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General Internal Medicine Labs

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  • Anika Alvanzo Lab

    Work in the Anika Alvanzo Lab focuses on screening and interventions for at-risk substance use, and race, ethnicity and sex differences in substance use disorders.

    Research Areas: substance abuse, race, health disparities

    Principal Investigator

    Anika Alvanzo, M.D.

    Department

    Medicine

  • Bimal Ashar Lab

    Research in the Bimal Ashar Lab focuses on preventive medicine, medical education and dietary supplements. Recent research explored medical residents' knowledge of dietary supplements and examined the reported validity and reliability of methods for evaluating continuing medical education.

    Research Areas: primary care, medical education, preventive medicine, dietary supplements

    Principal Investigator

    Bimal Ashar, M.B.A., M.D.

    Department

    Medicine

  • Carrie Herzke Lab

    The Carrie Herzke Lab focuses on patient safety and quality improvement. We’re also interested in infectious diseases, particularly infection control, and the education of resident and medical students.

    Research Areas: patient safety, quality improvement, infectious disease

    Principal Investigator

    Carrie Herzke, M.D.

    Department

    Medicine

  • Christopher Chute Lab

    Work in the Christopher Chute Lab involves the management of clinical data to enable effective evidence-based clinical practice and translational research. Recently, we developed an EHR-based genetic testing knowledge base to be integrated into the genetic testing ontology (GTO) and identified potential barriers to pharmacogenomics clinical decision support (CDS) implementation.

    Research Areas: pharmacogenomics, genomics, electronic health records, bioinformatics, evidence-based medicine, phenotypes

  • Claire Snyder Lab

    Researchers in the Claire Snyder Lab study the quality of cancer care, with a special focus on two areas: the quality of life for cancer patients undergoing treatment and the coordination of care between cancer specialists and primary care providers. As part of our quality-of-life research, we're investigating the use of patient-reported outcome questionnaires in routine oncology practice as well as developing a website for collecting the questionnaires and linking them with the electronic medical record. As part of our cancer-survivorship research, we've conducted large database studies to identify the physician specialties involved in the care of cancer survivors and to determine how that relates to survivors receiving recommended follow-up care. We're also working with investigators in the Sydney Kimmel Comprehensive Cancer Center to develop care strategies for breast cancer survivors.

    Research Areas: breast cancer, cancer survivors, cancer, quality of life, care coordination

    Principal Investigator

    Claire Snyder, M.H.S., Ph.D.

    Department

    Medicine

  • Craig Pollack Lab

    Research in the Craig Pollack Lab focuses on cancer prevention and control, particularly prostate cancer. Our work aims to understand how the organization environment of health care affects the type and quality of care that patients receive. Other work investigates the broader social context of health and health care— specifically housing, financial hardship and socioeconomic status.

    Research Areas: sociodemographics, prostate, cancer, quality of care

    Principal Investigator

    Craig Pollack, M.D., M.H.S.

    Department

    Medicine

  • Daniel Brotman Lab

    Research in the Daniel Brotman Lab focuses on aspects of hospital medicine such as quality improvement, patient satisfaction and perioperative medicine. We recently conducted a cohort study of hypertensive African Americans to examine how access to care, treatment ambivalence and medication non-adherence affect long-term mortality.

    Research Areas: patient satisfaction, quality improvement, African Americans, hospital medicine

    Principal Investigator

    Daniel Brotman, M.D.

    Department

    Medicine

  • Daniel Ford Lab

    Research in the Daniel Ford Lab seeks to understand the relationships between depression and various chronic medical conditions. Recently, we've focused on depression and coronary artery disease as well as tactics for improving care for patients with medical comorbidity. Our research was among the first to document depression as a risk factor for myocardial infarction and stroke. Our team is also interested in exploring how information technology can be used to improve the care of patients with depression and tobacco abuse.

    Research Areas: coronary artery disease, tobacco use, depression, stroke, information technology, myocardial infarction

    Principal Investigator

    Daniel Ford, M.D., M.P.H.

