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October 2008
PUBLICATIONS - Back

Neurosurgery Archives

1. Pujari S, Kharkar S, Metellus P, Shuck J, Williams M, Rigamonti D. Normal pressure hydrocephalus: Very long term outcome after shunt surgery. J Neurol Neurosurg Psychiatry 2008 Mar 20. [Epub ahead of print]
Key words: normal pressure hydrocephalus, outcome, shunt
http://www.ncbi.nlm.nih.gov/pubmed/18356257?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Walczak P, Zhang J, Gilad AA, Kedziorek DA, Ruiz-Cabello J, Young RG, Pittenger MF, van Zijl PC, Huang J, Bulte JW. Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke. 2008 May;39(5):1569-74. Epub 2008 Mar 6.
Key words: cerebral ischemia, imaging, stem cells
http://www.ncbi.nlm.nih.gov/pubmed/18323495?ordinalpos=2&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

2. Zhang J, Yang ZJ, Klaus JA, Koehler RC, Huang J. Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouse.Stroke. 2008 Mar;39(3):967-74. Epub 2008 Jan 31.
Key words: cerebral ischemia, animal models, ischemic preconditioning
http://www.ncbi.nlm.nih.gov/pubmed/18239169?ordinalpos=2&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Ohara S, Wang L, Ku Y, Lenz FA, Hsiao SS, Hong B, Zhou Y-D. Neural activities of tactile cross-modal working memory in humans: An event-related potential study. Neuroscience 2008 Jan 12 [Epub ahead of print].
Key words: auditory; ERP; cross-modal; human; working memory
http://www.ncbi.nlm.nih.gov/pubmed/18304742?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Zhao CS, Chen L, Tao YX, Tall JM, Borzan J, Ringkamp M, Meyer RA, Raja SN.
Lumbar sympathectomy attenuates cold allodynia but not mechanical allodynia
and hyperalgesia in rats with spared nerve injury. J. Pain 2007 Dec; 8(12):931-937.
Key words: lumbar sympathectomy, allodynia, hyperalgesia, nerve injury
http://www.ncbi.nlm.nih.gov/pubmed/17693138?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Bagley CA, Bookland MJ, Pindrik JA, Ozmen T, Gokaslan ZL, Witham TF. Local delivery of oncogel delays paresis in rat metastatic spinal tumor model. J Neurosurg Spine. 2007 Aug;7(2):194-8.
Key words: local chemotherapy; metastatic spinal tumor; rat
http://thejns.org/doi/full/10.3171/spi.2007.7.2.194?prevSearch=allfield%3A%
28gokaslan%29
PMID: 17688059

2. Gallia GL, Sciubba DM, Bydon A, Suk I, Wolinsky JP, Gokaslan ZL, Witham TF. Total L-5 spondylectomy and reconstruction of the lumbosacral junction. Technical note. J Neurosurg Spine. 2007 Jul;7(1):103-11. Review.
Key words: lumbar spine; spinal reconstruction; spinal tumor; spondylectomy http://thejns.org/doi/full/10.3171/spi.2007.7.1.103?prevSearch=allfield%3A%
28gokaslan%29
PMID: 17633498

3. Mandir AS, Hilfiker J, Thomas G, Minahan RE, Crawford TO, Williams MA, Rigamonti D. Extrapyramidal signs in normal pressure hydrocephalus: an objective assessment. Cerebrospinal Fluid Research 2007 Aug 13; 4(1):7.
Key words: hydrocephalus, normal pressure hydrocephalus, extrapyramidal signs
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&
TermToSearch=17697324

4. Raza SM, Jabbour, S, Thai Q-A, Pradilla G, Kleinberg LR, Wharam M, Rigamonti D. Repeat stereotactic radiosurgery for high-grade and large intracranial arteriovenous malformations. Surgical Neurology 2007 Jul; 68:24-34.
Key words: large; high grade; arteriovenous malformations; repeat; radiosurgery
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&
TermToSearch=17586215

5. Shehadi JA, Sciubba DM, Suk I, Suki D, Maldaun MV, McCutcheon IE, Nader R, Theriault R, Rhines LD, Gokaslan ZL. Surgical treatment strategies and outcome in patients with breast cancer metastatic to the spine: a review of 87 patients. Eur Spine J. 2007 Aug;16(8):1179-92.
Key words: breast cancer; estrogen; metastases; prognosis; spine surgery http://www.springerlink.com/content/w7347220q527h03w/?p=f648e52e817744
a29c0386c5aef70c6f&pi=6
PMID: 17406908

6. Williams MA, Sharkey P, Van Doren D, Thomas G, Rigamonti D. Influence of shunt surgery on healthcare expenditures of elderly fee-for-service Medicare beneficiaries with hydrocephalus. J Neurosurg 2007; 107:21-28.
Key words: age, healthcare cost, healthcare disparity, hydrocephalus, medicare, shunt surgery
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&
TermToSearch=17639869

