Phone: (410) 955-6050
Education and Training
1990-1994 Stanford University,
B.S. in Chemistry with University and Departmental High Honors.
1994-2002 Johns Hopkins University School of Medicine
M.D. and Ph.D. in Molecular Biology and Genetics
2002-2003 Mercy Hospital of Maryland
Internship, Internal Medicine.
2003-2006 Wilmer Ophthalmological Institute, Johns Hopkins Hospital
2006-2007 Bascom-Palmer Eye Institute, University of Miami
2007-2009 Johns Hopkins School of Public Health
MHS, Graduate Training Program in Clinical Investigation
When we talk about curing glaucoma, our minds invariably race to ways that we can restore people’s vision back to normal. Unfortunately, that day is still not here (though scientists here at Wilmer are working on it!). So, in the meantime, how can we “cure” individuals who now suffer from glaucoma-related vision loss? Pradeep Ramulu M.D., Ph.D., is studying how people are affected by glaucoma, and seeks to improve the lives of glaucoma patients by obtaining an understanding of how vision loss disables them, and ultimately providing them means to overcome their visual disability.
As many of you likely know, glaucoma affects several major tasks important to in our daily lives, i.e. driving, walking, and reading. The question to be asked is not if these activities are affected by glaucoma, but rather when are they affected, how are they affected, and what can we do about it? Dr. Ramulu’s research in an elderly population found that 1 in 10 individuals with glaucoma had stopped driving because of their vision loss. This translated into 1% of all the elderly population studied! A surprising number of glaucoma patients also describe difficulty reading, despite the fact that their central vision remains intact. In fact, most patients with glaucoma can read a short paragraph at a normal speed. Dr. Ramulu has constructed new tests of reading, and his early work suggests that individuals with glaucoma may become more tired (and slow down their reading) while reading over a longer period of time. Understanding the nature of reading problems will allow for follow-up work to see if reading in glaucoma patients can be improved.
When evaluating how patients are disabled by their vision, it is also important to examine them in their normal daily routine, not just in the clinic. Dr. Ramulu has been doing this over the last year by examining activity with accelerometers (a fancy pedometer) and GPS trackers which are worn on the waist. Early results from these devices show that patients with significant glaucoma in both eyes walk less and are less physically active, predisposing them to medical problems such as heart disease, diabetes, and osteoporosis. With these sophisticated measures of physical activity in hand, Dr. Ramulu plans on examining how rehabilitative services can be used to make people more confident in their walking, and encourage them to live more active and healthy lives.
Dr. Ramulu also has projects ongoing internationally. He is currently collaborating with investigators at the Aravind Eye Institute in India examining whether family members of angle closure glaucoma patients have a higher risk of angle closure glaucoma and comparing how eyes with advanced stages of angle closure differ from eyes in the benign, early disease stages. Findings will provide insights into whether screening relatives will be a useful method for identifying patients at risk of going blind from angle closure glaucoma who might otherwise remain unaware of their disease, and will also examine the genetic basis of angle closure glaucoma to identify new potential targets for disease treatment.
Ramulu PY, Loyd T, Ferrucci L, Friedman DS. Indoor and outdoor localization using assisted global positioning system technology. International Journal of Health Geographics. Submitted for publication January 2010.
Ramulu PY, Do DV, Corcoran KJ, Corcoran SL, Robin AL. Utilization of Retinal Procedures in Medicare Beneficiaries from 1997 to 2007. Arch Ophthal. Accepted for puclication January 2010.
Ramulu PY, West SK, Munoz B, Jampel HD, Friedman DS. Glaucoma and Reading Ability: The Salisbury Eye Evaluation Project. Archives Ophthalmol. 2009 Jan;127(1):82-7.
Quigley HA, Silver DM, Friedman DS, He M, Jasti S, Plyler RJ, Jampel HD, Ramulu PY. Iris Cross-Sectional Area Decreases With Pupil Dilation and Its Dynamic Behavior Is a Risk Factor in Angle Closure. J Glaucoma. 2009 Mar;18(2):173-9.
Ramulu PY, West SK, Munoz B, Jampel HD, Friedman DS. Driving Cessation and Driving Limitation in Glaucoma: The Salisbury Eye Evaluation Project. Ophthalmology. 2009 Oct;116(10):1846-53.
Ramulu P, Corcoran KJ, Corcoran SL, Robin AL. Utilization of various glaucoma surgeries and procedures in Medicare Benefiaries from 1995 to 2004. Ophthalmology. 2007 December;114(12):2265-70.
Ramulu P, Kennedy M, Xiong WH, Williams J, Cowan M, Blesh D, Yau KW, Hurley JB, Nathans J. Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking protein phosphatases with EF hands (PPEF-1 and PPEF-2). Mol Cell Biol. 2001 Dec;21(24):8605-14.
Ramulu P, Nathans J. Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis protein phosphatase with EF-hands. J Biol Chem. 2001 Jul 6;276(27):25127-35.
Read Dr. Ramulu's complete CV