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Nanotechnology and Gene Therapy for Retinopathies

Nanotechnology and Gene Therapy for Retinopathies

Dr. Lutty's Lab is also using nanotechnology to develop unique approaches to treating the retinopathies mentioned in this section.  Many labs are using viruses to deliver genes that can be used to treat diseases.  Viruses, however, can themselves cause problems in that they may initiate inflammation and the genes may be expressed at too high a level or for too long.  Our goal is delivery of therapeutic genes without a virus, using nanoparticles to deliver the genes.  The particles can be made with multiple layers so the outer layer will have a peptide that can target the particles to cells of interest.  A schematic of an iron nanoparticle with multiple layers is seen in Picture 10. These nanoparticles can be delivered to cells in the retina (Picture 11). 

picture 10

Picture 10

Once the particles get into the target cell, the genes are expressed for a limited time period.  Using the genes for naturally occurring antiangiogenic factors, we hope to treat neovascularization without using a virus or a drug.  The nanoparticles can also carry a biosensor DNA that will allow the gene to be expressed only when it is needed.

picture 12

Picture 11

Sanford Greenberg Elected to the American Academy of Arts and Sciences

Dr. Jennifer Thorne Appointed President-elect of American Uveitis Society- 5/17/16

Dr. Ingrid Zimmer-Galler Elected to the ATA College of Fellows- 5/13/16

Dr. Arevalo Launches New Book at ARVO 2016- 5/09/16

Dr. Elia J. Duh is elected to the American Society for Clinical Investigation- 4/28/16

Dr. Maria Valeria Canto Soler Wins BrightFocus Award for Macular Degeneration Research- 4/27/16

Three Wilmer Faculty Voted Most Influential in Field of Ophthalmology- 4/22/2016

Dr. Pradeep Ramulu Wins Pisart Award for Significant Achievement in Vision Science Research- 4/21/16

Dr. Eghrari Receives Alcon Early Career Research Award- 4/13/16

Dr. Quigley Honored by American Glaucoma Society- 4/11/16

Dr. Ian Pitha Awarded Grants for Glaucoma Research- 4/11/16

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