7. Woodworth GF, Chaichana KL, McGirt MJ, Sciubba DM, Jallo GI, Gokaslan Z, Wolinsky JP, Witham TF. Predictors of ambulatory function after surgical resection of intramedullary spinal cord tumors. Neurosurgery. 2007 Jul;61(1):99-105.
Key words: hyperglycemia; intramedullary spine tumor; outcome; predictors; radiation
http://gateway.tx.ovid.com/gw2/ovidweb.cgi
PMID: 17621024


08/07

1. Zhou YD, Ardestani A, Fuster JM. Distributed and associative working memory. Cereb Cortex 2007 Jul 5 [Epub ahead of print].
Key words: cross-modal, haptic, monkey, network, parietal cortex, units
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17615249

1. Shafi M, Zhou Y-D, Quintana J, Chow C, Fuster J, Bodner M. Variability in neuronal activity in primate cortex during working memory tasks. Neuroscience. 2007 May 25;146(3):1082-108.
Key words: spike trains, monkeys, memory networks, parietal cortex, prefrontal cortex, computational models
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17418956

1. Bookland MJ, Bagley CA, Schwarz J, Burger P, Brem H. Intracavernous trigeminal ganglion myloidoma: Case Reports. Neurosurgery 2007 March;60(3):E574.
Key words: Amyloidoma, intracavernous, trigeminal ganglion
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17327767

2. Shim B, Ringkamp M, Lambrinos GL, Hartke TV, Griffin JW, Meyer RA. Activity-dependent slowing of conduction velocity in uninjured L4 C fibers increases after an L5 spinal nerve injury in the rat. Pain 2007; 128:40-51.
Key words: Neuropathic pain, nerve injury, neuropathy, Wallerian
degeneration, unmyelinated afferent
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17030437

1. Piccirillo SGM, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, DiMeco F, Vescovi AL. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006 Dec 7;444:761-65.
Key words: Bone morphogenetic proteins, neural stem cells, oncogenic precursors
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17151667

1. Sampath P, Rhines LD, DiMeco F, Tyler BM, Park MC, Brem H. Interstitial docetaxel: A novel agent against experimental malignant glioma. J Neurooncol. 2006 Oct;80(1):9-17.
Key words: docetaxel, malignancy, glioma
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=16636748

1. Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron 2006 Oct 5; 52 (1): 77-92.
Key words: Neuropathy, chronic pain, hyperalgesia, sensitization, animal models
http://www.neuron.org/content/article/abstract?uid=PIIS0896627306007288
PMID: 17015228

1. Caplan J, Pradilla G, Hdeib A, Tyler BM, Legnani FG, Bagley CA, Brem H, Jallo G. A novel model of intramedullary spinal cord tumors in rats: Functional progression and histopathological characterization." Neurosurgery 2006 Jul;59(1):193-200.
Key words: 9L gliosarcoma, animal model, F98 glioma, intramedullary spinal cord tumor
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=16823316

1. Guan Y, Borzan J, Meyer RA, S.N.Raja. Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanisms. J. Neuroscience 2006;26:4298-4307.
Key words: Windup, temporal summation, endogenous opioids
http://www.jneurosci.org/cgi/content/full/26/16/4298
PMID: 16624950

2. Haque RM, Amundson E, Dorsi M, Brem H. Interstitial Chemotherapy and Polymer Drug Delivery, In: Handbook of Brain Tumor and Chemotherapy, Editor, Herbert B. Newton, (Elsevier Inc, The Netherlands) 2006; Chapter 19, pp 274-294.
Key words: Interstitial chemotherapy, local drug delivery, CNS tumors

3. Ringkamp M, Meyer RA, "Does peripheral sensitization of primary afferents play a role in neuropathic pain?" In: Emerging Strategies for the treatment of neuropathic pain (Eds: J.N.Campbell, A.I. Basbuam, A. Dray, R. Dubner, R.H. Dworkin, C.N. Sang), IASP press (2006) 87-102.
Key words: neuropathic pain, primary afferents, sensitization

1. Renard VM, North RB. Prevention of percutaneous electrode migration in spinal cord stimulation by a modification of the standard implantation technique. J Neurosurg: Spine 2006;4:300-3.
Key words, spinal cord stimulation, electrode migration, percutaneous electrode, complications, operative technique
http://www.thejns-net.org/spine/issues/current/toc.html
PMID: 16619676

1. Ohara S, Lenz FA, Zhou YD. Modulation of somatosensory event-related potential components in a tactile-visual cross-modal task. Neuroscience. 2006 Jan 24; [Epub ahead of print]
Key words: EEG; N140; human; frontal; SII
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16442738

1. North RB, Kidd DH, Olin J, Sieracki JN, Petrucci L. Spinal cord stimulation for axial low back pain: A prospective controlled trial comparing 16-contact insulated electrodes with 4-contact percutaneous electrodes. Neuromodulaton 2006;9(1):56-67.
Key words: low back pain, failed back surgery syndrome, spinal cord stimulation, electrode design
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16284568

