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September 2016
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Biological Chemistry Archives

1. Fahie K, Zachara NE. Molecular functions of glycoconjugates in autophagy. J Mol Biol. 2016 Jun 23. pii: S0022-2836(16)30219-4. doi: 10.1016/j.jmb.2016.06.011. [Epub ahead of print] Review.
Key words: Autophagy; Glycoconjugate; Glycosylation; Lectin; O-GlcNAc
http://www.ncbi.nlm.nih.gov/pubmed/27345664

2. Meier EL, Razavi S, Inoue T, Goley ED. A novel membrane anchor for FtsZ is linked to cell wall hydrolysis in Caulobacter crescentus. Mol Microbiol. 2016 Jul; 101(2):265-80.
Key words: FtsZ, FzlC, membrane, cell division, Caulobacter
http://www.ncbi.nlm.nih.gov/pubmed/27028265

1. Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J and Semenza GL. Protein kinase a-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Sci Signal. 2016 May 31;9(430):ra56.
Key words: HIF, PKA, hypoxia, cardiomyocyte, cancer cell, cAMP, phosphorylation
http://www.ncbi.nlm.nih.gov/pubmed/27245613

2. Jattani RP, Tritapoe JM, Pomerantz JL. Cooperative control of caspase recruitment domain-containing protein 11 (CARD11) signaling by an unusual array of redundant repressive elements. J. Biol Chem. 2016 Apr 15;291(16):8324-36.
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26884335

3. Jattani RP, Tritapoe JM, Pomerantz JL. Intramolecular interactions and regulation of cofactor binding by the four repressive elements in the caspase recruitment domain-containing protein 11 (CARD11) inhibitory domain. J. Biol Chem. 2016 Apr 15;291(16):8338-48.
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26884334

4. Khan SY, Vasanth S, Kabir F, Gottsch JD, Khan AO, Chaerkady R, Lee MC, Leitch CC, Ma Z, Laux J, Villasmil R, Khan SN, Riazuddin S, Akram J, Cole RN, Talbot CC, Pourmand N, Zaghloul NA, Hejtmancik JF and Riazuddin SA. Foxe3 contributes to peters anomaly through transcriptional regulation of an autophagy-associated protein termed dnajb1. Nat Commun. 2016 Apr 6;7:10953.
Key words: Quantitative proteomics, proteogenomics, glaucoma, cateracts, autophagy
http://www.ncbi.nlm.nih.gov/pubmed/27218149

5. Lee SE, West KP, Jr., Cole RN, Schulze KJ, Wu LS, Yager JD, Groopman J and Christian P. General intelligence is associated with subclinical inflammation in nepalese children: A population-based plasma proteomics study. Brain Behav Immun. 2016 Aug;56:253-63.
Key words: Children; Cohort study; Inflammation; Intelligence; Mass spectrometry; Nepal; Plasma proteomics; Universal Nonverbal Intelligence Test
http://www.ncbi.nlm.nih.gov/pubmed/27039242

6. Lin X, Steinberg S, Kandasamy S, Afzal J, Mbiyangandu B, Liao S, Guan Y, Corona-Villalobos C, Matkovich S, Epstein N, Tripodi D, Huo Z, Cutting G, Abraham T, Fukunaga R, Abraham R
Common MiR-590 Variant rs6971711 present only in African Americans reduces miR-590 biogenesis.
PLoS ONE. 2016 May 19;11(5):e0156065.
Key words: microRNA, SNP, hypertrophic cardiomyopathy, miR-590
http://www.ncbi.nlm.nih.gov/pubmed/27196440

7. O'Connor TJ, Zheng H, VanRheenen SM, Ghosh S, Cianciotto NP, Isberg RR. Iron limitation triggers early egress by the intracellular bacterial pathogen Legionella pneumophila. Infect Immun. 2016 May 16. pii: IAI.01306-15.
Key words: host-pathogen interactions, Legionella, iron, egress
http://www.ncbi.nlm.nih.gov/pubmed/27185787

8. Schulze KJ, Cole RN, Chaerkady R, Wu LS, Nonyane BA, Lee SE, Yager JD, Groopman JD, Christian P and West KP, Jr. Plasma selenium protein p isoform 1 (sepp1): A predictor of selenium status in nepalese children detected by plasma proteomics. Int J Vitam Nutr Res. 2016 May 10:1-10.
Key words: Nepal; apolipoprotein; glutathione reductase (GPX); micronutrient assessment; proteomics; selenium; selenoprotein P isoform 1 (SEPP1)
http://www.ncbi.nlm.nih.gov/pubmed/27164173

9. Taparra K, Tran PT, Zachara NE. Hijacking the hexosamine biosynthetic pathway to promote EMT-mediated neoplastic phenotypes. Front Oncol. 2016 Apr 18;6:85.
http://www.ncbi.nlm.nih.gov/pubmed/27148477
Key words: Glycosylation, Metabolism, O-GlcNAc, Cancer

1. Hamblet CE, Makowski SL, Tritapoe JM, Pomerantz JL. NK cell maturation and cytotoxicity are controlled by the intramembrane aspartyl protease SPPL3. J. Immunol. 2016 March 15;196(6):2614-2626.
Key words: NK cell, Innate immunity, membrane aspartyl protease, CRISPR, SPPL3
http://www.ncbi.nlm.nih.gov/pubmed/26851218

2. Hillion J, Roy S, Heydarian M, Cope L, Xian L, Koo M, Luo LZ, Kellyn K, Ronnett BM, Huso T, Armstrong D, Reddy K, Huso DL, Resar LMS. The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors. Gynecol Oncol. 2016 Jun;141(3):580-7.
Key words: gene, uterine serous carcinoma, carcinosarcomas, MMP-2
http://www.ncbi.nlm.nih.gov/pubmed/27001612

3. Jattani RP, Tritapoe JM, Pomerantz JL. Cooperative control of caspase recruitment domain-containing protein 11 (CARD11) signaling by an unusual array of redundant repressive elements. J. Biol Chem. 2016 Apr 15;291(16):8324-36.
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26884335

