Dr. Gramatikov has been a member of the Hopkins faculty since 1996, and is currently Assistant Professor in the Division of Pediatric Ophthalmology and Adult Strabismus at The Wilmer Eye Institute. He is a biomedical engineer with expertise in medical instrumentation, electronic hardware, computer software and signal processing. His current research interests are in focus detection and retinal birefringence scanning, including transition from the laboratory bench to clinical settings. The main goal is to identify and treat children with strabismus (misaligned eyes) or anisometropia (unequal refractive error) before irreversible amblyopia (functional monocular blindness) results. Dr. Gramatikov is the former Chairman of the Baltimore Chapter of the IEEE-EMBS (Institute of Electrical and Electronics Engineers, Engineering in Medicine and Biology Society), which is a part of the Baltimore Section of the IEEE. Presently he is an ExCom member and the Chair of the Baltimore Section. current projects
curriculum vitae
reviewer
projects and achievemnts
invention disclosures
patents
grants
invited talks
affiliations
awards
address
publications
Current projects
Determination of ocular defocus using the double-pass blur image of a point source of light
The double-pass blur image of a point source is used to determine the quality of focus of the human eye. This project is based on earlier work by Dr. David Guyton, Dr. David Hunter and Nainesh Gandhi. An apparatus that can determine a threshold of defocus was devised using a circle/annulus (bulls-eye) photodiode that can distinguish focused from defocused light. A monochromatic near-infrared light source (laser diode) is employed. The light reflected from the fundus of the eye is projected by a beamsplitter onto the bulls-eye detector, which is optically conjugate to the laser diode. The photodetector signal obtained is a function of the amount of defocus caused by the double-pass point spread reflected from the retina. The signal is affected by refractive error, incomplete accommodation, media opacities, and abnormalities of retinal reflection. One of the major risk factors for amblyopia is refractive error, or, more accurately, the degree of defocus the eye experiences. The defocus is perhaps best quantified by measuring the size of the retinal blur circle. Such defocus detection can be combined with eye-fixation monitoring to be used as a screening tool to detect risk factors for amblyopia.
Retinal Birefringence Scanning utilizes the optical polarization properties of the human retina. This method was developed by Dr. David Guyton and Dr. David Hunter ("Automated detection of eye fixation by use of retinal birefringence scanning", Applied Optics 38,OT&BO:1273-9, March 1999; Diagnosis of "Lazy Eye" in Infants - Whitaker Project; Retinal Birefringence Scanner), and is related to the Haidinger brush phenomenon - a bow-tie or propeller-like pattern that appears to rotate about the fixation point when a polarizing filter is placed over the eye and rotated. This phenomenon reflects the retinal nerve fiber axon arrangement about the fovea and can be utilized in a variety of useful applications. In our settings, foveal fixation is monitored in human subjects remotely and continuously by use of a noninvasive retinal scan. Polarized near-infrared light is imaged onto the retina and scanned in a 3-deg annulus at frequency f. Reflections are analyzed by differential polarization detection. The detected signal is predominantly 2f during central fixation, and f during paracentral fixation. Phase shift at f correlates with the direction of eye displacement. Mathematical modeling of birefringence in retinal birefringence scanning has confirmed the experimental and clinical results. Potential applications of this technique include screening for eye disease, eye position monitoring during clinical procedures, and use of eye fixation to operate devices. Considering that the structure of the fovea is the basis of the retinal birefringence scan signal, the experience gained from bringing retinal birefringence scanning to the clinic will also increase our understanding of foveal structure in health and other forms of disease. Dr. Gramatikov is involved in the design of a portable Bilateral Retinal Birefringence Scanner (BRBS) with improved noise performance, to be used as a pediatric vision screener. The new design incorporates binocular foveal birefringence scanning, and separate channels for binocular focus detection. This combination of focus and alignment detection should identify over 95% of all children at risk for amblyopia. This work is being performed in collaboration with AURA (Association of Universities for Research in Astronomy, Inc.), the Space Telescope Science Institute and the Instrument Development Group (IDG) at the Department of Physics and Astronomy at the Johns Hopkins University. Curriculum Vitae EDUCATION 1983 | Ph.D. in Technical Sciences from the Technical University of Sofia, Bulgaria - School of Electronic Engineering and Technology.
Ph.D. Thesis: Electronic Devices for Automatic Processing of Phonocardiographic Signals. Technical University of Sofia, 1983, UDK 616-7. Central Library of Science and Technology - Sofia, Ref. No. DS 3168. | 1973-78 | Dipl.-Eng. from the Technical University of Ilmenau, Germany, School of Technical and Biomedical Cybernetics,
Major: Biomedical Engineering and Bionics (today: Institute of Biomedical Engineering and Informatics).