2. North RB, Linderoth B. Spinal cord stimulation for chronic, intractable pain. In: Schmidek HH, Roberts DW, eds. Schmidek & Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results, volume 2, 5th edition. Philadelphia, PA: Elsevier, pp 2165-86.
Key words: spinal cord stimulation, chronic pain, mechanism of action, indications, cost effectiveness

1. Khanna AJ, Shindle MK, Wasserman BA, Gokaslan ZL, Gonzales RA, Buchowski JM, Riley LH III: Use of magnetic resonance imaging in differentiating compartmental location of spinal tumors. Am J Orthop 2005; 34(10):472-476.
Key words: MRI, spinal tumors
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16304794

2. Kumar K, North R, Taylor R, Sculpher M, Van den Abeele C, Gehring M, Jacques L, Eldabe S, Meglio M, Molet J, Thomson S, O'Callaghan J, Eisenberg E, Milbouw G, Fortini G, Richardson J, Buchser E, Tracey S, Reny P, Brookes M, Sabene S, Cano P, Banks C, Pengelly L, Adler R, Leruth S, Kelly C. Spinal cord stimulation vs. conventional medical management: A prospective, randomized, controlled, multicenter study of patients with failed back surgery syndrome (PROCESS Study). Neuromodulation 2005;8:213-8.
Key words: dorsal column stimulation, neuropathic pain, spinal cord stimulation, failed back surgery syndrome

3. North RB, Kidd DH, Petrucci L, Dorsi MJ. Spinal cord stimulation electrode design: A prospective, randomized, controlled trial comparing percutaneous and laminectomy electrodes. Part II: Clinical outcomes. Neurosurgery 2005; 57:990-6.
Key words: electrical stimulation, electrode design, failed back surgery syndrome, low back pain, spinal cord stimulation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16284568

1. Meyer RA, Ringkamp M, Campbell JN, Raja SN. Neural mechanisms of hyperalgesia after tissue injury. Johns Hopkins APL Tech Digest 2005;26:56-66
Key words: hyperalgesia, neuropathic pain, nociceptor

2. Rand V, Huang J, Stockwell T, Ferriera S, Buzko O, Levy S, Busam D, Li K, Edwards JB, Eberhart C, Murphy KM, Tsiamouri A, Beeson K, Simpson AJ, Venter JC, Riggins GJ, Strausberg RL. Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14344-9. Epub 2005 Sep 26.
Key words: cancer, genome, mutation, fibroblast growth receptor 1, platelet-derived growth factor receptor-a
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16186508

1. North RB, Kidd DH, Olin J, Sieracki JM, Farrokhi F, Petrucci L, Cutchis PN. Spinal cord stimulation for axial low back pain: A prospective, controlled trial comparing dual with single percutaneous electrodes. 2005 Jun 15;30(12):1412-1418.
Key words: low back pain, failed back surgery syndrome, electrical stimulation, spinal cord stimulation, electrode design
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15959371

1. Bodner M, Shafi M, Zhou Y-D, Fuster JM. Patterned firing of parietal cells in haptic working memory. Eur J Neurosci 2005;21: 2538-2546.
Key words: haptic working memory, monkeys, parietal cortex, recurrent networks, spike patterns
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1460-9568.2005.04085.x

2. Fuster J, Guiou M, Ardestani A, Cannestra A, Sheth S, Zhou Y-D, Toga A, Bodner M. Near-Infrared Spectroscopy (NIRS) in neuroscience of the primate brain. Neuroimage 2005; 26: 215-220.
Key words: near-infrared spectroscopy, cognitive neuroscience, working memory, slow potentials
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15862221

3. Ni Y, Zhou Y-D. Teaching and learning rational numbers: The origin and implications of whole number bias. Educational Psychologist 2005; 40: 27-52.
Key words: teaching, rational numbers, whole number bias

4. North RB, La Rocca VR, Schwartz J, North CA, Zahurak M, Davis RF, McAfee PC. Surgical management of spinal metastases: Analysis of prognostic factors during a ten-year experience. J Neurosurg: Spine 2005;2:564-73.
Key words: spinal metastases; ambulatory ability; survival; surgical techniques; radiation therapy
http://www.thejns-net.org/spine/issues/v2n5/pdf/s0020564.pdf

5. Ohara S, Lenz F, Zhou Y-D. Sequential neural processes of tactile-visual crossmodal working memory. Neuroscience 2005 (in press).
Key words: ERP, EEG, working memory, human, crossmodal

1. Mantha A, Legnani FG, Bagley CA, Gallia G, Garonzik I, Pradilla G, Amundson E, Tyler BM, Brem H, Gokaslan ZL. A novel rat model for the study of intraosseous metastatic spine cancer. J Neurosurg Spine 2005;2:303-7.
Key words: Animal model, spinal metastasis, breast metastasis
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15796355


