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November 2008
PUBLICATIONS - Back

Molecular Biology and Genetics Archives

1. Celic I, Verreault A, Boeke JD. Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damange. Genetics 2008 Aug; 179:1769-84.
Key words: acetylation; histone H3 K56; DNA damage
http://www.ncbi.nlm.nih.gov/pubmed/18579506?ordinalpos=5&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_
RVDocSum

2. Lin YY, Qi Y, Lu JY, Pan X, Yuan DS, Zhao Y, Bader JS, Boeke JD. A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev. 2008 Aug 1;22(15):2062-74.
Key words: histone acetylation; yeast; NuA4
http://www.ncbi.nlm.nih.gov/pubmed/18676811?ordinalpos=4&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_
RVDocSum

3. O'Donnell KA, Burns KH, Boeke JD. A descent into the nuage: the maelstrom of transposon control. Dev Cell. 2008 Aug;15(2):179-81.
Key words: mammalian maelstrom protein; transposon silencing; DNA damage
http://www.ncbi.nlm.nih.gov/pubmed/18694557?ordinalpos=3&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_
RVDocSum

4. Han Y, Lin YB, An W, Xu J, Yang HC, O'Connell K, Dordai D, Boeke JD, Siliciano JD, Siliciano RF. Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe. 2008 Aug 14;4(2):134-46.
Key words: HIV-1; gene expression; HPRT
http://www.ncbi.nlm.nih.gov/pubmed/18692773?ordinalpos=2&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_
RVDocSum

5. Scheifele LZ, Boeke JD. From the shards of a shattered genome, diversity. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11593-4.
Key words: genome; diversity; retrotransposons
http://www.ncbi.nlm.nih.gov/pubmed/18701721?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_
RVDocSum

1. An W, Han JS, Schrum CM, Maitra A, Koentgen F, Boeke JD. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 2008 Jul; 46(7):373-83.
Key words: LINE-1; retrotransposon; transgenic mouse; Cre/lox system
http://www.ncbi.nlm.nih.gov/pubmed/18615728?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

2. Wheelan SJ, Martinez Murillo F, Boeke JD. The incredible shrinking world of DNA microarrays. Mol Biosyst. 2008 Jul; 4(7):726-32.
Key words: microarrays; gene expression; genome structure; microRNA expression
http://www.ncbi.nlm.nih.gov/pubmed/18563246?ordinalpos=2&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Cahill H, Nathans J. The optokinetic reflex as a tool for quantitative analyses of nervous system function in mice: application to genetic and drug-induced variation. PLoS ONE 2008 Apr 30;3(4):e2055.
Key words: optokinetic reflex, nervous system
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002055
PMID: 18446207

2. Liu C, Wang Y, Smallwood PM, Nathans J. An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci. 2008 May 28;28(22):5641-53.
Key words: Frizzled5, neuron, parafascicular, thalamus
http://www.jneurosci.org/cgi/content/full/28/22/5641
PMID: 18509025

1. Ben-Aroya S, Coombes C, Kwok T, O'Donnell KA, Boeke JD, Hieter P. Toward a comprehensive temperture-sensitive mutant respository of the essential genes of Saccharomyces cerevisiae. Mol Cell. 2008 Apr 25; 30(2):248-58.
Key words: Saccharomyces cerevisiae, chromosome stability, synthetic lethality
http://www.ncbi.nlm.nih.gov/pubmed/18439903?ordinalpos=3&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

2. Li F, Dong J, Pan X, Oum JH, Boeke JD, Lee SE. Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination inermediates. Mol Cell. 2008 May 9; 30(3):325-35
Key words: Microarray, single strand annealing, SAW1
http://www.ncbi.nlm.nih.gov/pubmed/18471978?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

3. Mitra R. Fain-Thornton J, Craig NL. piggyBac can bypass DNA synthesis during cut and paste transposition. EMBO J 2008 27(7):1097-1109.
Key words: piggyBac, precise excision, transposase, transposition
http://www.nature.com/emboj/journal/v27/n7/abs/emboj200841a.html
PMID: 18354502

4. Pan X, Yuan D, Ye P, Bader J, Boeke JD. Response to Dr. Stephen Cooper's "On the use of metaphor to understand, explain, or rationalize redundant genes in yeast". FEMS Yeast Res. 2008 May; 8(3):349-350.
Key words: genetic redundancy, yeast, genetic damage
http://www.ncbi.nlm.nih.gov/pubmed/18312372?ordinalpos=4&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

5. Urban S, Shi Y. Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases. Curr Opin Struct Biol. 2008 Apr 25. [Epub ahead of print] doi:10.1016/j.sbi.2008.03.005
Key words: intramembrane proteolysis, rhomboid, protease
http://www.ncbi.nlm.nih.gov/pubmed/18440799?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. O'Donnell KA, Boeke JD. Domesticated DNA transposon proteins mediate retrotransposon control. Cell Res. 2008 Mar; 18(3):331-3
Key words: DNA transposon proteins, retrotransposition, gene structure, gene expression
http://www.ncbi.nlm.nih.gov/pubmed/18311163?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Burns, KH, Boeke JD. Great exaptations. J Biol 2008 Feb 15; 7(2):5.
Key words: LINEs, retrotransposons, neomorphic alleles
http://www.ncbi.nlm.nih.gov/pubmed/18279541?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

2. Ghosh D, Seydoux G. Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation. Genetics. 2008 Jan;178(1):235-43.
Key words: transcription, C. elegans, germline protein PIE-1
http://www.ncbi.nlm.nih.gov/pubmed/18202370?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

