Web notes  

October 2017

Anesthesiology and Critical Care Archives

1. Frank SM, Ejaz A, Pawlik TM. Blood transfusion strategy and clinical outcomes. Ann Surg. 2015 Jul;262(1):7-8. doi: 10.1097/SLA.0000000000001276.
Key words: Blood, Outcomes, Strategy, Transfusion

2. Gani F, Kim Y, Weiss MJ, Makary MA, Wolfgang CL, Hirose K, Cameron JL, Wasey JO, Frank SM, Pawlik TM. Effect of surgeon and anesthesiologist volume on surgical outcomes. J Surg Res. 2015 Aug 14. pii: S0022-4804(15)00823-9. doi: 10.1016/j.jss.2015.08.010. [Epub ahead of print]
Key words: Anesthesiologist, Outcomes, Surgeon, Surgery

3. Kim Y, Ejaz A, Gani F, Wasey JO, Xu L, Frank SM, Pawlik TM. Crystalloid administration among patients undergoing liver surgery: Defining patient- and provider-level variation. Surgery. 2015 Aug 8. pii: S0039-6060(15)00536-X. doi: 10.1016/j.surg.2015.06.037. [Epub ahead of print]
Key words: Crystalloid, Fluid, Liver, Surgery, Variation

4. Kim Y, Spolverato G, Lucas DJ, Ejaz A, Xu L, Wagner D, Frank SM, Pawlik TM. Red cell transfusion triggers and postoperative outcomes after major surgery. J Gastrointest Surg. 2015 Aug 26. [Epub ahead of print]
Key words: Blood, Outcomes, Surgery, Transfusion, Trigger

5. Mavros MN, Xu L, Maqsood H, Gani F, Ejaz A, Spolverato G, Al-Refaie WB, Frank SM, Pawlik TM. Perioperative blood transfusion and the prognosis of pancreatic cancer surgery: systematic review and meta-analysis. Ann Surg Oncol. 2015 Aug 21. [Epub ahead of print]
Key words: Blood, Cancer, Meta-analysis, Pancreatic, Transfusion

6. Spolverato G, Kim Y, Ejaz A, Frank SM, Pawlik TM. Effect of relative decrease in blood hemoglobin concentrations on postoperative morbidity in patients who undergo major gastrointestinal surgery. JAMA Surg. 2015 Jul 29. doi: 10.1001/jamasurg.2015.1704. [Epub ahead of print]
Key words: Blood, Decrease, Hemoglobin, Relative, Trigger, Transfusion

1. Han X, Lan X, Li Q, Gao Y, Zhu W, Cheng T, Maruyama T, Wang J. Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin toxicity. JCBFM. 2015. In process.
Key words: intracerebral hemorrhage, prostaglandin EP3 receptor, Rho-Rho kinase

1. Chang DS, Raghavan R, Christiansen S, Cohen SP. Emerging targets in treating pain. Curr Opin Anaesthesiol. 2015; 28: 379-97.
Key words: Neuropathic pain; nociceptive pain; pain mechanism; nerve growth factor inhibitor; glial cell; sodium channel; opioid

2. Cohen SP, Moon JY, Brummett CM, White RL, Larkin TM. Medial branch blocks or intra-articular injections as a prognostic tool before lumbar facet radiofrequency denervation: a multicenter, case-control study. Reg Anesth Pain Med. 2015; 40: 376-83.
Key words: Facet joint; zygapophyseal joint; radiofrequency; predictive value

3. Cohen SP. Botulinum toxin Type B for chronic pain: panacea or snake oil? the need for more and better preclinical studies. Anesth Analg. 2015; 121: 20-1.
Key words: Botulinum toxin; Botox; neuropathic pain; pain model

4. Cohen SP. Oral steroids for improved function but not pain in acute radiculopathy due to disc herniation. Evid Based Med. 2015 Jul 1. pii: ebmed-2015-110240. doi: 10.1136/ebmed-2015-110240. [Epub ahead of print]
Key words: Steroid; radiculopathy; sciatica; herniated disc

1. Bicket MC, Chakravarthy K, Chang D, Cohen SP. Epidural steroid injections: An updated review on recent trends in safety and complications. Pain Manag. 2015; 5: 129-46.
Key words: Epidural steroid injectionl; back pain; neck pain; radiculopathy; complication

