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Current Research in Retina
The faculty in the Retina Division are currently working on the following research projects:
- Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy
- Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
- Intravitreal Bevacizumab for Diabetic Macular Edema: 5-year Results
- Intravitreal Bevacizumab for Exudative Age-related Macular Degeneration: 5-year Results
- Retinal Complications after Anterior versus Posterior Chamber Phakic Intraocular Lens Implantation in Myopia
- Retinal Detachment in Down Syndrome: Characteristics and Surgical Outcomes
- Surgical Outcomes of Pars Plana Vitrectomy in the Management of Chronic Traumatic Macular Hole
- Clinical Characteristics and Treatment of Panuveitis
- Retinal Detachment in Uveitis
- Developing a more tailored approach to radiation dosimetry for eye tumors. The aim is to improve radiation delivery to ocular tumors with less radiation damage to important surrounding ocular structures compared to conventional radiotherapy.
Telemedicine and improving care to underserved populations in the U.S. and abroad:
- Leveraging mobile technologies such as smartphones and tablets to improve eye health globally
- Developing new software solutions utilizing crowdsourcing to aid in interpretation of fundus photos
- Working on community eye health delivery and research projects in the developing world
All active protocols for the DRCR.net (Diabetes Clinical Research Network) including:
- Comparison of ranibizumab + prompt or deferred laser vs triamcinolone + prompt laser vs focal/drid laser in the management of diabetic macular edema
- Assessment of the reproducibility of multiple different spectral domain OCT instruments and comparison to time domain OCT among individuals with diabetes
- Comparison of ranibizumab/bevacizumab/aflibercept in the management of diabetic macular edema
- Evaluation of observation vs laser vs anti-VEGF therapy for eyes with diabetic macular edema and good vision
Assessment of home-monitoring of patients with age-related macular degeneration who are at high risk of progression to neovascular AMD.
- Drug delivery with nanomedicine - directing medicine directly to the retina that can last for up to six month
- Identifying mechanisms on how diabetic retinopathy and AMD progress and the molecules that might cause progression
- Identifying protective factors against retinal disease so that the protective factors can be enhanced
The Ethics of the Doctor-Patient Relationship: Using questionnaires and video recording to understand ways to encourage that relationship in order to foster “healing” and compliance.
Incontinentia pigmenti: Dr. Goldberg is re-evaluating patients he initially studied up to two decades ago in order to determine the natural course and proper treatment of this often severe disease, which is inherited only in females and can cause severe retinal (and cerebral) shutdown and overgrowth of arteries and veins, including major hemorrhages in the eye and brain.
- Studying how oxidized stress magnifies immune response and how the retina protects itself
- How oxidized lipids damage the retina
- Designing cell therapy to treat myopia
- Creating new drugs to treat Stargardt's disease
- Using robotic surgery to improve retina surgery and to improve surgery education
Central serous chorioretinopathy:
- Determining the optimal intervention time
- Investigating novel medical treatments
Inherited retinal degenerations:
- Leading ProgStar, a multi-center clinical study to determine the yearly progression of Stargardt Disease in a large population of both children and adults over a two-year period
- Developing better tools to prove therapeutic efficacy for upcoming clinical trials
- Epidemiology on health disparities in eye care
- Sickle cell anemia
- Age-related macular degeneration
- Retinal vein occlusion
The role of HIF (hypoxic-inducible factor) regulation and dysregulation in ocular disease, with the goal of identifying novel therapeutic approaches for treatment of a variety of vision-threatening diseases:
- Identification of a novel “bad” HIF target gene that promotes macular edema
- Examination of the role of “good” HIF target genes in protecting the retina in dry AMD
- Using HIF target genes to target and destroy pathological blood vessels in ocular neovascular disease.
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