4. Jattani RP, Tritapoe JM, Pomerantz JL. Intramolecular interactions and regulation of cofactor binding by the four repressive elements in the caspase recruitment domain-containing protein 11 (CARD11) inhibitory domain. J. Biol Chem. 2016 Apr 15;291(16):8338-48.
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26884334

5. Lis P, Jurkiewicz P, Cal-B?kowska M, Ko YH, Pedersen PL, Goffeau A, U?aszewski S. Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate. Oncotarget. 2016 Mar 1;7(9):10153-73.
Key words: 3-bromopyruvate (3-BP); Saccharomyces cerevisiae; Whi2; energetic metabolism; genomic screen
http://www.ncbi.nlm.nih.gov/pubmed/26862728

6. Pedersen SM, Chan W, Jattani RP, Mackie DS, Pomerantz JL. Negative regulation of CARD11 signaling and lymphoma cell survival by the E3 ubiquitin ligase RNF181. Mol Cell Biol. 2016; 36:794-808.
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26711259

1. Hamblet CE, Makowski SL, Tritapoe JM, Pomerantz JL. NK Cell maturation and cytotoxicity are controlled by the intramembrane aspartyl protease SPPL3. J. Immunol. 2016 Mar 15;196(6):2614-26.
Key words: NK cell, Innate immunity, membrane aspartyl protease, CRISPR, SPPL3
http://www.ncbi.nlm.nih.gov/pubmed/26851218

2. Jattani RP, Tritapoe JM, Pomerantz JL. Cooperative control of caspase recruitment domain-containing protein 11 (CARD11) signaling by an unusual array of redundant repressive elements. J. Biol Chem. 2016 Feb 16. pii: jbc.M115.683714. [Epub ahead of print]
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26884335

3. Jattani RP, Tritapoe JM, Pomerantz JL. Intramolecular interactions and regulation of cofactor binding by the four repressive elements in the caspase recruitment domain-containing protein 11 (CARD11) inhibitory domain. J. Biol Chem. 2016 Feb 16. pii: jbc.M116.717322. [Epub ahead of print]
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26884334

4. Pedersen SM, Chan W, Jattani RP, Mackie dS, Pomerantz JL. Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181. Mol Cell Biol. 2016; 36:794-808.
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26711259

1. Goldschmidt HL, Tu-Sekine B, Volk L, Anggono V, Huganir RL, Raben DM. DGK? catalytic activity is required for efficient recycling of presynaptic vesicles at excitatory synapses. Cell Rep. 2016 Jan 12;14(2):200-7. doi: 10.1016/j.celrep.2015.12.022.
Key words: diacylglycerol kinase, lipids, neurons, synaptic vesicle cycling, endocytosis
http://www.sciencedirect.com/science/article/pii/S2211124715014357
PMID: 26748701

2. Hamblet CE, Makowski SL, Tritapoe JM, Pomerantz JL. NK cell maturation and cytotoxicity are controlled by the intramembrane aspartyl protease SPPL3. J. Immunol. 2016;196:2614-2626.
Key words: NK cell, Innate immunity, membrane aspartyl protease, CRISPR, SPPL3 http://www.ncbi.nlm.nih.gov/pubmed/26851218

3. Jattani RP, Tritapoe JM, Pomerantz JL. Cooperative control of caspase recruitment domain-containing protein 11 (CARD11) signaling by an unusual array of redundant repressive elements. J. Biol Chem. 2016 Feb 16. pii: jbc.M115.683714. [Epub ahead of print]
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor
http://www.ncbi.nlm.nih.gov/pubmed/26884335

4. Jattani RP, Tritapoe JM, Pomerantz JL. Intramolecular interactions and regulation of cofactor binding by the four repressive elements in the caspase recruitment domain-containing protein 11 (CARD11) inhibitory domain. J. Biol Chem. 2016 Feb 16. pii: jbc.M116.717322. [Epub ahead of print]
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor http://www.ncbi.nlm.nih.gov/pubmed/26884334

5. Lee J, Choi J, Aja S, Scafidi S, Wolfgang MJ. Loss of adipose fatty acid oxidation does not potentiate obesity at thermoneutrality. Cell Rep. 2016; 14:1308-1316.
Key words: fatty acid, diabetes, energy expenditure, body weight, mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/26854223

6. Lee J, Choi J, Wong GW, Wolfgang MJ. Neurometabolic roles of ApoE and Ldl-R in mouse brain. J Bioenerg Biomembr. 2016 Feb;48(1):13-21.
Key words: Alzheimer's disease, lipoprotein, lipid
http://www.ncbi.nlm.nih.gov/pubmed/26686234

7. Lee SE, Schulze KJ, Cole RN, Wu LS, Yager JD, Groopman J, Christian P, West KP, Jr. Biological systems of vitamin k: A plasma nutriproteomics study of subclinical vitamin K deficiency in 500 nepalese children. OMICS. 2016 Feb 25. [Epub ahead of print]
Key words: Nutritional biomarkers, Plasma proteomics, Vitamin K deficiency
http://www.ncbi.nlm.nih.gov/pubmed/26913649

8. Nomura M, Liu J, Rovira IL, Gonzalez-Hurtado E, Lee J, Wolfgang MJ, Finkel T. The role of fatty acid oxidation in macrophage polarization. Nat Immunol. 2016 Feb 16; 17(3):216-217.
Key words: innate immunity, metabolism, obesity, LPS, IL4
http://www.ncbi.nlm.nih.gov/pubmed/26882249

9. Pedersen SM, Chan W, Jattani RP, Mackie dS, Pomerantz JL. Negative regulation of CARD11 signaling and lymphoma cell survival by the E3 ubiquitin ligase RNF181. Mol Cell Biol. 2016; 36:794-808.
Key words: CARD11; Lymphoma; NF-kappaB; Signal transduction; Antigen Receptor http://www.ncbi.nlm.nih.gov/pubmed/26711259

1. Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AM, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HP, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HM, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015 Dec;35 Suppl:S276-304. doi: 10.1016/j.semcancer.2015.09.007. Review.
Key words: cancer, metabolism, hexokinase 2, mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/26590477