1. Bicket M, Horowitz J, Benzon HT, Cohen SP. Epidural injections for spinal pain: A systematic review and meta-analysis evaluating need for surgery in randomized controlled trials. Spine J. 2015 Feb; 15: 348-62.
Key words: Surgery; epidural steroid injection; prevention

2. Cohen SP. Epidemiology, diagnosis and treatment of neck Pain. Mayo Clin Proc. 2015 Feb; 90(2): 284-99.
Key words: Neck pain, radiculopathy, cervical, myelopathy

3. Ejaz A, Spolverato G, Kim Y, Gupta R, Amini N, Frank SM, Pawlik TM. Impact of blood transfusions and transfusion practice on long term outcomes following hepatopancreatobiliary surgery. J Gastrointest Surg. 2015 Feb 24. [Epub ahead of print]
Key words: blood, outcomes, target, transfusion, trigger

4. Hooten WM, Cohen SP, Rathmell JP. Introduction to the symposium on pain medicine. Mayo Clin Proc 2015; 90: 4-5.
Key words: chronic pain, pain medicine

5. Hsu E, Murphy S, Chang D, Cohen SP. Expert opinion on emerging drugs: Chronic low back pain. Exp Opin Emerg Drugs. 2015 Mar;20(1):103-27.
Key words: low back pain, cannabinoid, opioid, glial cell, cytokine, channel blocker

6. Zuckerberg GS, Scott AV, Wasey JO, Wick EC, Pawlik TM, Ness PM, Patel ND, Resar LM, Frank SM: Efficacy of education followed by computerized provider order entry with clinician decision support to reduce red blood cell utilization. Transfusion. 2015 Feb 3. doi: 10.1111/trf.13003. [Epub ahead of print]
Key words: blood, CPOE, education, management, transfusion

1. Ness PM, Frank SM. Enhancing patient blood management: a long-term FOCUS. Lancet. 2014 Dec 9. pii: S0140-6736(14)62344-8. doi: 10.1016/S0140-6736(14)62344-8.
Key words: blood, outcomes, transfusion, trigger

2. Zuckerberg GS, Scott AV, Wasey JO, Wick EC, Pawlik TM, Ness PM, Patel ND, Resar LM, Frank SM. Efficacy of education followed by computerized provider order entry with clinician decision support to reduce red blood cell utilization. Transfusion. 2015 Feb 3. doi: 10.1111/trf.13003. [Epub ahead of print]
Key words: blood, CPOE, decision, support

1. Fan C, Meuchel LW, Su Q, Angelini DJ, Zhang A, Cheadle C, Kolosolva I, Makarevich OD, Yamaji-Kegan K, Rothenberg ME, Johns RA. Resistin-like molecule alpha in allergen-induced pulmonary vascular remodeling. Am J Respir Cell Mol Biol. 2015 Jan 8.
Key words: resistin-like molecule alpha; pulmonary hypertension; vascular remodeling; inflammation; T helper 17

2. Ness PM, Frank SM. Enhancing patient blood management: A long term focus. Lancet. 2014 Dec 9. pii: S0140-6736(14)62344-8. doi: 10.1016/S0140-6736(14)62344-8. [Epub ahead of print]
Key words: Blood, Clinical, Lesion, Outcomes, Storage

3. Noel S, Zheng L, Navas-Acien A, Fuchs RJ. The effect of ex vivo CDDO-Me activation on nuclear factor erythroid 2-related factor 2 pathway in white blood cells from patients with septic shock. Shock. 2014 Nov;42(5):392-9.
Key words: critical illness, septic shock, NRF2, CDDO-Me, antioxidants

1. Bicket MC, Horowitz J, Benzon H, Cohen SP. Epidural injections in prevention of surgery for spinal pain: systematic review and meta-analysis of randomized controlled trials. Spine J. 2014 Oct 13. pii: S1529-9430(14)01569-1.
Key words: low back pain; radiculopathy; sciatica; neck pain; surgery; prevention