2. Raza SM, Pradilla G, Legnani FG, Thai QA, Olivi A, Weingart JD, Brem H. Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumuors. Expert Opin Biol Ther 2005;5(4):477-94.
Key words: Angiogenesis, controlled release polymers, glioblastoma multiforme

3. Wang P, Brem H. Neurosurgical applications for polymeric drug delivery systems. In Progress in Neurological Surgery, Series Editor: L.D.Lunsford. Vol 18, Principles of Molecular Neurosurgery Volume Editors: A. Freese, F.A. Simeone, P. Leone, C. Janson. (Karger Publishers, Switzerland), 2005, pp. 458-498.
Key words: Drug delivery systems, angiogenesis inhibitors, malignant brain tumors

1. Chang SM, Parney IF, Huang W, Anderson FA, Asher AL, Bernstein M, Lillehei KO, Brem H, Berger MS, Laws ER, and the Glioma Outcomes Project Investigators. Patterns of care for adults with newly diagnosed malignant glioma. JAMA 2005;293(5):557-564.
Key words: Glioma Outcomes, malignant glioma
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15687310

2. Koenig MA, Geocadin RG, Kulesza P, Olivi A, Brem H. Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. J Neurosurg , 2005;102:371-375.
Key words: Rhabdoid meningioma, leptomeningeal carcinomatosis

3. Lesniak M, Frazier J, Brem H. Targeting drugs to tumors of the Central Nervous System. In Contemporary Cancer Research: Brain Tumors, editor, F. Ali-Osman (Humana Press, Totowa, NJ), 2004; Chapter 18, pp 343-358.
Key words: CNS, brain tumors, drug targeting

1. Ho NC, Guarnieri M, Brant LJ, Park SS, Sun B, North M, Francomano CA, Carson BS Sr. Living with achondroplasia: Quality of life evaluation following cervico-medullary decompression. Am J Med Genetics 2004; 131A:163-7.
Key words: achondroplasia, decompression, outcome
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15487008

2. Khan A, Jallo GI, Liu YJ, Carson BS Sr, Guarnieri M. Infusion rates and drug distribution in brain tumor models. J Neurosurgery (Pediatrics 1) 2005;102: 53-58.
Key words: brain tumor, infusion rate, local therapy

3. Komotar RJ, Burger PC, Carson BS, Brem H, Olivi A, Goldthwaite PT, Tihan T. Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas. Neurosurgery 2004; 54:72-80.
Key words: brain tumors, histology, pediatric
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15617606

4. North RB, Brigham DD, Khalessi A, Calkins S, Piantadosi S, Campbell DS, Daly MJ, Dey B, Barolat G, Taylor R. Spinal cord stimulator adjustment to maximize implanted battery longevity: A randomized, controlled trial using a computerized, patient-interactive programmer. Neuromodulation 2004; 7:13-25.
Key words: spinal cord stimulation, pain drawing, paresthesia mapping, personal computer

5. North RB. Spinal cord stimulation. In: Wallace M, Staats PS, eds. Pain Medicine and Management: Just the Facts. New York, NY: McGraw-Hill, 2004;285-9.
Key words: Spinal cord stimulation, Mechanism of action, Patient selection, Technical aspects, Outcomes

6. North RB. Spinal cord stimulation for failed back surgery syndrome: technique, results, and cost-effectiveness. In: Szpalski M, Gunzberg R (eds). The Failed Spine. Philadelphia, PA: Lippincott, Williams & Wilkins, 2004.
Key words: Spinal cord stimulation, Failed back surgery syndrome, Surgical technique, Outcomes, Cost effectiveness

7. North RB, Kidd DH, Farrokhi F, Piantadosi SA. Spinal cord stimulation versus repeated lumbosacral spine surgery for chronic pain: A randomized, controlled trial. Neurosurgery 2005;56:98-107.
Key words: chronic pain, electrical stimulation, failed back surgery syndrome, low back pain, lumbar radiculopathy, randomized controlled trial, spinal cord stimulation
http://gateway.ut.ovid.com/gw2/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=
00006123-200501000-00017&NEWS=N&CSC=Y&CHANNEL=PubMed

PMID: 15617591

8. Wu QZ, Guarnieri M, Tyler B, DiMeco F, Clatterbuck RE, Li K, Brem H, Carson BS Sr: Local release of carboplatin via an Alzet mini-osmotic pump prolongs survival in a rat brainstem tumor model. Clinical Neurosurgery 2004;51: 332-339.
Key words: brainstem tumor, local therapy, rodent model, carboplatin
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15571163

1. Basaria S, Westra WH, Brem H, Salvatori R. Metastatic renal cell carcinoma with hyperproactinemia. J Endocrinological Investigation 2004; 27:471-474.
Key words: renal cell carcinoma, hyperproactinemia

