Jim Mahoney, Ph.D.

Assistant Professor of Medicine

• Ph.D.: The Johns Hopkins University School of Medicine, Department of Pharmacology
• Post-doctoral Fellowship: The Johns Hopkins University, School of Medicine, Rheumatology; University of Oxford, Sir William Dunn School of Pathology

Dr. Mahoney’s research interests involve the control of cellular functions by proteases.  As a member of Dr. Antony Rosen’s group, he studies the roles of the protein UFD2 in development and disease states.  UFD2 is a human autoantigen cleaved by caspases and granzyme B during apoptosis, and is a member of a family of proteins implicated in ubiquitination, the dominant mechanism for disposal of damaged proteins and for regulation of proteins critical for the cell cycle.  Dr. Mahoney is also studying whether aberrant glycosylation may, in some cases, be a trigger for autoimmune disease.  He is the Manager of the Rheumatology Bioassay Core Program, which affords clinical researchers opportunities to collaborate with basic scientists on questions relevant to human disease. 

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