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Retinopathy of Prematurity

Retinopathy of Prematurity

When children are born prematurely, they are placed into an incubator in which they breath oxygen levels that are higher than normal (hyperoxic).  This is because their lungs are not fully developed and require supplemental oxygen.  This hyperoxic environment stops the process of retinal vasculogenesis and causes newly formed retinal blood vessels to die.  This poorly vascularized, ischemic retina makes angiogenic factors that cause abnormal growth of retinal blood vessels (angiogenesis).  The new blood vessels grow up and out of the retina where they can bleed and cause blindness; this is called retinopathy of prematurity (ROP).

The Lutty lab uses an animal model of ROP and retinal cells in culture to study the death of retinal endothelial cells in hyperoxia and their abnormal regrowth afterwards. Our lab has identified inhibitors of neovascularization that can limit the growth of the new blood vessels.

retinopathy of prematurityThe normal appearance of a newborn retina (top).The retina of an animal exposed to to hyperoxia after the new blood vessels have grown (middle). There is a y-shaped veil of neovascularization growing above the retina (arrow). A section through the ROP retina shown in the middle picture that shows the new blood vessels over the retina (arrow) that are tugging on the retina, causing the retina to detach in two areas from the back of the eye (bottom).

Sanford Greenberg Elected to the American Academy of Arts and Sciences

Dr. Gehlbach Project Selected by Johns Hopkins-Coulter Translational Project Partnership- 06/23/16

Dr. Neil Bressler Speaks at Senate Briefing on Special Diabetes Program- 06/09/16

Dr. Neil Bressler Discusses Blue Light Effects on the Eyes in the Washington Post- 06/02/16

Dr. Arevalo Honored by National Institute of Ophthalmology in Peru- 5/31/16

Dr. Jennifer Thorne Appointed President-elect of American Uveitis Society- 5/17/16

Dr. Ingrid Zimmer-Galler Elected to the ATA College of Fellows- 5/13/16

Dr. Arevalo Launches New Book at ARVO 2016- 5/09/16

Dr. Elia J. Duh is elected to the American Society for Clinical Investigation- 4/28/16

Dr. Maria Valeria Canto Soler Wins BrightFocus Award for Macular Degeneration Research- 4/27/16

Three Wilmer Faculty Voted Most Influential in Field of Ophthalmology- 4/22/2016

Dr. Pradeep Ramulu Wins Pisart Award for Significant Achievement in Vision Science Research- 4/21/16

Dr. Eghrari Receives Alcon Early Career Research Award- 4/13/16

Dr. Quigley Honored by American Glaucoma Society- 4/11/16

Dr. Ian Pitha Awarded Grants for Glaucoma Research- 4/11/16