3. Huang Z, Sucgang RS, Lin YY, Shi X, Boeke JD, Pan X. Plasmid-chromosome shuffling for non-deletion alleles in yeast. Nat Methods 2008 Feb; 5(2):167-9.
Key words: non-deletion alleles, Saccharomyces cerevisiae, PCR mutagenesis
http://www.ncbi.nlm.nih.gov/pubmed/18193055?ordinalpos=2&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

4. Marton HA, Desiderio S. The Paf1 complex promotes displacement of histones upon rapid induction of transcription by RNA polymerase II. BMC Mol Biol. 2008 Jan 14;9(1):4
Key words: Pafl, histones, RNA polymerase II
http://www.ncbi.nlm.nih.gov/pubmed/18194564?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Chen J, Nathans J. Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis. Dev Cell. 2007 Sep;13(3):325-37.
Key words: estrogen, NR3B2, epithelial cells, endolymph
http://linkinghub.elsevier.com/retrieve/pii/S1534-5807(07)00272-9
PMID: 17765677

2. Sulek M, Yarrington R, McGibbon G, Boeke JD, Junop M. A critical role for the C-terminus of Nej1 protein in Lif1p assocation, DNA binding and non-homologous end-joining. DNA Repair (Amst). 2007 Dec 1;6(12):1805-18.
Key words: DNA binding, non-homologous end-joining, protein Nej1
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17765666

1. Dong J, Feldman G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007 Sept 21; 130: 1120-1133.
Key words: organ size, tumor suppressor, oncogene, the Hippo pathway, cancer
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17889654

2. Urban S. Rhomboid intramembrane serine proteases. In: Proteases in Disease Volume 6: Intramembrane-Cleaving Proteases, Pages 51-78 (eds. Hooper, N.M. & Lendeckel, U.), Springer Press, New York, 2007.
Key words: membrane, cell signalling, malaria, protease

3. Zurita-Martinez SA, Puria R, Pan X, Boeke JD, Cardenas ME. Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics 2007 Aug; 176(4):2139-2150.
Key words: Saccharomyces cerevisiae; Tor signaling; class C Vps complex
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17565946

1. Chen J, Nathans J. Genetic ablation of cone photoreceptors eliminates retinal folds in the retinal degeneration 7 (rd7) mouse. Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2799-805.
Key words: cone, photoreceptors, retina, retinal degeneration
http://www.iovs.org/cgi/content/full/48/6/2799
PMID: 17525215

2. Zurita-Martinez SA, Puria R, Pan X, Boeke JD, Cardenas ME. Efficient Tor signaling requires a functional Class C Vps protein complex in saccharomyces cerevisiae. Genetics 2007 Aug;176(4):2139-50.
Key words: Tor signaling; Class C Vps complex; vacuole; rapamycin
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17565946

1. Stitzel ML, Seydoux G. Regulation of the oocyte-to-zygote transition. Science. 2007 Apr 20;316(5823):407-8.
Key words: oocyte, zygote, RNA, embryogenesis
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17446393

2. Yarrington RM, Chen J, Bolton EC, Boeke JD. Mn2+ suppressor mutations and biochemical communication between Ty1 reverse transcriptase and RNase H domains. J Virol 2007 May 30; [Epub ahead of print]
Key words: reverse transcriptase; Manganese; PMR1; yeast; retrotransposon
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17537863

1. Baker RP, Young K, Feng L, Shi Y, Urban S. Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8257-62. Epub 2007 Apr 26.
Key words: malaria, cell signaling, proteases
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17463085

2. Chen EH, Grote E, Mohler W, Vignery A. Cell-cell fusion. FEBS Lett 2007 May 29;581(11):2181-93.
Key words: cell-cell fusion, yeast mating, myoblast fusion, C elegans cell fusion, macrophage fusion
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17395182

3. Kim S, Shilagardi K, Zhang S, Hong SN, Sens KL, Bo J, Gonzalez GA, Chen EH. A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion. Dev. Cell 2007;12, 571-86.
Key words: myoblast fusion, actin cytoskeleton, targeted exocytosis, prefusion vesicles
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17419995

4. O'Donnell KA, Boeke JD. Mighty Piwis defend the germline against genome intruders. Cell 2007; 129:37-44.
Key words: transposons; argonaute, piRNAs
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17418784

5. Pan D. Hippo signaling in organ size control. Genes Dev. 2007; 21: 886-897.
Key words: organ size, cell proliferation, cell death, signal transduction
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17437995&query_hl=7&itool=pubmed_docsum

6. Yin F, Pan D. Fat flies expanded the hippo pathway: a matter of size control. Sci STKE. 2007 Apr 3;2007(380):pe12.
Key words: organ size, cell proliferation, cell death, receptor
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17406009&query_hl=7&itool=pubmed_docsum

1. Pan X, Yuan DS, Ooi SL, Wang X, Sookhai-Mahadeo S, Meluh P, Boeke JD. dSLAM analysis of genome-wide genetic interactions in Saccharomyces cerevisiae. Methods Feb; 41(2):206-21.
Key words: Saccharomyces cerevisiae; synthetic lethality; dSLAM; TAG-array PCR
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17189863

2. Jacobs GH, Williams GA, Cahill H, Nathans J. Emergence of novel color vision in mice engineered to express a human cone photopigment. Science 2007 Mar 23; 315(5819): 1723-7125.
Key words: color vision, cone, photopigment, mice
http://www.sciencemag.org/cgi/content/full/315/5819/1723
PMID: 17379811

3. Wang Y, Nathans J. Tissue/planar cell polarity in vertebrates: new insights and new questions.
Development 2007 Feb;134(4) 647-58.
Key words: cell polarity, vertebrates
http://dev.biologists.org/cgi/content/full/134/4/647
PMID: 17259302

1. An W, Han JS, Wheelan SJ, Davis ES, Coombes CE, Ye P, Triplett C, Boeke JD. Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18662-7
http://www.pnas.org/cgi/content/full/103/49/18662
PMID: 17124176

2. Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J. Mutational analysis of Norrin-frizzled4 recognition. J Biol Chem. 2007 Feb 9;282(6):4057-68.
Key words: mutation, Norrin-frizzled4
http://www.jbc.org/cgi/reprint/M609618200v1
PMID: 17158104

3. Wang Y, Badea T, Nathans J. Order from disorder: Self-organization in mammalian hair patterning. PNAS 2006 Dec; 103:52
Key words: mammal, hair, self-organization
http://www.pnas.org/cgi/content/full/103/52/19800
PMID: 17172440

1. An W, Han JS, Wheelan SJ, Davis ES, Coombes CE, Ye P, Triplett C, Boeke JD. Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18662-7.
Key words: retrotransposition, L1, mice, mutagenesis
http://www.pnas.org/cgi/content/full/103/49/18662
PMID: 17124176

2. Feldser D, Strong M, Greider CW. Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres. Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 2249-2251.
Key words: ataxia telangiectasia, telomerase, telomeres
http://www.pnas.org/cgi/reprint/103/7/2249

3. Frank CJ, Hyde M., Greider CW. Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Mol Cell, (2006) 24, 423-432.
Key words: telomere, cyclin, kinase, CDK1
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17070718

4. Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J. Mutational analysis of Norrin-frizzled4 recognition. J Biol Chem. 2006 Dec 6; [Epub ahead of print]
Key words: mutation, Norrin-frizzled4, mice
PMID: 17158104
http://www.jbc.org/cgi/reprint/M609618200v1

5. Wang Y, Badea T, Nathans J. Order from disorder: Self-organization in mammalian hair patterning. PNAS 2006 Dec 26;103(52):19800-5.
Key words: Fz6, hair, mammals, mice
http://www.pnas.org/cgi/content/full/103/52/19800
PMID: 17172440

1. Urban S. Rhomboid proteins: conserved membrane proteases with divergent biological functions. Genes Dev. 2006 Nov 15;20(22):3054-68.
Key words: membrane proteases, cell signaling, malaria
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17114579

2. Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nature Structural and Molecular Biology 2006 Dec;13(12):1084-91.
Key words: membrane proteases, cell signaling, malaria
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17099694

1. Baker RP, Wijetilaka R., Urban S. Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria. PLoS Pathogens 2006; 2(8): e113.
Key words: malaria, cell signaling, protease
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17040128

2. Caraveo G, van Rossum DB, Patterson RL, Snyder SH, Desiderio S. Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. Science. 2006 Oct 6;314(5796):122-5.
Key words: cell signaling, calcium entry, cognitive disorders
http://www.sciencemag.org/cgi/content/abstra ct/314/5796/122
PMID: 17023658

3. Frank CJ, Hyde M, Greider CW. Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Molecular Cell 2006; 24(3) 423-432.
Key words: telomere, kinase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17070718

4. Rattner A, Nathans J. Macular degeneration: recent advances and therapeutic opportunities. Nat Rev Neurosci. 2006 Nov;7(11):860-72. Epub 2006 Oct 11.
Key words: macular degeneration; therapies
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17033682

5. Wheelan SJ, Martinez-Murillo F, Irizarry RA, Boeke JD. Stacking the deck: double-tiled DNA microarrays. Nat. Methods 2006 Nov; 3(11):903-907.
Key words: tiling array, expression profile, yeast
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17060914

1. Arigo JT, Eyler DE, Carroll KL and Corden JL. Termination of cryptic unstable transcripts is directed by yeast RNA-binding proteins Nrd1 and Nab3. Mol Cell. 2006 Sep 15;23(6):841-51.
Key words: RNA, yeast, transcripts
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=16973436

2. Blackburn EH, Greider CW, Szostak JW. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006 Oct;12(10):1133-8.
Key words: telomere history, telomerase discovery, Lasker awards
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17024208

3. Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prevot B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods 2006 October 3; 777-779.
Key words: false positives, RNA
http://www.nature.com/nmeth/journal/v3/n10/abs/nmeth1006-777.html

4. Fry CJ, Norris A, Cosgrove M, Boeke JD, Peterson CL. The LRS and SIN domains: Two structurally equivalent but functionally distinct nucleosomal surfaces required for transcriptional silencing. Mol Cell Biol. 2006 Oct 2; [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17015465

5. Gallo CM, Seydoux G. Toti "potent" repressors. Bioessays. 2006 Sep;28(9):865-7.
Key words: C. elegans, germ cells, totipotency, teratoma
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=16937341

6. Ma Y, Creanga A, Lum L, Beachy PA. Prevalence of off-target effects in Drosophila RNA interference screens. Nature 2006; 443, 359-363.
Key words: RNA, drosophila
http://www.nature.com/nature/journal/v443/n7109/abs/nature05179.html;jsessionid
=12DA78F11AC4F1689163D70C8873CA37

1. Dorner S, Lum L, Kim M, Paro R, Beachy PA, Green R. A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11880-5. Epub 2006 Aug 1.
Key words: RNAi, siRNA, argonaute, posttranscriptional regulation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=16882716

1. Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD, Verreault A. The sirtuins Hst3 and Hst4 preserve genome integrity by controlling histone H3 lysine 56 deacetylation. 2006; [Epub ahead of print]
Key words: Sir2, nucleosome assembly, DNA damage, mass spectrometry, NAD+
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
Abstract&list_uids=16815704

2. Chen J, Rattner A, Nathans J. Effects of L1 retrotransposon insertion on transcript processing, localization and accumulation: lessons from the retinal degeneration 7 mouse and implications for the genomic ecology of L1 elements. Hum Mol Genet. 2006 Jul 1;15(13):2146-56. Epub 2006 May 24.
Key words: L1 retrotransposon, transcript processing, retinal degeneration
http://hmg.oxfordjournals.org/cgi/content/full/15/13/2146
PMID: 16723373

