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General Internal Medicine Labs

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  • J. Hunter Young Lab

    Research in the J. Hunter Young Lab focuses on the genetic epidemiology and physiology of cardiovascular disease and its risk factors, especially hypertension, diabetes and obesity. Current activities include an observational study of hypertension among African Americans; a genetic epidemiology study of worldwide cardiovascular disease susceptibility patterns; and several population-based observational studies of cardiovascular and renal disease. A recent focus group study found that changes in housing and city policies might lead to improved environmental health conditions for public housing residents.

    Research Areas: epidemiology, kidney diseases, obesity, hypertension, diabetes, genomics, physiology, cardiovascular diseases

    Principal Investigator

    Jeffery Young, M.D., M.H.S.

    Department

    Medicine

  • Jeanne Clark Lab: GIM Research

    Research in the Jeanne Clark Lab covers a wide range of fields, employing various research techniques, methods and procedures to generate and disseminate the knowledge required to prevent disease and its consequences. Our most recent research program, Look AHEAD, focuses on the health of overweight volunteers with type 2 diabetes. We are examining the long-term effects of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity.

    Research Areas: epidemiology, obesity, diabetes, liver diseases

    Lab Website

    Principal Investigator

    Jeanne Clark, M.D., M.P.H.

    Department

    Medicine

  • Jeremy Sugarman Lab

    Research in the Jeremy Sugarman Lab focuses on biomedical ethics—particularly, the application of empirical methods and evidence-based standards to the evaluation and analysis of bioethical issues. Our contributions to medical ethics and health policy include work on the ethics of informed consent, umbilical cord blood banking, stem cell research, international HIV prevention research, global health and research oversight.

    Research Areas: global health, medical ethics, stem cells, HIV, evidence-based medicine, bioethics

    Principal Investigator

    Jeremy Sugarman, M.A., M.D., M.P.H.

    Department

    Medicine

  • Jodi Segal Lab

    Research in the Jodi Segal Lab focuses on developing methodologies to use observational data to understand the use of new drugs, particularly drugs for treating diabetes, blood disorders and osteoporosis. We apply advanced methods for evidence-based review and meta-analysis, and—in collaboration with Johns Hopkins biostatisticians—we have developed new methodologies for observational research (using propensity scores to adjust for covariates that change over time) and methods to account for competing risks and heterogeneity of treatment effects in analyses.

    Research Areas: blood disorders, osteoporosis, diabetes, drugs, evidence-based medicine

    Principal Investigator

    Jodi Segal, M.D., M.P.H.

    Department

    Medicine

  • John Flynn Lab

    Research in the John Flynn Lab deals primarily with innovations in ambulatory medical education, electronic medical records and the advancement of care for patients with spondyloarthritis. Recent work has focused on ankylosing spondylitis, superior mesenteric artery syndrome, and principles of treating Lyme disease and other tickborne illnesses in an ambulatory care setting.

    Research Areas: medical education, rheumatology, Lyme disease, spondyloarthritis, arthritis

    Principal Investigator

    John Flynn

    Department

    Medicine

  • Johns Hopkins Evidence-Based Practice Center

    The Johns Hopkins Evidence-Based Practice Center conducts comprehensive, systematic reviews of important medical topics using interdisciplinary teams that integrate clinical expertise in evidence-based methods, including meta-analysis, decision analysis, benefit-harms analysis and cost-effectiveness analysis.

    Research Areas: translational research, evidence-based medicine

    Principal Investigator

    Karen Robinson, M.Sc., Ph.D.

    Department

    Medicine

  • Joseph Cofrancesco Jr. Lab

    Research in the Joseph Cofrancesco Jr. Lab focuses primarily on health care for HIV-positive patients. Our recent studies have explored topics such as HIV antiretroviral treatments, HIV resistance and the long-term complications of HIV treatment. In addition, we are part of the U.S. Fat Redistribution and Metabolism (FRAM) study and have had a long-standing involvement in projects that examine metabolic and fat complications in Thailand.

    Research Areas: antiretroviral therapies, infectious disease, AIDS, disease resistance, metabolism, HIV

    Principal Investigator

    Joseph Cofrancesco, M.D., M.P.H.

    Department

    Medicine

  • Liliana Florea Lab

    Research in the Liliana Florea Lab applies computational techniques toward modeling and problem solving in biology and genetic medicine. We work to develop computational methods for analyzing large-scale sequencing data to help characterize molecular mechanisms of diseases. The specific application areas of our research include genome analysis and comparison, cDNA-to-genome alignment, gene and alternative splicing annotation, RNA editing, microbial comparative genomics, miRNA genomics and computational vaccine design. Our most recent studies seek to achieve accurate and efficient RNA-seq correction and explore the role of HCV viral miRNA in hepatocellular carcinoma.

    Research Areas: evolutionary genomics, vaccines, carcinoma, cancer, genomics, bioinformatics, RNA, comparative genomics

    Principal Investigator

    Liliana Florea, M.Sc., Ph.D.

    Department

    Medicine

  • Lisa Cooper Lab

    The Lisa Cooper Lab is dedicated to researching patient-centered interventions for improving health outcomes and overcoming racial and ethnic disparities in health care. Our primary focus is on the factors of physician communication skills and cultural competence training, patient shared decision-making and self-management skills training. Recently, we have explored patient-centered depression care for African Americans, tactics for improving patient-physician communication about management of hypertension, and reducing ethnic and social disparities in health. In addition, we are currently researching racial disparities in cardiovascular health outcomes for patients living in Baltimore.

    Research Areas: epidemiology, patient-centered health care, patient-provider relationships, hypertension, race, health services research, cultural competence, health disparities

    Lab Website

    Principal Investigator

    Lisa Cooper, M.D., M.P.H.

    Department

    Medicine

  • Mariana Lazo Lab

    The Mariana Lazo Lab studies the epidemiology of nonalcoholic fatty liver disease, diabetes and obesity in adults. We also study the effects of moderate alcohol consumption on liver and cardiovascular diseases.

    Research Areas: fatty liver disease, epidemiology, alcohol, alcohol use, obesity, nonalcoholic fatty liver disease, diabetes, cardiovascular diseases, liver diseases

    Lab Website

    Principal Investigator

    Mariana Lazo

    Department

    Medicine

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