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Research in the John Aucott Lab focuses on the development of accurate diagnostic tests for all stages of Lyme disease. We work closely with Dr. Mark Soloski on the Study of Lyme disease Immunology and Clinical Events (SLICE), a longitudinal, matched-control study of patients diagnosed with early untreated Lyme disease. The objective is to use the collected biological samples to help identify novel Lyme disease biomarkers that can inform diagnoses, outcomes and the knowledge about disease pathophysiology.
The Laura Hummers Lab participates in a number of clinical trials and clinical investigations at the Scleroderma Center at Johns Hopkins. We have a particular interest in the predictors of outcomes in scleroderma. We’ve established a prospective cohort of 300 scleroderma patients to identify incident vascular outcomes in the hopes of identifying new biomarkers for disease development and progression.
Research in the Paul Rothman Lab has focused on cytokines. We’ve investigated the role these molecules play in the normal development of blood cells as well as the abnormal blood-cell development that leads to leukemia. We’ve also studied the function of cytokines in immune system responses to asthma and allergies.
Research interests in the Philip Seo Lab include the assessment and treatment of ANCA-associated vasculitides, particularly Churg-Strauss syndrome, granulomatosis with polyangiitis and microscopic polyangiitis.
The Rebecca Manno Lab studies the effects of rheumatic diseases, particularly inflammatory arthritis and vasculitis, on older adults’ muscles, strength and function. Other research examines the impact of resistance exercise and nutrition on muscle, strength and inflammation in patients with inflammatory arthritis and vasculitis.
Research in the Thomas Grader-Beck Lab aims to understand the pathogenesis of systemic autoimmune diseases—particularly systemic lupus erythematosus (SLE) and Sjögren’s syndrome—by taking a translational approach. Autoantibodies (antibodies that target self-molecules) are believed to contribute significantly to the disease process. We are studying mechanisms that may make self-structures immunogenic. We theorize that certain post-translational antigen modifications, which can occur in infections or malignant transformation, result in the expression of neoepitopes that spread autoimmunity in the proper setting. The team has combined studies that employ a number of mouse strains, certain gene-deficient mice and human biological specimens.
The Zsuzsanna McMahan Lab conducts translational research that seeks to identify the novel antigens in scleroderma and to define the target tissue in this disease. We are conducting two active clinical research trials, including one that studies skin biopsy specimens as biomarkers of scleroderma and the response to mycophenolate mofetil (MMF or Cellcept). The other study is a gastrointestinal involvement registry that follows patients who are experiencing GERD, small bowel bacterial overgrowth, constipation, fecal incontinence and gastroparesis to see if there is improvement in symptoms after a change in treatment is implemented.
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