2. Goldschmidt HL, Tu-Sekine B, Volk L, Anggono V, Huganir RL, Raben DM. DGK? catalytic activity is required for efficient recycling of presynaptic vesicles at excitatory synapses. Cell Rep. 2016 Jan 12;14(2):200-7. doi: 10.1016/j.celrep.2015.12.022. Epub 2015 Dec 31.
Key words: Neurotransmission, Diacyglycerol kinase-theta, Synaptic vesicle cycle, Presynaptic, lipids
http://www.sciencedirect.com/science/article/pii/S2211124715014357
PMID: 26748701

3. Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE; Target Validation Team. Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol. 2015 Dec;35 Suppl:S129-50. Key words: cancer, metabolism, hexokinase 2, mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/26454069

1. Dong Q, Giorgianni F, Beranova-Giorgianni S, Deng X, O'Meally R N, Bridges D, Park EA, Cole RN, Elam MB, Raghow R. Glycogen synthase kinase-3 mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (srebp-1c) for proteasomal degradation. Biosci Rep. 2015 Nov 20;36(1). pii: e00284. doi: 10.1042/BSR20150234.
Key words: SREBP, GSK3 Phosphorylation, Ubiquitination, Mass spectrometry (MS), cdc4 phosphodegron (CPD)
http://www.ncbi.nlm.nih.gov/pubmed/26589965

2. Kumar A, Baycin-Hizal D, Wolozny D, Pedersen LE, Lewis NE, Heffner K, Chaerkady R, Cole RN, Shiloach J, Zhang H, Bowen MA, Betenbaugh MJ. Elucidation of the cho super-ome (cho-so) by proteoinformatics. J Proteome Res. 2015 Nov 6;14(11):4687-703.
Key words: CHO; host cell proteins; immunogenicity; ontology; proteomics; secretome; signal peptides
http://www.ncbi.nlm.nih.gov/pubmed/26418914

3. Lee SE, West KP, Jr., Cole RN, Schulze KJ, Christian P, Wu LS, Yager JD, Groopman J, Ruczinski I. Plasma proteome biomarkers of inflammation in school aged children in nepal. PLoS ONE. 2015 Dec 4;10(12):e0144279.
Key words: plasma proteomics, inflammation, host defense, nutrient metabolism
hormonal metabolism , tissue remodeling

http://www.ncbi.nlm.nih.gov/pubmed/26636573

4. Sur S, Qiao Y, Fries A, O'Meally RN, Cole RN, Kinzler KW, Vogelstein B, Zhou S. Print: A protein bioconjugation method with exquisite n-terminal specificity. Sci Rep. 2015 Dec 17;5:18363.
Key words: PEGylation, Site-specific modification, protein stability
http://www.ncbi.nlm.nih.gov/pubmed/26678960

5. Suresh K, Servinsky L, Reyes J, Baksh S, Undem C, Caterina M, Pearse DB, Shimoda LA. Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1467-77.
Key words: reactive oxygen species, ion channel, pulmonary, src kinase, acute respiratory distress syndrome
http://www.ncbi.nlm.nih.gov/pubmed/26453519

6. West KP, Jr., Cole RN, Shrestha S, Schulze KJ, Lee SE, Betz J, Nonyane BA, Wu LS, Yager JD, Groopman JD and Christian P. A plasma alpha-tocopherome can be identified from proteins associated with vitamin e status in school-aged children of nepal. J Nutr. 2015 Dec;145(12):2646-56.
Key words: Nepal; bioinformatics; micronutrient assessment; plasma proteomics; tocopherome; vitamin E; ?-tocopherol; ?-tocopherol
http://www.ncbi.nlm.nih.gov/pubmed/26446483

1. Chung HS, Murray CI, Venkatraman V, Crowgey EL, Rainer PP, Cole RN, Bomgarden RD, Rogers JC, Balkan W, Hare JM, Kass DA and Van Eyk JE. Dual labeling biotin switch assay to reduce bias derived from different cysteine subpopulations: A method to maximize s-nitrosylation detection. Circ Res. 2015 Oct 23;117(10):846-57.
Key words: S-nitrosothiols; nitric oxide; oxidation-reduction; proteomics
http://www.ncbi.nlm.nih.gov/pubmed/26338901

2. Kumar A, Baycin-Hizal D, Wolozny D, Pedersen LE, Lewis NE, Heffner K, Chaerkady R, Cole RN, Shiloach J, Zhang H, Bowen MA and Betenbaugh MJ. Elucidation of the cho super-ome (cho-so) by proteoinformatics. J Proteome Res. 2015 Nov 6;14(11):4687-703.
Key words: CHO; host cell proteins; immunogenicity; ontology; proteomics; secretome; signal peptides
http://www.ncbi.nlm.nih.gov/pubmed/26418914

3. Lee SE, West KP, Jr., Cole RN, Schulze KJ, Christian P, Wu LS, Yager JD, Groopman J and Ruczinski I. Plasma proteome biomarkers of inflammation in school aged children in nepal. PLoS ONE. 2015 Dec 4;10(12):e0144279.
Key words: plasma proteomics, inflammation, host defense, nutrient metabolism, hormonal metabolism, tissue remodeling
http://www.ncbi.nlm.nih.gov/pubmed/26636573

4. Ramirez-Correa GA, Ma J, Slawson C, Zeidan Q, Lugo-Fagundo NS, Xu M, Shen X, Gao WD, Caceres V, Chakir K, DeVine L, Cole RN, Marchionni L, Paolocci N, Hart GW and Murphy AM. Removal of abnormal myofilament o-glcnacylation restores ca2+ sensitivity in diabetic cardiac muscle. Diabetes. 2015 Oct;64(10):3573-87.
Key words: Myocardial contractility, Diabetic Cardiomyopathy, Glucose, Contractile Proteins, Myofilament proteins, Myofilament O-GlcNAcylation, Myofilament Ca2+ Sensitivity, O-GlcNAcase, O-GlcNAc transferase
http://www.ncbi.nlm.nih.gov/pubmed/26109417

