February 2012
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Physiology Archives

1. Beckstein O, Denning EJ, Perilla JR, Woolf TB. Zipping and unzipping of adenylate kinase: atomistic insights into the ensemble of open ? closed transitions. J Mol Biol. 2009 Nov 20;394(1):160-76.
Key words: conformational transitions, molecular dynamics, rational drug design
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-4X6VMNK-
2&_user=75682&_coverDate=11%2F20%2F2009&_alid=1091656910&_rdoc=
2&_fmt=high&_orig=search&_cdi=6899&_sort=r&_docanchor=&view=c&_ct=
3&_acct=C000006078&_version=1&_urlVersion=0&_userid=75682&md5=
9a7c49aa12a048160d04f7a1a8d6efdf
PMID: 19751742

2. Denning EJ, Woolf TB. Cooperative nature of gating transitions in K+ channels as seen from dynamic importance sampling calculations. Proteins (published in early-view: DOI 10.1002/prot.22632)
Key words: K-channel gating, conformational change, molecular dynamics
http://www3.interscience.wiley.com/search/allsearch?mode=viewselected&product=
journal&ID=122651100&view_selected.x=46&view_selected.y=7&view_selected=
view_selected

3. Denning EJ, Crozier PS, Sachs JN, Woolf TB. From the gating charge response to pore domain movement: Initial motions of Kv1.2 dynamics under physiological voltage changes. Mol Membr Biol. 2009 Dec;26(8):397-421.
Key words: K-channels, molecular basis of membrane voltage, molecular dynamics
http://informahealthcare.com/toc/mbc/26/8?cookieSet=1
PMID: 19883299

4. Flotte TR, Fischer AC, Goetzmann J, Mueller C, Cebotaru L, Yan Z, Wang L, Wilson JM, Guggino WB, Engelhardt JF. Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway. Mol Ther. 2009 Oct 13. [Epub ahead of print].
Key words: rAAV vectors, chimpanzee
http://www.ncbi.nlm.nih.gov/pubmed/19826405?itool=EntrezSystem2.PEntrez.Pubmed.
Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

5. Li Y, Santoso NG, Woodward OM, Qian F, Guggino WB. Polycystin-1 interacts with IP3R to modulate intracellular Ca2+ signaling, with implications for polycystic kidney disease. J Biol Chem. 2009 Oct 23. [Epub ahead of print]
Key words: polycystin-1, IP3R, Ca2+ signaling, polycystic kidney disease
http://www.ncbi.nlm.nih.gov/pubmed/19854836?itool=EntrezSystem2.PEntrez.Pubmed.
Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

6. Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, Cai H. WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. J Am Soc Nephrol. 2009 Oct 29. [Epub ahead of print]
Key words: WNK4, NCC, sortilin, lysosomal pathway
http://www.ncbi.nlm.nih.gov/pubmed/19875813?itool=EntrezSystem2.PEntrez.Pubmed.
Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

1. Claypool SM, Oktay Y, Boontheung P, Loo JA, Koehler CM. Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane. J Cell Biol 2008 Sep 8;182(5):937-50.
Key words: ADP/ATP carrier; cardiolipin; apoptosis; mitochondria; oxidative phosphorylation
http://www.jcb.org/cgi/content/full/182/5/937
PMID: 18779372

2. Claypool SM, Boontheung P, McCaffery JM, Loo JA, Koehler CM. The cardiolipin transacylase, tafazzin, associates with two distinct respiratory components providing insight into Barth Syndrome. Mol. Biol. Cell 2008 Sep 17. [Epub ahead of print]
Key words: ADP/ATP Carrier; ATP synthase; cardiolipin; cristae morphology; oxidative phosphorylation
http://www.molbiolcell.org/cgi/content/abstract/E08-09-0896v1
PMID: 18799610

3. Law CJ, Maloney PC, Wang DN. Ins and outs of major facilitator superfamily antiporters. Ann. Rev. Microbiol. 2008 Oct 13;62:289-305.
Key words: membrane transport, crystal structure, major facilitator superfamily
http://www.ncbi.nlm.nih.gov/pubmed/18537473?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_
RVDocSum

