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AMD

Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a disease that affects human retina and choroids and eventually causes loss of central vision in the elderly.  Using our technique to study

the human choroid, the Lutty lab has evaluated and quantified the loss of small choroidal blood vessels or capillaries (called choriocapillaris) and the cells that lie just above the choriocapillaris, the retinal pigment epithelium (RPE), to determine which cells die first and what conditions are associated with their degeneration.  When either of these cell types dies, the photoreceptors also die because they lack proper nutrition and their cellular waste cannot be removed.  Using this approach, our lab has found that RPE cells appear to die first in one form of AMD called Geographic Atrophy (dry AMD), and then the blood vessels of choroid die later.  In wet or exudative AMD, choroidal neovascularization (CNV) forms in the macular area, the center of vision.  In wet AMD, it appears that the choriocapillaris dies first, causing the RPE to become unhealthy, and then choroidal neovascularization formsin an attempt to compensate for the loss of choriocapillaris.

picture 9

Picture 9 (right, top) shows the appearance of the retina and choroid in a wet AMD subject. With our technique (bottom of Picture 9), the choroidal blood vessels are stained blue and the RPE cells are brown; a fan-like CNV formation can be clearly seen, and it is apparent that the RPE are still present over the growing tips of the CNV (edge of the fan-like formation). We have recently found that three inhibitors of neovascularization that are normally found in RPE cells and choriocapillaris are greatly reduced in AMD, perhaps creating an environment where the choroidal neovascularization can form and invade retina.

                               

Dr. Sheila West on the Link Between Smoking and Eye Disease in Women - 7/23/2014

Dr. Pradeep Ramulu and Colleagues Study Relationship Between Vision Loss and Work Status - 7/18/2014

Wilmer Resident Receives Lindstrom Research Grant - 7/11/2014

Four Wilmer Researchers Receive BrightFocus Foundation Awards - 7/10/2014

Dr. Michael Repka Part of Team Researching Telemedicine and ROP - 6/27/2014

Dr. M. Valeria Canto-Soler and Colleagues Featured on WBAL-TV - 6/24/2014

Dr. M. Valeria Canto-Soler and Colleagues Use Human Stem Cells to Create Light-Sensitive Retina in a Dish - 6/10/2014

Wilmer's Division of Ocular Immunology Announces "Living With Uveitis" Support Group - 6/10/2014

Dr. Neil Bressler to Speak on Diabetic Retinopathy at National Eye Health Summit and Webcast - 6/10/2014

Dr. Donald Zack Receives a Research to Prevent Blindness Nelson Trust Award for Retinitis Pigmentosa - 6/9/2014

Dr. Michael Boland Leads Study on Effectiveness of Automated Telecommunication-Based Reminders on Adherence to Glaucoma Medication Dosing - 6/4/2014

Dr. Christina Prescott Discusses Summer Eye Protection on Fox 45 News - 6/1/2014

Dr. Jonathan Song Discusses Treatment Options for Pediatric Cataracts - 5/23/2014

Johns Hopkins' Jordan Green Discusses His Work at Wilmer's Translational Tissue Engineering Center - 5/21/2014

Longtime Wilmer Employee Lillie Alston Honored by Hopkins - 5/19/2014

Dr. Richard Semba: Diets Rich in Antioxidant Resveratrol Fail to Reduce Deaths, Heart Disease or Cancer - 5/12/2014

Dr. Neil Miller Explains Eye Twitching in The Wall Street Journal - 5/12/2014

Dr. Hendrik Scholl Receives ARVO Award - 5/7/2014

 

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