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Diabetic Retinopathy

Dr. Lutty's lab has also studied why blood vessels get blocked in diabetic retina as well.  They found that a type of white blood cell called a neutrophil appears to get stuck in diabetic retina.  An example of a normal retinal vasculature stained with the ADPase technique that was developed in the Lutty labs as shown (bottom left).  The retinal blood vessels will be removed and the blood vessels of choroid will come into focus (bottom right). 

normal blood vessel vasculature
blood choroidal vessels

We have also developed a technique to study the choroidal blood vessels in two dimensions.  The choroid provides nutrition and oxygen to keep the photoreceptors healthy; photoreceptors are cells that see light and record images which are sent to the brain.  We have demonstrated that not only are retinal blood vessels occluded in diabetes (bottom left) but that diabetic choroidal vessels become blocked as well (bottom right). 

retinal blood vessels occluded in diabetes
diabetic choroidal vessels

The same cells, neutrophils, appear to block the choroidal blood vessels (below - left), as well as retinal blood vessels (below - right) in diabetic subjects.  Prevention of neutrophil binding to the blood vessel wall in diabetes could be a therapeutic target in the future.

choiroiral blood vessels
retinal blood vessels