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Diabetic Retinopathy

Diabetic Retinopathy

Dr. Lutty's lab has also studied why blood vessels get blocked in diabetic retina as well.  They found that a type of white blood cell called a neutrophil appears to get stuck in diabetic retina.  An example of a normal retinal vasculature stained with the ADPase technique that was developed in the Lutty labs as shown (bottom left).  The retinal blood vessels will be removed and the blood vessels of choroid will come into focus (bottom right). 

normal blood vessel vasculature
blood choroidal vessels

We have also developed a technique to study the choroidal blood vessels in two dimensions.  The choroid provides nutrition and oxygen to keep the photoreceptors healthy; photoreceptors are cells that see light and record images which are sent to the brain.  We have demonstrated that not only are retinal blood vessels occluded in diabetes (bottom left) but that diabetic choroidal vessels become blocked as well (bottom right). 

retinal blood vessels occluded in diabetes
diabetic choroidal vessels

The same cells, neutrophils, appear to block the choroidal blood vessels (below),

choiroiral blood vessels

as well as retinal blood vessels (below) in diabetic subjects.  Prevention of neutrophil binding to the blood vessel wall in diabetes could be a therapeutic target in the future.

retinal blood vessels

Sanford Greenberg Elected to the American Academy of Arts and Sciences

Dr. Gehlbach Project Selected by Johns Hopkins-Coulter Translational Project Partnership- 06/23/16

Dr. Neil Bressler Speaks at Senate Briefing on Special Diabetes Program- 06/09/16

Dr. Neil Bressler Discusses Blue Light Effects on the Eyes in the Washington Post- 06/02/16

Dr. Arevalo Honored by National Institute of Ophthalmology in Peru- 5/31/16

Dr. Jennifer Thorne Appointed President-elect of American Uveitis Society- 5/17/16

Dr. Ingrid Zimmer-Galler Elected to the ATA College of Fellows- 5/13/16

Dr. Arevalo Launches New Book at ARVO 2016- 5/09/16

Dr. Elia J. Duh is elected to the American Society for Clinical Investigation- 4/28/16

Dr. Maria Valeria Canto Soler Wins BrightFocus Award for Macular Degeneration Research- 4/27/16

Three Wilmer Faculty Voted Most Influential in Field of Ophthalmology- 4/22/2016

Dr. Pradeep Ramulu Wins Pisart Award for Significant Achievement in Vision Science Research- 4/21/16

Dr. Eghrari Receives Alcon Early Career Research Award- 4/13/16

Dr. Quigley Honored by American Glaucoma Society- 4/11/16

Dr. Ian Pitha Awarded Grants for Glaucoma Research- 4/11/16