1975 Probation training at the (then) Medical Academy, Erfurt, Germany, Department of Audiometry and Acoustic Evoked Potentials
1977 Pre-graduation training at the Regional Hospital, Eisenhuettenstadt, Germany: Instrumentation Design - Impedance Plethysmography; 1977 Clinical Engineering training - Regional Hospital, Eisenhuettenstadt, Germany
1978 Received Dipl.-Eng. degree in Biomedical Engineering with honors ("Auszeichnung") | 1966-71 | English Language High School in Plovdiv, Bulgaria; all subjects taught in English; graduated with honors. |
EMPLOYMENT 2003-present
| Assistant Professor
| Laboratory of Ophthalmic Optics, Division of Pediatric Ophthalmology and Adult Strabismus at The Wilmer Ophthalmological Institute, Johns Hopkins University, Johns Hopkins School of Medicine, Baltimore, MD, USA | 2000 | Research Associate | Laboratory of Ophthalmic Optics, Division of Pediatric Ophthalmology and Adult Strabismus at The Wilmer Ophthalmological Institute, Johns Hopkins University, Johns Hopkins School of Medicine, Baltimore, MD, USA | 1996 - 2000 | Research Associate | Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA | 1995-1996 | Associate Professor | Centre of Biomedical Engineering (CBME pdf), Bulgarian Academy of Sciences | 1994 | Research Associate | Centre of Biomedical Engineering (CBME pdf), Bulgarian Academy of Sciences | 1993-1994 | Visiting scientist | Medical University Hannover, Germany
Department of Biosignal Processing
A 7-month sabbatical sponsored by the Commission for Science and Technological Development of the European Community, DG XII. | 1993 | Visiting scientist | Department of Biomedical Engineering, Johns Hopkins University - School of Medicine, Baltimore, MD, USA
A 4-month exchange visit, sponsored by the Fogarty International Center, NIH, Bethesda, MD. | 1987-1993 | Research Associate | Department of Biomedical Engineering, (CLEMA), Medical Academy, Sofia, Bulgaria and EMA Engineering - a state-owned enterprise for medical equipment, Sofia, Bulgaria | 1986-1987 | Visiting scientist | Medical University Hannover, Germany
Department of Biosignal Processing
4 months sabbatical sponsored by the German Academic Exchange Service (DAAD) | 1979-1986 | R&D Engineer | Department of Biomedical Engineering, (CLEMA), Medical Academy, Sofia, Bulgaria
Duties included design from specifications to delivery, requirement analysis, coding, debugging and final testing. Research and development. Signal processing of biomedical signals, mainly related to Electrocardiology, Pulmology, Plethysmography and Ophtalmology. Performed Assembly language programming for a variety of microprocessor based medical instruments. |
Journal Reviewer for: IEEE Transactions on Biomedical Engineering
Biomedical Engineering OnLine (also member of the Editorial Board )
Biomedical Instrumentation & Technology
Iranian Journal of Electrical and Computer Engineering
Book Reviewer: “One-Chip Microcomputers” by Z. Karakehayov and S. Grigorov (ISBN 954-03-0146) LANGUAGES: Fluent in English, German, Bulgarian and Russian
PROJECTS AND ACHIEVEMENTS
Year | Project | Institution | Role | 2003-present
| | Department of Pediatric Ophthalmology and Adult Strabismus at The Wilmer Ophthalmological Institute, Johns Hopkins Medicine | Research Faculty | 2000-2002 | - Determination of ocular defocus using the double-pass blur image of a point source
- Retinal birefringence scanning
- Building a prototype of a Pediatric Vision Screener
| Department of Pediatric Ophthalmology and Adult Strabismus at
The Wilmer Ophthalmological Institute,
Johns Hopkins Medicine | Research Collaborator and Design Engineer | 1999-2000 | Developed an optical fluorescence imaging system for recording of transmembrane action potentials of beating isolated perfused rabbit hearts. | Department of Biomedical Engineering, Johns Hopkins University | Project Leader | 1999-2000 | Developing a portable device for long-term ECG recording and analysis in patients with chest pain - Supported by a Maryland Industrial Partnerships (MIPS) award. | Department of Biomedical Engineering, Johns Hopkins University. A joint project with a company, DVP, Inc. (now InHand Electronics, Inc.) | Co-PI; Designer of the ECG amplifier and data acquisition, ECG analysis algorithms. | 1997 | Examined autoregressive methods for differentiation between ventricular fibrillation caused by different types of stimulation during implantation of ICDs. | Johns Hopkins University, Baltimore, MD in collaboration with Mid-Carolina Cardiology, Charlotte, NC, supported in part by Medtronic, Inc. | Project Leader | 1996-97 | Studied dynamic differences between ventricular fibrillation types | Johns Hopkins University, Baltimore, MD, and the Institute of Electronic Circuits, Genova, Italy, Section Signal Analysis in Cardiology - SAC | Research Collaborator | 1998-99 | Developed a computer model of myocardial depolarization under local ischemia. In collaboration with Mahesh Shenai, a graduate student at Johns Hopkins. | Department of Biomedical Engineering, Johns Hopkins University School of Medicine | Project Leader | 1997 | Studied different pacing patterns on isolated heart models (Langendorff preparations) | Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD | Project Leader | 1996-97 | Examined Ischemic changes in isolated Langendorff hearts. | Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD | Project Leader | 1996 | Studied the dynamical difference obtained from different simultaneously recorded leads of ECG signals, using the MIT-BIH Arrhythmia Data Base | Bulgarian Academy of Sciences, Sofia, and the Institute of Electronic Circuits, Genova, Italy | Research collaborator | 1994-95 | Conducted research on Identification of ischemic changes in the ECG during PTCA using conventional ST and spectral methods for inta-QRS analysis. | Bulgarian Academy of Sciences, Sofia, and Third Regional Hospital - Sofia, Division of Cardiology | Project Leader | 1993-94 | A project on Body Surface Mapping. Conducted a study on Reducing the number of leads in body surface potential mapping and Variability of body surface maps in normal patients. | Medical University Hannover, Germany Department of Biosignal Processing | Independent Project | 1993 | Introduced a series of improvements to the Bulgarian interpretive ECG machine ECG 321. | CLEMA, Medical Academy - Sofia, Enterprise for Medical Instrumentation (EMA) - Sofia, Bulgaria | Project Leader | 1993 | Worked on detection of ischemic changes in the ECG by means of the Wavelet transform applied to signals from animal models and from human patients before and after PTCA. | Johns Hopkins University School of Medicine, and Johns Hopkins Hospital, Department of Cardiology, Baltimore, MD | Project Leader | 1992-93 | Examined the potential of time-frequency distributions obtained from the signal-averaged ECG for prediction of late potentials and ventricular tachycardia - STFT and Wavelet transform. | CLEMA, Medical Academy - Sofia and Bulgarian Academy of Sciences | Project Leader | 1994-96 | Directed a team of software engineers for ECG acquisition and analysis (C++, Windows) using a PC-based ECG system. | Bulgarian Academy of Sciences | Project Leader | 1988-93 | Built an amplifier, computer hardware and software for detection of His- and Late potentials in the high resolution signal-averaged ECG. Developed and implemented improved methods for time- and frequency domain measurement and analysis. Examined the effect of different types of digital filters. Was responsible for the clinical probation of the device as well. | CLEMA, Medical Academy - Sofia | Independent Project, Hardware design, Programmer/Analyst | 1990-91 | Designed, built, programmed and implemented a Computer front-end module and real time custom software for studying test animals' behaviour under stress induced by means of controlled stimulation. | The Pharmaceutical Research Institute (NIHFI ) - Sofia, Bulgaria In close collaboration with Professor Mile Taskov, MD | Project Leader, Hardware design, Programmer/Analyst | 1989-90 | Designed, programmed and implemented a PC-based Data Aqcuisition and Data Processing System for experimental investigation of the mechanical responses of isolated biological