    Department

    Medicine

  • David Levine Lab

    Research in the David Levine Lab focuses on the behavioral aspects of heart and vascular disease.

    Research Areas: heart disease, behavioral medicine, vascular diseases

    Lab Website

    Principal Investigator

    David Levine

    Department

    Medicine

  • Dhananjay Vaidya Lab

    Research conducted in the Dhananjay Vaidya Lab focuses on the prevention of heart disease, with special emphasis on cardiometabolic risk factors, genetics in high-risk families, cardiovascular epidemiology, statistics and vascular biology. We also provide consultation on study design as well as plan and oversee data analyses for projects supported by the Center for Child and Community Health Research.

    Research Areas: heart disease, epidemiology, data analysis, cardiometabolic risk factors, statistics, study design, cardiovascular, genomics, vascular biology

    Principal Investigator

    Jay Vaidya, M.B.B.S., M.P.H., Ph.D.

    Department

    Medicine

  • Edgar Miller Lab

    Research in the Edgar Miller Lab focuses on nutrition, hypertension and kidney disease. Current projects include a National Heart, Lung, and Blood Institute study on dietary carbohydrate and glycemic index effects on markers of oxidative stress, inflammation and kidney function; and a National Institute of Diabetes and Digestive and Kidney Diseases randomized controlled trial that examines the effects of omega-3 fatty acid supplementation on urine protein excretion in diabetic kidney disease.

    Research Areas: nutrition, kidney diseases, diabetes, inflammation

    Principal Investigator

    Edgar Miller, M.D., Ph.D.

    Department

    Medicine

  • Eric Bass Lab

    Work in the Eric Bass Lab focuses on evidence-based medicine, comparative effectiveness research, and community health partnerships. Our work is closely aligned with the Center for Health Services and Outcomes Research and the Johns Hopkins Evidence-Based Practice Center.

    Research Areas: clinical medicine, research methods, public health, health care policy, evidence-based medicine

    Principal Investigator

    Eric B. Bass, M.D., M.P.H.

    Department

    Medicine

  • Felicia Hill-Briggs Lab

    Research in the Felicia Hill-Briggs Lab focuses on assessment methods and clinical intervention in behavioral medicine, with an emphasis on patient self-management and outcomes in ethnic minorities with chronic diseases. We are interested in the application of problem-solving and decision-making models to self-management and health behavior change. Our recent research involves examining problem-solving training for cardiovascular disease risk self-management in African Americans with type 2 diabetes. We also have a long-standing interest in cognitive/neuropsychological processes in chronic diseases, translation of research to clinical practice settings and community-based settings, and evidence-based behavioral medicine.

    Research Areas: neuropsychology, psychology, African Americans, diabetes, self-management, behavioral medicine, evidence-based medicine

    Principal Investigator

    Felicia Hill-Briggs, Ph.D.

    Department

    Medicine

  • Gail Daumit Lab

    Research in the Gail Daumit Lab is devoted to improving overall health and decreasing premature mortality for people with serious mental illnesses, such as schizophrenia and bipolar disorder. We have conducted observational studies to determine and convey the burden of physical health problems in this vulnerable population, and are currently leading a randomized trial funded by the National Heart, Lung, and Blood Institute to test a comprehensive cardiovascular risk reduction program in people with serious mental illness.

    Research Areas: mental health, schizophrenia, bipolar disorder, cardiovascular diseases

    Principal Investigator

    Gail Daumit, M.D., M.H.S.

    Department

    Medicine

  • Gail Geller Lab

    The Gail Geller Lab primarily conducts empirical quantitative and qualitative research on the ethical and social implications of genetic testing in the adult, pediatric and family contexts. We have focused on clinical-patient communication under conditions of uncertainty; professionalism and humanism in medical education; cross-cultural variation in concepts of health and disease; and clinician suffering and moral distress. We explore these topics in a range of health care contexts, including genomics, complementary and alternative medicine (CAM) and palliative care. Our researchers have a longstanding interest in medical socialization, provider-patient communication under conditions of uncertainty and cultural differences in attitudes toward health and disease. We also explore the intersection of CAM and bioethics, as well as the role of palliative care in chronic diseases, such as muscular dystrophy and sickle cell disease.