1. Christensen EI, Devuyst O, Dom G, Nielsen R, Van der Smissen P, Verroust P, Leruth M, Guggino WB, Courtoy PJ. Loss of chloride channel CIC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Proc Natl Acad Sci 2003; 100: 8472-7.
Key words: CIC-5, endocytosis, megalin, cubilin, proximal tubules
http://www.pnas.org/cgi/content/full/100/14/8472

2. Hryciw DH, Wang Y, Devuyst O, Pollack CA, Poronnik P, Guggino, WB. Cofilin interacts with CIC-5 and regulates albumin uptake in proximal tubule cell lines. J Biol Chem 2003. [Epub ahead of print]
Key words:
cofilin, CIC-5, albumin, proximal tubules
http://www.jbc.org/cgi/reprint/278/41/40169.

3. Santos OD, Grozovsky R, Goldenberg RC, Carvalho DP, Fong P, Guggino WB, Morales, M. Thyroid hormone modulates CIC-2 chloride channel gene expression in rat renal proximal tubules. J Endocrinol 2003; 178: 503-11.
Key words: thyroid hormone; CIC-2, gene expression, proximal tubules
http://journals.endocrinology.org/joe/178/joe1780503.htm

1. Feller SE, Gawrisch K, Woolf TB Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. J Am Chem Soc 2003; 125 (15): 4434-4435
Key words: rhodopsin, GPCR, lipidprotein interaction

2. Saran, NG, Pletcher, MT, Natale, JE, Cheng, Y, Reeves, RH. Global disruption of the cerebellar transcriptome in a down syndrome mose model. Human Molecular Genetics 2003; 12 (16): 2013-2019.
Key words: down syndrome, microarray, transcriptome

1. Boyle MP, Enke RA, Mogayzel PJ, Guggino WB, Martin DB, Agarwal S, Zeitlin PL. Effect of adeno-associated virus-specific immunoglobulin G in human amniotic fluid on gene transfer. Human Gene Therapy 2003; 14:365-373.
Key words: channels, CF, kidney, lung, cysteines
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=12659677&dopt=Abstract

2. Hirai T, Heymann JA, Maloney PC, Subramaniam S. Structural model for 12-helix transporters belonging to the major facilitator superfamily. J Bacteriol 2003; 185:1712-1718.
Key words: transporter, electron crystallography, major facilitator superfamily, structure, 12-helix membrane protein
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=12591890&dopt=Abstract

3. Roman LM. Signal Transduction. In: Medical Physiology. A cellular and molecular approach. Saunders 2003; 87-114
Key words: cell signaling, ligand, receptors, effectors, physiology

4. Sachs JN, Petrache HI, Zuckerman DM, Woolf TB. Molecular dynamics simulations of ionic concentration gradients across model bilayers. J Chemical Physics 2003 Jan 22; 118(4):1957-1969.
Key words: interfacial electric-fields, long-range forces, lipid bilayers, surface-charge, electrolyte systems, computer-simulation, membrane surfaces
http://ojps.aip.org/getabs/servlet/GetabsServlet?prog=normal
&id=JCPSA6000118000004001957000001&idtype=cvips&
gifs=yes

5. Silva IV, Cebotaru V, Wang H, Wang XT, Wang SS, Guo G, Devuyst, Takker RV, Guggino WB, Guggino, SE. The CIC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover. J Bone Miner Res 2003; 18:615-623.
Key words: channels, CF, kidney, lung, cysteines
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=12674322&dopt=Abstract

6. Wang SX, Ikeda M, Guggino WB. The cytoplasmic tail of large conductance, voltage- and Ca2+-activated K+ (MaxiK) channel is necessary for its cell surface expression. J Biol Chem 2003; 2713-2722.
Key words: channels, CF, kidney, lung, cysteines
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=12438308&dopt=Abstract


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