Visual Electrophysiology as an End-Point in
Clinical Trials and Animal Research
Disclaimer: Please be advised that Johns Hopkins University does not endorse any particular products or manufacturers. This notice is to advise you that there will be several companies and products that will be exhibiting at the conference.
CONFERENCE PROGRAM:
Friday September 14, 2007
Afternoon 2:00 – 5:30
Basic Aspects of Electroretinogram Interpretation
- Cellular Basis of ERG Signals
Laura J. Frishman, PhD
An update on the current understanding of the cellular mechanisms involved in generating retinal electric currents.
- Applying the ERG to Special Situations
Gislin Dagnelie, PhD
An examination of how the current technology of the ERG can be applied to understanding retinal pathophysiology, with focus on its use in advanced vision loss.
- Functionally Dissecting the Retina
John G. Robson, PhD
An in-depth review of how the ERG can be used to dissect the retina and assess function based on cell-types.
- ERG for Clinical Diagnoses
Rafael C. Caruso, MD
An overview on how the ERG can be used to determine retinal pathophysiology.
- The Multifocal ERG: Interpretations
Jonathan S. Lyons, MD
An examination of current multifocal ERG interpretation methodologies, including use of ring ratios.
Saturday September 15, 2007
Morning 7:30 – 11:30
The Electroretinogram in Animal Models of Eye Disease
- Electroretinography in Rodent Models of Retinal Degenerations and Therapies
Yves Sauve, PhD
A detailed talk on methodologies of ERG testing in rodents.
- Interpreting the ERG in Animal Models
Jeffrey A. Jamison, PhD
Applying the ERG to drug discovery in animal models of ERG in human eye disease.
- Species Differences in ERG Testing
Andras M. Komaromy, DMV, PhD
A focused talk on methodologies of ERG testing in small and large animal models.
- The ERG for Non-Clinical Safety Testing of Ophthalmic Drugs
Kai Ming Zhang, PhD
An examination of methods used for pre-clinical safety testing of ophthalmic compounds.
- The ERG as an End-Point in Animal Models of Eye Disease
Mary A. Johnson, Ph.D.
The use of the ERG as a primary end-point in animal models of retinal and optic nerve disease.
11:30 – 12:30 Lunch
Saturday September 15, 2007:
Afternoon 12:30 – 5:30
The Electroretinogram in Clinical Trials of Retinal Disease
- The ERG and Molecular Genetics
Rafael C. Caruso, MD
An introduction to the molecular genetics of retinal diseases and their correlation with ERG findings.
- The Role of the ERG in Clinical Trials
Mitchell Brigell, PhD
Electrophysiology in clinical drug trials: the pharmaceutical perspective.
- Electrophysiology in Retinal Ischemia
Matthew L. Severns, PhD
Assessing the ERG in retinal ischemia, with focus on oscillatory potentials.
- The Role of the ERG and Combined Functional and Structural Imaging Using MRI
Machelle T. Pardue, PhD
The use of ERG combined with morphology and MRI to characterize early changes in retinal function and structure.
- The ERG for Clinical Safety Testing of Ophthalmic Drugs
James N. Ver Hoeve, PhD
A focused talk on large-scale pre-clinical safety evaluation using ERG.
- The ERG as an End-Point in Clinical Trials
Panel discussion
Question-and-answer panel discussion on recent advances and ongoing controversies on using the ERG as a primary end-point in clinical trials.
Sunday September 16, 2007
Concurrent Sessions
Morning 8:30 – 11:30/11:30 – 12:30 Lunch/Afternoon 12:30 – 3:30
- ERG Testing Protocols in Animal Models
Wet-Lab with Rodents and Small Mammals
Interpretation Module
- ERG Testing Protocols in Humans
Wet-Lab with Full-Field ERG and Multifocal ERG
Interpretation Module
CONFERENCE FACULTY:
Course Director
Neal Adams, MD
Chief of Division of Visual Physiology
The Wilmer Eye Institute, Baltimore, Maryland
Wet-Lab Director
Sam A. D’Anna, MS, RLAT
Assistant Professor of Ophthalmology
The Wilmer Eye Institute, Baltimore, Maryland
Guest Faculty
Mitchell Brigell, PhD
Senior Clinical Scientist, Translational Medicine
Novartis Institutes of Biomedical Research, Cambridge, Massachusetts
Rafael C. Caruso, MD
National Eye Institute, National Institutes of Health, Bethesda, Maryland
Gislin Dagnelie, PhD
Associate Professor of Ophthalmology
Wilmer Eye Institute, Baltimore, Maryland
Laura J. Frishman, PhD
Moores Professor & Assoc. Dean
University of Houston, College of Optometry, Houston, Texas
Jeffrey A. Jamison, PhD
Senior Scientist III
Alcon Laboratories, Fort Worth, Texas
Mary A. Johnson, PhD
Assoc. Professor of Ophthalmology
University of Maryland, Baltimore, Maryland
Andras M. Komaromy, DMV, PhD
Assist. Professor of Ophthalmology
School of Veterinary Medicine
University of Pennsylvania, Philadelphia, Pennsylvania
Jonathan S. Lyons, MD
Retinal Electrophysiology Service
Georgetown University Washington, DC
Machelle T. Pardue, PhD
Assistant Professor & Research Biologist
Atlanta VA Medical Center, Emory University, Atlanta, Georgia
John G. Robson, PhD
Senior Research Professor of Vision Science
University of Houston, College of Optometry, Houston, Texas
Yves Sauve, PhD
Assistant Professor of Ophthalmology & Physiology
University of Alberta, Edmonton, Alberta
Matthew L. Severns, PhD
LKC Technologies, Inc. Gaithersburg, Maryland
James N. Ver Hoeve, PhD
Senior Scientist University of Wisconsin at Madison, Madison, Wisconsin
Kai Ming Zhang, PhD
Dept. of Biological Sciences, Allergan Inc., Irvine, California
Space is Limited! -- Early Registration is Suggested!
