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Allergy and Clinical Immunology Labs

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  • Antoine Azar Lab

    The Antoine Azar Lab conducts research on topics related to primary immunodeficiency diseases, allergies and lung disease. Specifically, we explore the role of primary immunodeficiency in certain difficult-to-treat chronic lung diseases, such as COPD, emphysema and asthma.

    Research Areas: emphysema, immunology, asthma, allergies, lung disease, COPD

    Principal Investigator

    Antoine Azar, M.D.

    Department

    Medicine

  • Bradley Undem Lab

    Research in the Bradley Undem Lab centers around the hypothesis that the peripheral nervous system is directly involved in the processes of inflammation. This hypothesis is being studied primarily in the central airways and sympathetic ganglia. We are addressing this in a multidisciplinary fashion, using pharmacological, electrophysiological, biochemical and anatomical methodologies.

    Research Areas: biochemistry, electrophysiology, inflammation, pharmacology, nervous system

    Principal Investigator

    Bradley Undem, Ph.D.

    Department

    Medicine

  • Brendan J. Canning Lab

    Research in the Brendan J. Canning Lab is focused on mechanistic studies of the cough reflex. Through our work, we identified the afferent nerves that play an essential role in regulating cough. We have also been characterizing the CNS pathways regulating the cough reflex and interactions amongst various afferent nerve subtypes in regulating cough. We have identified key sites of integration of airway afferent nerve input and mechanisms by which afferent nerve subtypes act synergistically to regulate cough. Our experimental approaches include electrophysiological recordings, CNS microinjection techniques, in vivo preparations for monitoring cough and reflex bronchospasm, neuronal tracing and immunohistochemistry.

    Research Areas: airway reflexes, coughs, immunohistochemistry

    Principal Investigator

    Brendan Canning, Ph.D.

    Department

    Medicine

  • David MacGlashan Laboratory

    Research in the Donald MacGlashan Laboratory aims to understand the regulation of secretion from human basophils and mast cells—two cells thought to play key roles in allergic reactions and other diseases. The hallmark reaction in these cells is degranulation through cell-bound IgE. Our interests lie in the signaling mechanisms that control this dramatic cell response and the factors that regulate the degree of the reaction.

    Research Areas: mast cells, allergies, basophils

    Principal Investigator

    Donald MacGlashan, M.D., Ph.D.

    Department

    Medicine

  • Emily McGowan Lab

    Research in the Emily McGowan Lab focuses on food-allergy prevalence, the relationship between maternal folate and food allergy in children, and the risk factors for food allergy in inner-city children. We frequently use data from the Urban Environment and Childhood Asthma (URECA) birth cohort and Boston Birth Cohort to conduct our research.

    Research Areas: children, food allergies, asthma

    Principal Investigator

    Emily McGowan

    Department

    Medicine

  • Jody Tversky Lab

    The Jody Tversky Lab studies dendritic cells in allergy and immunotherapy; cluster immunotherapy clinical observations and immune tolerance; and clinical diagnostic sensitivity of 10 allergy skin prick devices.

    Research Areas: allergies, immunotherapy

    Principal Investigator

    Jody Tversky, M.D.

    Department

    Medicine

  • John Schroeder Lab

    The John Schroeder Lab focuses on understanding the role human basophils and mast cells play in allergic reactions, as it relates not only to their secretion of potent inflammatory mediators (e.g., histamine and leukotriene C4) but also to their production of pro-inflammatory cytokines. We have long utilized human cells rather than cell lines in order to address the parameters, signal transduction and pharmacological aspects underlying clinically relevant basophil and mast cell responses. As a result, the lab has established protocols for rapidly isolating large numbers of basophils at high purity from human blood and for growing culture-derived mast cells/basophils from human progenitor cells. A variety of assays and techniques are also in place for concurrently detecting cytokines and mediators following a wide range of stimuli. These have facilitated the in vitro testing of numerous anti-allergic drugs for inhibitory activity on basophil and mast cell activation. The lab also studie...s counter-regulation between the IgE and innate immune receptors on human immature dendritic cell subtypes. view more

    Research Areas: cell biology, allergies, inflammation

    Principal Investigator

    John Schroeder, Ph.D.

    Department

    Medicine

  • Johns Hopkins University Dermatology, Allergy and Clinical Immunology (DACI) Reference Laboratory

    The mission of the Johns Hopkins University Dermatology, Allergy and Clinical Immunology (DACI) Reference Laboratory is to provide comprehensive, high-quality diagnostic allergy and immunology testing to patients throughout North America with asthma, allergy and immunologic disorders. We offer an extensive menu of laboratory tests that includes allergen-specific IgE measurements to approximately 300 pollen, epidermal, mold spore, mite, food, drug, venom and occupational allergen specificities. We specialize in Hymenoptera (insect sting) venom-specific IgE and IgG antibody measurements. In addition, the DACI Laboratory performs hypersensitivity pneumonitis precipitin panels, serum cotinine, and environmental mold measurements.

    Research Areas: immunology, asthma, allergies, allergens, dermatology

    Lab Website

    Principal Investigator

    Robert Hamilton, M.S., Ph.D.

    Department

    Medicine

  • Kathleen Barnes Lab

    Work in the Kathleen Barnes Lab focuses on the genetic basis for acute and chronic airway disease and is based on family-based and independent clinical populations, largely of African descent, recruited both locally and from various locales in the Caribbean and South America. Our studies are also focused on gene-environment interactions and the interface of innate and adaptive immunity in the immunogenetics of various complex lung, allergic, rheumatologic and infectious diseases, including asthma, pulmonary hypertension, scleroderma, atopic dermatitis and schistosomiasis. In addition, we have had a long-standing interest in the potential beneficial role of microbial exposures for the development of asthma, allergies and autoimmune disorders, or the “hygiene hypothesis.”

    Research Areas: airway diseases, asthma, immunogenetics, dermatitis, allergies, genomics, atopic dermatitis, health disparities

    Principal Investigator

    Kathleen Barnes

    Department

    Medicine

  • Li Gao Lab

    The Li Gao Lab researches functional genomics, molecular genetics and epigenetics of complex cardiopulmonary and allergic diseases, with a focus on translational research applying fundamental genetic insight into the clinical setting. Current research includes implementation of high-throughput technologies in the fields of genome-wide association studies (GWAS), massively parallel sequencing, gene expression analysis, epigenetic mapping and integrative genomics in ongoing research of complex lung diseases and allergic diseases including asthma, atopic dermatitis (AD), pulmonary arterial hypertension, COPD, sepsis and acute lung injury/ARDS; and epigenetic contributions to pulmonary arterial hypertension associated with systemic sclerosis.

    Research Areas: pulmonary arterial hypertension, molecular genetics, cardiopulmonary diseases, asthma, epigenetics, complex lung disease, allergies, genomics, COPD, atopic dermatitis

    Principal Investigator

    Li Gao, M.D., Ph.D.

    Department

    Medicine

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