tissues to electrical stimulation (Coding in Pascal and C-language). | Institute of Physiology, Bulgarian Academy of Sciences - Sofia, Bulgaria In close collaboration with Professor Lubomir Kasakov, MD | Independent Project, Hardware design, Programmer/Analyst | 1989-90 | Studied abnormalities of the auditory system by conducting statistical analysis of parameters obtained from X-ray images of the inner and middle ear (histograms, t-statistics, etc.). | Department of Radiology, Medical Academy, Sofia In close collaboration with Professor Angel Tomov, MD. | Independent Project, Statistical analysis | 1984-89 | Developed and implemented a PC based ECG System 1222 for acquisition, diagnostic interpretation and disk archival of the 12-lead ECG. (Coding in Forth, C-language and Assembler) The system is commercially available as the interpretive ECG-Computers 1222, of which 35 units were produced and installed in various Bulgarian hospitals. | CLEMA, Medical Academy - Sofia. Project received quality awards. | Project Leader Hardware design Programmer/Analyst | 1986-90 | Designed and implemented a PC-based data acquisition and data processing lab system for a fully automated real-time control of cardiological experiments in mid-large animal research. Performed requirement analysis, algorithm, hardware and software development. Stimulation and signal acquisition from 8 analog channels, real time display, measurement and evaluation of various electrophysiological, haemodynamical and mechanical parameters during an 8-hour experiment, and off-line statistical analysis (coding in Pascal and C-language) | The Pharmaceutical Research Institute (NIHFI ) - Sofia, Bulgaria In close collaboration with Professor Mile Taskov, MD | Project Leader Hardware design Programmer/Analyst | 1987-89 | Responsible for the collection of two clinically anotated clinical ECG data bases for validation of interpretive ECG devices. | CLEMA, Medical Academy - Sofia. | Team work | 1987 | Developed software for data acquisition and analysis of biomechanical signals and body movements (1D, 2D) recorded during rowing (coding in Pascal language). Patent issued. | An independent contract with the Bulgarian Federation of Rowing - Sofia. | Independent Project | 1986-87 | Developed a technique and a software module for identification of the WPW syndrome in the ECG (coding in Fortran language) | Medical School Hannover, Germany Institute of Medical Informatics Department of Biosignal Processing | Independent Project, Fellowship | 1987-90 | Developed ECG processing modules (digital filtering, QRS detection etc.) in Assembly language for the ECG Intensive Care Monitors M 101, 203, 301. | CLEMA, Medical Academy - Sofia | Team participant | 1983 | Designed, coded and built a microprocessor controlled Forced Expiration Analyser - an early prototype of the Expiration Analyzer SpiroComp for diagnostic Purposes (Coding in Macro-Assembler) | CLEMA, Medical Academy - Sofia | Team work | 1983-88 | Developed algorithms and code for ECG analysis for the Bulgarian microprocessor-based Interpretive Electrocardiographs with measurement and classification capabilities), Series 123X, 126X, 331 - commercially available. (Coding was done in Assembly and Forth language) | CLEMA, Medical Academy - Sofia | Team member | 1983-90 | Participated in the development of various diagnostic equipment: SpiroComp, Pace-Stop, PaceComp etc. | CLEMA, Medical Academy - Sofia | Team member | 1983-84 | Responsible for different hardware support projects for facilitating R&D in biomedical instrumentation: EPROM programmers, floppy disk controllers, A-D converters, microprocessor emulators, asynchronous serial and parallel communications. | CLEMA, Medical Academy - Sofia | Independent Project | 1980 | Developed an enhanced Microprocessor Development System (MDS) for embedded hardware design, emulation and programing for 8-bit Motorola microprocessors. | CLEMA, Medical Academy - Sofia | Independent Project | 1980-83 | Designed and built two microprocessor-based devices called PhonoCardioSelectors for automatic signal acquisition and screening diagnostics of phonocardiographic signals (PCG) in children. Performed feature extraction and developed diagnostic classification criteria.
(Device coded in Assembly language) | Pediatric Clinic, Medical Academy - Sofia, CLEMA (Biomedical Engineering Department), Medical Academy, Sofia Technical University, Sofia In collaboration with: - Prof. Paraskeva Ninova, MD
- Prof. Ivan Daskalov, D.Sc.
- Prof. Ivan Dotsinsky, DSc.
| PhD Thesis | 1982 | Participated in the development of a Nystagmus analyzer. | Bulgarian Academy of Sciences - Sofia | Team work | 1981 | An Electronic Device for Objective Neurophysiological Examinations on Human Subjects by measuring the responses to different types of random stimulations | Sports Academy, Sofia | Team work | 1978-79 | Developed 4 models of portable digital plethysmographic heart rate meters | CLEMA, Medical Academy - Sofia. | Team work | 1977 | Designed and built programmable logic for automated experimental investigations of the peripheral nervous system in insects | Technical University, Ilmenau, Germany | Graduation project | 1976 | Designed and built a Two-Channel Impedance Plethysmograph (Rheograph) using the 4-electrode principle. | Technical University, Ilmenau, and Regional Hospital, Eisenhuettenstadt, Germany. | Independent student project |
INVENTION DISCLOSURES to Johns Hopkins University: | Name of invention | Authors | Date of disclosure | | Myocardial Ischemia Monitor | Nitish V. Thakor, Boris Gramatikov | August 1997 | | Ischemia Detection in Implantable Devices | Ananth Natarajan, Boris Gramatikov and Nitish V. Thakor | August 1997 |
PATENTS - Registered with and issued by the Bulgarian Patent Office
(in collaboration with other investigators and designers) A device for control of the training process in rowing | N. 46420, 1988 | | A device for fixing and measurement of distances and time intervals | N. 38613, 1984 | | A method for recording of phonocardiograms | N 34472, 1982 | | A method for analog-to-digital conversion and storage of the PCG | N 32434, 1981 | | Method for automatic analysis of phonocardiographic signals | N 32433, 1981 | | Automatic gain control of phonocardiographic signals | N 31523, 1981 | | A generator of random time intervals | N 32557, 1981 | | Portable heart rate meter | N 28285, 1978 | | Electronic cell counter for the clinical laboratory | N 28669, 1978 | | Mechanical percent counter | N 27685, 1978 |
All patents are institutionally owned and cover Bulgaria only. INNOVATION CERTIFICATES: 7 (Issued by the Ministry of Health and the Medical Academy, Sofia)
INVITED SPEAKER (most significant talks)
2001 | “Application of Contemporary Signal Processing and Imaging Methods to Basic Biomedical Research and Clinical Diagnostics”, Baltimore Section, IEEE | 1997 | IEEE Engineering in Medicine and Biology, Baltimore Chapter, Baltimore, Maryland, USA - "Detection of Coronary Ischemia using Time-Frequency Methods" | 1997 | Mid-Carolina Cardiology - Charlotte, NC, USA - "Differentiation of different ventricular fibrillation patterns in human patients, using autoregressive spectral methods" | 1996 | Institute of Electronic Circuits, Genova, Italy, Section Signal Analysis in Cardiology - SAC - "Wavelet Analysis for Time Frequency Distributions and Multiresolution Orthogonal Decompositions" (Use of compact orthonormal wavelets for data compression and intra-QRS ischemic changes) | 1996 | | 1996 | | 1996 | | 1996 | | 1994 | |
SUPERVISOR OF STUDENT PROJECTS AT JOHNS HOPKINS UNIVERSITY
| Year | Student (Advisee) | Project | Awards | | 1997-1998 | Anshul Thakral, Louis Stein, Mahesh Shenai | Efficiency of Anodal Pacing Patterns applied to Isolated Perfused Rabbit Hearts | Provost Award, JHU | | 1998-1999 | Mahesh Shenai | Computer Network Modeling of Myocardial Depolarization under normal and ischemic conditions. Feasibility of detecting ischemia from extracellular leads in the vicinity an ischemic spot. | - Provost Award, JHU
- Barry Goldwater Award
- 2000 USA Today's ALL-USA College Academic Second Team
| | 1999-2000 | Vivek Iyer | - Intra-QRS detection of Ischemia in the European ST-T Data Base.
