Academic Office:
Division of Ocular Immunology
The Wilmer Eye Institute
550 North Broadway, Suite 700
Baltimore, MD 21205
Phone: 410-955-1966
FAX: 410-955-0629
E-mail: jthorne@jhmi.edu
Current Academic Appointments:
Associate Professor of Ophthalmology, The Division of Ocular Immunology, The Wilmer Eye Institute, The Johns Hopkins School of Medicine
Post Doctoral Fellow, Center for Clinical Trials, The Johns Hopkins Bloomberg School of Public Health
Education:
8/87 - 5/91 BS The College of William and Mary (Biology-Magnum Cum Laude)
8/91 - 5/96 MD University of Virginia School of Medicine
9/01 - present PhD The Johns Hopkins Bloomberg School of Public Health (Epidemiology)
Postdoctoral Training:
6/96 - 6/97 Intern in Medicine, University of Maryland, Baltimore, MD
7/97 - 6/00 Resident, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA
5/99 - 6/00 Chief Resident, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, PA
Academic Appointments:
7/00 - 1/02 Assistant, Advanced Specialty Training Program, Division of Ocular Immunology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD
RESEARCH ACTIVITIES
Publications:
Articles
Thorne JE, Galetta SL: Disc edema and retinal periphlebitis as the initial manifestation of sarcoidosis. Arch Neurol 1998;55:862-863.
Thorne JE, Jabs DA, Vitale S, Miller TA, Dunn JP, Semba RD: Incidence of catheter complications in the treatment of cytomegalovirus retinitis in AIDS patients. AIDS 1998;12:2321-2327.
Thorne JE, Maguire AM, Lanciano R: Lack of association between latanoprost and cystoid macular edema. Ophthalmology 1998;105:1971-1972.
Thorne JE, Volpe NJ, Liu GT: Magnetic resonance imaging of acquired Brown=s syndrome in a patient with psoriasis. Am J Ophthalmol 1999;127:233-234.
Thorne JE, Maguire AM: Good visual outcome following laser therapy for proliferative radiation retinopathy. Arch Ophthalmol 1999;117:125-126.
Thorne JE, Syed NA: Iritis. Current Concepts in Ophthalmology. March 1999.
Thorne JE, Maguire AM: Resolution of hydroxychloroquine maculopathy. Br J Ophthalmol 1999;83:1201.
Thorne JE, Maguire AM: Hemophilus aegyptius endophthalmitis following strabimus surgery. J Ped Ophthalmol Strabismus 2000;37:52-53.
Thorne JE, Brucker AJ: Choroidal white lesions as an early manifestation of sarcoidosis. Retina 2000;20:8-15.
Holbrook JT, Davis MD, Hubbard LD, Martin BK, Holland GN, Jabs DA, Gilpin AK, Meinert C, Reshef DS. Risk factors for advancement of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Studies of Ocular Complications of AIDS
Research Group. (Dr. Thorne is a member of the SOCA Research Group.) Arch Ophthalmol 2000;118:1196-1204.
Thorne JE, Jabs DA: Ocular manifestations of systemic vasculitis. Rheum Dis Clin North Am 2001;27(4):761-779.
Jabs DA, Martin BK, Forman MS, Dunn JP, Davis JL, Weinberg DV, Biron KK,
Baldanti F, Hu H; The Cytomegalovirus Retinitis and Viral Resistance Study
Group. (Dr. Thorne is a member of the CRVR Study Group.) Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group Report Number 8. Am J Ophthalmol 2001;132:700-710.
Holbrook JT, Meinert CL, Jabs DA; The Studies of Ocular Complications of AIDS
Research Group. (Dr. Thorne is a member of the SOCA Research Group.) Patient notification and follow-up after suspension of treatment protocols: experience from four clinical trials of treatments for AIDS-related CMV retinitis. Control Clin Trials 2001;22:62-68.
Holbrook JT, Meinert CL, Van Natta ML, Davis M, Hubbard L, Jabs DA; the Studies
of Ocular Complications of AIDS Research Group. (Dr. Thorne is a member of the SOCA
Research Group.) Photographic measures of cytomegalovirus retinitis as surrogates for visual outcomes in treated patients. Arch Ophthalmol 2001;119:554-563.
Jabs DA, Martin BK, Forman MS, Dunn JP, Davis JL, Weinberg DV, Biron KK,
Baldanti F; Cytomegalovirus Retinitis and Viral Resistance Study Group. (Dr. Thorne
is a member of the CRVR Study Group.) Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis.
J Infect Dis 2001;183:333-337.
Thorne JE, Volpe NJ, Wulc AE, Galetta SL. Caught by a masquerade: sclerosing pseudotumor. Surv Ophthalmol 2002;47:50-54.
Jabs DA, Van Natta ML, Kempen JH, Reed Pavan P, Lim JI, Murphy RL, Hubbard LD. (Representing the Longitudinal Study of Ocular Complications of AIDS. Dr. Thorne is a member of LSOCA.) Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy. Am J Ophthalmol 2002;133:48-61.
Thorne JE, Jabs DA: Treatment of ocular cicatricial pemphigoid. Dermatologic Therapy
2002. (In press).
Latkany PA, Jabs DA, Smith JR, Rosenbaum JT, Tessler H, Schwab IR, Walton RC, Thorne JE, Maguire AM: Multifocal choroiditis in patients with Familial Juvenile Systemic Granulomatosis. (Submitted)
Kempen JH, Martin BK, Wu AW, Barron B, Thorne JE, Jabs DA. The effect of CMV retinitis on quality of life of patients with the acquired immune deficiency syndrome in the era of HAART. (Submitted)
Thorne JE, Brown DM, Jabs DA. Posterior intracorneal deposits in patients with HIV. (Submitted)
Book Chapters
Jabs DA, Thorne JE: Ophthalmologic disease. In: AIDS Therapy 2002. In press.
