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Retinopathy of Prematurity

Retinopathy of Prematurity

When children are born prematurely, they are placed into an incubator in which they breath oxygen levels that are higher than normal (hyperoxic).  This is because their lungs are not fully developed and require supplemental oxygen.  This hyperoxic environment stops the process of retinal vasculogenesis and causes newly formed retinal blood vessels to die.  This poorly vascularized, ischemic retina makes angiogenic factors that cause abnormal growth of retinal blood vessels (angiogenesis).  The new blood vessels grow up and out of the retina where they can bleed and cause blindness; this is called retinopathy of prematurity (ROP).

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The Lutty lab uses an animal model of ROP and retinal cells in culture to study the death of retinal endothelial cells in hyperoxia and their abnormal regrowth afterwards.  Picture 2 shows the normal appearance of a newborn retina (top), and then the retina of an animal exposed to to hyperoxia after the new blood vessels have grown (middle).  There is a y-shaped veil of neovascularization growing above the retina (arrow).  The bottom picture is a section through the ROP retina shown in the middle picture that shows the new blood vessels over the retina (arrow) that are tugging on the retina, causing the retina to detach in two areas from the back of the eye.  Our lab has identified inhibitors of neovascularization that can limit the growth of the new blood vessels.

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Dr. Sheila West on the Link Between Smoking and Eye Disease in Women - 7/23/2014

Dr. Pradeep Ramulu and Colleagues Study Relationship Between Vision Loss and Work Status - 7/18/2014

Wilmer Resident Receives Lindstrom Research Grant - 7/11/2014

Four Wilmer Researchers Receive BrightFocus Foundation Awards - 7/10/2014

Dr. Michael Repka Part of Team Researching Telemedicine and ROP - 6/27/2014

Dr. M. Valeria Canto-Soler and Colleagues Featured on WBAL-TV - 6/24/2014

Dr. M. Valeria Canto-Soler and Colleagues Use Human Stem Cells to Create Light-Sensitive Retina in a Dish - 6/10/2014

Wilmer's Division of Ocular Immunology Announces "Living With Uveitis" Support Group - 6/10/2014

Dr. Neil Bressler to Speak on Diabetic Retinopathy at National Eye Health Summit and Webcast - 6/10/2014

Dr. Donald Zack Receives a Research to Prevent Blindness Nelson Trust Award for Retinitis Pigmentosa - 6/9/2014

Dr. Michael Boland Leads Study on Effectiveness of Automated Telecommunication-Based Reminders on Adherence to Glaucoma Medication Dosing - 6/4/2014

Dr. Christina Prescott Discusses Summer Eye Protection on Fox 45 News - 6/1/2014

Dr. Jonathan Song Discusses Treatment Options for Pediatric Cataracts - 5/23/2014

Johns Hopkins' Jordan Green Discusses His Work at Wilmer's Translational Tissue Engineering Center - 5/21/2014

Longtime Wilmer Employee Lillie Alston Honored by Hopkins - 5/19/2014

Dr. Richard Semba: Diets Rich in Antioxidant Resveratrol Fail to Reduce Deaths, Heart Disease or Cancer - 5/12/2014

Dr. Neil Miller Explains Eye Twitching in The Wall Street Journal - 5/12/2014

Dr. Hendrik Scholl Receives ARVO Award - 5/7/2014

 

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