- Modeling of Myocardial Depolarization in the presence of Ischemia. Effects of drugs and genes.
| - William R. Kenan Award 1999-2000
- Howard Hughes Summer Research Program 2000
| | 1993 | Jim Stefansic | Detection of morphologic changes in the ECG with removal of myocardial ischemia by means of PTCA |
|
TEACHING ACTIVITIES
| Year | Course | Location | 1885, 1986 | Lectures on "Microprocessor systems" for biomedical and clinical engineers (each year 60 hours) | Postgraduate Training Center at the Meditech Enterprise for medical equipment - Sofia, Bulgaria | 1989 | Practical Course "Fundamentals of computing technology" (70 hours) | Technical University, Sofia, Section Computing Technology | 1990 | Programming in Pascal on 16-bit computers (60 hours) | National Center for Informatics, Software products and Systems (SPS), Sofia, Bulgaria | 1990 | Assembly language programming for 16 bit computers (60 hours) | Technological Center for Automation, Central Research Institute for Complex Automation, Sofia, Bulgaria | 1983-86 | Supervised 3 graduation projects (Dipl. Eng. degree) in Biomedical Engineering | Technical University, Sofia, Section Electronic Devices and Biomedical Engineering. |
AFFILIATIONS
1999-present | IEEE (The Institute of Electrical and Electronic Engineers) -
The Engineering in Medicine and Biology Society (EMBS), - Chairman, ExCom, Baltimore IEEE Section: Jan 2006
- Vice Chair, ExCom, Baltimore IEEE Section: Jan 2005
- Secretary, ExCom, Baltimore IEEE Section: Jan 2004
- ExCom member and Treasurer, Baltimore IEEE Section: Jan 2003
- Chairman of the Baltimore Chapter of the Engineering in Medicine and Biology Society (EMB-18): Nov 1999 - Dec 2002
- Senior Member, IEEE since Nov 2001
| 2002-present | | 1997-1999 | | 1994 -1998 | | 1994-1998 | | 1986-1996 | | 1980-1996 | | 1988-1996 | |
GRANTS Name | Funding source | Dates | Collaborator | Retinal birefringence analysis in strabismus and amblyopia
Role: Co-investigator, percent effort: 50% | NIH1R01 EY12883 | 2000-2003 | David G. Hunter, MD, PhD
Ophthalmology
Children's Hospital Boston | A Portable Physiological Signal Processor, for a Novel Programmable Cardiac Monitor (Phase I and II)
Role: Co-Principal Investigator, percent effort: 35% | The Maryland Industrial Partnerships (MIPS) | August 1998
- July 2000 | DVP, Inc.
now
InHand Electronics, Inc. | Implantable Myocardial Ischemia Detection Technology
Role: Principal Investigator at the time of the award; percent effort: 50% | NIH, 1 R43 HL61995-01A1,
SBIR, Phase I | October 1999 -
August 2000 | Infinite Biomedical Technologies, Inc.
(IBT, Inc) | An Optical System for Epicardial Fluorescence Imaging
Role: Co-Investigator, percent effort: 10% | NIH, 1 R43 HL61128-01,
SBIR, Phase I | October 1999 - July 2000 | Infinite Biomedical Technologies, Inc.
(IBT, Inc) | An Interactive Two-Dimensional Computer Model of Myocardial Depolarization
Role: Co-Investigator | Kenan Fund - Johns Hopkins University, 1999-2000 | October 1999 - July 2000 |
Vivek Iyer,
undergraduate student,
Johns Hopkins
| Detection of specific morphologies and measurement of diagnostic parameters in the electrocardiogram. Role: Co-Investigator, percent effort: 10% (PI: Prof. Ivan Daskalov) | Bulgarian National Research Fund,
L-516/95 | 1995-1996 | Center for Biomedical Engineering, Bulgarian Academy of Sciences, and
Bulgarian National Cardiological Center | Development of a computer-based system for electrocardiographic body-surface potential mapping of the human torso. Initial application to myocardial ischemia detection.