2. Cohen SP. Precision targeting for neuroablative therapies: the future of interventional pain medicine. Reg Anesth Pain Med. 2014; 39: 447-9.
Key words: Neck pain; facet joint; cervical medial branch; radiofrequency ablation; denervation

3. Cohen SP, Hayek S, Semenov Y, Pasquina PF, White RL, Veizi E, et al. Epidural steroid injections, conservative treatment, or combination treatment for cervical radicular pain: A multicenter, randomized, comparative-effectiveness study. Anesthesiology. 2014; 121: 1045-55.
Key words: Neck pain; cervical radiculopathy; epidural steroid injections; gabapentin; nortriptyline


1. Dietz AS, Pronovost PJ, Mendez-Tellez PA, Wyskiel R, Marsteller JA, Thompson DA, Rosen MA. A systematic review of teamwork in the intensive care unit: What do we know about teamwork, team tasks, and improvement strategies? J Crit Care. 2014 Dec;29(6):908-914.
Key words: group processes, intensive care unit, patient safety, teamwork

2. Hsu YJ, Weeks K, Yang T, Sawyer MD, Marsteller JA. Impact of self-reported guideline compliance: Bloodstream infection prevention in a national collaborative. Am J Infect Control. 2014 Oct;42(10 Suppl):S191-6.
Key words: central line-associated bloodstream infections, guidelines, hospital-acquired infection, intensive care unit

3. Marsteller JA, Hsu YJ, Weeks K. Evaluating the impact of mandatory public reporting on participation and performance in a program to reduce central line-associated bloodstream infections: evidence from a national patient safety collaborative. Am J Infect Control. 2014 Oct;42(10 Suppl):S209-15.
Key words: central line-associated bloodstream infections, Comprehensive Unit-based Safety Program, health policy, hospital-acquired infections, mandatory reporting

4. Rosen MA, Lee BH, Sampson JB, Koka R, Chima AM, Ogbuagu OU, Marx MK, Kamara TB, Koroma M, Jackson EV Jr. Failure mode and effects analysis applied to the maintenance and repair of anesthetic equipment in an austere medical environment. Int J Qual Health Care. 2014 Aug;26(4):404-10.
Key words: austere medical environments, failure mode and effects analysis, biomedical engineering, developing country

5. Weeks KR, Hsu YJ, Yang T, Sawyer M, Marsteller JA. Influence of a multifaceted intervention on central line days in intensive care units: results of a national multisite study. Am J Infect Control. 2014 Oct;42(10 Suppl):S197-202.
Key words: CLABSI bundle, central line denominator; central line denominator days, central line-associated bloodstream infections, central venous catheters

1. Ali KJ, Farley DO, Speck K, Catanzaro M, Wicker KG, Berenholtz SM. Measurement of implementation components and contextual factors in a two-state healthcare quality initiative to reduce ventilator-associated pneumonia. Infect Control Hosp Epidemiol. 2014 Oct;35 Suppl 3:S116-23.
Key words: ventilator-associated pneumonia, patient safety and quality, implementation components and contextual factors, interview surveys, barriers to progress in quality improvement

2. DeVita MA, Winters B. It's Not "Do" but "Why Do" Rapid Response Systems Work? Crit Care Med. 2014 Sep;42(9):2133-4.
Key words: cardiac arrest, patient safety, quality improvement, rapid response systems

3. Goutier JM, Holzmueller CG, Edwards KC, Klompas M, Speck K, Berenholtz SM. Strategies to enhance adoption of ventilator-associated pneumonia prevention interventions: a systematic literature review. Infect Control Hosp Epidemiol. 2014 Aug;35(8):998-1005.
Key words: ventilator-associated pneumonia, prevention, hospital-acquired infection, quality improvement

4. Herzer KR, Niessen L, Constenla DO, Ward WJ Jr, Pronovost PJ. Cost-effectiveness of a quality improvement programme to reduce central line-associated bloodstream infections in intensive care units in the USA.BMJ Open. 2014 Sep 25;4(9):e006065.
Key words: quality improvement, hospital-acquired infection, cost analysis, central line-associated bloodstream infection, intensive care unit

5. Hicks CW, Rosen M, Hobson DB, Ko C, Wick EC. Improving safety and quality of care with enhanced teamwork through operating room briefings. JAMA Surg. 2014 Aug 1;149(8):863-8.
Key words: operating room, briefings, debriefings, surgery, teamwork