5. West KP, Jr., Cole RN, Shrestha S, Schulze KJ, Lee SE, Betz J, Nonyane BA, Wu LS, Yager JD, Groopman JD and Christian P. A plasma alpha-tocopherome can be identified from proteins associated with vitamin e status in school-aged children of nepal. J Nutr. 2015 Dec;145(12):2646-56.
Key words: Nepal; bioinformatics; micronutrient assessment; plasma proteomics; tocopherome; vitamin E; ?-tocopherol; ?-tocopherol
http://www.ncbi.nlm.nih.gov/pubmed/26446483

1. Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE; Target Validation Team (2015). Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol. 2015 Dec; 35 Suppl:S129-50.
Key words: mitochondria, outer membrane, hexokinase 2, cancer
http://www.ncbi.nlm.nih.gov/pubmed/26454069

2. Hou CW, Mohanan V, Zachara NE, Grimes CL. Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2. Glycobiology. 2015 Sep 14. pii: cwv076. [Epub ahead of print]
Key words: Crohn's disease; NF-?B; Nod2; O-GlcNAcylation; OGT
http://www.ncbi.nlm.nih.gov/pubmed/26369908

3. Pedersen PL, Ko YH. The Outer Mitochondrial Membrane, a Smooth 'Coat' with Many Holes and Many Roles:Preparation, Protein Components, Interactions with Other Membranes, Involvement in Health, Disease, and as a Drug Target. In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology. 2016; Vol 1, 237-243.
Key words: mitochondria, outer membrane, hexokinase 2, cancer, heart disease

1. Chung HS, Murray CI, Venkatraman V, Crowgey EL, Rainer PP, Cole RN, Bomgarden RD, Rogers JC, Balkan W, Hare JM, Kass DA and Van Eyk JE. Dual labeling biotin switch assay to reduce bias derived from different cysteine subpopulations: A method to maximize s-nitrosylation detection. Circ Res. 2015. Oct 23;117(10):846-57.
Key words: Basic Science Research, Functional Genomics, Cell Signaling/Signal Transduction
http://www.ncbi.nlm.nih.gov/pubmed/26338901

2. Feng X, Coulombe PA. Complementary Roles of Specific Cysteines in Keratin 14 toward the Assembly, Organization, and Dynamics of Intermediate Filaments in Skin Keratinocytes. J Biol Chem. 2015 Sep 11;290(37):22507-19. doi: 10.1074/jbc.M115.654749.
Key words: Keratin, cytoskeleton, keratinocytes, cysteine, live imaging
http://www.ncbi.nlm.nih.gov/pubmed/26216883

3. Hobbs RP, DePianto DJ, Jacob JT, Han MC, Chung BM, Batazzi AS, Poll BG, Guo Y, Han J, Ong S, Zheng W, Taube JM, ?iháková D, Wan F, Coulombe PA. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015 Aug;47(8):933-8. doi: 10.1038/ng.3355.
Key words: Keratin, skin, cancer, inflammation, immunity, Aire
http://www.ncbi.nlm.nih.gov/pubmed/26168014

4. Hou CW, Mohanan V, Zachara NE, Grimes CL. Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2. Glycobiology. 2015 Sep 14. pii: cwv076. [Epub ahead of print]
Key words: Crohn's disease; NF-?B; Nod2; O-GlcNAcylation; OGT
http://www.ncbi.nlm.nih.gov/pubmed/26369908

5. Kumar A, Baycin-Hizal D, Wolozny D, Pedersen LE, Lewis NE, Heffner K, Chaerkady R, Cole RN, Shiloach J, Zhang H, Bowen MA and Betenbaugh MJ. Elucidation of the cho super-ome (cho-so) by proteoinfomatics. J Proteome Res. 2015 Oct 13 [Epub ahead of print].
Key words: proteomics, secretome, CHO, signal peptides, ontology, host cell proteins, immunogenicity
http://www.ncbi.nlm.nih.gov/pubmed/26418914

6. Ramirez-Correa GA, Ma J, Slawson C, Zeidan Q, Lugo-Fagundo NS, Xu M, Shen X, Gao WD, Caceres V, Chakir K, DeVine L, Cole RN, Marchionni L, Paolocci N, Hart GW and Murphy AM. Removal of abnormal myofilament o-glcnacylation restores ca2+ sensitivity in diabetic cardiac muscle. Diabetes. 2015 Oct;64(10):3573-87.
Key words: Myocardial contractility, Diabetic Cardiomyopathy, Glucose
Contractile Proteins, Myofilament proteins, Myofilament O-GlcNAcylation, Myofilament Ca2+ Sensitivity, O-GlcNAcase, O-GlcNAc, transferase

http://www.ncbi.nlm.nih.gov/pubmed/26109417

7. Subramanian M, Timmerman CK, Schwartz JL, Pham DL, Meffert MK. Characterizing autism spectrum disorders by key biochemical pathways. Front. Neurosci. 2015 Sep 24;9:313.
Key words: autism spectrum disorders, neurotrophic factors, mTOR, Erk, protein synthesis
http://dx.doi.org/10.3389/fnins.2015.00313
PMID: 26483618

8. Wear MP, Kryndushkin D, O'Meally R, Sonnenberg JL, Cole RN and Shewmaker FP. Proteins with intrinsically disordered domains are preferentially recruited to polyglutamine aggregates. PLoS ONE. 2015 Aug 28;10(8):e0136362.
Key words: Amyloid aggregates, Protein Structure, Neurodegenerative diseases.
http://www.ncbi.nlm.nih.gov/pubmed/26317359

9. West KP, Jr., Cole RN, Shrestha S, Schulze KJ, Lee SE, Betz J, Nonyane BA, Wu LS, Yager JD, Groopman JD and Christian P. A plasma alpha-tocopherome can be identified from proteins associated with vitamin e status in school-aged children of nepal. J Nutr. 2015. Oct 7. pii: jn210682.
Key words: Nepal; bioinformatics, micronutrient assessment, plasma, proteomics, tocopherome, vitamin E, ?-tocopherol; ?-tocopherol
http://www.ncbi.nlm.nih.gov/pubmed/26446483

