Shukti Chakravarti Lab

  • The Shukti Chakravarti Lab studies the regulation of cellular functions and tissue homeostasis by the extracellular matrix (ECM). We investigate functions of collagen-associated extracellular matrix proteins and proteoglycans, lumican, fibromodulin and biglycan in maintaining connective tissue architecture and cellular functions. Lumican regulates collagen fibril structure such that gene-targeted mice that are deficient in lumican manifest Ehlers-Danlos Syndrome-like skin fragility, tendon weaknesses and corneal opacity. Our investigation of the ECM centers on two barrier tissues, the cornea of the eye and the intestinal mucosa and submucosa.

    Research Areas: inflammatory bowel disease, extracellular matrix, biochemistry, cell biology

    Lab Website

    Principal Investigator

    Shukti Chakravarti, M.S., Ph.D.

    Department

    Medicine