Andrew Wolfe Laboratory

  • The Andrew Wolfe Laboratory researches the development and functional regulation of the hypothalamic-pituitary-gonadal axis which controls reproduction. We have had a long-standing interest in the regulation of GnRH gene expression. In addition to performing standard in vitro analysis, we have developed a variety of transgenic and knock-out mouse models that have revealed both cis- and trans-regulatory elements underlying the cell-specific expression of GnRH. Our laboratory is also interested in understanding how metabolic status impacts reproductive function. We've developed a mouse model of obesity-induced infertility. Used in conjunction with mouse models of tissue-specific gene deletion, we are able to probe the role of various molecular signals mediating the effects of obesity on reproductive function.

    Research Areas: reproduction, obesity, genomics, fertility, mouse models

    Principal Investigator

    Andrew Wolfe, Ph.D.

    Department

    Pediatrics