10. Wilky BA, Kim C, McCarty G, Montgomery EA, Kammers K, DeVine LR, Cole RN, Raman V and Loeb DM. Rna helicase ddx3: A novel therapeutic target in ewing sarcoma. Oncogene. 2015 Sep 14. doi: 10.1038/onc.2015.336. [Epub ahead of print]
Key words: quantitative proteomics , pharmacologic inhibitors , anti-neoplastic strategy
http://www.ncbi.nlm.nih.gov/pubmed/26364611

11. Yan K, Fu Z, Yang C, Zhang K, Jiang S, Lee DH, Heo HY, Zhang Y, Cole RN, Van Eyk JE, Zhou J. Assessing amide proton transfer (apt) mri contrast origins in 9 l gliosarcoma in the rat brain using proteomic analysis. Mol Imaging Biol. 2015 August; 17(4):479-87.
Key words: APT imaging, CEST imaging, Glioma, Mobile protein, Proteomics
http://www.ncbi.nlm.nih.gov/pubmed/25622812

12. Zhu Y, Liu TW, Madden Z, Yuzwa SA, Murray K, Cecioni S, Zachara N, Vocadlo DJ. (2015) Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter. J Mol Cell Biol. 2015, In Press.
Key words: O-GlcNAcylation; glycosylation; nuclear pore complex; nucleoporin; post-translational modification; protein stability; ubiquitination
http://www.ncbi.nlm.nih.gov/pubmed/26031751

1. Kammers K, Cole RN, Tiengwe C and Ruczinski I. Detecting significant changes in protein abundance. EuPA Open Proteom. 2015:7:11-9.
Key words: Empirical Bayes, Inference, Protein abundance
http://www.ncbi.nlm.nih.gov/pubmed/25821719

2. Tan HL, Queenan BN, Huganir RL. GRIP1 is required for homeostatic regulation of AMPAR trafficking. Proc Natl Acad Sci USA. 2015 Jul 27. pii: 201512786. [Epub ahead of print].
Key words: PDZ domain; glutamate receptor; postsynaptic density; synaptic scaling
http://www.pnas.org/content/early/2015/07/22/1512786112.long
PMID: 26216979

3. Yan K, Fu Z, Yang C, Zhang K, Jiang S, Lee DH, Heo HY, Zhang Y, Cole RN, Van Eyk JE and Zhou J. Assessing amide proton transfer (apt) mri contrast origins in 9 l gliosarcoma in the rat brain using proteomic analysis. Mol Imaging Biol. 2015:17:479-87.
http://www.ncbi.nlm.nih.gov/pubmed/25622812

1. Caterina MJ. An Introduction to Transient Receptor Potential Ion Channels and their Roles in Disease. In: TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Elsevier, Arpad Szallasi, Ed., 2015 pp. 1-12.
Key words: channelopathy, pain, TRP, ion channel

2. Nomura J, Jaaro-Peled H, Lewis E, Nuñez-Abades P, Huppe-Gourgues F, Cash-Padgett T, Emiliani F, Kondo MA, Furuya A, Landek-Salgado MA, Ayhan Y, Kamiya A, Takumi T, Huganir R, Pletnikov M, O'Donnell P, Sawa A. Role for neonatal D- serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice. Mol Psychiatry. 2015 May 26. doi: 10.1038/mp.2015.61.
Key words: schizophrenia, synaptic plasticity, NMDA receptor

http://rdcu.be/dnrk
PMID: 26008737

3. Sundararajan K, Miguel A, Desmarais SM, Meier EL, Huang KC, and Goley ED. The bacterial tubulin FtsZ requires its intrinsically disordered linker to direct robust cell wall construction. Nat Commun. 2015; 6:7281.
Key words: FtsZ, peptidoglycan, cell division, divisome, intrinsically disordered protein
http://www.nature.com/ncomms/2015/150623/ncomms8281/full/ncomms8281.html
PMID: 26099469

4. Toda AM, Huganir RL. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Proc Natl Acad Sci USA. 2015 May 26;112(21):6712-7.
Key words: PACAP38; AMPA receptor phosphorylation; synaptic transmission
www.pnas.org/content/112/21/6712.full

1. Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Ko YH, Pedersen PL, Preto A, Casal M. The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH. Biochem J. 2015 Apr 15;467(2):247-58. doi: 10.1042/BJ20140921.
Key words: Cancer, 3-bromopyruvate, Anti-Cancer Agent
http://www.ncbi.nlm.nih.gov/pubmed/2561640

2. Braiterman LT, Gupta A, Chaerkady R, Cole RN and Hubbard AL. Communication between the n and c termini is required for copper-stimulated ser/thr phosphorylation of cu(i)-atpase (atp7b). J Biol Chem. 2015 April; 290(14):8803-19.
Key words: Copper, Copper Transport, Phosphoproteomics, Phosphorylation, Protein Kinase, Trafficking
http://www.ncbi.nlm.nih.gov/pubmed/25666620

3. Kammers K, Cole RN, Tiengwe C and Ruczinski I. Detecting significant changes in protein abundance. EuPA Open Proteom. 2015 June; 7:11-9.
Key words: Empirical Bayes, Inference, Protein abundance
http://www.ncbi.nlm.nih.gov/pubmed/25821719

4. Kunjithapatham R, Geschwind JF, Devine L, Boronina TN, O'Meally RN, Cole RN, Torbenson MS and Ganapathy-Kanniappan S. Occurrence of a multimeric high-molecular-weight glyceraldehyde-3-phosphate dehydrogenase in human serum. J Proteome Res. 2015 April 3; 14(4):1645-56.
Key words: 2D gel electrophoresis, DEAE Affigel Blue column chromatography, extracellular GAPDH, multimer, serum GAPDH
http://www.ncbi.nlm.nih.gov/pubmed/25734908

1. Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Ko YH, Pedersen PL, Preto A, Casal M.
Biochem J. 2015 Apr 15;467(2):247-58. doi: 10.1042/BJ20140921. The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH.
Key words: Cancer, 3-bromopyruvate, Anti-Cancer Agent
http://www.ncbi.nlm.nih.gov/pubmed/25641640

2. Braiterman LT, Gupta A, Chaerkady R, Cole RN and Hubbard AL. Communication between the n and c termini is required for copper-stimulated ser/thr phosphorylation of cu(i)-atpase (atp7b). J Biol Chem. 2015:290:8803-19.
Key words: Copper, Copper Transport, Phosphoproteomics, Phosphorylation, Protein Kinase, Trafficking
http://www.ncbi.nlm.nih.gov/pubmed/25666620

