Skip Navigation
 
 
 
 
Wilmer Eye Institute
 
Print This Page
Share this page: More
 

Types of Fuchs

Early-onset vs. Late-onset Fuchs Dystrophy

Both types of Fuchs' dystrophy share the same general features of pathological progression. Endothelial guttae are formed, which eventually leads to the formation of corneal edema (swelling).  There are, however, subtle differences in physical appearance that can be observed through examination of the two types of disease.

Early-onset guttae are usually more coarse and distinct while those in late-onset appear more fine and patchy. The excrescences (dewdrop-like protrusions) in early-onset Fuchs possess sharper margins. Areas of coalescence (where the guttae merge together into one big patch) are clearly evident with definite intervening areas that had not been affected. Those in late-onset, however, are uniformly elevated and spread out. Furthermore, confocal microscopy indicated that late-onset guttae are generally associated with individual endothelial cells while this correlation is not present for early-onset Fuchs. The association of guttae with individual endothelial cells may be related to the subtle yet numerous guttae viewed through the slit lamp.

   

Late-Onset

Late-Onset of the Endothelium


Confocal Spectrometry
Images of the Endothelium

Early-Onset

Early-Onset of the Endothelium



Late-Onset


Late-Onset Slit Lamp




Slit Lamp Images
of the Cornea

Arrows point
to side-view
of cornea

Early-Onset


Early-Onset Slit Lamp

One gene that has been discovered to be responsible for Early Onset Fuchs Dystrophy is COL8A (on chromosome 1).  It is shown below:

Chromosome 1 for Early Onset Fuchs Dystrophy


Mutations in Chromosomes 13 and 18 have also been discovered.  These are linked to late-onset Fuchs dystrophy.  These mutations are illustrated below:

Chromosome 13 for late-onset fuchs dystrophy 
Chromosome 13.  The mutation linked to late-onset Fuchs Dystrophy
has been named FCD1.  Shown on the right are some of the genes that
may be the reaseon that this mutation leads to Fuchs Dystrophy.



Chromosome 18 for late-onset fuchs dystrophy
Chromosome 18.  FCD2 was discovered to be linked to late-onset Fuchs
Dystrophy in three different families with the disease.
 


> Read more about the discovery of these genes.

Dr. Sheila West on the Link Between Smoking and Eye Disease in Women - 7/23/2014

Dr. Pradeep Ramulu and Colleagues Study Relationship Between Vision Loss and Work Status - 7/18/2014

Wilmer Resident Receives Lindstrom Research Grant - 7/11/2014

Four Wilmer Researchers Receive BrightFocus Foundation Awards - 7/10/2014

Dr. Michael Repka Part of Team Researching Telemedicine and ROP - 6/27/2014

Dr. M. Valeria Canto-Soler and Colleagues Featured on WBAL-TV - 6/24/2014

Dr. M. Valeria Canto-Soler and Colleagues Use Human Stem Cells to Create Light-Sensitive Retina in a Dish - 6/10/2014

Wilmer's Division of Ocular Immunology Announces "Living With Uveitis" Support Group - 6/10/2014

Dr. Neil Bressler to Speak on Diabetic Retinopathy at National Eye Health Summit and Webcast - 6/10/2014

Dr. Donald Zack Receives a Research to Prevent Blindness Nelson Trust Award for Retinitis Pigmentosa - 6/9/2014

Dr. Michael Boland Leads Study on Effectiveness of Automated Telecommunication-Based Reminders on Adherence to Glaucoma Medication Dosing - 6/4/2014

Dr. Christina Prescott Discusses Summer Eye Protection on Fox 45 News - 6/1/2014

Dr. Jonathan Song Discusses Treatment Options for Pediatric Cataracts - 5/23/2014

Johns Hopkins' Jordan Green Discusses His Work at Wilmer's Translational Tissue Engineering Center - 5/21/2014

Longtime Wilmer Employee Lillie Alston Honored by Hopkins - 5/19/2014

Dr. Richard Semba: Diets Rich in Antioxidant Resveratrol Fail to Reduce Deaths, Heart Disease or Cancer - 5/12/2014

Dr. Neil Miller Explains Eye Twitching in The Wall Street Journal - 5/12/2014

Dr. Hendrik Scholl Receives ARVO Award - 5/7/2014

 

Traveling for care?

blue suitcase

Whether crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

U.S. 1-410-464-6713 (toll free)
International +1-410-614-6424

 

 
 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer