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Lutty, Gerard

Gerard A. Lutty, Ph.D.

G. Edward and G. Britton Durell Professor of Ophthalmology
Director of the Ocular Vasculogenesis and Angiogenesis Laboratory

The Wilmer Eye Institute
170 Woods Research Building

Johns Hopkins Hospital
Baltimore, MD 21287-9115

Phone: (410) 955-6750
Fax: (410) 955-3447

The laboratory of Professor Gerard “Jerry” Lutty, Ph.D. studies the development of  blood vessels in the eye and how they change in diseases like age-related macular degeneration (AMD), retinopathy of prematurity (ROP; formerly called retrolental fibroplasia or RLF), and sickle cell and diabetic retinopathies.  Dr. Lutty believes that a better understanding of the normal development and function of blood vessels will result in a greater understanding of what happens to them in disease processes like AMD.  One group of diseases, called ischemic retinopathies, which includes diabetic and sickle cell retinopathies, occurs because blood vessels in the retina become blocked or occluded by cells sticking to the to endothelial cells, which line the blood vessel wall.  This change in blood flow causes the neural tissue in retina to have insufficient nutrients and oxygen, i.e. become ischemic.  Ischemic retina or choroid, in the case of AMD, releases substances that stimulate the growth of abnormal new blood vessels (neovascularization), which can leak and break and eventually can cause blindness. Dr. Lutty’s lab studies the factors that stimulate new blood vessels, angiogenic factors, and naturally occurring inhibitors of angiogenesis, antiangiogenic factors.  The ultimate goal of the lab is to develop therapies to stop the blood vessels from being blocked in ischemic retinopathies and inhibit the growth of neovascularization in retina and choroid.

To enter the Lutty Labs website, click here.

Research Interests:

Angiogenic and anti-angiogenic growth factors
The involvement of angiogenic and anti-angiogenic factors in vasculogenic and angiogenic processes in the eye using immunochemistry, enzyme histochemistry, in situ hybridization, and in vitro cell assays. Vasculogenic and angiogenic processes of interest include diabetic and sickle cell retinopathies, retinopathy of prematurity, and corneal neovascularization.

Angioblasts or vascular precursors
Substances that drive their differentiation into endothelial cells within retina and how this process is affected by hyperoxia. Determine if both the primary and secondary retinal vasculature develop by aggregation and differentiation of angioblasts.

Oxygen radicals
The generation and effects of oxygen radicals in reperfusion events like retinopathy of prematurity and myocardial infarction. Determine if oxygen radicals are generated during microwave interaction with melanin and visual pigments.

Vaso-occlusion mechanisms that cause nonperfusion of the retinal and choroidal vasculatures in diabetic and sickle cell retinopathy
The mechanisms under investigation are imbalance in components of the fibrinolytic system, increased aggregation and adhesiveness of platelets, adhesion of sickled erythrocytes in sickle cell disease, and neutrophil adhesion to endothelium in choroid and retina.

Read Dr. Lutty's CV

Dr. Sheila West on the Link Between Smoking and Eye Disease in Women - 7/23/2014

Dr. Pradeep Ramulu and Colleagues Study Relationship Between Vision Loss and Work Status - 7/18/2014

Wilmer Resident Receives Lindstrom Research Grant - 7/11/2014

Four Wilmer Researchers Receive BrightFocus Foundation Awards - 7/10/2014

Dr. Michael Repka Part of Team Researching Telemedicine and ROP - 6/27/2014

Dr. M. Valeria Canto-Soler and Colleagues Featured on WBAL-TV - 6/24/2014

Dr. M. Valeria Canto-Soler and Colleagues Use Human Stem Cells to Create Light-Sensitive Retina in a Dish - 6/10/2014

Wilmer's Division of Ocular Immunology Announces "Living With Uveitis" Support Group - 6/10/2014

Dr. Neil Bressler to Speak on Diabetic Retinopathy at National Eye Health Summit and Webcast - 6/10/2014

Dr. Donald Zack Receives a Research to Prevent Blindness Nelson Trust Award for Retinitis Pigmentosa - 6/9/2014

Dr. Michael Boland Leads Study on Effectiveness of Automated Telecommunication-Based Reminders on Adherence to Glaucoma Medication Dosing - 6/4/2014

Dr. Christina Prescott Discusses Summer Eye Protection on Fox 45 News - 6/1/2014

Dr. Jonathan Song Discusses Treatment Options for Pediatric Cataracts - 5/23/2014

Johns Hopkins' Jordan Green Discusses His Work at Wilmer's Translational Tissue Engineering Center - 5/21/2014

Longtime Wilmer Employee Lillie Alston Honored by Hopkins - 5/19/2014

Dr. Richard Semba: Diets Rich in Antioxidant Resveratrol Fail to Reduce Deaths, Heart Disease or Cancer - 5/12/2014

Dr. Neil Miller Explains Eye Twitching in The Wall Street Journal - 5/12/2014

Dr. Hendrik Scholl Receives ARVO Award - 5/7/2014


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