Role: Principal Investigator, percent effort 20% | Bulgarian National Research Fund,
L-613/96 | 1996-1997 | Center for Biomedical Engineering, Bulgarian Academy of Sciences, and
Bulgarian National Cardiological Center |
OTHER AREAS OF EXPERTISE AND SCIENTIFIC UTTERANCE - Scientific Committee Member and Session Chairman of three international conferences on Biomedical Engineering
AWARDS, FELLOWSHIPS and DISTINCTIONS
| 2005 | Certificate for contributions as a Vice Chair of the Baltimore Section of IEEE | | 2004 | Certificate for contributions as a Secretary of the Baltimore Section of IEEE | 2003 | Certificate for contributions as a Treasurer of the Baltimore Section of IEEE | 2000 and
2001 | Certificates for contributions to IEEE as a Chairman of the Baltimore Chapter of IEEE Engineering in Medicine and Biology Society (EMBS) | 1996 | An award by the Italian CNR (Consiglio Nazionale di Richerche) for a two-week visit to a research collaborator at the Institute of Circuits and Systems, Genova, Italy | 1993 | Fellowship by the Fogarty International Center, NIH: a 4-month exchange visit to the Biomedical Engineering Department of the Johns Hopkins University - School of Medicine, Baltimore, MD | 1993 | Fellowship by DG XII-B, Research and Development, Commission of the European Communities: a 7-month research visit to the Medical University, Hannover, Germany, Dept.of Biosignal processing. | 1989 | A gold medal "Honoured Inventor and Innovator" of the Department of Health and Social Care and the Department of Industry, Sofia, Bulgaria | 1986 | A Testimonial from the Committee for Science and Technical Progress and the National Council for Industrial Aesthetics, for the development and design of a Three-channel Electrocardiograph, Sofia, Bulgaria | 1985 | A gold medal of the Republican Young Investigators' Center for a project called "An intelligent Electrocardiograph", the 13-th Young Investigators' Review, Sofia, Bulgaria | 1985 | Fellowship by the German Academic Exchange Service (DAAD): sabbatical (4 months) at the Department of Biosignal processing, Medical University Hannover, Germany. | 1980 | A Testimonial for successful participation in the 11-th Young Investigators' Review, Sofia, Bulgaria | 1978 | A Distinction (Auszeichnung) upon graduating the Technical University of Ilmenau, Germany | 1977 | A gold medal "For Excellent Studies" from the Bulgarian Committee for Science, Technical Progress and Higher Education, handed by the Bulgarian Ambassador to Germany in Berlin, Germany | 1977 | A Testimonial for excellent studies from the Bulgarian Embassy, Berlin, Germany | 1976 | Third prize - Second Scientific Review of the Bulgarian undergraduate and and graduate students in Germany, Berlin | 1975 | First prize - Eighth Republican Young Investigators' Symposium, Sofia, Bulgaria | 1971 | A gold medal upon graduating from the English Language School - Plovdiv, Bulgaria |
SEMINARS / SPECIAL TRAINING Matlab for Image Procesing (MathWorks IP01), Columbia, MD 2005
Real-Time and Embedded Computing Conference, The RTC Group, Martin's Crosswinds, 2004
Ophthalmology for the Pediatrician. Conference, Johns Hopkins University, 2000.
Human Subjects Research. Web-based course, Johns Hopkins University, 2000.
Clinical Trials. Conference, Johns Hopkins University, 1999.
Essential Business Writing Skills. Seminar, Johns Hopkins University, 1999.
Grant Writing. Seminar, Johns Hopkins University, 1997 and 2001.
Clinical Engineering, International Workshop, Boston, 1993
Medical Device Marketing. Short course, WHO/Bulgarian Ministry of Health, Sofia, 1992
Authority and Leadership. Group-Dynamics School, The Free German University, Berlin (West), 1989
HOBBIES
Piano, windsurfing, skiing, tennis, photography, swimming Boris Gramatikov, PhD, Assistant Professor
Laboratory of Ophthalmic Optics
Krieger Children's Eye Center
The Wilmer Ophthalmological Institute, Room 233
The Johns Hopkins University School of Medicine
The Johns Hopkins Hospital
600 N. Wolfe St., Baltimore, Maryland 21287-9028
PHONE: 410-614-6017
FAX: 410-955-0809
e-mail: bgramat@ jhmi.edu Publications 1. Nitish V. Thakor, Boris Gramatikov and David Sherman. Wavelet (Time-Scale) Analysis in Biomedical Signal Processing. In The Biomedical Engineering Handbook, Ed. Joseph Bronzino, 2nd Edition., Volume I, Section VI (Biomedical Signal Analysis), Chapter 56, pp. 56.1 - 56.27. CRC Press LLC, IEEE Press, December 1999. PUBLICATIONS IN PEER-REVIEWED JOURNALS 1. Gramatikov B.I., Zalloum O.H.Y., Wu Y.K., Hunter D.G., Guyton D.L. Birefringence-based eye fixation monitor with no moving parts. Accepted Feb 2006, Journal of Biomedical Optics. 2. Nusz K.J., Congdon N.G., Tang Ho, Gramatikov B.I., Friedman D.S., Guyton D.L., Hunter D.G. Rapid, objective detection of cataract-induced blur using a bull's eye photodetector. J Cataract Refract Surg. 2005 Apr;31(4):763-70. 3. Hunter D.G., Nassif D.S., Piskun N.V., Winsor R., Gramatikov B.I., Guyton D.L. Pediatric Vision Screener 1: instrument design and operation. Journal of Biomedical Optics, 2004 Nov;9(6):1363-1368. 4. Nassif D.S., Piskun N.V., Gramatikov B.I., Guyton D.L., Hunter D.G. Pediatric Vision Screener 2: pilot study in adults. Journal of Biomedical Optics, 2004 Nov;9(6):1369-1374. 5. Hunter D.G., Nusz K.J., Gandhi N.K., Quraishi I.H., Gramatikov B.I., Guyton D.L. Automated detection of ocular focus. Journal of Biomedical Optics, 2004, Sep-Oct; 9(5):1103-9 6. Murabayashi T., Fetics B., Kass D, Nevo E, Gramatikov B, Berger RD. Beat-to-Beat QT Interval Variability Associated with Acute Myocardial Ischemia. Journal of Electrocardiology, Vol. 35, No. 1, 2002, pp. 19-25. 7. Gramatikov, B., Brinker, J., Yi-chun, S., Thakor, N. Wavelet analysis and time-frequency distributions of the Body Surface ECG before and after angioplasty. Computer Methods and Programs in Biomedicine, Vol. 62, No. 2, June 2000, pp.87-98. 8. Shenai M., Gramatikov, B.I., Thakor, N.V. Computer models of depolarization alterations Induced by myocardial ischemia. The effect of superimposed ischemic inhomogeneities on propagation in space and time-frequency domains. Journal of Biological Systems, Vol. 7, No.4, 1999, pp. 553-574. 