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April 2018

Biophysics and Biophysical Chemistry Archives

1. Parker MW, Botchan MR, Berger JM. Mechanisms and regulation of DNA replication initiation in eukaryotes. Crit Rev Biochem Mol Biol. 2017 Apr;52(2):107-144.
Key words: DNA replication, Helicase, Loader, AAA+, ATPase, CMG; Cdc6; Cdt1; DNA replication; MCM2-7; ORC; helicase; initiator

1. Harden BJ, Frueh DP. Molecular cross-talk between nonribosomal peptide synthetase carrier proteins and unstructured linker regions. Chembiochem. 2017 Jan 24. doi: 10.1002/cbic.201700030.
Key words: allostery; nonribosomal peptide synthetase; nuclear magnetic resonance; protein dynamics; protein folding

1. Thomsen ND, Lawson MR, Witkowsky LB, Qu S, Berger JM. Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7691-E7700.
Key words: Transcription, Helicase, ATPase, Motor Protein, translocase

2. Lawson MR, Dyer K, Berger JM. Ligand-induced and small-molecule control of substrate loading in a hexameric helicase. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13714-13719.
Key words: Transcription, Helicase, ATPase, Drug Discovery, Motor Protein

1. Yu A, Alberstein R, Thomas A, Zimmet A, Grey R, Mayer ML, Lau AY. Molecular lock regulates binding of glycine to a primitive NMDA receptor. Proc Natl Acad Sci USA. 2016 Nov 1;113(44):E6786-E6795.
Key words: X-ray crystallography; electrophysiology; free energy calculations; glutamate receptors; molecular dynamics simulations

1. Bleichert F, Botchan MR, Berger JM. Crystal structure of the eukaryotic origin recognition complex. Nature. 2015 519:321-6.
Key words: DNA replication, Helicase, MCM, CMG, ORC, clamp loader, AAA+ ATPase

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April 2018 articles:
Training Sessions: Relying on an External IRB (JHM IRB)
Fee Schedule Adjustment for Hospital Services Charged to Clinical Trial Budgets
Change in Federalwide Assurance [FWA] Numbers
Changes to NIH-funded Human Subjects Research
Free Resources for Longitudinal Clinical Research Studies
NIH requirement for Single IRB (sIRB)
JHM IRB Reliance Requests
Sharing Partnership for Innovative Research in Translation
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Research Network
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
Takeda Pharmaceutical Company Innovators in Science Award
Arnold and Mabel Beckman Foundation Scholars Program
Michael J. Fox Foundation (MJFF) Challenge
Why Project Outcomes Matter in your Interim and Final Research Performance Progress Report (RPPR)
NIH Matchmaker, A Tool For Finding Similar NIH Projects
NIH Video Tutorials on How to Apply for Grants
NIH Policy: Foreign Components Added to a Grant to a Domestic or Foreign Organization

This Month's Departmental Listings

Upcoming Deadlines for April, May and June

April Events at the Genetic Resources Core Facility



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