Published Abstracts
Thorne JE, Mohrmann J, Bobak DA: Toxin A of Clostridium difficile promotes apoptosis in human granulocytes and cultured fibroblasts. J Invest Med. 43:A291, 1995.
Thorne JE, Brucker AJ: Choroidal white lesions as an early manifestation of sarcoidosis. Invest Ophth Vis Sci. 40(4):785B745, May 15, 1999.
Thorne JE, Maguire AM, Ho AC: Good visual outcome after submacular surgery for choroidal neovascularization in two patients with multifocal choroiditis. Invest Ophth Vis
Sci. 41(4):4152B99 Suppl. S Mar 15, 2000.
Kempen JH, for the Studies of Ocular Complications of AIDS Research Group, in collaboration with the AIDS Clinical Trials Group: Ganciclovir implant and oral ganciclovir vs. cidofovir for cytomegalovirus retinitis in patients with AIDS. The Ganciclovir Cidofovir Cytomegalovirus Retinitis Trial. Invest Ophthalmol Vis Sci. 42(4):S567.
Presentations and Posters
Thorne JE, Bobak DA: AToxin A of C. difficile causes apoptosis in human granulocytes."
April 1995, Department of Medicine 14th Annual Research Day, The University of Virginia School of Medicine, Charlottesville, VA.
Thorne JE, Mohrmann J, Bobak DA: AToxin A of C. difficile promotes apoptosis and
disrupts the small G-protein rho in human granulocytes.@ May 1995, American Federation
of Clinical Research, San Diego, CA.
Thorne JE, Ho AC, Maguire AM: "Good visual outcome following submacular surgery for
subfoveal choroidal neovascularization in patients with multifocal choroiditis." May 2000,
Scheie Eye Institute Alumni Meeting, Philadelphia, PA.
Dunn JP, Kempen JH, Bolton S, Thorne JE, Jabs DA: AThe fluocinolone implant.@ April
27, 2001, The Wilmer Resident=s Clinical Meeting.
Latkany PA, Thorne JE, Jabs DA: Familial Systemic Juvenile Granulomatosis. Annual Meeting of the American Uveitis Society. ARVO, Fort Lauderdale, FL. April 28, 2001.
Extramural Sponsorship:
Grants
Effects of Clostridium difficile Toxin A on apoptosis in human neutrophils; June 1994 to June 1995; Howard Hughes Medical Institute Fellowship; Award #70394-501903; Effort: 100%, PI: Jennifer E. Thorne.
Visual outcomes and quality of life in patients with CMV retinitis and AIDS; February 2002 to January 2007; NIH Mentored patient-Oriented Research Career Development Award, grant #1 K23 EY 013707-01; 01 February 2002 - 31 January 2007. Effort: 90%, PI: Jennifer E. Thorne.
Fellowships
Heed Fellowship, July 2000 through June 2001.
AIDS Training Award, Department of Infectious Diseases, The Johns Hopkins University School of Medicine, January 2001 through June 2001.
Maumenee Clinician Scientist Award, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, July 2001 to June 2002.
Center for Clinical Trial Vision Research Training Program, Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, September 2001 to present.
Clinical Trials and Studies:
· The Longitudinal Study of Ocular Complications of AIDS (LSOCA), co-investigator, Coordinating Center member, 2000 -
· The Cytomegalovirus Retinitis and Viral Resistence Study (CRVR), co-investigator, 2000 -
· Fluocinolone Acetonide Implant Trial, co-investigator, 2001 -
· Neovascular Age-related Macular Degeneration, Periocular Steroids, and Photodynamic Therapy Trial (NAPP), co-investigator, 2001 -
Editorial Activities:
Journal peer review activities:
Reviewer for Retina,1999 to present
Reviewer for AIDS, 2001 to present
Reviewer for Ophthalmology, 2002 to present
CLINICAL ACTIVITIES
Certification:
· Diplomate, American Board of Ophthalmology
· Medical Licensure:
Maryland 4/00 - 9/03 D0055886
Pennsylvania 7/98 - 12/00 MD-066770-L
ORGANIZATIONAL ACTIVITIES
Professional Societies:
National Societies:
American Uveitis Society, 2001
Society for Heed Fellows, 2001
American Academy of Ophthalmology, 1997
Association for Research in Vision and Ophthalmology, 1997
American Society of Cataract and Refractive Surgery, 1997
American Medical Association, 1991 B 1996
Local Societies:
Pennsylvania Academy of Ophthalmology, 1997 - present
Pennsylvania Medical Society, 1997 - 2000
RECOGNITION
Awards, Honors:
1990 Mortar Board
Omicron Delta Kappa
1991 Magna Cum Laude, The College of William and Mary
The James Frederic Carr Memorial Cup
The Benjamin Stoddert Ewell Award
1994 Howard Hughes Medical Student Research Fellowship
1995 Alpha Omega Alpha
Geographic Medicine Scholarship
American Federation of Clinical Research, Travel Scholarship
1996 American Medical Women's Association Scholars' Award
2000 National Eye Institute Travel Scholarship, ARVO
Heed Ophthalmic Foundation Fellowship
2001 Center for Clinical Trials Research in Vision Award
Maumenee Clinician Scientist Award
AIDS Training Award
2002 National Institutes of Health Research Training Award (K-23)
Invited Talks, Panels:
Thorne JE: AClostridium difficile Toxin A and apoptosis. September 1995, Guest lecturer at the University of Ceará, Fortaleza, Brazil.