    Research Areas: palliative care, patient-provider relationships, genomics, complementary and alternative medicines, bioethics

    Principal Investigator

    Gail Geller, M.H.S., Sc.D.

    Department

    Medicine

  • Geetanjali Chander Lab

    Our research focuses at the nexus of HIV and alcohol and other substance use. We examine epidemiological aspects of HIV and alcohol use/other drug use among persons with HIV (PWH), and work on the adaptation and testing of person and computer-delivered interventions for unhealthy alcohol use, particularly among women.

    Research Areas: Ressearch at the intersection of alcohol and other substance use and HIV, intervention, substance abuse, alcohol use, HIV, hepatitis C

    Principal Investigator

    Geetanjali Chander, M.D., M.P.H.

    Department

    Medicine

  • GeneSTAR Research Program

    Research at the GeneSTAR Research Center focuses primarily on discovering and amplifying mechanisms of atherogenic vascular diseases and attendant comorbidities. We search for genetic and nongenetic factors and biological cascades that are associated with successful vascular aging and well-being. Our work includes biological, lifestyle and genetic models of both health and disease in families who are putatively at high risk for premature disease. We collect data on diet, physical activity, smoking, mental stress, cognition, sociodemographic and psychological factors, as well as traditional lipid, metabolic and inflammatory biomarkers, cardiovascular and cerebrovascular phenotypes, and measures of vascular function. Our research also seeks to better understand racial disparities and translation to population-based and patient approaches to enhancing health and wellness in diverse high-risk populations.

    Research Areas: psychology, epidemiology, sociodemographics, metabolism, genomics, vascular diseases

    Lab Website

    Principal Investigator

    Diane Becker

    Department

    Medicine

  • Howard Levy Lab

    Research interests in the Howard Levy Lab center on the integration of genetics into primary care, education of non-geneticist providers about genetics, and the natural history and management of Ehlers-Danlos syndrome and related disorders of connective tissue.

    Research Areas: primary care, tissue connectivity disorders, genomics, Ehlers-Danlos syndrome

    Principal Investigator

    Howard Levy, M.D., Ph.D.

    Department

    Medicine

  • Hsin-Chieh Yeh Lab

    Work in the Hsin-Chieh Yeh Lab focuses on clinical trials and cohort studies of diabetes, obesity and behavioral intervention, cancer and hypertension. Recent investigations have focused on novel risk factors and complications related to obesity and type 2 diabetes, particularly lung function, smoking and cancer. We recently co-led a randomized clinical trial of tailored dietary advice for consumption of dietary supplements to lower blood pressure and improve cardiovascular disease risk factors in hypertensive urban African Americans.

    Research Areas: epidemiology, African Americans, cancer, obesity, hypertension, diabetes, behavioral medicine

    Lab Website

    Principal Investigator

    Hsin-Chieh Yeh, Ph.D.

    Department

    Medicine

  • Hypertension Center

    The Hypertension Center at Johns Hopkins performs clinical research to advance the science of the diagnosis and treatment of hypertension.

    Research Areas: hypertension

    Lab Website

    Principal Investigator

    Gregory Prokopowicz, M.D., M.P.H.

    Department

    Medicine

  • J. Hunter Young Lab

    Research in the J. Hunter Young Lab focuses on the genetic epidemiology and physiology of cardiovascular disease and its risk factors, especially hypertension, diabetes and obesity. Current activities include an observational study of hypertension among African Americans; a genetic epidemiology study of worldwide cardiovascular disease susceptibility patterns; and several population-based observational studies of cardiovascular and renal disease. A recent focus group study found that changes in housing and city policies might lead to improved environmental health conditions for public housing residents.

