Skip Navigation
Search Menu

Wilmer Eye Institute
Print This Page
Share this page: More

Types of Fuchs

Early-onset vs. Late-onset Fuchs Dystrophy

Both types of Fuchs' dystrophy share the same general features of pathological progression. Endothelial guttae are formed, which eventually leads to the formation of corneal edema (swelling).  There are, however, subtle differences in physical appearance that can be observed through examination of the two types of disease.

Early-onset guttae are usually more coarse and distinct while those in late-onset appear more fine and patchy. The excrescences (dewdrop-like protrusions) in early-onset Fuchs possess sharper margins. Areas of coalescence (where the guttae merge together into one big patch) are clearly evident with definite intervening areas that had not been affected. Those in late-onset, however, are uniformly elevated and spread out. Furthermore, confocal microscopy indicated that late-onset guttae are generally associated with individual endothelial cells while this correlation is not present for early-onset Fuchs. The association of guttae with individual endothelial cells may be related to the subtle yet numerous guttae viewed through the slit lamp.

One gene that has been discovered to be responsible for Early Onset Fuchs Dystrophy is COL8A (on chromosome 1).  It is shown below:

Chromosome 1 for Early Onset Fuchs Dystrophy

Mutations in Chromosomes 13 and 18 have also been discovered.  These are linked to late-onset Fuchs dystrophy.  These mutations are illustrated below:

chromosome 18

> Read more about the discovery of these genes.

Sanford Greenberg Elected to the American Academy of Arts and Sciences

Dr. Gehlbach Project Selected by Johns Hopkins-Coulter Translational Project Partnership- 06/23/16

Dr. Neil Bressler Speaks at Senate Briefing on Special Diabetes Program- 06/09/16

Dr. Neil Bressler Discusses Blue Light Effects on the Eyes in the Washington Post- 06/02/16

Dr. Arevalo Honored by National Institute of Ophthalmology in Peru- 5/31/16

Dr. Jennifer Thorne Appointed President-elect of American Uveitis Society- 5/17/16

Dr. Ingrid Zimmer-Galler Elected to the ATA College of Fellows- 5/13/16

Dr. Arevalo Launches New Book at ARVO 2016- 5/09/16

Dr. Elia J. Duh is elected to the American Society for Clinical Investigation- 4/28/16

Dr. Maria Valeria Canto Soler Wins BrightFocus Award for Macular Degeneration Research- 4/27/16

Three Wilmer Faculty Voted Most Influential in Field of Ophthalmology- 4/22/2016

Dr. Pradeep Ramulu Wins Pisart Award for Significant Achievement in Vision Science Research- 4/21/16

Dr. Eghrari Receives Alcon Early Career Research Award- 4/13/16

Dr. Quigley Honored by American Glaucoma Society- 4/11/16

Dr. Ian Pitha Awarded Grants for Glaucoma Research- 4/11/16