9. Thakral, A., Stein, L., Shenai, M., Gramatikov, B.I. and Thakor, N.V. Effects of Anodal versus Cathodal Pacing on the Mechanical Performance of the Isolated Rabbit Heart. Journal of Applied Physiology, Vol. 89, Issue 3, 1159-1164, September 2000. 10. Thakor, N.V., Ferrero, J.M.Jr., Saiz, J., Gramatikov, B., Ferrero, J.M. Sr. Electrophysiologic models of heart cells and cell networks. IEEE Engineering in Medicine and Biology, Vol. 17, No.5, Sept./Oct. 1998, pp. 73-83. 11. Gramatikov, B. Variability maps of body surface ECG in normal subjects. Physiological Measurement, IOP publishing, Vol. 16, 1995, pp. 239-252. 12. Gramatikov, B., Georgiev, I. Wavelets as an Alternative to STFT in signal-averaged electrocardiography. Medical and Biological Engineering and Computing, Vol.33, No.3, May 1995, pp. 482-487. 13. Gramatikov, B., Yi-chun, S., Rix, H., Caminal, P., Thakor, N. Multiresolution wavelet analysis of the body surface ECG before and after angioplasty. Annals of Biomedical Engineering, Vol. 23, 1995, pp. 553-561. 14. Nikolov, Z., Georgiev, I., Gramatikov, B., Daskalov, I. Use of the Wavelet Transform for Time-Frequency Localization of Late Potentials. Congress '93 of the German, Austrian and Swiss Society for Biomedical Engineering, Graz, Austria, Sept 16-18 , 1993. Published as a short article in Biomedizinische Technik, Suppl.38 (1993), pp. 87-89. 15. Gramatikov, B. Detection of late potentials in the signal-averaged ECG - combining time and frequency domain analysis. Medical and Biological Engineering and Computing, Vol.31, No.4, July 1993, pp.333-339. 16. Gramatikov, B. Digital filters for detection of late potentials. Medical and Biological Engineering and Computing, Vol.31, No.4, July 1993, pp.416-420. 17. Dotsynsky, I. A., Gramatikov, B. I., Dascalov, I. K. A digital heart-ratemeter using an EPROM converter. Medical and Biological Engineering and Computing, 1980, Vol.18, pp. 481-482. 18. Gramatikov, B. I. An acoustical amplifier for phonocardiographic monitoring. Medical Technology (in Bulgarian language), No.1, 1982, pp. 65-69. 19. Dotsynsky, I. A., Gramatikov, B. I. An enhanced counter for counting microscopic cells in the clinical laboratory. Medical Technology (in Bulgarian language), No. 1, 1979, pp. 68-71 20. Gramatikov, B. I. Enhancing the microprocessor KIT-D2 (Motorola) for the development of medical instrumentation. Medical Technology (in Bulgarian language), No.1, 1981, pp. 73-75. 21. Gramatikov, B., Ivanov, E. Using triacs for programmed intensity control of electric light sources Radio, Television and Electronics (in Bulgarian language), No. 7, 1985, pp.33-34, UDK 621.382 NON-PEER REVIEWED ARTICLES 22. Nassif, D., Gramatikov, B., Guyton, D., Hunter, D. Pediatric Vision Screening using Binocular Retinal Birefringence Scanning. In Proceedings of SPIE Vol. 4951 Ophthalmic Technologies XIII, edited by Fabrice Manns, Per G. Soederberg, Arthur Ho, (SPIE, Bellingham, WA, 2003), pp 9-20. 23. Gramatikov, B. Iyer, V. Ischemia-Related Depolarization Changes Detected in Body-Surface Ambulatory ECG Recordings. Chicago 2000 World Congress on Medical Physics and Biomedical Engineering, July 23-28, 2000. Short paper (3 pages). In Congress 2000 Proceedings. ABSTRACTS - NORTH AMERICAN AND EUROPEAN CONFERENCES 24. Repka, M. X., Gramatikov, B. I. The reproducibility of blur with a Bangerter filter. AAPOS (American Association for Pediatric Ophthalmology and Strabismus), 2006 Annual Meeting, Keystone, Colorado, March 15-19, 2006. 25. Guyton, D.L., Gramatikov, B.I., Wu, Y.K. Pediatric vision screener using retinal birefringence screening: new developments. The 64-th Wilmer Residents Association Clinical Meeting. April 22-23, 2005, Wilmer Ophthalmological Institute, Johns Hopkins, Baltimore, MD 26. Gramatikov, B.I., Zalloum, O.H.Y., Wu, Y.K., Hunter, D.G., Guyton, D.L. Birefringence-Based Eye Fixation Monitor with No Moving Parts. ARVO (Association for Research in Vision and Ophthalmology), 2004 Annual Meeting, April 25-29, Ft. Lauderdale, Florida, Abstract #2534-B169. 27. Guyton, D.L., Zalloum, O.H.Y., Gemp,K.R., Hunter, D.G., Gramatikov, B.I. Simplified Polarization Birefringence Technique for Detecting Eye Fixation. ARVO (Association for Research in Vision and Ophthalmology), 2004 Annual Meeting, April 25-29, Ft. Lauderdale, Florida, Abstract #3489. 28. Hunter, D.G., Piskun, N.V., Guyton, D.L., Gramatikov, B.I., Nassif, D. Clinical performance of the Pediatric Vision Screener. ARVO (Association for Research in Vision and Ophthalmology), 2004 Annual Meeting, April 25-29, Ft. Lauderdale, Florida, Abstract #3488. 29. Hunter, D.G., Piskun, N., Guyton, D.L., Gramatikov, B.I., Nassif, D. Clinical performance of the Pediatric Vision Screener. AAPOS (American Association for Pediatric Ophthalmology and Strabismus), 2004 Annual Meeting , March 27-31, 2004, Washington DC. 30. Gramatikov, B.I., Tarczy-Hornoch, K., Nassif, D.S., Hunter, D.G., Guyton, D.L. Improved fixation target for accommodation in a focus-detection photoscreener. ARVO (Association for Research in Vision and Ophthalmology), 2003 Annual Meeting, May 4 - 9, 2003, Ft. Lauderdale, Florida, Abstract #2640. 31. Hunter, D.G., Nassif, D., Gramatikov, B., Guyton, D.L. Simultaneous detection of ocular focus and alignment using the Pediatric Vision Screener. ARVO (Association for Research in Vision and Ophthalmology), 2003 Annual Meeting, May 4-9, 2003, Ft. Lauderdale, Florida, Abstract #4423. 32. Nassif, D., Gramatikov, B., Guyton, D., Hunter, D. Pediatric Vision Screening using Binocular Retinal Birefringence Scanning. In Proceedings of SPIE Vol. 4951 Ophthalmic Technologies XIII, edited by Fabrice Manns, Per G. Soederberg, Arthur Ho, (SPIE, Bellingham, WA, 2003) in press. 33. Nusz, K., Congdon, N., Gramatikov, B., Friedman, D., Guyton, D.L., Hylton, C., Hunter, D.G. Rapid, Objective Detection of Cataract-induced Blur Using a Bull's Eye Photodetector. ARVO (Association for Research in Vision and Ophthalmology) 2002 Annual Meeting, May 5-10, 2002, Fort Lauderdale, Florida. Poster Board Number: B536; Presentation Number: 1526. 