3. Frey JL, Li Z, Ellis JM, Zhang, Q, Farber CR, Aja S, Wolfgang MJ, Clemens TL, Riddle RC. Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast. Mol Cell Biol 2015; 35(11):1979-91.
Key words: Fatty acids, Bone, Metabolism
http://www.ncbi.nlm.nih.gov/pubmed/25802278

4. Kammers K, Cole RN, Tiengwe C and Ruczinski I. Detecting significant changes in protein abundance. EuPA Open Proteom. 2015:7:11-9.
Key words: Empirical Bayes, Inference, Protein abundance
http://www.ncbi.nlm.nih.gov/pubmed/25821719

5. Kunjithapatham R, Geschwind JF, Devine L, Boronina TN, O'Meally RN, Cole RN, Torbenson MS and Ganapathy-Kanniappan S. Occurrence of a multimeric high-molecular-weight glyceraldehyde-3-phosphate dehydrogenase in human serum. J Proteome Res. 2015:14:1645-56.
Key words: 2D gel electrophoresis, DEAE Affigel Blue column chromatography, extracellular GAPDH Multimer, serum GAPDH
http://www.ncbi.nlm.nih.gov/pubmed/25734908

1. Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Young KH, Pedersen PL, Preto A, Casal M.
The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH.
Biochem J. 2015 Apr 15;467(2):247-58. doi: 10.1042/BJ20140921.
Key words: 3-bromopyruvate, breast cancer, pH
http://www.ncbi.nlm.nih.gov/pubmed/25641640

2. Ellis JM, Bowman CE, Wolfgang MJ. Metabolic and tissue-specific regulation of acyl-CoA metabolism. Plos One. 2015 Mar 11;10(3):e0116587.
Key words: fatty acid, metabolism, Acyl-CoA Thioesterase, Acyl-CoA Synthese, transgenic
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116587
PMID: 25760036

3. Mihalas AB, Meffert MK. IKK kinase assay for assessment of canonical NF-kB activation in neurons.
Methods Mol Biol. 2015;1280:61-74. doi: 10.1007/978-1-4939-2422-6_5.
Key words: IKK kinase, NF-kB, neurons
http://www.ncbi.nlm.nih.gov/pubmed/25736744

4. Pang Z, Sakamoto T, Tiwari V, Kim YS, Yang F, Dong X, Güler AD, Guan Y, Caterina MJ.Selective keratinocyte stimulation is sufficient to evoke nociception in mice. Pain. 2015 Apr;156(4):656-65.
Key words: pain, transient receptor potential, capsaicin, skin

http://www.ncbi.nlm.nih.gov/pubmed/25790456

1. Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Young KH, Pedersen PL, Preto A, Casal M.The cytotoxicity of 3-Bromopyruvate in breast cancer cells depends on extracellular pH. Biochem J. 2015 Feb 2. [Epub ahead of print]
Key words: cytotoxicity, 3-bromopyruvate, breast cancer, pH
http://www.ncbi.nlm.nih.gov/pubmed/25641640

2. Braiterman LT, Gupta A, Chaerkady R, Cole RN and Hubbard AL. Communication between the n- and c-termini is required for cu-stimulated ser/thr phosphorylation of cu-(i)atpase (atp7b). J Biol Chem. 2015 Feb 9. pii: jbc.M114.627414. [Epub ahead of print]
Key words: copper transport, phosphoproteomics, phosphorylation, trafficking, kinase
http://www.ncbi.nlm.nih.gov/pubmed/25666620

3. Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R and Donowitz M. Cyclic gmp kinase ii (cgkii) inhibits nhe3 by altering its trafficking and phosphorylating nhe3 at three required sites: Identification of a multifunctional phosphorylation site. J Biol Chem. 2015 Jan 23;290(4):1952-65.
Key words: NHERF, brush boarder, phosphopeptide proteomics, cGMP, Forskolin, cAMP
http://www.ncbi.nlm.nih.gov/pubmed/25480791

4. Kunjithapatham R, Geschwind JF, Hitt L, Boronina T, O'Meally R, Cole RN, Torbenson M and Ganapathy-Kanniappan S. Occurrence of a multimeric high molecular weight glyceraldehyde-3-phosphate dehydrogenase in human serum. J Proteome Res. 2015 March 18 [Epub ahead of print].
Key words: Serum GAPDH, extracellular GAPDH, multimer 2D-gel electrophoresis, DEAEAffigel Blue column chromatography
http://www.ncbi.nlm.nih.gov/pubmed/25734908

5. Makowski SL, Wang Z, Pomerantz JL. A protease-independent function for SPPL3 in NFAT activation. Mol Cell Biol. 2015 Jan;35(2):451-67.
Key words: SPPL3, STIM1, Orai1, Store-Operated Calcium Entry (SOCE), NFAT
http://www.ncbi.nlm.nih.gov/pubmed/25384971

6. Munns CH, Chung MK, Sanchez YE, Amzel LM, Caterina MJ. Role of the outer pore domain in transient receptor vanilloid 1 dynamic permeability to large cations. J Biol Chem. 2015 Feb 27;290(9):5707-24.
Key words: Channel, Capsaicin, Pore Dilation, TRPV1
http://www.ncbi.nlm.nih.gov/pubmed/25568328

7. Yan K, Fu Z, Yang C, Zhang K, Jiang S, Lee DH, Heo HY, Zhang Y, Cole RN, Van Eyk JE and Zhou J. Assessing amide proton transfer (apt) mri contrast origins in 9 l gliosarcoma in the rat brain using proteomic analysis. Mol Imaging Biol. 2015 Jan 27 [Epub ahead of print].
Key words: APT imaging, CEST imaging, glioma, mobile protein, proteomics
http://www.ncbi.nlm.nih.gov/pubmed/25622812

