Burton E. Grossman Professor of Ophthalmology
Wilmer 116, The Johns Hopkins Hospital
Phone: 410 955 8179
MD: Johns Hopkins University
MPH: Johns Hopkins University
Residency: Massachusetts Eye and Ear Infirmary, Harvard University
Fellowship: Massachusetts Eye and Ear Infirmary, Harvard University
MBA: Johns Hopkins University
Microbial Keratitis and Contact Lens Wear
Contact lenses are currently worn by more than 30 million people in the United States, and many more worldwide. Dr. Schein and colleagues published the first epidemiologically rigorous studies on the most clinically important complication of contact lens wear, corneal inflammation due to microbial infection. This research, published in 1989, led directly to a change in approval for overnight wear of contact lenses by the FDA and a coincident change in professional practice. Recently, a new generation of contact lens materials with approximately 5 times the oxygen permeability of the conventional soft contact lenses has become available. Dr. Schein led a large post-market surveillance study documenting the rate of microbial keratitis associated with this technology.
Outcomes Research and Cataract Surgery
Cataract is the most common cause of blindness and visual disability in the world. Cataract surgery is the most commonly performed operation in the United States and other developed and developing countries where adequate surgical resources exist. Dr. Schein and colleagues have devoted more than 15 years to the study of outcomes research related to cataract surgery. This body of work has included health services research related to the provision of cataract care, complications of surgery studied using a variety of different epidemiologic techniques, perioperative management of cataract surgical patients, and the patient perspective on disability from cataract and functional outcomes of surgery.
Refractive Error and Surgery
We have developed and validated the Refractive Surgery and Vision Profile(RSVP), a questionnaire that assesses visual function related to refractive error and its correction. This instrument has been rigorously translated into more than 8 foreign languages and is in use in multiple practices and clinical trials internationally.
Epidemiology of Dry Eye
Dry eye is a highly prevalent condition with significant patient impact. We performed the first population-based study of dry eye and found that symptoms of dry eye occur in approximately 14% of the elderly. In this group, the most important risk factor for dry eye was use of a number of classes of systemic medications, such as antihistamines, anticholinergics, diuretics and others.
1. Schein OD, Glynn RJ, Poggio EC, Seddon JM, Kenyon KR, and the Microbial Keratitis Study Group. The relative risk of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses: A case-control study. N Engl J Med 1989;321:773-778.
2. Poggio EC, Glynn RJ, Schein OD, Seddon JM, Shannon MJ, Scardino VA, Kenyon KR. The incidence of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses. N Engl J Med 1989;321:779-783.
3. Buehler PO, Schein OD, Stamler JF, Verdier DD, Katz J. The increased risk of ulcerative keratitis among disposable soft contact lens users. Arch Ophthalmol 1992;110:1555-1558.
4. Schein OD, McNally JJ, Katz J, Chalmers RL, Tielsch JM, Alfonso E, Bullimore M, O’Day, D, Shovlin J. The incidence of microbial keratitis among wearers of a 30-day silicone hydrogel extended-wear contact lens. Ophthalmology 2005;112:2172-2179.
5. Vitale S, Schein OD, Meinert CL, Steinberg EP. The Refractive Status and Vision Profile (RSVP): A questionnaire to measure vision-related quality of life in persons with refractive error. Ophthalmology 2000;107:1529-1539.
6. Schein OD, Vitale S, Cassard SD, Steinberg EP. Patient outcomes of refractive surgery: The Refractive Surgery and Vision Profile (RSVP). J Cat Refractive Surg 2001;27:665-673.
7. Schein OD, Tielsch JM, Muñoz B, Bandeen-Roche K, West S. Relation between signs and symptoms of dry eye in the elderly. A population-based perspective. Ophthalmology 1997;104:1395-1401.
8. Schein OD, Muñoz B, Tielsch JM, Bandeen-Roche K, West SK. Prevalence of dry eye among the elderly. Am J Ophthalmol 1997;124:723-728.
9. Bandeen-Roche K, Schein OD, Muñoz B, Tielsch JM, West SK, and SEE Project Team. A self?reported assessment of dry eye in a population-based setting. Invest Ophthalmol Vis Sci 1997;38:2469-2475.
10. Hochberg MC, Schein OD, Muñoz B, Tielsch JM, Bandeen-Roche K, West SK. Prevalence of symptoms of dry mouth and their relationship to salivary production in community-dwelling elderly: The Salisbury Eye Evaluation Project. J Rheumatol 1998;25:486?491.