34. Hunter, D.G., Gandhi, N.K., Quraishi, I.H., Gramatikov, B.I., Guyton, D.L. Automated Detection of Ocular Defocus Using a Bull?s Eye Photodetector. Poster presentation, American Association for Pediatric Ophthalmology and Strabismus (AAPOS) annual meeting, March 2001. 35. Gramatikov, B.I., Hunter, D.G., Guyton, D.L. Determination of Ocular Defocus Using the Double-Pass Blur Image of a Point Source of Light in Model Eyes with or without Astigmatism. Abstracts of The 12th Annual Wilmer Research Meeting. March 9, 2001, Johns Hopkins University School of Medicine. 36. Thakral, A., Stein, L., Shenai, M., Gramatikov, B., Thakor, N. and Mower, M. Effects of varying the pacing waveform on mechanical performance in the rabbit heart. Pace, Vol.22, April 1999, Part II, p.750 (Abstracts of the 20th Annual Scientific Sessions of the North American Society of Pacing and Electrophysiology, NASPE, Toronto, May 12-15, 1999). 37. Thakral, A., Stein, L., Shenai, M., Gramatikov, B., Thakor, N. and Mower, M. Comparison of anodal vs. cathodal pacing patterns in isolated Langendorff perfused rabbit hearts. Abstracts of the Biomedical Engineering Society 1998 Annual Fall Meeting, 10-13 October 1998, Cleveland, OH. In Annals of Biomedical Engineering, Vol. 26, Suppl. 1, p. S-22, Abstract CB.46. 38. Shenai, M., Gramatikov, B., Thakor, N.V. Computer modeling of depolarization changes induced by myocardial ischemia. Computers in Cardiology 1998, Vol. 25, Cleveland, Ohio, Sept.13-16, 1998. pp. 321-324. 39. Gramatikov, B.I., Provaznik, I., Thakor, N.V. Depolarization Changes During Ischemia Detected Through Time-Frequency Analysis of the Intracardiac Electrogram. Computers in Cardiology 1998, Vol. 25, Cleveland, Ohio, Sept.13-16, 1998, pp. 289-292. 40. Casaleggio, A., Gramatikov, B., Thakor N. V. Dynamic Differences Between Ventricular Fibrillation Types Induced in Human Patients by Different Types of Stimulation. Computers in Cardiology 1997, Vol. 24, Lund, Sweden, Sept. 7-10, 1997, Publ. IEEE, Inc, pp.89-92 41. Casaleggio, A., Gramatikov, B., Thakor, N. On the use of Wavelets to separate dynamical activities embedded in a time series. Computers in Cardiology, Indianapolis, Sept. 8-11, 1996, Publ. IEEE, Inc, pp. 181-184. 42. Gramatikov, B., Detschew, V., Grieszbach, G. Dynamische Spektralanalyse des EKG zur fruehzeitigen Erkennung von Myokardischaemie (Dynamic spectral analysis of the ECG for early detection of myocardial ischaemia). 39th International Colloquium of the Technical University Ilmenau, Sept.27-30, 1994, Ilmenau, Germany. In Proceedings, B-2.2.2., Vol.2, pp. 384-388. 43. Gramatikov, B. Comparison of ECG maps reconstructed from irregular grids of limited number of electrodes. 39th International Colloquium of the Technical University Ilmenau, Sept.27-30, 1994, Ilmenau, Germany. In Proceedings, B-2.3.1., Vol.2, pp. 411-415. 44. Thakor, N., Yi-chun, S., Gramatikov, B., Rix, H., Caminal, P. Multiresolution wavelet analysis of ECG: Detection of ischemia and reperfusion in angioplasty. World Congress on Medical Physics and Biomedical Engineering, Rio de Janeiro, Brazil, August 1994, In Proceedings: RT15-2.4, p.392 45. Gramatikov, B, Thakor, N. Wavelet analysis of coronary artery occlusion related changes in ECG. 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, October 28-31, 1993, San Diego, California, USA. In Proceedings, p.731. 46. Thakor, N., Gramatikov, B., Mita, M. Multiresolution Wavelet Analysis of ECG during ischemia and reperfusion. Computers in Cardiology, London, 5-8 Sept. 1993. In Proceedings (IEEE Comp.Soc.Press), pp.895-898. 47. Gramatikov, B. I., Lolov, V.R. Application of Microcomputers in ECG analysis (in German) Congress'88 of the East-German Society for Biomedical Engineering and Computing. Dresden, Germany, 7.03 - 11.03.1988. In Abstracts., C-16. 48. Gramatikov, B. I. Phonocardiographic filters (in German). Congress'85 of the East-German Society for Biomedical Engineering and Computing. Leipzig, Germany, April 1985; In Proceedings, presentation B-32, pp. 110-111. 49. Gramatikov, B. I., Dotsinski, I. A. Automatic gain conrtol of phonocardiographic signals. (in German) Congress'82 of the East-German Society for Biomedical Engineering and Computing. Dresden, Germany, March 1982 . In Abstracts., C-43, p.58. 50. Dotsynsky, I. A., Gramatikov, B. I., Ninova, P. P. Microprocessor analysis of phonocardiosignals in children. Fifth conference on Bioengineering, 20-24 Sept., 1981, Budapest. (in English), In Collected Abstracts, pp.64-65. 51. Mintschew, W., Schektow, W., Gramatikow, B., Jossifow, W. An upgraded microprocessor development system based on Motorola?s Kit D2. Scientific achievements of the Bulgarian students and post-graduate students in Germany. A Publication of the Technical University Ilmenau, 1981, pp. 64-72. 52. Gramatikov, B. Measurement of heart- and respiration rate using integrated circuits (in German). Congress '79 of the East-German Society for Biomedical Engineering and Computing. Berlin, Germany, Nov., 1979. In Abstracts: C34-P. 53. Gramatikov, B. Estimation of an efficiency criterion for optimization of multilevel control systems. Review of the scientific achievements of the Bulgarian students in Germany, Berlin 1975. (in German). In Proceedings, paper No.12, pp. 10-21. ABSTRACTS - BULGARIAN CONFERENCES with international participation 54. Gramatikov, B., Daskalov, I. Changes in the ECG with PTCA. Proceedings of the Bulgarian Seventh National Conference on Biomedical Physics and Engineering (with international participation), Sofia, 17-19 Oct 1996, in English, pp. 114-116. 55. Gramatikov, B., Casaleggio, A. On the dynamical difference obtained from different simultaneously recorded leads of ECG signals. Proceedings of the Bulgarian Seventh National Conference on Biomedical Physics and Engineering (with international participation), Sofia, 17-19 Oct 1996, in English, pp. 110-113. 56. Gramatikov, B. Serial comparison of multilead ECG recordings used for mapping. Proceedings of the Bulgarian Seventh National Conference on Biomedical Physics and Engineering (with international participation), Sofia, 17-19 Oct 1996, in English, pp. 117-120. 