2. Greenspan JD, Ohara S, Sarlani E, Lenz FA . Allodynia in patients with post-stroke central pain (CPSP) studied by statistical quantitative sensory testing within individuals. Pain 2004; 109 (3) 357-366
Key words: allodynia, post-stroke central pain (CPSP)
http://www.ncbi.nlm.nih.gov//entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=
Citation&list_uids=15157697

3. Kleinberg LR, Weingart J, Burger P, Carson K, Grossman SA, Ki K, Olivi A, Wharam MD, Brem H. Clinical course and pathologic findings after Gliadel® and radiotherapy for newly diagnosed malignant glioma: Implications for patient management. Cancer Investigation 2004; 22(1):1-9.
Key words: Gliadel, radiotherapy, malignant glioma

4. Lenz FA, Patel SH, Gracely RH, Dougherty PM, Ohara S. Pain encoding in the human forebrain: Binary and analogue channels. J.Neurosci. 2004; In press.
Key words: pain encoding, human forebrain

5. Lesniak MS, Brem, H. Targeted therapy for brain tumours. Nature Review, Drug Discovery 2004; 3(6):499-508.
Key words: local therapy, blood-brain barrier, Gliadel, polymer delivery system

6. Ohara S, Crone NE, Weiss N, Lenz FA. Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans. Clin.Neurophysiol. 2004; 115 (7) 1641-52
Key words: electrocorticographic, desynchronization
http://www.ncbi.nlm.nih.gov//entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=
Citation&list_uids=15203065

7. Ohara S, Crone NE, Weiss N, Treede RD, Lenz FA. Cutaneous painful laser stimuli evoke responses recorded directly from primary somatosensory cortex in awake humans. J Neurophysiol. 2004; 91 (6) 2734-46
Key words: electric stimulation; evoked potentials, somatosensory; human; somatosensory cortex
http://www.ncbi.nlm.nih.gov//entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=
Citation&list_uids=14602841

8. Ohara S, Crone NE, Weiss N, Vogel H, Treede RD, Lenz FA. Attention to pain is processed at multiple cortical sites in man. Exp.Brain Res. 2004; 156(4) 513-17
Key words: attention, pain, cortical
http://www.ncbi.nlm.nih.gov//entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=
Citation&list_uids=15127169

9. Ohara S, Crone NE, Weiss N, Treede RD, Lenz FA. Amplitudes of laser evoked potential recorded from somatosensory, parasylvian and medial frontal cortex are graded with stimulus intensity. Pain 2004; In press.
Key words: anterior cingulated cortex, human, laser evoked potential, parasylvian cortex, somatosensory cortex, stimulus intensity, subdural recording

10. Samdani AF, Kuchner EB, Rhines L, Adamson DC, Lawson C, Tyler B, Brem H, Dawson VL, Dawson TM. Astroglia induced cytotoxic effects on brain tumors via a nitric oxide dependent pathway both in vitro and in vivo. Neurosurgery 2004; 54(5):1231-1238.
Key words: astroglia, cytotoxicity, nitric oxide
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15113479

11. Sinha SR, Crone NE, Fotta R., Lenz FA, Boatman D. Transient contralateral hearing loss induced by cortical stimulation of the dominant hemisphere. Neurology (Minn) 2004; In press
Key words: cortical stimulation, hearing loss, human, contralateral

1. Bagley C, Gokaslan Z. Cauda equina syndrome Caused by primary and metastatic neoplasms. Neurosurg Focus 2004: June 15; 16(6)
Key words: cauda equina, neoplasm, surgery, metastasis

2. Hentschel S, Rhines L, Wong F, Gokaslan Z, McCutcheon I. Subarachnoid-pleural fistula after resection of thoracic tumors. J Neurosurg: Spine 2004;100:332-336.
Key words: spinal tumor, subarachnoid-pleural fistula, and thoracicspine

3. Slugg RM, Campbell JN, Meyer RA. The population response of A- and C-fiber nociceptors in monkey encodes high-intensity mechanical stimuli. J Neuroscience. 2004 May 12;24(19):4649-56.
Key words: afferent; C-fiber; cutaneous; mechanosensory; nociception; pain
http://www.jneurosci.org/cgi/content/full/24/19/4649
PMID: 15140936

4. Strausberg RL, Simpson AJ, Old L, Riggins GJ. Oncogenomics and the development of new cancer therapies. Nature. 2004; 429:469.
Keywords: drug discovery, oncogenomics, cancer genome
http:// www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v429/
n6990/abs/nature02627_fs.html&dynoptions=doi1086622011

5. Wang Z , Shen D, Parsons W, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang T, Riggins GJ, Powell SM, Willison, JKV, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science 2004; 304:1164-66.
Key words: diagnostic markers, thyroid cancer, gene expression
http://www.jci.org/cgi/content/full/113/8/1234

6. Zhao C, Tall JM, Meyer RA, Raja SN. Antiallodynic effects of systemic and intrathecal morphine in the spared nerve injury model of neuropathic pain in rats. Anesthesiology. 2004 Apr;100(4):905-11.
Key words: neuropathic pain, opioids, morphine, animal models
PMID: 15087626