    Research Areas: epidemiology, kidney diseases, obesity, hypertension, diabetes, genomics, physiology, cardiovascular diseases

    Principal Investigator

    Jeffery Young, M.D., M.H.S.

    Department

    Medicine

  • Jeanne Clark Lab: GIM Research

    Research in the Jeanne Clark Lab covers a wide range of fields, employing various research techniques, methods and procedures to generate and disseminate the knowledge required to prevent disease and its consequences. Our most recent research program, Look AHEAD, focuses on the health of overweight volunteers with type 2 diabetes. We are examining the long-term effects of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity.

    Research Areas: epidemiology, obesity, diabetes, liver diseases

    Lab Website

    Principal Investigator

    Jeanne Clark, M.D., M.P.H.

    Department

    Medicine

  • Jeremy Sugarman Lab

    Research in the Jeremy Sugarman Lab focuses on biomedical ethics—particularly, the application of empirical methods and evidence-based standards to the evaluation and analysis of bioethical issues. Our contributions to medical ethics and health policy include work on the ethics of informed consent, umbilical cord blood banking, stem cell research, international HIV prevention research, global health and research oversight.

    Research Areas: global health, medical ethics, stem cells, HIV, evidence-based medicine, bioethics

    Principal Investigator

    Jeremy Sugarman, M.A., M.D., M.P.H.

    Department

    Medicine

  • Jodi Segal Lab

    Research in the Jodi Segal Lab focuses on developing methodologies to use observational data to understand the use of new drugs, particularly drugs for treating diabetes, blood disorders and osteoporosis. We apply advanced methods for evidence-based review and meta-analysis, and—in collaboration with Johns Hopkins biostatisticians—we have developed new methodologies for observational research (using propensity scores to adjust for covariates that change over time) and methods to account for competing risks and heterogeneity of treatment effects in analyses.

    Research Areas: blood disorders, osteoporosis, diabetes, drugs, evidence-based medicine

    Principal Investigator

    Jodi Segal, M.D., M.P.H.

    Department

    Medicine

  • John Flynn Lab

    Research in the John Flynn Lab deals primarily with innovations in ambulatory medical education, electronic medical records and the advancement of care for patients with spondyloarthritis. Recent work has focused on ankylosing spondylitis, superior mesenteric artery syndrome, and principles of treating Lyme disease and other tickborne illnesses in an ambulatory care setting.

    Research Areas: medical education, rheumatology, Lyme disease, spondyloarthritis, arthritis

    Principal Investigator

    John Flynn

    Department

    Medicine

  • Johns Hopkins Evidence-Based Practice Center

    The Johns Hopkins Evidence-Based Practice Center conducts comprehensive, systematic reviews of important medical topics using interdisciplinary teams that integrate clinical expertise in evidence-based methods, including meta-analysis, decision analysis, benefit-harms analysis and cost-effectiveness analysis.

    Research Areas: translational research, evidence-based medicine

    Principal Investigator

    Karen Robinson, M.Sc., Ph.D.

    Department

    Medicine

  • Joseph Cofrancesco Jr. Lab

    Research in the Joseph Cofrancesco Jr. Lab focuses primarily on health care for HIV-positive patients. Our recent studies have explored topics such as HIV antiretroviral treatments, HIV resistance and the long-term complications of HIV treatment. In addition, we are part of the U.S. Fat Redistribution and Metabolism (FRAM) study and have had a long-standing involvement in projects that examine metabolic and fat complications in Thailand.

    Research Areas: antiretroviral therapies, infectious disease, AIDS, disease resistance, metabolism, HIV

    Principal Investigator

    Joseph Cofrancesco, M.D., M.P.H.

    Department

    Medicine

  • Liliana Florea Lab

    Research in the Liliana Florea Lab applies computational techniques toward modeling and problem solving in biology and genetic medicine. We work to develop computational methods for analyzing large-scale sequencing data to help characterize molecular mechanisms of diseases. The specific application areas of our research include genome analysis and comparison, cDNA-to-genome alignment, gene and alternative splicing annotation, RNA editing, microbial comparative genomics, miRNA genomics and computational vaccine design. Our most recent studies seek to achieve accurate and efficient RNA-seq correction and explore the role of HCV viral miRNA in hepatocellular carcinoma.