3. Suave AA, Wolberger C, Schramm VL, Boeke JD. The biochemistry of sirtuins. Annu Rev Biochem. 2006; 75: 435-465.
Key words: Sir2, histone deacetylase, substrate specificity, inhibitors, review
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
Abstract&list_uids=16756498

4. Tsunenari T, Nathans J, Yau K-W. Ca2+-activated Cl- current from human bestrophin-4 in excised membrane patches. J Gen Physiol. 2006 Jun;127(6):749-54. Epub 2006 May 15.
Key words: calcium, bestrophin-4, membrane patches
http://www.jgp.org/cgi/content/full/127/6/749
PMID: 16702355

1. McKenzie GJ, Craig NL. Fast, easy and efficient: site-specific insertion of transgenes into Enterobacterial chromosomes using Tn7without need for selection of the insertion event. BMC Microbiol. 2006 Apr 28;6(1):39 [Epub ahead of print].
Key words: transgenes, enterobacterial chromosomes, Tn7
http://www.biomedcentral.com/1471-2180/6/39
PMID: 16646962

2. Arigo JT, Carroll KL, Ames JM, Corden JL Regulation of yeast NRD1 expression by premature transcription termination. Mol Cell. 2006 Mar 3;21(5):641-51.
Key words: yeast, NRD1, transcription
http://linkinghub.elsevier.com/retrieve/pii/S1097-2765(06)00085-2
PMID: 16507362

3. D'Agostino I, Merritt C, Chen PL, Seydoux G, Subramaniam K. Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline. Dev Biol. 2006 Apr 1;292(1):244-52.
Keywords: C. elegans, germline, translation, nanos
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDG-4JBGJ8T-
1&_coverDate=04%2F01%2F2006&_alid=400093180&_rdoc=1&_fmt=&_orig=
search&_qd=1&_cdi=6766&_sort=d&view=c&_acct=C000006078&_version=
1&_urlVersion=0&_userid=75682&md5=9c8cc94ca92c5848a7c1611b4465c236
PMID: 16499902

1. Richardson SM, Wheelan SJ, Yarrington RM, Boeke JD. GeneDesign: Rapid, automated design of multikilobase synthetic genes. Genome Res 2006 Apr; 16(4):550-6.
Key words: Synthetic biology, software, web site
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16481661

1. Rattner A, Nathans J. An evolutionary perspective on the photoreceptor damage response . Am J Ophthalmol 2006 Mar;141(3):558-562.
Key words: retinal, degeneration
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VK5-4J98216-
R&_coverDate=03%2F31%2F2006&_alid=377043102&_rdoc=1&_fmt=&_orig=
search&_qd=1&_cdi=6113&_sort=d&view=c&_acct=C000006078&_version=
1&_urlVersion=0&_userid=75682&md5=75aff6bd1247d57474088b7397b26562

2. Arigo JT, Carroll KL, Ames JM, Corden JL. Regulation of yeast NRD1 expression by premature transcription termination. Mol Cell. 2006 Mar 3;21(5):641-51.
Key words: yeast, NRD1, transcription
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSR-4JCSS16-
6&_coverDate=03%2F03%2F2006&_alid=377046110&_rdoc=1&_fmt=&_orig=
search&_qd=1&_cdi=7053&_sort=d&view=c&_acct=C000006078&_version=
1&_urlVersion=0&_userid=75682&md5=628a28f74b0151ecc9e715906fa57053

3. D'Agostino I, Merritt C, Chen PL, Seydoux G, Subramaniam K. Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline. Dev Biol. 2006 Feb 22; [Epub ahead of print]
Key words: C. elegans, germline, translation
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDG-4JBGJ8T-
1&_coverDate=02%2F24%2F2006&_alid=377048154&_rdoc=1&_fmt=&_orig=
search&_qd=1&_cdi=6766&_sort=d&view=c&_acct=C000006078&_version=
1&_urlVersion=0&_userid=75682&md5=6964bba8603087d96942ad469da97a81

4. Dorner S, Brunelle JL, Sharma D, Green R. The hybrid state of tRNA binding is an authentic translation elongation intermediate. Nat Struct Mol Biol. 2006 Mar;13(3):234-41. Epub 2006 Feb 26.
Key words: ribosome, hybrid state, sparsomycin, translation
http://www.nature.com/nsmb/journal/v13/n3/abs/nsmb1060.html

5. Gandhi TK, Zhong J, Mathivanan S, Karthick L, Chandrika KN, Mohan SS, Sharma S, Pinkert S, Nargaraju S, Periaswamy B, Mishra G, Nandakumar K, Shen B, Deshpande N, Nayak R, Sarker M, Boeke JD, Parmigiani G, Schultz J, Bader JS, Pandey A. Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat Genet.
2006 Mar;38(3):285-93.
Key words: comparative genomics, interaction networks, Saccharomyces cerevisiae
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16501559

6. Pan X, Xe P, Yuan DS, Wang X, Bader JS, Boeke JD. A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell. 2006 Mar 10;124(5):1069-81. Epub 2006 Feb 16.
Key words: DNA damage response, DNA replication checkpoint, synthetic lethality
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16487579

7. Richardson SM, Wheelan SJ, Yarrington RM, Boeke JD. GeneDesign: rapid, automated design of multikilobase synthetic genes. Genome Res. 2006 Feb 15; [Epub ahead of print]
Key words: gene synthesis, sequence analysis software, protein engineering
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16481661

8. Wang Y, Guo N, Nathans J. The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci. 2006 Feb 22;26(8):2147-56.
Key words: development, patterning
http://www.jneurosci.org/cgi/content/full/26/8/2147