8. Yanagisawa T, Ishii R, Hikida Y, Fukunaga R, Sengoku T, Sekine S, Yokoyama S. A SelB/EF-Tu/aIF2?-like protein from Methanosarcina mazei in the GTP-bound form binds cysteinyl-tRNA(Cys.). J Struct Funct Genomics. 2015 Jan; 16: 25-41.
Key words: Crystal structure, Translation factor, GTP, tRNA
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329189/

9. Zhong J, Martinez M, Sengupta S, Lee A, Wu X, Chaerkady R, Chatterjee A, O'Meally RN, Cole RN, Pandey A and Zachara NE. Quantitative phosphoproteomics reveals crosstalk between phosphorylation and o-glcnac in the DNA damage response pathway. Proteomics. 2015 Jan;15(2-3):591-607.
Key words: ATM, cell biology, glycobiology, glycosylation, OGT, signal transduction
http://www.ncbi.nlm.nih.gov/pubmed/25263469

1. Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Young KH, Pedersen PL, Preto A, Casal M. The cytotoxicity of 3-Bromopyruvate in breast cancer cells depends on extracellular pH.
Biochem J. 2015 Feb 2. [Epub ahead of print]
Key words: breast cancer, extracellular pH, 3-Bromopyruvate
http://www.ncbi.nlm.nih.gov/pubmed/25641640

2. Makowski SL, Wang Z, Pomerantz JL. A protease-independent function for SPPL3 in NFAT Activation. Mol Cell Biol. 2015;35:451-67.
Key words: SPPL3, STIM1, Orai1, Store-Operated Calcium Entry (SOCE), NFAT
http://www.ncbi.nlm.nih.gov/pubmed/25384971

3. Munns CH, Chung MK, Sanchez YE, Amzel LM, Caterina MJ. Role of the outer pore domain in Transient Receptor Potential Vanilloid 1 dynamic permeability to large cations. J Biol Chem. 2015 Feb 27;290(9):5707-24. pii: jbc.M114.597435.
Key words: Channel, Selectivity, TRPV1, Pain
http://www.jbc.org/content/early/2015/01/07/jbc.M114.597435.long
PMID: 25568328

4. Yan K, Fu Z, Yang C, Zhang K, Jiang S, Lee DH, Heo HY, Zhang Y, Cole RN, Van Eyk JE and Zhou J. Assessing amide proton transfer (apt) mri contrast origins in 9 l gliosarcoma in the rat brain using proteomic analysis. Mol Imaging Biol. 2015 Jan 27 [Epub ahead of print].
Key words: APT imaging, CEST imaging, Glioma, Mobile protein, Proteomics http://www.ncbi.nlm.nih.gov/pubmed/25622812

5. Zhong J, Martinez M, Sengupta S, Lee A, Wu X, Chaerkady R, Chatterjee A, O'Meally RN, Cole RN, Pandey A and Zachara NE. Quantitative phosphoproteomics reveals crosstalk between phosphorylation and o-glcnac in the DNA damage response pathway. Proteomics. 2015 Jan; 15 (2-3):591-607.
Key words: ATM, Cell biology, Glycobiology, Glycosylation, OGT,Signal transduction
http://www.ncbi.nlm.nih.gov/pubmed/25263469

1. Harr JC, Luperchio TR, Wong X, Cohen E, Wheelan SJ, Reddy KL. Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins. The Journal of Cell Biology 2015 Jan;208(1):33-52.
Key words: chromatin, nuclear lamina, chromatin, A-type lamins
http://www.ncbi.nlm.nih.gov/pubmed/25559185

2. Kim A, Hartman IZ, Poore B, Boronina T, Cole RN, Song N, Ciudad MT, Caspi RR, Jaraquemada D and Sadegh-Nasseri S. Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources. Nat Commun. 2014 Nov 21;5:5369.
Key words: Cathepsin, epitope capture, HLA-DM, Immunodominance, Reductionist Antigen Processing
http://www.ncbi.nlm.nih.gov/pubmed/25413013

3. Lee J, Ellis JM, Wolfgang MJ. Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress induced inflammation. Cell Reports 2015; 10(2):266-79.
Key words: metabolism, mitochondria, obesity, diabetes
http://www.cell.com/cell-reports/fulltext/S2211-1247(14)01052-3

4. Makowski SL, Wang Z, Pomerantz JL. A Protease-Independent Function for SPPL3 in NFAT Activation. Mol Cell Biol. 2015;35:451-67.
Key words: SPPL3, STIM1, Orai1, Store-Operated Calcium Entry (SOCE), NFAT
http://www.ncbi.nlm.nih.gov/pubmed/25384971

1. Fukunaga R, Zamore PD. A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis. Cell Cycle. 2014 Jun 1;13(11):1671-6.
Key words: siRNA, miRNA, phosphate, Dicer
http://www.ncbi.nlm.nih.gov/pubmed/24787225

2. Majkowska-Skrobek G, Augustyniak D, Lis P, Bartkowiak A, Gonchar M, Ko YH, Pedersen PL, Goffeau A, Ulaszewski S. Killing multiple myeloma cells with the small molecule 3-bromopyruvate: implications for therapy. Anticancer Drugs. 2014 Jul;25(6):673-82.
Key words: cancer, multiple myeloma, Warburg effect, 3-bromopyruvate, anti-cancer drugs
http://www.ncbi.nlm.nih.gov/pubmed/2455701

1. Reeves RA, Lee A, Henry R, Zachara NE. Characterization of the specificity of O-GlcNAc reactive antibodies under conditions of starvation and stress. Anal Biochem. 2014 Apr 18;457C:8-18.[Epub ahead of print]
Key words: O-GlcNAc, Signaling, Antibodies, Chitobiose, Stress
http://www.ncbi.nlm.nih.gov/pubmed/24747005

1. Heydarian M, Luperchio TR, Cutler J, Mitchell CJ, Kim MS, Pandey A, Sollner-Webb B, Reddy KL. Prediction of gene activity in early B cell development based on an integrative multi-omics analysis. J Proteomics Bioinform. 2014;7: 050-063. doi: 10.4172/jpb.1000302
Key words: RNA-seq. iTRAQ, B cell development, chromatin, proteome, transcriptome
No PMID available

