. Our objective is to facilitate independence in older adults. We provide funding; access to biostatistical, biological and clinical research core resources; and mentoring and oversight to completion of pilot and exploratory studies.

    Research Areas: frailty, gerontology

    Lab Website

    Principal Investigator

    Neal Fedarko, Ph.D.

    Department

    Medicine

  • Qian-Li Xue Lab

    The primary area of statistical expertise in the Qian-Li Xue Lab is the development and application of statistical methods for: (1) handling the truncation of information on underlying or unobservable outcomes (e.g., disability) as a result of screening, (2) missing data, including outcome (e.g., frailty) censoring by a competing risk (e.g., mortality) and (3) trajectory analysis of multivariate outcomes. Other areas of methodologic research interests include multivariate, latent variable models. In Women's Health and Aging Studies, we have closely collaborated with scientific investigators on the design and analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation and micronutrient deficiencies to the development and progression of frailty and disability, as well as characterizing the natural history of change in cognitive and physical function over time.

    Research Areas: epidemiology, disabilities, longitudinal data, hormonal dysregulation, women's health, inflammation, frailty, biostatistics, gerontology, latent variables

    Principal Investigator

    Qian-Li Xue, Ph.D.

    Department

    Medicine

  • Samuel Durso Lab

    The Samuel Durso Lab researches effective education models for preparing the next generation of geriatric educators. Specifically, we have developed and evaluated the "Train the Trainer" program to prepare faculty to teach geriatric medicine.

    Research Areas: medical education, gerontology

    Principal Investigator

    Samuel Durso, M.D.

    Department

    Medicine

  • Sean Leng Lab

    The Sean Leng Lab studies the biology of healthy aging. Specific projects focus on chronic inflammation in late-life decline; immunosenescence and its relationship to the basic biological and physiological changes related to aging and frailty in the human immune system; and T-cell repertoire analysis.

    Research Areas: immunology, aging, inflammation, gerontology, T cells

    Principal Investigator

    Sean Leng, M.D., Ph.D.

    Department

    Medicine

  • Sevil Yasar Lab

    Research areas in the Sevil Yasar Lab include dementia, cognitive decline, hydrocephalus and pharmacoepidemiology. Recently, we studied the ability of fatty acid amide hydrolase (FAAH) inhibitors to block the rewarding effects of nicotine in squirrel monkeys.

    Research Areas: cognition, epidemiology, pharmacoepidemiology, dementia, gerontology, hydrocephalus

    Principal Investigator

    Sevil Yasar, M.D., Ph.D.

    Department

    Medicine

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