9. Seydoux G. The 2006 Genetics Society of America medal. Genetics. 2006 Feb;172(2):721-2.
Key words: C. elegans, microRNA, heterochronic gene
http://www.genetics.org/cgi/content/full/172/2/72

1. Feldser D, Strong MA, Greider CW. Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres. Proc Natl Acad Sci U S A. 2006 Feb 7; [Epub ahead of print]
Key words: ataxia telangiectasia, telomerase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16467146

2. Valdivia RH, Cormack BP, Falkow S. The uses of green fluorescent protein in prokaryotes. Methods Biochem Anal. 2006;47:163-78.
Key words: protein, prokaryotes
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16335713

3. Hao Y, Boyd Lynn, Seydoux G. Stabilization of cell polarity by the C. elegans RING protein PAR-2. Developmental Cell 2006; Feb;10(2):199-208.
Key words: cell polarity, C. elegans, RING protein, PAR-2
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WW3-4J6NRGG-
B&_coverDate=02%2F28%2F2006&_alid=365637963&_rdoc=1&_fmt=&_orig=
search&_qd=1&_cdi=7119&_sort=d&view=c&_acct=C000006078&_version=
1&_urlVersion=0&_userid=75682&md5=b81884129edaeadd135f58c74c471501
PMID: 16459299

1. Brunelle JL, Youngman EM, Sharma D, Green R. The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity. RNA. 2006 Jan;12(1):33-9.
Key words: tRNA, ribosome, peptidyl transferase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16396443

2. Stitzel ML, Pellettieri J, Seydoux G. The C. elegans DYRK kinase MBK-2 marks oocyte proteins for degradation in response to meiotic maturation. Curr Biol. 2006 Jan 10;16(1):56-62. Epub 2005 Dec 15.
Key words: C. elegans, oocyte, meiosis
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16338136

3. Stultz BG, Jackson DG, Mortin MA, Yang X, Beachy PA, Hursh DA. Transcriptional activation by extradenticle in the Drosophila visceral mesoderm. Dev Biol. 2006 Jan 2; [Epub ahead of print]
Key words: transcription, Drosophila, mesoderm
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16403493

4. Wang Y, Zhang J, Mori S, Nathans J.Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling. J Neurosci. 2006 Jan 11;26(2):355-64
Key words: knockout mice, MRI, cell labeling, neurofilament staining
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16407530

1. Ooi SL, Pan X, Peyser BD, Meluh PB, Yuan DS, Irizarry RA, Bader JS, Spencer FA, Boeke JD. Global synthetic-lethality analysis and yeast functional profiling. Trends in Genetics 2005 Nov 22; [Epub ahead of print]
Key words: Saccharomyces cerevisiae, yeast, gene knockouts, genetic interactions
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16309778

2. Hyland EM, Cosgrove MS, Molina H, Wang D, Pandey A, Cottee RJ, Boeke JD. Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae. Mol Cell Biol. 2005; 25:10060-70.
Key words: Saccharomyces cerevisiae, yeast, acetylation, silencing, DNA damage
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16260619

1. Armanios M, Chen JL, Chang YP, Brodsky RA, Hawkins A, Griffin CA, Eshleman JR, Cohen AR, Chakravarti A, Hamosh A, Greider CW. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15960-4. Epub 2005 Oct 24.
Key words: telomerase, dyskeratosis congenita, telomere, haploinsuffiency, stem cell http://www.pnas.org/cgi/content/full/102/44/15960

2. Hyland EM, Cosgrove MS, Molina H, Wang D, Pandey A, Cottee RJ, Boeke JD. Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae. Mol Cell Biol. 2005 Nov;25(22):10060-70.
Key words: nucleosome core modifications, transcriptional silencing http://mcb.asm.org/cgi/content/full/25/22/10060?view=long&pmid=16260619

3. Maity T, Fuse N, Beachy PA. Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci U S A. 2005 Nov 10
Key words: Sonic hedgehog, holoprosencephaly
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16282375

1. Peyser BD, Irizarry RA, Tiffany CW, Chen O, Yuan DS, Boeke JD, Spencer FA. Improved statistical analysis of budding yeast TAG microarrays revealed by defined spike-in pools.
Nucleic Acids Res. 2005 Sep 15;33(16):e140.
Key words: polyadenylation, alternative splicing, retrotransposon
http://nar.oxfordjournals.org/cgi/content/full/33/16/e140

2. Jackson TA, Taylor HE, Sharma D, Desiderio S, Danoff SK. Vascular endothelial growth factor receptor-2: counter-regulation by the transcription factors, TFII-I and TFII-IRD1.
J Biol Chem. 2005 Aug 19;280(33):29856-63.
Key words: TFII-I, TFII-IRD1, VEGF, VEGFR-2, flk-1, KDR, Williams syndrome, initiator
http://www.jbc.org/cgi/content/full/280/33/29856

3. Segall AM, Craig NL. New wrinkles and folds in site-specific recombination.
Mol Cell. 2005 Aug 19;19(4):433-5.
Key words: site-specific recombination, lysogeny, recombinase
http://www.molecule.org/content/article/abstract?uid=PIIS1097276505015170

4. Wheelan SJ, Aizawa Y, Han JS, Boeke JD. Gene-breaking: a new paradigm for human retrotransposon-mediated gene evolution. Genome Res. 2005 Aug;15(8):1073-8. Epub 2005 Jul 15.
Key words: polyadenylation, alternative splicing, retrotransposon
http://www.genome.org/cgi/content/full/15/8/1073

1. Han JS, Boeke JD. LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression? Bioessays. 2005 Aug;27(8):775-84.
Key words: transcription, polyadenylation, splicing, L1
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16015595

