Mehboob Hussain Laboratory

  • The Mehboob Hussain Laboratory studies diabetes mellitus and pancreatic beta-cell biology. We are trying to better understand the pancreatic beta-cell biology and its relevance for the treatment of diabetes mellitus. Our work focuses on the differentiation and regeneration of pancreatic endocrine cells from progenitor/stem cells. We use in vitro cell culture and in vivo animal models to elucidate the molecular mechanisms differentiation of stem cells. We also use these techniques to identify the extra- and intracellular signals and transcription factors that regulate differentiation pathways of stem cells. A second line of investigation addresses the role of intracellular signals in the function and proliferation of insulin-producing pancreatic beta cells.

    Research Areas: stem cells, pancreatic beta cell, insulin, diabetes, progenitor cells

    Lab Website

    Principal Investigator

    Mehboob Hussain, M.D.

    Department

    Pediatrics