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Nanotechnology and Gene Therapy for Retinopathies

Nanotechnology and Gene Therapy for Retinopathies

Dr. Lutty's Lab is also using nanotechnology to develop unique approaches to treating the retinopathies mentioned in this section.  Many labs are using viruses to deliver genes that can be used to treat diseases.  Viruses, however, can themselves cause problems in that they may initiate inflammation and the genes may be expressed at too high a level or for too long.  Our goal is delivery of therapeutic genes without a virus, using nanoparticles to deliver the genes.  The particles can be made with multiple layers so the outer layer will have a peptide that can target the particles to cells of interest.  A schematic of an iron nanoparticle with multiple layers is seen in Picture 10. These nanoparticles can be delivered to cells in the retina (Picture 11). 

picture 10

Picture 10

Once the particles get into the target cell, the genes are expressed for a limited time period.  Using the genes for naturally occurring antiangiogenic factors, we hope to treat neovascularization without using a virus or a drug.  The nanoparticles can also carry a biosensor DNA that will allow the gene to be expressed only when it is needed.

picture 12

Picture 11

Dr. Sheila West on the Link Between Smoking and Eye Disease in Women - 7/23/2014

Dr. Pradeep Ramulu and Colleagues Study Relationship Between Vision Loss and Work Status - 7/18/2014

Wilmer Resident Receives Lindstrom Research Grant - 7/11/2014

Four Wilmer Researchers Receive BrightFocus Foundation Awards - 7/10/2014

Dr. Michael Repka Part of Team Researching Telemedicine and ROP - 6/27/2014

Dr. M. Valeria Canto-Soler and Colleagues Featured on WBAL-TV - 6/24/2014

Dr. M. Valeria Canto-Soler and Colleagues Use Human Stem Cells to Create Light-Sensitive Retina in a Dish - 6/10/2014

Wilmer's Division of Ocular Immunology Announces "Living With Uveitis" Support Group - 6/10/2014

Dr. Neil Bressler to Speak on Diabetic Retinopathy at National Eye Health Summit and Webcast - 6/10/2014

Dr. Donald Zack Receives a Research to Prevent Blindness Nelson Trust Award for Retinitis Pigmentosa - 6/9/2014

Dr. Michael Boland Leads Study on Effectiveness of Automated Telecommunication-Based Reminders on Adherence to Glaucoma Medication Dosing - 6/4/2014

Dr. Christina Prescott Discusses Summer Eye Protection on Fox 45 News - 6/1/2014

Dr. Jonathan Song Discusses Treatment Options for Pediatric Cataracts - 5/23/2014

Johns Hopkins' Jordan Green Discusses His Work at Wilmer's Translational Tissue Engineering Center - 5/21/2014

Longtime Wilmer Employee Lillie Alston Honored by Hopkins - 5/19/2014

Dr. Richard Semba: Diets Rich in Antioxidant Resveratrol Fail to Reduce Deaths, Heart Disease or Cancer - 5/12/2014

Dr. Neil Miller Explains Eye Twitching in The Wall Street Journal - 5/12/2014

Dr. Hendrik Scholl Receives ARVO Award - 5/7/2014

 

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