7. Zhao C, Wacnik PW, Tall JM, Johns DC, Wilcox GL, Meyer RA, Raja SN. Analgesic effects of a soy-containing diet in three murine bone cancer pain models. J Pain. 2004 Mar;5(2):104-10.
Key words: cancer pain, bone pain, alternative medicine, animal models
PMID: 15042518

1. Brem H, Sawaya R. Brain Tumors: General Considerations. In: Youmans Neurological Surgery 5th Edition, Vol. I, editors, M. Kliot, H. Brem, R. Saway. H. Richard Winn, editor, (Saunders, Philadelphia, PA.), 2004, pp 659-660.
Key words: brain tumor, local chemotherapy, polymer implants

2. Komotar RJ, Burger PC, Carson BS, Brem H, Olivi A, Goldthwaite PT, Tihan T. Pilocytic and pilomyxoid hypothalmamic/chiasmatic astrocytomas. Neurosurgery 2004;54(1):72-80.
Key words: astrocytoma, hypothalamic, optic-chiasm, pilocytic, pilomyxoid

3. Weingart J, Brem H. Basic Priinciples of Cranial Surgery for Brain Tumors. In: Youmans Neurological Surgery 5th Edition, Vol. I, editors, M. Kliot, H. Brem and R. Sawaya. H. Richard Winn, editor, (Saunders, Philadelphia, PA.), 2004, pp 899-907.
Key words: brain tumor, cranial surgery, craniotomy postoperative care

1. Lancelotta MP, Sheth RN, Meyer RA, Belzberg AJ, Griffin JW, Campbell JN. Severity and duration of hyperalgesia in rat varies with type of nerve lesion. Neurosurgery 2003;53:1200-09
Key words: axotomy, causalgia, complex regional pain syndrome, nerve injury, neuropathic pain

2. Sampath P, Long DM. Acoustic Neuroma. Youmans Neurological Surgery Fifth Edition. 2003 Chapter 65: 1147-1168
Key words: acoustic neuroma, surgical management, tumor, seventh-nerve palsy

3. Moses MA, Brem H, Langer R. Advancing the field of drug delivery: Taking aim at cancer. Cancer Cell 2003;4:337-341.
Key words: drug delivery, local chemotherapy, polymer implants

1. Guerin C, Olivi A, Weingart JD, HC Lawson, Brem H. Recent advances in brain tumor therapy: Local intracerebral drug delivery by polymers. Investigational New Drugs 2003; 22:27-37
Key words: brain tumor therapy, drug delivery, polymers

2. Richards-Grayson AC, Choi IS, Tyler BM, Wang PP, Brem H, Cima MJ, Langer R. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nature Materials 2003; 2:767-772
Key words: microchip, polymer, drug delivery

1. Brem H, Amundson E. Preparing Hopkins medical students for a career in academic neurosurgery. Surgery 2003;134:414-415.
Key words: academic neurosurgery, medical students

2. Chang SM, Parney IF, McDermott M, Barker FG II, Schmidt MH, Huang W, Laws ER, Lillehei KO, Berstein M, Brem H, Sloan AE, Berger M, and the Glioma Outcomes Investigators. Perioperative complications and neurological outcome of first and second craniotomies among patients enrolled in the Glioma Outcome Project. J Neurosurg 2003;98(6):1175-1181.
Key words: neurological outcome, craniotomies, glioma outcome

3. Frazier JL, Wang PP, Case D, Tyler BM, Pradilla G, Weingart JD, Brem H. Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma. Journal of Neuro-Oncology 2003;64:203-209.
Key words: Minocycline, BCNU, glioma

4. Laws ER, Parney IF, Huang W, Anderson F, Morris A, Asher T, Lillehei K, Bernstein M, Brem H, Sloan A, Berger M, Chang S, and the Glioma Outcomes Investigators. Survival following surgery, and prognostic factors for newly diagnosed malignant glioma: Data from the glioma outcomes project. J of Neurosurgery 2003;99:467-471.
Key words: glioma, glioma outcome

5. Legnani FG, Pradilla G, Wang PP, Brem H, Olivi A, DiMeco F. Local delivery of antineoplastic agents using biodegradable polymers for the treatment of malignant brain tumors. Expert Review Neurotherapeutics 2003;3(4):533-546.
Key words: antineoplastic agents, polymers, malignant brain tumors

6. Lesnak MS, Tyler BM, Pardoll DM, Brem H. Gene therapy for experimental brain tumors using a xenogenic cell line engineered to secrete hIL-2. J Neuro-Onc 2003;64:155-160.
Key words: Gene therapy, xenogenic cell line, hIL-2

7. Li KW, Dang W, Tyler BM, Troiano G, Tihan T, Brem H, Walter K. Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies. Clinical Cancer Research 3003;9:3441-3447.
Key words: polilactofate microspheres, cns malignancies

