February 2013

Pharmacology and Molecular Sciences
[Pharmacology and Molecular Sciences archives]

1. Patel H, Nemeria N, Brammer L, Freel Meyers C, Jordan F. Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate. J Am Chem Soc 2012;134:18374-79.
Key words: thiamin diphosphate, isoprenoid biosynthesis, anti-infectives

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