6. Klompas M, Branson R, Eichenwald EC, Greene LR, Howell MD, Lee G, Magill SS, Maragakis LL, Priebe GP, Speck K, Yokoe DS, Berenholtz SM. Strategies to prevent ventilator-associated pneumonia in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014 Aug;35(8):915-36.
Key words: ventilator-associated pneumonia, prevention, quality improvement

7. Murphy DJ, Pronovost PJ, Lehmann CU, Gurses AP, Whitman GJ, Needham DM, Berenholtz SM. Red blood cell transfusion practices in two surgical intensive care units: a mixed methods assessment of barriers to evidence-based practice.Transfusion.2014 Oct;54(10pt2):2658-2667.
Key words: transfusion practice, adherence, intensive care unit, evidence-based practice, barriers

8. Pronovost PJ, Marsteller JA. Creating a fractal-based quality management infrastructure.J Health Organ Manag. Jul/Aug 2014;28(4):576-86.
Key words: quality improvement, management infrastructure, hospital-level organization, capacity building

9. Rawat N, Yang T, Speck K, Helzer J, Barenski C, Berenholtz S. An evaluation of ventilator-associated pneumonia process measure sampling strategies in a surgical ICU. Am J Med Qual. 2014 Sep-Oct;29(5):397-402.
Key words: critical care; process assessment; quality of health care; ventilator-associated pneumonia

10. Rosen MA, Sampson JB, Jackson EV Jr, Koka R, Chima AM, Ogbuagu OU, Marx MK, Koroma M, Lee BH. Failure mode and effects analysis of the universal anaesthesia machine in two tertiary care hospitals in Sierra Leone. Br J Anaesth. 2014 Sep;113(3):410-5.
Key words: Sierra Leone, austere anaesthesia, failure mode and effects analysis, FMEA, quality improvement

11. Stonemetz, J and Dutton, R "Anesthesia Information Management System (AIMS) Market Update" ASA Newsletter 2014 (78)10: 38-40.
Key words: AIMS; Anesthesia Information Management Systems; Market Update

12. Weaver SJ, Weeks K, Pham JC, Pronovost PJ. On the CUSP: Stop BSI: Evaluating the relationship between central line-associated bloodstream infection rate and patient safety climate profile. Am J Infect Control. 2014 Oct;42(10 Suppl):S203-8.
Key words: central line-associated bloodstream infection, organizational culture, patient safety

13. Yokoe DS, Anderson DJ, Berenholtz SM, Calfee DP, Dubberke ER, Ellingson KD, Gerding DN, Haas JP, Kaye KS, Klompas M, Lo E, Marschall J, Mermel LA, Nicolle LE, Salgado CD, Bryant K, Classen D, Crist K, Deloney VM, Fishman NO, Foster N, Goldmann DA, Humphreys E, Jernigan JA, Padberg J, Perl TM, Podgorny K, Septimus EJ, VanAmringe M, Weaver T, Weinstein RA, Wise R, Maragakis LL. A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals: 2014 Updates. Am J Infect Control. 2014 Aug;42(8):820-8.
Key words: healthcare-associated infection, hospital-acquired infection, prevention, compendium of strategies

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October 2017 articles:
Changes to NIH-funded Human Subjects Research
Free Resources for Longitudinal Clinical Research Studies
New Fee Schedule for Commercially Funded Studies
NIH requirement for Single IRB (sIRB)
JHM IRB Reliance Requests
Sharing Partnership for Innovative Research in Translation
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Research Network
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
Understanding, Preventing, and Managing Immunotherapy-related Adverse Events (irAEs) Associated with Checkpoint Inhibition for Melanoma and Other Cancers
AHA Institute for Precision Cardiovascular Medicine
National Science Foundation (NSF) Major Research Instrumentation Program (MRI) Instrument Acquisition or Development
Camille Dreyfus Teacher-Scholar Award
Michael J. Fox Foundation (MJFF) Challenge
NIH Video Tutorials on How to Apply for Grants
NIH Policy: Foreign Components Added to a Grant to a Domestic or Foreign Organization

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