Web notes  

January 2017

Biophysics and Biophysical Chemistry Archives

1. Yu A, Alberstein R, Thomas A, Zimmet A, Grey R, Mayer ML, Lau AY. Molecular lock regulates binding of glycine to a primitive NMDA receptor. Proc Natl Acad Sci USA. 2016 Nov 1;113(44):E6786-E6795.
Key words: X-ray crystallography; electrophysiology; free energy calculations; glutamate receptors; molecular dynamics simulations

1. Bleichert F, Botchan MR, Berger JM. Crystal structure of the eukaryotic origin recognition complex. Nature. 2015 519:321-6.
Key words: DNA replication, Helicase, MCM, CMG, ORC, clamp loader, AAA+ ATPase

1. Gabelli SB, Boto A, Kuhns VH, Bianchet MA, Farinelli F, Aripirala S, Yoder J, Jakoncic J, Tomaselli GF, Amzel LM. Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nat Commun. 2014 Nov 5;5:5126. doi: 10.1038/ncomms6126.
Key words: cytoplasm, calmodulin

1. Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3K?. Oncotarget. 2014 Jul 30;5(14):5198-208.

1. Vos SM, Lyubimov AY, Hershey DM, Schoeffler AJ, Sengupta S, Nagaraja V, Berger JM. Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein. Genes Dev. 2014 Jul 1;28(13):1485-97
Key words: Topoisomerase, Enzyme inhibitors, Antibiotics, Gene Regulation, Transcription, Supercoiling, Energy metabolism

2. Nicola J, Carrasco N, Amzel LM. Physiological sodium concentrations enhance the iodide affinity of the Naþ/I_ symporter. Nature Communications. 2014 June 3. doi:10.1038/ncomms4948
Key words: sodium, iodide
No PMID available

1. Berndsen CE, Wolberger C. New insights into ubiquitin E3 ligase mechanism. Nat Struct Mol Biol. 2014 Apr 4;21(4):301-7. doi: 10.1038/nsmb.2780.
Key words: ubiquitin, E3 ligase, E2 enzyme

2. Wolberger C. Mechanisms for regulating deubiquitinating enzymes. Protein Sci. 2014 Apr;23(4):344-53. doi: 10.1002/pro.2415.
Key words: deubiquitinating enzymes; UB, UBL, ubiquitin

1. Harden BJ, Frueh DP. SARA: a software environment for the analysis of relaxation data acquired with accordion spectroscopy. J Biomol NMR. 2014 Feb;58(2):83-99.
Key words: software, accordion spectroscopy

2. Frueh DP. Practical aspects of NMR signal assignment in larger and challenging proteins. Prog Nucl Magn Reson Spectrosc. 2014 Apr;78C:47-75.
Key words: NMR, proteins

3. Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K. Fluoroquinolone-Gyrase-DNA complexes: two modes of drug binding. J Biol Chem. 2014 Feb 4 [Epub ahead of print].
Key words: Antibiotics action, Bacteria, DNA topoisomerase, Enzyme inhibitors, Escherichia coli, Mycobacterium smegmatis, bacterium, cleaved complexes, crosslinking, resistance mutations

4. Strycharska MS, Arias-Palomo E, Lyubimov AY, Erzberger JP, O'Shea VL, Bustamante CJ, Berger JM. Nucleotide and partner-protein control of bacterial replicative helicase structure and function. Mol Cell. 2013 Dec 26;52(6):844-54.
Key words: DNA replication, Helicase, Primase, Clamp Loader, AAA+ ATPase, RecA

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January 2017 articles:
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Research Network
JHM HSR Recertification Training
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
CDC - Rapid-Cycle Survey Collaborative for Provider Input on Immunization Issues
Camille Dreyfus Teacher-Scholar Awards Program
Rita Allen Foundation (RAF) and the American Pain Society (APS)2017 Award in Pain Guidelines for the Grant Application
New National Science Foundation Science of Learning Programs
The American Heart Association Institute for Precision Cardiovascular Medicine Data Mining Grants
Packard Fellowships for Science and Engineering
Young Investigator Grant for Probiotics Research (YIGPRO)
Bay Area Lyme Foundation Emerging Leader Award
Society for Vascular Surgery Foundation Clinical Research Seed Grant Program
Progeria Research Foundation Grants
Michael J. Fox Foundation (MJFF) Challenge
NIH Postdoctoral Fellow Supplements
NIH Policy: Foreign Components Added to a Grant to a Domestic or Foreign Organization

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