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May 2017

Biophysics and Biophysical Chemistry Archives

1. Harden BJ, Frueh DP. Molecular cross-talk between nonribosomal peptide synthetase carrier proteins and unstructured linker regions. Chembiochem. 2017 Jan 24. doi: 10.1002/cbic.201700030.
Key words: allostery; nonribosomal peptide synthetase; nuclear magnetic resonance; protein dynamics; protein folding

1. Thomsen ND, Lawson MR, Witkowsky LB, Qu S, Berger JM. Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7691-E7700.
Key words: Transcription, Helicase, ATPase, Motor Protein, translocase

2. Lawson MR, Dyer K, Berger JM. Ligand-induced and small-molecule control of substrate loading in a hexameric helicase. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13714-13719.
Key words: Transcription, Helicase, ATPase, Drug Discovery, Motor Protein

1. Yu A, Alberstein R, Thomas A, Zimmet A, Grey R, Mayer ML, Lau AY. Molecular lock regulates binding of glycine to a primitive NMDA receptor. Proc Natl Acad Sci USA. 2016 Nov 1;113(44):E6786-E6795.
Key words: X-ray crystallography; electrophysiology; free energy calculations; glutamate receptors; molecular dynamics simulations

1. Bleichert F, Botchan MR, Berger JM. Crystal structure of the eukaryotic origin recognition complex. Nature. 2015 519:321-6.
Key words: DNA replication, Helicase, MCM, CMG, ORC, clamp loader, AAA+ ATPase

1. Gabelli SB, Boto A, Kuhns VH, Bianchet MA, Farinelli F, Aripirala S, Yoder J, Jakoncic J, Tomaselli GF, Amzel LM. Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nat Commun. 2014 Nov 5;5:5126. doi: 10.1038/ncomms6126.
Key words: cytoplasm, calmodulin

1. Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3K?. Oncotarget. 2014 Jul 30;5(14):5198-208.

1. Vos SM, Lyubimov AY, Hershey DM, Schoeffler AJ, Sengupta S, Nagaraja V, Berger JM. Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein. Genes Dev. 2014 Jul 1;28(13):1485-97
Key words: Topoisomerase, Enzyme inhibitors, Antibiotics, Gene Regulation, Transcription, Supercoiling, Energy metabolism

2. Nicola J, Carrasco N, Amzel LM. Physiological sodium concentrations enhance the iodide affinity of the Naþ/I_ symporter. Nature Communications. 2014 June 3. doi:10.1038/ncomms4948
Key words: sodium, iodide
No PMID available

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May 2017 articles:
ICTR Symposium on Learning Health Systems: Working at the Intersection of Research, Operations, and Big Data
3rd Annual IRB Open House
NIH requirement for Single IRB (sIRB)
JHM IRB Reliance Requests
Improving Long Term Outcomes Research Presentation
New Approaches to Metabolomics Research Symposium
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Research Network
JHM HSR Recertification Training
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
Sharing Partnership for Innovative Research in Translation (SPIRiT) Award Program
Neurofibromatosis Therapeutic Acceleration Program (NTAP) at Johns Hopkins Requests for Applications: Understanding of Cutaneous Neurofibromas
The Hartwell Foundation 2017 Individual Biomedical Research Award Program
William T. Grant Scholars Program
Pew Scholars Program in the Biomedical Sciences
NIH Directors' Early Independence Awards (DP5)
Michael J. Fox Foundation (MJFF) Challenge
NIH Policy: Foreign Components Added to a Grant to a Domestic or Foreign Organization

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