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OMIM Turns 50: A Genetic Database’s Past, Present, and Future

Published in 1966, the Mendelian Inheritance in Man (MIM) catalog consisted of 1,487 descriptions of human genes, genetic disorders and traits compiled by Victor McKusick. Fifty years later, and now online, OMIM of more than 24,000 entries and accessed thousands of times every day by clinicians, researchers and others around the world.

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Ubiquitin Signals

Cynthia Wolberger’s team studies how a protein called ubiquitin switches genes on and off or notifies the cell about DNA damage.  Studying this protein might help scientists to develop new drugs for certain types of cancer that currently have no effective treatment.

Jody Tversky on a New Method to Analyze Skin Testing for Allergies

Jody Tversky, MD is Assistant Professor and former Clinical Director of the Division of Allergy and Clinical Immunology. Here he discusses what scotch tape and drones have to do with allergy testing.

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Highlights

Engineering mosquitoes that block dengue

Researchers have succeeded in producing a mosquito in the lab that, while not quite dengue-proof, is significantly more disease-resistant.

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Removing old cells could prevent joint degradation after injury

Getting rid of senescent cells from the joint not only reduces the development of osteoarthritis, but creates an environment for new cartilage to grow and repair joints. 

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Ensuring biomedical research remains trustworthy and transparent

Hopkins' program expands education for investigators and creates a better system for storing and sharing primary data. 

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brain erasing

"Memory protein" is another culprit in Alzheimer's disease

Low levels of a specific protein in the brains of people with Alzheimer's disease changes the communication among neurons that leads to learning and memory loss in this disease. 
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Revolutionary Prosthetics

A program helps amputees regain a sense of touch through a mind-controlled prosthetic robotic arm.

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