2. Hickman AB, Perez ZN, Zhou L, Musingarimi P, Ghirlando R, Hinshaw JE, Craig NL, Dyda F. Molecular architecture of a eukaryotic DNA transposase. Nat Struct Mol Biol. 2005 Aug;12(8):715-21. Epub 2005 Jul 24.
Key words: hAT transposon, DNA hairpin, RNaseH fold, integrase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16041385

3. Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005 Aug 12;122(3):421-34.
Key words: Hippo signaling pathway, cell proliferation, apoptosis
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16096061

4. Jiang H, Chang FC, Ross AE, Lee J, Nakayama K, Nakayama K, Desiderio S. Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle. Mol Cell. 2005 Jun 10;18(6):699-709.
Key words: ubiquitylation, RAG-2, Skp2-SCF, V(D)J recombinase, cell cycle
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15949444

5. Kaur R, Domergue R, Zupancic ML, Cormack BP. A yeast by any other name: Candida glabrata and its interaction with the host. Curr Opin Microbiol. 2005 Aug;8(4):378-84.
Key words: adhesins, secreted-hydrolases, Candida glabrata, azole, mating
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15996895

6. Qi L, Strong MA, Karim BO, Huso DL, Greider CW. Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation. Nat Cell Biol. 2005 Jul;7(7):706-11. Epub 2005 Jun 19.
Key words:Telomere fusion, chromosome, oncogenic translocations, tumour formation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15965466

7. Segall AM, Craig NL. New wrinkles and folds in site-specific recombination. Mol Cell. 2005 Aug 19;19(4):433-5.
Key words: integrase, bacteriophage, lysogeny, pathogenicity, Vibrio cholera
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16109368

8. Wheelan SJ, Aizawa Y, Han JS, Boeke JD. Gene-breaking: a new paradigm for human retrotransposon-mediated gene evolution. Genome Res. 2005 Aug;15(8):1073-8. Epub 2005 Jul 15.
Key words: Transcription, polyadenylation, splicing, L1
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16024818

9. Youngman EM, Green R. Affinity purification of in vivo-assembled ribosomes for in vitro biochemical analysis. Methods. 2005 Jul;36(3):305-12.
Key words: Ribosome, Mutagenesis, Affinity purification
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16076457

10. Yuan DS, Pan X, Ooi SL, Peyser BD, Spencer FA, Irizarry RA, Boeke JD. Improved microarray methods for profiling the Yeast Knockout strain collection. Nucleic Acids Res 2005 Jul 1;33(12):e103.
Key words: TAG array, synthetic lethality, DNA microarray, Saccharomyces cerevisiae
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15994458

1. Bachman N, Gelbart ME, Tsukiyama T, Boeke JD. TFIIIB subunit Bdp1p is required for periodic integration of the Ty1 retrotransposon and targeting of Isw2p to S. cerevisiae tDNAs. Genes Dev. 2005 Apr 15;19(8):955-64.
Key words: RNA polymerase III; chromatin; integrase; retrotransposon; transcription factor; tRNA gene
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15833918

2. Chen EH, Olson EN. Unveiling the mechanisms of cell-cell fusion. Science. 2005 Apr 15;308(5720):369-73. Review.
Key words: cell fusion
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15831748

3. Chen JL, Greider CW. Functional analysis of the pseudoknot structure in human telomerase RNA. Proc Natl Acad Sci U S A. 2005 Apr 22; [Epub ahead of print]
Key words: reverse transcriptase; ribonucleoprotein; telomere
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15876367

4. Cukras AR, Green R. Multiple effects of s13 in modulating the strength of intersubunit interactions in the ribosome during translation. J Mol Biol. 2005 May 27;349(1):47-59. Epub 2005 Apr 12.
Key words: ribosome; translation; subunit interface; rpsM(S13); fidelity
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15876367

5. Domergue R, Castano I, De Las Penas A, Zupancic M, Lockatell V, Hebel JR, Johnson D, Cormack BP. Nicotinic acid limitation regulates silencing of Candida adhesins during UTI. Science. 2005 May 6;308(5723):866-70. Epub 2005 Mar 17.
Key words: nicotinic acid; Candida, urinary tract infection
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15774723

6. Gelbart ME, Bachman N, Delrow J, Boeke JD, Tsukiyama T. Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant. Genes Dev. 2005 Apr 15;19(8):942-54.
Key words: Chromatin; ATP-dependent chromatin remodeling; ISWI; genome-wide localization; retrotransposon; tRNA
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=1583391

7. Rattner A, Nathans J. The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia. J Neurosci. 2005 May 4;25(18):4540-9.
Key words: photoreceptor; retinal degeneration; retinal disease; endothelin; light damage; retinal detachment; microarray
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15872101

1. Bolton EC, Coombes C, Eby Y, Cardell M, Boeke JD. Identification and characterization of critical cis-acting sequences within the yeast Ty1 retrotransposon. RNA. 2005 Mar;11(3):308-22.
Key words: Mutagenesis, retrotransposition, reverse transcription
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15661848

2. Brannon AR, Maresca JA, Boeke JD, Basrai MA, McBride AA. Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2998-3003.
Key words: replication, yeast, segregation, bovine papillomavirus, human papillomavirus
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15710895

3. Coombes CE, Boeke JD. An evaluation of detection methods for large lariat RNAs.RNA. 2005 Mar;11(3):323-31.
Key words: Introns, Ty1, retrotransposon, lariat debranching enzyme
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15661842

1. Castano I, Pan SJ, Zupancic M, Hennequin C, Dujon B, Cormack BP. Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata. Mol Microbiol. 2005 Feb;55(4):1246-1258.
Key words: telomere, adhesions, Candida glabrata
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15686568