    Research Areas: evolutionary genomics, vaccines, carcinoma, cancer, genomics, bioinformatics, RNA, comparative genomics

    Principal Investigator

    Liliana Florea, M.Sc., Ph.D.

    Department

    Medicine

  • Lisa Cooper Lab

    The Lisa Cooper Lab is dedicated to researching patient-centered interventions for improving health outcomes and overcoming racial and ethnic disparities in health care. Our primary focus is on the factors of physician communication skills and cultural competence training, patient shared decision-making and self-management skills training. Recently, we have explored patient-centered depression care for African Americans, tactics for improving patient-physician communication about management of hypertension, and reducing ethnic and social disparities in health. In addition, we are currently researching racial disparities in cardiovascular health outcomes for patients living in Baltimore.

    Research Areas: epidemiology, patient-centered health care, patient-provider relationships, hypertension, race, health services research, cultural competence, health disparities

    Lab Website

    Principal Investigator

    Lisa Cooper, M.D., M.P.H.

    Department

    Medicine

  • Mariana Lazo Lab

    The Mariana Lazo Lab studies the epidemiology of nonalcoholic fatty liver disease, diabetes and obesity in adults. We also study the effects of moderate alcohol consumption on liver and cardiovascular diseases.

    Research Areas: fatty liver disease, epidemiology, alcohol, alcohol use, obesity, nonalcoholic fatty liver disease, diabetes, cardiovascular diseases, liver diseases

    Lab Website

    Principal Investigator

    Mariana Lazo

    Department

    Medicine

  • Mary Catherine Beach Lab

    Research in the Mary Catherine Beach Lab focuses on physician mindfulness and the patient-provider relationship and how such factors impact health care quality. Current research involves investigating the theoretical foundations of respect, as well as the impact of physician attitudes and communication on patients in the primary care setting, with a specific focus on HIV, substance abuse and sickle cell disease patients. We also explore issues such as patients’ rights, mental health parity, human subject protection, genetic discrimination, human cloning and stem cell research.

    Research Areas: physician mindfulness, mental health, sickle cell diseases, substance abuse, patient-provider relationships, HIV, patients’ rights

    Principal Investigator

    Mary Catherine Beach, M.D., M.P.H.

    Department

    Medicine

  • Matthew DeCamp Lab

    Research in the Matthew DeCamp Lab focuses on ethical issues in health reform using both conceptual and empirical methods. We examine how accountable care organizations (ACOs) are engaging patients in an effort to improve patient engagement strategies. In addition, we study social media and medical professionalism as well as ethics in global health, with a special emphasis on short-term global health training.

    Research Areas: intellectual property, accountable care organizations, social media, health training, bioethics, health care reform

    Principal Investigator

    Matthew DeCamp

    Department

    Medicine

  • Nae-Yuh Wang Lab

    The Nae-Yuh Wang Lab concentrates on a wide range of multicenter studies and randomized controlled trials. Recent studies have focused on pediatric cochlear implantation and longitudinal data analysis. One recent study found that partnering with primary care providers to deliver weight loss programs may promote greater participant satisfaction and weight loss. Another active study is assessing the effectiveness of promising interventions to reduce race disparities in live donor kidney transplantation.

    Research Areas: epidemiology, longitudinal data, kidney transplants, cochlear implant, biostatistics, weight loss

    Principal Investigator

    Nae-Yuh Wang, M.S., Ph.D.

    Department

    Medicine

  • Nisa Maruthur Lab

    The Nisa Maruthur Lab studies primary care; individualized medicine for the prevention and treatment of type 2 diabetes and obesity; pharmacogenomics of type 2 diabetes; and comparative effectiveness.

    Research Areas: primary care, obesity, pharmacogenomics, diabetes

    Principal Investigator

    Nisa Maruthur, M.D., M.H.S.