2. Luperchio TR, Wong X, Reddy KL. Genome regulation at the peripheral zone: lamina associated domains in development and disease. Curr Opin Genet Dev. 2014 Feb 17;25C:50-61.
Key words: nuclear architecture, genome organization, chromatin, gene regulation, nuclear lamina
http://www.ncbi.nlm.nih.gov/pubmed/24556270

3. Watkin EE, Arbez N, Waldron-Roby E, O'Meally R, Ratovitski T, Cole RN and Ross CA. Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity. PLoS ONE. 2014 Feb 5;9(2):e88284.
Key words: Huntington's Disease; N-terminal Htt; therapeutic targets
http://www.ncbi.nlm.nih.gov/pubmed/24505464

1. Fukunaga R, Colpan C, Han BW, Zamore PD. Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J. 2014 Feb 18;33(4):371-84. doi: 10.1002/embj.201387176.
Key words: miRNA, siRNA, Dicer, phosphate, PAZ
http://www.ncbi.nlm.nih.gov/pubmed/24488111

2. Kim YS, Chu Y, Han L, Li M, Li Z, Lavinka PC, Sun S, Tang Z, Park K, , MJ, Ren K, Dubner R, Wei F, Dong X. Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain. Neuron. 2014;81:873-87.
Key words: nociception, optogenetics, calcium, chronic pain
http://www.ncbi.nlm.nih.gov/pubmed/24462040

3. Majkowska-Skrobek G, Augustyniak D, Lis P, Bartkowiak A, Gonchar M, Ko YH, Pedersen PL, Goffeau A, Ulaszewski S. Killing multiple myeloma cells with the small molecule 3-bromopyruvate: implications for therapy. Anticancer Drugs. 2014 Feb 19 [Epub ahead of print].
Key words: cancer, multiple myeloma, 3-bromopyruvate, therapy
http://www.ncbi.nlm.nih.gov/pubmed/24557015

4. Meier EL, Goley ED. Form and function of the bacterial cytokinetic ring. Curr Opin Cell Biol. 2014 Feb; 26:19-27.
Key words: cytokinesis, FtsZ, super-resolution imaging, biomimetic systems
http://www.ncbi.nlm.nih.gov/pubmed/24529242

1. Fukunaga R, Colpan C, Han BW, Zamore PD. Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J. 2014 Feb 18;33(4):371-84.
Key words: miRNA, siRNA, Dicer, phosphate, PAZ
http://www.ncbi.nlm.nih.gov/pubmed/24488111

2. Tardio L, Andrés-Bergós J, Zachara NE, Larrañaga-Vera A, Rodriguez-Villar C, Herrero-Beaumont G, Largo R.O-linked N-acetylglucosamine (O-GlcNAc) protein modification is increased in the cartilage of patients with knee osteoarthritis.Osteoarthritis Cartilage. 2014 Feb;22(2):259-63.
Key words: Intracellular Glycosylation, Signaling, Osteoarthritis, Inflammation
http://www.ncbi.nlm.nih.gov/pubmed/24333294

3. Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH and Dinkova-Kostova AT. Sulphoxythiocarbamates modify cysteine residues in hsp90 causing degradation of client proteins and inhibition of cancer cell proliferation. Br J Cancer. 2014 Jan 7;110(1):71-82
Key words: Hsp90; NRF2; cysteine; HSF1
http://www.ncbi.nlm.nih.gov/pubmed/24322890

1. Caterina MJ. Boosting that tan with a bit of voltage. Channels (Austin). 2013 Oct 2;7(6), 1.
Key words: channel, ultraviolet, TRPA1, melanin, melanocyte
http://www.ncbi.nlm.nih.gov/pubmed/24088950

2. Cole RN, Ruczinski I, Schulze K, Christian P, Herbrich S, Wu L, Devine LR, O'Meally RN, Shrestha S, Boronina TN, Yager JD, Groopman J and West KP, Jr. The plasma proteome identifies expected and novel proteins correlated with micronutrient status in undernourished nepalese children. Journal of Nutrition. 2013 Oct; 143(10):1540-8.
Key words: Quantitative proteomics, nutrition, protein proxies
http://www.ncbi.nlm.nih.gov/pubmed/23966331

3. Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH and Dinkova-Kostova AT. Sulphoxythiocarbamates modify cysteine residues in hsp90 causing degradation of client proteins and inhibition of cancer cell proliferation. Br J Cancer. 2013 Dec 5. doi: 10.1038/bjc.2013.710.
Key words: Hsp90; NRF2; cysteine; HSF1
http://www.ncbi.nlm.nih.gov/pubmed/24322890

1. Mihalas AB, Araki Y, Huganir RL, Meffert MK. Opposing action of nuclear factor kB and polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation. J. Neurosci. 2013 Oct 16; 33(42):16490-501.
Key words: Synaptic plasticity, nuclear factor kappaB, homeostatic plasticity, hippocampus, gene expression
http://www.ncbi.nlm.nih.gov/pubmed/24133254

1. Ueda S, Tu-Sekine B, Yamanoue M, Raben DM, Shirai Y. The expression of diacylglycerol kinase theta during the organogenesis of mouse embryos. BMC Dev Biol. 2013 Oct 1;13(1):35.
Key words: Diacylglycerol kinase, development, mice
http://www.ncbi.nlm.nih.gov/pubmed/24079595

1. Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN and O'Rourke B. The cardiac acetyl-lysine proteome. PLoS One. 2013 13 Jul 2;8(7):e67513.
Key words: cardiovascular disease, post-translational modifications, mass spectrometry
http://www.ncbi.nlm.nih.gov/pubmed/23844019

2. Kunjithapatham R, Geschwind JF, Rao PP, Boronina TN, Cole RN and Ganapathy-Kanniappan S. Systemic administration of 3-bromopyruvate reveals its interaction with serum proteins in a rat model. BMC Res Notes. 2013 Jul 17;6(1):277.
Key words: alpha1 antitrypsin, chemical adduct modification, 2D gel electrophoresis, mass spectrometry
http://www.ncbi.nlm.nih.gov/pubmed/2386682

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Henrietta Lacks Memorial Lecture
Johns Hopkins Institute for Clinical and Translational Research
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JHM HSR Recertification Training
 
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