2. Chen J, Rattner A, Nathans J. The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes. J Neurosci. 2005 Jan 5;25(1):118-29.
Key words: retina; rod photoreceptor; gene expression; nuclear receptor; retinal disease; vision; development
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15634773

3. Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science. 2004 Dec 24;306(5705):2257-60.
Key words: Smoothened, beta-arrestin 2, GRK2
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15618519

4. Kuduvalli PN, Mitra R, Craig NL. Site-specific Tn7 transposition into the human genome. Nucleic Acids Res. 2005 Feb 08;33(3):857-63.
Key words: Tn7, human genome, transposition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15701757

5. Zhang C, Williams EH, Guo Y, Lum L, Beachy PA. Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17900-7.
Key words: Hedgehog, Smoothened, phosphorylation, pathway activation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15598741

6. Zhou L, Mitra R, Atkinson PW, Hickman AB, Dyda F, Craig NL. Transposition of hAT elements links transposable elements and V(D)J recombination. Nature. 2004 Dec 23;432(7020):995-1001.
Key words: double-strand breaks, hAT element, Hermes, hairpin, V(D)J recombination, retroviral integrase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15616554

1. Badea TC, Nathans J. Quantitative analysis of neuronal morphologies in the mouse retina visualized by using a genetically directed reporter. J Comp Neurol. 2004 Dec 20;480(4):331-51.
Key words: neuronal morphology, ganglion cell, amacrine cell, bipolar cell, horizontal cell, genetically marked cells
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids= 15558785

2. Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. 2004 Nov 18;432(7015):324-31.
Key words: Tissue repair, stem cell renewal, carcinogenesis
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15549094

3. Cochella L, Green R. Wobble during decoding: more than third-position promiscuity. Nat Struct Mol Biol. 2004 Dec;11(12):1160-2.
Key words: decoding, third-position promiscuity
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15549094

4. Cosgrove MS, Boeke JD, Wolberger C. Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol. 2004 Nov;11(11):1037-43.
Key words: Regulated nucleosome mobility, histone code
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15523479

5. Ferguson SB, Anderson ES, Harshaw RB, Thate T, Craig NL, Nelson HC. Protein kinase A regulates constitutive expression of small heat shock genes in an Msn2p/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae. Genetics. 2004 Nov 15; [Epub ahead of print]
Key words: HSF, Ras/cAMP, PKA, HSP12, HSP26
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15545649

6. Maxwell PH, Coombes C, Kenny AE, Lawler JF, Boeke JD, Curcio MJ. Ty1 mobilizes subtelomeric Y' elements in telomerase-negative Saccharomyces cerevisiae survivors. Mol Cell Biol. 2004 Nov;24(22):9887-98.
Key words: Ty1, subtelomeric Y' elements, Saccharomyces cerevisiae survivors
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15509791

7. Pan X, Yuan DS, Xiang D, Wang X, Sookhai-Mahadeo S, Bader JS, Hieter P, Spencer F, Boeke JD. A robust toolkit for functional profiling of the yeast genome. Mol Cell. 2004 Nov 5;16(3):487-96.
Key words: functional profiling, yeast genome
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15525520

1. Bachman N, Eby Y, Boeke JD. Local definition of Ty1 target preference by long terminal repeats and clustered tRNA genes. Genome Res. 2004 Jul;14(7):1232-47.
Key words: retrotransposon, genomics, hotspots, yeast, chromosomes
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15197163

2. Carroll KL, Pradhan DA, Granek JA, Clarke ND, Corden JL. Identification of cis elements directing termination of yeast nonpolyadenylated snoRNA transcripts. Mol Cell Biol. 2004 Jul;24(14):6241-52.
Key words: RNA polymerase II, snoRNA, transcription termination
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15226427

3. DeRenzo C, Seydoux G. A clean start: degradation of maternal proteins at the oocyte-to-embryo transition. Trends Cell Biol. 2004 Aug;14(8):420-6.
Key words: maternal proteins, oocyte, embryo
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15308208

4. Hao LY, Greider CW. Genomic instability in both wild-type and telomerase null MEFs. Chromosoma. 2004 Sep;113(2):62-8.
Key words: chromosome stability, telomeres, cell culture
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15258806

5. Hao LY, Strong MA, Greider CW. Phosphorylation of H2AX at short telomeres in T cells and fibroblasts. J Biol Chem. 2004 Aug 17 [Epub ahead of print]
Key words: DNA damage response, telomere dysfunction, telomerase null mouse
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15322096

6. Karhadkar SS, Bova SG, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature. 2004 Sep 12 [Epub ahead of print]
Key words: Hedgehog signalling, prostate cancer, metastasis, regeneration, cyclopamine
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15361885

7. Kulaga HM, Leitch CC, Eichers ER, Badano JL, Lesemann A, Hoskins BE, Lupski JR, Beales PL, Reed RR, Katsanis N. Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. Nat Genet. 2004 Sep;36(9):994-8. Epub 2004 Aug 22
Key words: Bardet-Biedl syndrome, olfaction, ciliogenesis
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15322545

8. Rattner A, Chen J, Nathans J. Proteolytic shedding of the extracellular domain of photoreceptor cadherin: implications for outer segment assembly. J Biol Chem. 2004 Jul 28 [Epub ahead of print]
Key words: retina, outer segment, proteolysis, photoreceptor
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15284225

9. Ronning DR, Li Y, Perez ZN, Ross PD, Hickman AB, Craig NL, Dyda F. The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA. EMBO J. 2004 Aug 4;23(15):2972-81.
Key words: differential scanning calorimetry, protein–protein complex, Tn7 transposition, X-ray crystallography
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15257292

10. Seydoux G. Surfing the actomyosin wave; polarization of the C. elegans zygote. Dev Cell. 2004 Sep;7(3):285-6.
Key words: actomyosin, C. elegans zygote
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15363402