    Department

    Medicine

  • Raquel Greer Lab

    Work in the Raquel Greer Lab focuses primarily on health disparities in chronic kidney disease. Our most recent research explored the challenges perceived by primary care providers in educating patients about chronic kidney disease as well as physicians’ views on barriers to adequate preparation of patients for renal replacement therapy. We also are interested in examining how clinical-patient communication can impact quality of care in the primary care setting.

    Research Areas: primary care, kidney diseases, patient-provider relationships

    Principal Investigator

    Raquel Greer, M.D., M.H.S.

    Department

    Medicine

  • Richard Moore Lab

    Research interests in the Richard Moore Lab include clinical epidemiology, costs, cost-effectiveness and outcomes of HIV/AIDS. We recently examined whether the effect of delaying antiretroviral therapy initiation in HIV-positive adults is modified by age at entry into care.

    Research Areas: epidemiology, antiretroviral therapies, AIDS, HIV

    Principal Investigator

    Richard Moore, M.D.

    Department

    Medicine

  • Romsai Boonyasai Lab

    Research in the Romsai Boonyasai Lab focuses on systems-based approaches for improving health care quality, including reducing harm during care transitions after hospital discharge and improving outcomes related to hypertension and other chronic diseases. We recently have focused on developing and evaluating practice-based tools for improving the accuracy of blood pressure measurement, overcoming clinical inertia to treatment, and engaging patients in self-management of their health.

    Research Areas: health care quality, hypertension, care coordination, chronic illnesses

    Lab Website

    Principal Investigator

    Romsai Boonyasai, M.D., M.P.H.

    Department

    Medicine

  • Sarah Clever Lab

    Work in the Sarah Clever Lab focuses on medical education, patient-provider communication and the role of shared decision-making in patient recovery. We recently examined the ethical dilemmas of caring for “influential” patients whose attributes and characteristics (for example, social status, occupation, or position), coupled with their behavior, have the potential to significantly affect a clinician's judgment or actions.

    Research Areas: medical education, medical decision making, patient-provider relationships

    Principal Investigator

    Sarah Clever, M.D.

    Department

    Medicine

  • Sonal Singh Lab

    Investigators in the Sonal Singh Lab work to translate biomedical evidence into sound public policy and clinical care—and to ensure that stakeholders are informed enough about treatment choices to make evidence-based decisions. We're experts in conducting rigorous, systematic epidemiologic reviews, observational studies, multi-criteria decision analysis and benefit-risk assessment of drugs. Our studies of medication safety include detecting pancreatitis risk with GLP-based therapies for type 2 diabetes and detecting the risk of cardiovascular events with varenicline, inhaled anticholinergics and rosiglitazone. This work has influenced policy and been incorporated into national and international guidelines. We've also participated in studies of sexual violence against women and developed new scales to measure attacks on health workers in conflict settings and human-rights violations among men who have sex with men in Nepal.

    Research Areas: diabetes, drugs, human rights, sexual violence, cardiovascular diseases, evidence-based medicine, public policy

    Principal Investigator

    Sonal Singh

    Department

    Medicine

  • Spyridon Marinopoulos Lab

    Research interests in the Spyridon Marinopoulos Lab include evidence-based medicine. Recently, we examined the impact of health information technology (IT) that supports patient-centered care (PCC) and found substantial evidence that health IT applications with PCC-related components have a positive effect on health care outcomes.

    Research Areas: breast cancer, patient-centered health care, health IT, diabetes, evidence-based medicine

    Principal Investigator

    Spyridon Marinopoulos, M.B.A., M.D.

    Department

    Medicine

  • Wendy Bennett Lab

    Research in the Wendy Bennett Lab focuses on weight management and women's health. We also examine health disparities in low-income children and pregnant and postpartum women.

    Research Areas: women, weight loss, health disparities

    Principal Investigator

    Wendy Bennett, M.D., M.P.H.

    Department

    Medicine

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