8. Pradilla G, Azzam T, Wang PP, Domb A, Brem H. Gene therapy for malignant brain tumors. Expert Review of Neurotherapeutics 2003;3(5):685-701.
Key words: Gene therapy, malignant brain tumor

1. Bhardwaj A, Cowan J, Garonzik I, Port J, Rigamonti D, Ziai W, Decompressive craniectomy for intractable cerebral edema; experience of a single center. Journal of Neurosurgical Anesthesiology 15(1):25-32,2003
Key words: decompressive hemicraniectomy, intractable cerebral edema, herniation

2. Legnani FG, Pradilla G, Wang PP, Brem H, Olivi A and DiMeco F. Local Delivery of Antineoplastic Polymers for the Treatment of Malignant Brain Tumors. Expert Rev. Neurotherapeutics 2003;3(4):533-46.
Key words: brain tumor, biodegradable polymers, drug delivery, glioblastoma multiforme, microspheres

3. Long DM. Chronic back pain. in Handbook of Pain Management, a Clinical Companion to Wall and Melzack's Textbook of Pain. Editors: Wall & Melzack. Churchill Livingson, Elsevier. 2003; 67-76
Key words: back pain, laminectomy, surgery, fusion

4. Long DM. Microarrays for the Neurosciences: An Essential Guide, eds Geschwind and Gregg JP. Book Review. Neurosurgery Quarterly 2003; 12(1):56-57.
Key words: microarrays, research, brain function

5. Long DM. Neurological Foundations of Cognitive Neuroscience by Mark D'Esposito. Book review. Neurosurgery Quarterly 2003; 13(2):149.
Key words: perceptual learning, education, cognition

6. Long DM. Perceptual Learning by Fahle M and Poggio T. Book Review. Neurosurgery Quarterly 2003; 13(2):149.
Key words: perceptual learning, education, cognition

7. Long DM. Perioperative Care in Spinal Operations. MedLink Neurology online (www.medlink.com) September 2003
Key words: perioperative care, spinal surgery, low back pain

8. Long DM, Wilson CB, Bates EA. OR-21 - A Modular Operating Room Concept for the 21st Century. in The Operating Room of the 21st Century. Editor: Apuzzo MLJ. AANS - Walsworth Printing, 2003; 197-204.
Key words: operating room, design, imaging integration

1. Clatterbuck RE, Gailloud P, Ogata L, Gebremariam A, Dietsch GN, Murphy KJ, Tamargo RJ. Prevention of cerebral vasospasm by a humanized anti-cd11/cd18 monoclonal antibody administered after experimental subarachnoid hemorrhage in nonhuman primates. J Neurosurg 2003;99:376-82.
Key words: subarachnoid hemorrhage, vasospasm, leukocyte, anti-cd11/18 monoclonal antibody

2. Gabikian P, Clatterbuck RE, Gailloud P, Rigamonti D. Developmental venous anomalies and sinus pericranii in the blue-rubber-bleb nevus syndrome. J Neurosurg 2003;99:409-11.
Key words: blue-rubber-bleb nevus syndrome, developmental anomaly, sinus pericranii

3. Hammoud D, Gailloud P, Olivi A, and Murphy KJ. Acute Vasogenic Edema Induced by Thrombosis of a Giant Intracranial Aneurysm: A cause of pseudostroke after therapeutic occlusion of the parent vessel. AJNR (Am J Neuroradiol) June/July, 2003;24:1237-39.
Key words: giant intracranial aneurysm, vasogenic edema, endovascular treatment of aneurysms

1. DiMeco F, Brem H, Weingart J, Olivi A. Gliadel® A new method for the treatment of malignant brain tumors. IN Drug Delivery Systems for Cancer, editor, Dennis Brown, (Humana Press Inc., Totowa, NJ) 2003;215-227.
Key words: Gliadel® , drug delivery systems, malignant glioma

2. Hammoud D, Belden CJ, Ho AC, Dal Pan GJ, Herskovits EH, Hilt DC, Brem H, Pomper MG. The surgical bed after BCNU-polymer wafer placement for recurrent glioma:serial assessment with CT and MR.AJR Am J Roentgenol 2003;180:1469-1475.
Key words: BCNU, polymer wafer, recurrent glioma

3. Peng YB, Ringkamp M, Meyer RA, Campbell JN. Fatigue and paradoxical enhancement of heat response in C-fiber nociceptors from cross-modal excitation. J Neurosci 2003 Jun 1;23(11):4766-74.
Key words: pain; somatosensory system; primary afferents; sensitization; nociceptors

1. Long DM, Gordon T, Bowman H, Etzel A, Burleyson G, Betchen S, Garonzik I, Brem H. Outcome and cost of craniotomy for tumor performed in regional academic referral centers. Neurosurgery 2003;52(5):1056-1065.
Key words: craniotomy, outcome and cost, academic referral center