1. Bennett MK, Reed RR. Silence sets on a sensory map. Neuron. 2004 May 27;42(4):521-2.
Key words: olfaction, spontaneous activity, sensory map
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15157412

2. Guo N, Hawkins C, Nathans J. Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci U S A. 2004 May 28 [Epub ahead of print]
Key words: frizzled6, hair patterning, mice
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15169958

3. Han JS, Boeke JD. A highly active synthetic mammalian retrotransposon. Nature. 2004 May 20;429(6989):314-8.
Key words: synthetic, mammals, retrotrsnposon
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15152256

4. Han JS, Szak ST, Boeke JD. Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Nature. 2004 May 20;429(6989):268-74.
Key words: L1 retrotransposon, mammalian transcriptomes

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15152245

5. Kaur R, Castano I, Cormack BP. Functional genomic analysis of fluconazole susceptibility in the pathogenic yeast Candida glabrata: roles of calcium signaling and mitochondria. Antimicrob Agents Chemother. 2004 May;48(5):1600-13.
Key words: fluconazole, Candida glabrata, calciium signaling, mitochondria
http://www.ncbi.nlm.nih.gov/entrez/q
uery.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15105111

6. Mann RK, Beachy PA. Novel lipid modifications of secreted protein signals. Annu Rev Biochem. 2004;73:891-923.
Key words: Hedgehog proteins, cholesterol, autoproteolysis, Wnt proteins, protein acylation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15189162

7. Youngman EM, Brunelle JL, Kochaniak AB, Green R. The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release. Cell. 2004 May 28;117(5):589-99.
Key words: ribosome; peptidyl transferase; peptide release; catalysis; mechanism
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15163407

1. Luo W, Williams J, Smallwood PM, Touchman JW, Roman LM, Nathans J. Proximal and distal sequences control UV cone pigment gene expression in transgenic zebrafish. J Biol Chem. 2004 Apr 30;279(18):19286-93.
Key words: rhodopsin promotor, UV cone expression
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=14966125

1. Avalos JL, Boeke JD, Wolberger C. Structural basis for the mechanism and regulation of Sir2 enzymes. Mol Cell. 2004 Mar 12;13(5):639-48.
Key words: Sir2 proteins; deacetylation; nicotinamide inhibition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15023335

2. Berman DM, Desai N, Wang X, Karhadkar SS, Reynon M, Abate-Shen C, Beachy PA, Shen MM. Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol. 2004 Mar 15;267(2):387-98.
Key words: Hedgehog; endoderm; organogenesis; ductal morphogenesis; tissue recombination; androgens
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15013801

3. Chen JL, Greider CW. Telomerase RNA structure and function: implications for dyskeratosis congenita. Trends Biochem Sci. 2004 Apr;29(4):183-92.
Key words: telomerase, RNA, dyskeratosis congenita
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15082312

4. Cochella L, Green R. Isolation of antibiotic resistance mutations in the rRNA by using an in vitro selection system. Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3786-91. Epub 2004 Mar 04.
Key words: antibiotic resistance, rRNA
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15001709

5. Cormack B. Can you adhere me now? Good. Cell. 2004 Feb 6;116(3):353-4. Review.
Key words: Saccharomyces cerevisiae, epigenetics, yeast cells
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15016368

6. Danoff SK, Taylor HE, Blackshaw S, Desiderio S. TFII-I, a candidate gene for Williams syndrome cognitive profile: parallels between regional expression in mouse brain and human phenotype. Neuroscience. 2004;123(4):931-8.
Key words: Williams syndrome; Purkinje cell; hippocampus; TFII-IRD1; Rubinstein-Taybi syndrome; BAP
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=14751286

7. Luo W, Marsh-Armstrong N, Rattner A, Nathans J. An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase. J Neurosci. 2004 Mar 17;24(11):2623-32.
Key words: outer segment; protein sorting; photoreceptor; palmitoylation; retinol dehydrogenase; inner segment; transgenic Xenopus
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15028754

8. Luo W, Williams J, Smallwood PM, Touchman JW, Roman LM, Nathans J. Proximal and distal sequences control UV cone pigment gene expression in transgenic zebrafish. J Biol Chem. 2004 Feb 13 [Epub ahead of print]
Key words: gene expression, transgenics, zebrafish, UV cone pigment
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=14966125

9. Reed RR. After the holy grail: establishing a molecular basis for Mammalian olfaction. Cell. 2004 Jan 23;116(2):329-36. Review.
Key words: olfaction; mammals
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=14744441

10. Starai VJ, Takahashi H, Boeke JD, Escalante-Semerena JC. A link between transcription and intermediary metabolism: a role for Sir2 in the control of acetyl-coenzyme A synthetase. Curr Opin Microbiol. 2004 Apr;7(2):115-9.
Key words: transcription, metabolism, Sir2 protein, acetyl-coenzyme A synthetase
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15063846

11. Wang SS, Lewcock JW, Feinstein P, Mombaerts P, Reed RR. Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection. Development. 2004 Mar;131(6):1377-88.
Key words: olfactory, axon targeting, transcription factor
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=14993187

12. Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell. 2004 Mar 19;116(6):883-95.
Key words: retina, inner ear, ligand-receptor, Norrin, Frizzled
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15035989

1. Chen JL, Greider CW. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross species incompatability. Embo J. 22, 304-14.
Key words: Telomerase activity, processivity, RNA structure, dyskeratosis congenita, telomere

2. Frieman MB, Cormack BP. The omega-site sequence of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae can determine distribution between the membrane and the cell wall. Mol Microbiol. 2003 Nov;50(3):883-96.
Key words: Candida, pathogen, gpi, cell wall, adhesin