57. Gramatikov, B. Electrocardiographic surface mapping of the human torso. Fourth National Conference of applied science ?Electronic Technology - ET?95? of The Technical University of Sofia. 27-29 Sept. 1995, Sozopol, Bulgaria. In Proceedings, pp. 122-126 (in Bulgarian language). 58. Gramatikov, B. Non-invasive recording of His-bundle activity by means of high-resolution signal-averaged electrocardiography. Sixth National Conference on Biomedical Physics and Engineering with International Participation. Sofia, 22-24 October 1992., (in English), In Proceedings, pp.3-8. 59. Gramatikov, B. Comparison of some linear phase FIR-filters for real-time ECG processing. Sixth National Conference on biomedical Physics and Engineering with international Participation. Sofia, 22-24 October 1992 (in Engl.) In Proceedings - pp.27-31. 60. Shachov, B., Gramatikov, B., Petkov, A., Dimitrov, E. Late potentials in patients with ventricular tachychardia - initial successful clinical experience with the new technology of CLEMA (Dept. of Biomedical Engineering, Medical Academy) . Fourth National Congress of Cardiology. Plovdiv, Bulgaria, June 4-5, 1992. In Abstracts - p.28, Abstract 62. ( in Bulgarian). 61. Gramatikov, B. Methods of generating and testing of digital filters for biological signals (in Bulgarian). Fourth national scientific session Automation in biotechnological processes and biomedical research, Sofia, 17-19 Sept. 1991; in Proceedings, pp. 210-217. 62. Gramatikov, B. I., Lolov, V. R. Hardware support of an ECG diagnostic system based on a 16-bit personal computer. (in English) Fifth National Conference on Biomedical Physics and Engineering with International participation Sofia, 14-16 October 1988. In conference Abstracts, pp.11-12. 63. Lolov, V.R., Gramatikov, B. I., Daskalov, I. K. A computer system for real-time processing of multiple-lead exercise ECG. (in English) Fifth National Conference on Biomedical Physics and Engineering with International participation. Sofia, 14-16 October 1988. In conference Abstracts, pp.13-14. 64. Gramatikov,B., Lolov,V. Acquisition and Processing of ECG signals using a personal computer (in Bulgarian). Third National Congress of Cardiology. Sofia, 23-25 Oct. 1987; In Abstracts, Abstr. No. 9. 65. Gramatikov, B., Zywietz, Ch. A method for computer aided detection of WPW Syndrome in conventional 12 Lead Electrocardiograms (in Bulgarian and German). A report of a 4-months' stay at the Medical University, Hannover - funded by the German Academic Exchange Service (DAAD). Published in Bulgarian in the Monthly Scientific Review of the Medical Academy, Sofia, May, 1987, pp.21-30. 66. Gramatikov, B. I. Isolated input sections of multichannel ECG amplifiers. Second Youth Conference on Biomedical Engineering with International Participation. Bulgaria, Varna, Oct., 1985. (in Bulgarian); In Abstracts: Abstr. No. 7, p 7. 67. Popov, K., Gramatikov, B. An electronic equipment for remote measurement and display of distances. (in Bulgarian) Proceedings of the National Symposium on life-guarding. Sozopol, 1984. A Red-Cross publication, Sofia 1985, pp. 164-167. 68. Gramatikov, B. I. Microprocessor Hardware of a three-channel digital storage electrocardiograph 1231. (in Bulgarian). Fourth National Conference on Biomedical Physics and Engineering with International Participation, Sofia, Nov., 1984. In Proceedings, pp. 52-54. 69. Christov, I., Dotsynsky, I., Lolov, V., Pundjev, V., Gramatikov, B. Automatic processing of nystagmograms by means of a microprocessor system. First Youth Scientific Conference on Biomedical Engineering with International Participation. Bulgaria, Varna, September, 1983. In conference Proceedings, pp. 19-22. 70. Gramatikov, B.I., Dotsynsky, I.A. Automatic gain conrtol of physiological signals in a microprocessor-based device. XVII Scientific Session dedicated to the National Radio Day. The Technical University, Sofia, May, 1982. (in Bulgarian) In conference Abstracts. Also filmed and available as micro-fiche at the Central Library for Science and Technology, Sofia. 71. Dotsynsky, I. A., Gramatikov, B. I., Christov, I., Pundjev,V. A Random time-interval generator for phycho- physiological investigations. XVII Scientific Session dedicated to the National Radio Day. The Technical University, Sofia, May, 1982. (in Bulgarian) In conference Abstracts. Also filmed and available as micro-fiche at the Central Library for Science and Technology, Sofia. 72. Gramatikov, B.I., Dotsynsky, I.A. Measuring the heart rate using a pocket calculator integerated circuit. ( in Bulgarian) Proceedings of the Youth Scientific-Technical Session at the Institute of Medical Engineering, Sofia, May, 1980. In Proceedings, pp. 63-74.
Gramatikov, B., Iyer, V. Intra-QRS Changes during Silent Ischemia as Observed in Patients with Single-Vessel LAD Occlusion in the European ST-T Database.
Ph.D. Thesis: Electronic Devices for Automatic Processing of Phonocardiographic Signals. Technical University of Sofia, 1983, UDK 616-7. Central Library of Science and Technology - Sofia, Ref. No. DS 3168.
by BORIS GRAMATIKOV
published in the Bulgarian journal "MEDICAL TECHNOLOGY" , ISSN 0324-1440 (in Bulgarian language) 1. Continuous monitoring of heart rate activity by means of ECG recording on magnetic tape with the aim of detecting and studying arrhythmias. Gramatikov, B. Medical Technology, Vol.13, 1989, No.3, pp. 21-33. 2. Automated infusion pumps for continuous insulin infusion in diabetic patients. Gramatikov, B. Medical Technology, Vol.15, 1989, No.3, pp. 3-17. 3. Comparative clinical studies on the precision of conventional and electronic devices for ambulatory blood pression measurement. Gramatikov, B. Medical Technology, Vol.15, 1982, No.3, pp. 17-23. 4. Electronical devices against diabetes. Gramatikov, B. Medical Technology, Vol.15, 1982, No.4, pp. 24-38. 5. Level and problems of the implantable cardiac pacemaker technology in Eastern Germany. Gramatikov, B. Medical Technology, Vol.12, 1979, No.4, pp. 3-13. 5. Level and problems of the implantable cardiac pacemaker technology in Eastern Germany. Gramatikov, B. Medical Technology, Vol.12, 1979, No.4, pp. 3-13.
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