Kelly Metcalf Pate Lab

  • The Kelly Metcalf Pate Lab focuses on the role of platelets in the innate immune response to viral infection, and how modulating the response of platelets to infection alters the course of disease. Platelets are known to participate in innate immunity through cytokine signaling and direct interactions with other cells, and the platelet has the potential to significantly influence disease outcomes. However, platelet immunology is still a relatively new discipline, and the downstream effects of platelet interactions with other immune cells have yet to be determined in the context of viral infection. Current research in our lab aims to further characterize the platelet-monocyte interaction during acute viral infection with the goals of establishing methods of pharmacologically manipulating this association, and establishing how platelet binding to a monocyte influences the monocyte's susceptibility to lentiviral infection and the monocyte's interactions with endothelium. Additionally, we are interested in the effect of physiologic stress on the platelet's future immune response to infection, and in the development and optimization of novel in vitro systems that better model in vivo conditions.

    Research Areas: immunology, platelets, viral infection, pharmacology