2. Lucey BP, Tihan T, Pomper MG, Olivi A, Laterra J. Spinal meningioma causing diffuse leptomeningeal enchancement. Neurology 2003;60:350-1.
Key words: spinal meningioma, leptomeningeal enhancement

3. Olivi A, Grossman SA, Tatter S, Barker F, Judy K, Olsen J, Bruce J, Hilt D, Fisher J, Piantadosi S. Dose escalation of carmustine in surgically implanted polymers in patients with recurrent malignant glioma: A New Approaches to Brain Tumor Therapy CNS Consortium Trial. Journal of Clinical Oncology 2003;21:1845-49
Key words: interstitial chemotherapy, malignant gliomas, local tumor therapy

4. Parwani AV, Taylor DC, Burger PC, Erozan YS, Olivi A, Ali SZ. Keratinized squamous cells in fine needle aspiration of the brain: Cytopathologic correlates and differential diagnosis. Acta Cytologica 2003;47:325-31.
Key words: stereotactic biopsy, differential diagnosis brain tumors

5. Tihan T, Viglione M, Rosenblum MK, Olivi A, Burger PC. Solitary fibrous tumors in the central nervous system: A clinicopathologic review of 18 cases and comparison to meningeal hemangiopericytomas. Arch Pathol Lab Med. 2003; 127:432-39.
Key words: solitary fibrous tumors, meningeal tumors

1. Rhines LD, Sampath P, DiMeco F, Lawson HC, Tyler BM, Hanes J, Pardoll D, Olivi A, Brem H. Local immunotherapy with interleukin-2 delivered via biodegradable polymer microspheres combined with interstitial chemotherapy: A novel treatment for experimental malignant glioma. Neurosurgery 2003;52:872-880.
Key words: interleukin-2, biodegradable polymer microspheres, interstitial chemotherapy

1. Antezana DF, Clatterbuck RE, Alkayed NJ, Murphy SJ, Anderson LG, Frazier J, Hurn PD, Traystman RJ, Tamargo RJ. High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats. J Neurosurgery 2003; 98:860-866.
Key words: Ibuprofen, cerebral ischemia, hypothermia, stroke, intercellular adhesion molecule-1

2. Fourney DR, York JE, Cohen ZR, Suki D, Rhines LD, Gokaslan ZL. Management of atlantoaxial metastases with posterior occipitocervical stabilization. J Neurosurg. 2003 Mar; 98(2 Suppl):165-70.
Key words: Myxopapillary, ependymoma, stabilization, instrumentation
PMID: 12650401

3. Fourney DR, Prabhu SS, Cohen ZR, Rhines LD, Gokaslan ZL. Thoracolumbopelvic stabilization for the treatment of instability caused by recurrent myxopapillary ependymoma. J Spinal Disord Tech. 2003 Feb;16(1):108-11.
Key words: percutaneous, vertebroplasty, kyphoplasty, fracture, cancer
PMID: 12571494

4. Fourney DR, Schomer DF, Nader R, Chlan-Fourney J, Suki D, Ahrar K, Rhines LD, Gokaslan ZL. Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg. 2003 Jan;98(1 Suppl):21-30.
Key words: spondylolisthesis fracture lumbosacral instrumentation sacral
PMID: 12546384

5. Sampath P, Amundson, E, Wall M, Tyler B, Wani, M, Alderson L, Colvin M, Brem H, Weingart J. Comptothecin analogs in malignant gliomas: comparative analysis and characterization.
J Neurosurg 2003; 98: 570-577.
Key words: camptothecin, camptothecin analog, glioma, drug delivery, polymer

6. Ziai W, Port J, Cowan J, Bhardwaj A, Garonzik I, Rigamonti D. Decompressive hemicraniectomy for intractable cerebral edema: Experience of a single center. Journal of Neurosurgical Anesthesiology 2003; 15(1):25-32.
Key words: hemicraniectomy; cerebral edema

1. Lugassy C, Haroun RI, Brem H, Tyler BM, Jones RV, Fernandez PM, Patierno SR, Kleinman K, Barnhill RL. Pericytic-like angiotropism of glioma and melanoma cells. Am J of DermatoPathology. 2003;24(6):473-478
Key words: glioma, melanoma

2. Justice CM, Miller NH, Marosy B, Zhang J, Wilson AF: Familial idiopathic scoliosis: Evidence of an x-linked susceptibility locus. Spine. 2003 Mar 15; 28(6):589-594.
Key words: scoliosis; spine

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October 2008 articles:

Seminar Series
Responsible Conduct of Research Guidelines
American Cancer Society Request for Applications (RFA): The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
American Health Assistance Foundation Accepting Applications for Alzheimer's Disease Research Program
Doris Duke Charitable Foundation (DDCF) Clinical Scientist Development Award Program 2009
Funding for Prostate Cancer Research
The McKnight Endowment Fund for Neuroscience 2009 McKnight Scholar Awards
NIH Roadmap Transformative R01 Program (R01)
 
NIH Loan Repayment Program

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