Associate Professor of Surgery
Director of Clinical Research
Johns Hopkins Department of Surgery
720 Rutland Ave, Ross 771
Baltimore, MD 21205
Phone: (410) 502-6115
Fax: (410) 614-7649
Medical appointments: (410) 614-3874
Dr. Segev is an abdominal transplant surgeon and the Director of Clinical Research for the Transplant Surgery division. His clinical focus is minimally invasive live donor surgery and incompatible organ transplantation. His research utilizes advanced statistical methods for mathematical modeling and simulation of medical data, analysis of large healthcare datasets, and outcomes research.
He has made numerous significant contributions to the field of transplantation including development of a mathematical model to facilitate a nationwide Kidney Paired Donation program in both the United States and in Canada. Dr. Segev is an NIH Clinical Research Scholar, an American Geriatrics Society Dennis Jahnigen Scholar, an invited member of the United Network for Organ Sharing Kidney Committee, and a Doris Duke Clinical Scientist Development Award recipient for his groundbreaking work in clinical decision-making for patients over 65 with renal failure.
Dr. Segev has authored more than 60 articles, and is regularly invited to review articles for journals such as New England Journal of Medicine, JAMA, American Journal of Transplantation, Annals of Surgery, Journal of the American Society of Nephrology, Annals of Internal Medicine, and others. His work has been featured in TIME magazine, Reader's Digest, the Discovery Channel, US News & World Report, and the New York Times.
Education and Training:
- B.A., Computer Science, Rice University (1988-1992)
- M.D., Johns Hopkins University (1992-1996)
- Surgical Residency, Johns Hopkins University (1996-2004)
- Research Fellow, Harvard University / Massachusetts General Hospital (1998-2001)
- Transplant Surgery Fellow, Johns Hopkins University (2004-2006)
- M.H.S. Biostatistics, Johns Hopkins University (2006-2008)
Ph.D. Clinical Investigaiton, Johns Hopkins University (2006-2009)
Clinical Interests
- Incompatible organ transplantation
- Kidney and liver transplantation
- Minimally invasive live donor surgery
Research Interests
- ABO Incompatible Transplantation
- Clinical decision-making in older patients with renal failure
- Kidney Paired Donation
- Mathematical modeling and optimization
- Allocation of non-directed donors
- Donor - recipient matching
- Expanding utilization of expanded criteria organs
- Gender disparities in transplantation
- Organ preservation solutions
- Decision-making algorithms for high infectious risk donors
Selected Honors:
- Fellowship Award, American Society of Transplant Surgeons, 2004
- Vanguard Prize, American Society of Transplant Surgeons, 2006
- Clinical Science Faculty Development Award, American Society of Transplantation, 2006
- Science of Hope Medicine Compassion Award, Johns Hopkins Transplant Center, 2006
- Dennis W Jahnigen Scholars Award, American Geriatrics Society, 2007
- Clinical Scientist Development Award, Doris Duke Charitable Foundation
Selected Publications:
Segev, DL, Gentry SE, Warren DS, Reeb B, Montgomery RA. Kidney Paired Donation and optimizing the use of live donor organs. JAMA. 2005 Apr 20; 293 (15) 1883-90.
Gentry SE, Segev DL, Montgomery RA. A comparison of populations served by Kidney Paired Donation and List Paired Donation. Am J Transplant. 2005 Aug; 5(8): 1914-21
Segev DL, Simpkins CE, Warren DS, King KE, Maley WR, Melancon JK, Cooper M, Kozlowski T, Montgomery RA. ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment. Am J 2005 Oct;5(10):2570-75.
Segev DL, Gentry SE, Melancon JK, Montgomery RA. Characterization of waiting times in a simulation of kidney paired donation. Am J Transplant. 2005 Oct; 5(10):2448-55.
Montgomery RA, Zachary AA, Ratner LE, Segev DL, Hiller JM, Houp J, Cooper M, Kavoussi L, Jarrett T, Burdick J, Maley WR, Melancon JK, Kozlowski T, Simpkins CE, Phillips M, Desai A, Collins V, Reeb B, Kraus E, Rabb H, Leffell MS, Warren DS. Kidney Paired Donation permits successful transplantation with incompatible live kidney donors. JAMA. 2005 Oct 5;294(13):1655-63.
Montgomery RA, Gentry SE, Marks WH, Warren DS, Hiller J, Houp J, Zachary AA, Melancon JK, Maley WR, Rabb H, Simpkins CE, Segev DL. Domino paired kidney donation: a strategy to make best use of live non-directed donation. Lancet. 2006 Jul 29;368:419-21.
Simpkins CE, Montgomery RA, Hawxby AM, Gentry SE, Locke JE, Warren DS, Segev DL. The Effect of Cold Ischemic Time on Live Donor Renal Transplantation: Is Organ Transport Feasible for Live Donors? Am J Transplant. 2006.
Segev DL, Gentry SE, Montgomery RA. Association between waiting times for deceased donor kidney transplantation and rates of live donation. Am J Transplant. 2007 Oct;7(10):2406-13.
Gentry SE, Segev DL, Simmerling M, Montgomery RA. Expanding kidney paired donation through voluntary participation by compatible donors. Am J Transplant. 2007 Oct;7(10):2361-70.
Segev DL, Maley WR, Simpkins CE, Locke JE, Montgomery RA, Nguyen GC, Thuluvath P. Minimizing risk associated with elderly liver donors by matching to preferred recipients. Hepatology. 2007 Dec;46(6):1907-18.
Segev DL, Simpkins CE, Thompson RE, Locke JE, Warren DS, Montgomery RA. Obesity impacts access to kidney transplantation. J Am Soc Nephrology. 2008 Feb;19(2):349-55.
Segev DL, Kucirka LM, Nguyen GC, Cameron AM, Locke JE, Simpkins CE, Thuluvath PJ, Montgomery RA, Maley WR. Effect modification in liver allografts with prolonged cold ischemic time. Am J Transplant. 2008 Mar;8(3):658-66.
Segev DL, Sozio S, Shin EJ, Nazarian SM, Nathan H, Thuluvath PJ, Cameron AM, Montgomery RA, Maley WR. Steroid avoidance in liver transplantation: meta-analysis and meta-regression of randomized trials. Liver Transplantation. 2008 Apr;14(4):512-25.
Segev DL, Montgomery RA. Regional and Racial Disparities in the Use of Live Non-Directed Kidney Donors. Am J Transplant. 2008 May;8(5):1051-5.
Segev DL, Kucirka LM, Gentry SE, Montgomery RA. Current practice of kidney paired donation in the United States. Transplantation. 2008 Aug 27;86(4):502-10.
Montgomery RA, Katznelson S, Bry WI, Zachary AA, Houp J, Hiller JM, Shridharani S, John D, Singer AL, Segev DL. Successful three-way kidney paired donation with cross-country live donor organ transport. Am J Transplant. 2008 Oct;8(10):2163-8.
Segev DL, Thompson RE, Locke JE, Simpkins CE, Thuluvath PJ, Montgomery RA, Maley WR. Prolonged waiting times for liver transplantation in obese patients. Ann Surg. 2008 Nov;248(5):863-870.
Stewart ZA, Cameron AM, Signer AL, Dagher NN, Montgomery RA, Segev DL. Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in pancreas transplantation. Am J Transplant. 2009 Jan;9(1):217-221.
Locke JE, Montgomery RA, Warren DS, Segev DL. Renal transplantation in HIV-positive recipients: long-term outcomes and risk factors for graft loss. Arch Surg. 2009 Jan;144(1):83-86.
Stewart ZA, Cameron AM, Signer AL, Montgomery RA, Segev DL. Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in deceased donor livers, especially those donated after cardiac death. Am J Transplant. 2009 Feb;9(2):286-293.
Kucirka LM, Alexander C, Namuyinga R, Hanrahan C, Montgomery RA, Segev DL. Viral nucleic acid testing (NAT) and OPO-level disposition of CDC high-risk donor organs. Am J Transplant. 2009 Mar;9(3):620-8.
Kucirka LM, Namuyinga R, Hanrahan C, Montgomery RA, Segev DL. Formal policies and special informed consent are associated with higher provider utilization of CDC high-risk donor organs. Am J Transplant. 2009 Mar;9(3):629-35.
Lonze BE, Warren DS, Shah A, Stewart ZA, Dagher NN, Singer AL, Montgomery RA, Segev DL. Kidney transplantation in previous heart or lung recipients. Am J Transplant. 2008 Mar;9(3):578-85.
Segev DL, Kucirka LM, Oberai PC, Parekh RS, Boulware LE, Powe NR, Montgomery RA. Age and comorbidities are effect modifiers of gender disparities in renal transplantation. J Am Soc Nephrology. 2009 Mar;20(3):621-8.
Rees MA, Jopke JE, Pelletier RP, Segev DL, Rutter ME, Fabrega AJ, Rogers J, Pankewycz OG, Hiller J, Roth AE, Sandholm T, Unver U, Montgomery RA. A non-simultaneous extended altruistic donor chain. NEJM. 2009 Mar 12;360(11):1096-101.
To reach this faculty member for an interview or comment, media are invited to contact:
Stephanie Desmon, Media Relations Staff Member at (410) 955-8665.
